Meds, Mind, Body & Benefits > Questions About Treatment & Side Effects

The right combo?

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Maestro:
I was looking at this page
http://www.aidsmeds.com/lessons/WhenToStart7.htm

and I notice my Uncle is on Kaletra, Invarase, and Ziagen.  He is on nothing from Column B.  Is this common?

Thanks
M

newt:
The rule of thumb is at least THREE DRUGS from TWO different classes, so this combo counts on that front.

However, first-line combo is typically 2 nukes (on the AIDSMEDS table, column B + column C) plus EITHER a non-nuke or PI (column A).  You might ask why he's on two PIs + 1 nuke, there could be a good reason, like resistance, or something else not med-related, but related to his current clinical picture.

This said, the mix of drugs he's on, it's a strong & good combo.

- matt

newt:
ADDED SAT 30 SEP - the combo choice may be because of his kidney function, I see from another of your posts that his creatine is v high - of the column C drugs, Viread will be hard on his kidneys, and others may not be good for his lactic acid levels, which is a closely related matter.

- matt

Maestro:
Matt,

Once someone has trouble with Viread due to Kidneys, is this the beginning of drugs not working as well?  Or is it unrelated?  He was on Viread for almost 7 years with no problems at all..Then all of the sudden..wham.

Maestro

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