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Author Topic: First time meds : Complera + Isentress  (Read 1878 times)

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Offline 2manyquestions

  • Member
  • Posts: 18
First time meds : Complera + Isentress
« on: April 21, 2012, 01:16:26 PM »
Hi everyone, I was diagnosed about 6 months back, now I have a bottle of Complera and Isentress, ready to start meds for the first time.  Not sure what to expect but I couldn't find much info on using these two (or really four) meds together, anyone else tried this?

My doc said to use them at the same time and once my high viral load goes down (last at 300k), I would just use the complera.

Just a little nervous getting started, especially since I can't find any info on them being used together, does this seem OK?
« Last Edit: April 21, 2012, 01:30:50 PM by 2manyquestions »

Offline wylidas

  • Member
  • Posts: 85
  • Trying to love this life, since it's all we got.
Re: First time meds : Complera + Isentress
« Reply #1 on: April 21, 2012, 02:04:13 PM »
Your doc most likely wants to get your VL below 100,000 to do just the Complera, since COmplera is not recommended for new patients with viral loads over 100k.
The studies showed that you may be less likely to remain undetectable with Complera alone if your VL is over 100k. So it sounds like your doc is trying to double up on regimens to get it under control.

But that being said, I am not so sure I would take all those together. Isentress is an integrase inhibitor and Complera contains Edurant which is another new integrase inhibitor approved last year. Taking them both together seems strange to me. I'd check with another doc or a pharmacist before taking. It would seem to make more sense for your doctor to try Truvada + Isentress first by itself then once your VL is lower, then maybe switch you to Complera. But I am no doctor, so I'd get a few opinions before starting this regimen.
Diagnosed + in 2006.
Atripla in 2006 (Bad dreams, nervous system reaction after a few weeks. Discontinued.)
Epzicom/Reyataz/Norvir October 2007 - February 2012 (anxiety and elevated BP primary s/x)
UD VL <30
CD4 - fluctuates between 250 - 500 with 25%+
Discontinued meds in February 2012 (due to adherence issues after detoxing from Ativan)
March 2012 - CD4 296, VL 120
4/22/2012 - Started Complera
5/1/2012 - Discontinued Complera, began monitored drug holiday
7/3/2012 - VL 55,000; CD4 211 - started Bactrim
8/5/2012 - Began Truvada + Isentress

Offline newt

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  • Posts: 3,887
  • the one and original newt
Re: First time meds : Complera + Isentress
« Reply #2 on: April 21, 2012, 02:13:47 PM »
Edurant is a non–nucleoside reverse transcriptase inhibitor (NNRTI).

There are no interactions to speak of with this combo. Isentress + Truvada alone should reduce your viral load real quick, then you can if you like switch to 1 x day Edurant + Truvada ie Complera. But you can take the whole caboodle together to start with if you like.

As wylidas says, your viral load needs to be below 100k before Complera alone is a viable option.

- matt
"The object is to be a well patient, not a good patient"

Offline wylidas

  • Member
  • Posts: 85
  • Trying to love this life, since it's all we got.
Re: First time meds : Complera + Isentress
« Reply #3 on: April 21, 2012, 02:40:32 PM »
Newt is right. Thanks for the correction. Edurant is more like a 2nd generation Intelence. I guess there would be no harm in taking them together, I just have never heard of doing this from any doctor before, and my theory is the fewer meds the better as less side effects and less chance for interactions.

To the OP, I would talk about it with your doctor and do what feels right for you.
Diagnosed + in 2006.
Atripla in 2006 (Bad dreams, nervous system reaction after a few weeks. Discontinued.)
Epzicom/Reyataz/Norvir October 2007 - February 2012 (anxiety and elevated BP primary s/x)
UD VL <30
CD4 - fluctuates between 250 - 500 with 25%+
Discontinued meds in February 2012 (due to adherence issues after detoxing from Ativan)
March 2012 - CD4 296, VL 120
4/22/2012 - Started Complera
5/1/2012 - Discontinued Complera, began monitored drug holiday
7/3/2012 - VL 55,000; CD4 211 - started Bactrim
8/5/2012 - Began Truvada + Isentress

Offline Cojo

  • Member
  • Posts: 201
Re: First time meds : Complera + Isentress
« Reply #4 on: April 21, 2012, 09:33:28 PM »
I have taken Isentress and Truvada (two of the three drugs in Complera) and never had a side effect after the first 24 hours. I am sure your quad combo will beat the sh%t out of the bug in no time to undetectable.
May 2011 - Tested Positive
June 2011 - CD4 330   16%   VL182,000 no resistance
Oct 6, 2011 - CD4 300  20%  VL 60,000
Oct 7, 2011 - start Truvada / Isentress
Nov 29, 2011 CD4 280 26% VL 54
Feb 7 2012 CD4 260 25% UD!
Mar 20 2012 CD4 400 28%
June 2012 CD4 330 26% UD
Sept 2012 CD4 450 32% UD
Dec 2012 CD4 310 28% UD
May 2013 CD4 500 32% UD
Oct 2013 CD4 460 33% UD
May 2014 CD4 360 33% UD
Aug 2014 swap out Isentress for Tivicay
Oct 2014 CD4 320 33% UD

Offline 2manyquestions

  • Member
  • Posts: 18
Re: First time meds : Complera + Isentress
« Reply #5 on: April 26, 2012, 09:37:42 PM »
Thanks everyone, I started these meds 5 days ago... so far just the standard side effects : insomnia, nausea, diarrhea, tired, etc. I don't feel great but I didn't feel great before I began either... with my VL at 370K and CD4 at 271, I suppose that's no surprise.  I just really hope this does the trick.

I'll keep posting to let everyone know how this combo works.

« Last Edit: April 26, 2012, 09:40:56 PM by 2manyquestions »

Offline Hellraiser

  • Member
  • Posts: 4,143
  • Semi-misanthropic
Re: First time meds : Complera + Isentress
« Reply #6 on: April 27, 2012, 08:40:07 PM »
Nevermind.

Offline 2manyquestions

  • Member
  • Posts: 18
Re: First time meds : Complera + Isentress
« Reply #7 on: June 05, 2012, 02:28:41 AM »
I am sure your quad combo will beat the sh%t out of the bug in no time to undetectable.

You weren't kidding... 4 1/2 weeks and VL was reduced to only 1K (from 370K), CD4 up slightly and ratio up quite a bit. 

I felt physically better in about 10 days.  Everything is still slowly improving.  I'm starting to feel like myself again.

 I would recommend it thus far, it's doing what it's supposed to be doing (albeit with some minor side effects).  Still having trouble with sleep and body aches.
« Last Edit: June 05, 2012, 02:32:12 AM by 2manyquestions »

 


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