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Author Topic: Experimental vaccine elicits robust response against both HIV and TB  (Read 1073 times)

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Offline Cosmicdancer

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An experimental vaccine in China, tested in mice, elicited a strong immune response against HIV and TB.  It doesn't say whether the mice had "humanized immune systems" or were challenged with HIV to see if the vaccine prevented infection.  More details would have been nice.  This article also doesn't say how quickly this experimental vaccine research in China will start testing in humans, but I assume they have a different protocol there. 

http://www.sciencedaily.com/releases/2012/05/120521152645.htm

Experimental Vaccine Elicits Robust Response Against Both HIV and Tuberculosis, Study Suggests

ScienceDaily (May 21, 2012) Clinician researchers in China have developed a vaccine that acts simultaneously against HIV-1 and M. tuberculosis (Mtb). An estimated 14 million people worldwide are coinfected with the two pathogens. The research is published in the May 2012 issue of Clinical and Vaccine Immunology.

The vaccine is composed of antigens from both pathogens. The team, led by Sidong Xiong of Fudan University, Shanghai, incorporated four Mtb epitopes (the part of an antigen that is recognized by the immune system) into a backbone composed of HIV-1 p24 protein, a protein that is known to produce protective immunity against HIV-1. The logic of this construction: many epitopes are short peptides, with poor immunogenicity unless they are introduced into a carrier protein -- which in this case was the p24 protein.

The vaccine induced cellular immune responses to both pathogens, in which immune system cells including macrophages search out and destroy pathogens; and humoral immune response against HIV-1, in which the immune system produces antibodies against the pathogen. The vaccine was tested in a mouse model.

Tuberculosis is one of the leading causes of death worldwide; third, after hepatitis C and then HIV/AIDS among infectious diseases, according to the World Health Organization (WHO). An estimated 2 billion -- 28 percent of the world's population -- are infected with M. tuberculosis, but most of these infections are latent.
However, HIV infection is the strongest risk factor for the progression of latent tuberculosis infection to active TB. And TB is the direct cause of death in about one quarter of all deaths among people with HIV/AIDS, according to the WHO.
Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
June, 2008 - undetectable, 612 cd4
January, 2009 - undetectable, 670 cd4
May, 2009 - undetectable, 593 cd4
Sept, 2009 - 83 vl, 763 cd4, 34%
Dec, 2009 - undetectable, 889 cd4, 32%
April, 2010 - undetectable, 860 cd4, 31%
October, 2010 - undetectable, 800 cd4, 38%
April, 2011 - undetectable, t-cell test not done
October, 2011 - undetectable
April, 2012 - undetectable, 850 cd4, 39%
November, 2012 - undetectable, 901 cd4, 41%
April, 2013 - undetectable, 846 cd4, 36%
October, 2013 - undetectable
May, 2014 - undetectable, 784 cd4, 48%

 


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