Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
July 24, 2014, 02:06:56 PM

Login with username, password and session length


Members
Stats
  • Total Posts: 631745
  • Total Topics: 47828
  • Online Today: 266
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online
Users: 7
Guests: 215
Total: 222

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: HIV prevalence in blood only 2-4%?  (Read 930 times)

0 Members and 1 Guest are viewing this topic.

Offline Common_ground

  • Member
  • Posts: 288
HIV prevalence in blood only 2-4%?
« on: July 01, 2012, 01:39:08 AM »
Ive been reading about the amount of HIV in the bloodstream which to me seems just to be a small part, so then how do docs and scientists knows if the meds are
really working by just being able to look at the blood? Is there are facts on "how much" HIV the meds are being able to surpress/delete from the body?

2011 May - Neg.
2012 June CD4:205, 16% VL:2676 Start Truvada/Stocrin
2012 July  CD4:234, 18% VL:88
2012 Sep  CD4:238, 17% VL:UD
2013 Feb  CD4:257, 24% VL:UD -viramune/truvada
2013 May CD4:276, 26% VL:UD

Offline newt

  • Member
  • Posts: 3,877
  • the one and original newt
Re: HIV prevalence in blood only 2-4%?
« Reply #1 on: July 01, 2012, 10:31:33 AM »
Quote
how do docs and scientists knows if the meds are
really working by just being able to look at the blood

An important question.

Blood tests are convenient for doctors and patients and therefore used for lots of things medical. Much effort goes into making sure they are reliable and reflect what they are trying to measure.

You can test HIV in other parts of the body, for example spinal cord fluid, genitals, gut, but the tests are inconvenient and sometimes carry risks (biopsy, spinal tap anyone?).

There's lots of research on viral load in the gentials and central nervous system, and these show that viral load in the blood and other parts of the body are the same after a few months of treatment (there are sometimes modest but usually unimportant variations).

I'd post some links to the research but have to go pick the broad beans, maybe if people want these will do so when I'm back from the fields.

- matt
"The object is to be a well patient, not a good patient"

Offline Common_ground

  • Member
  • Posts: 288
Re: HIV prevalence in blood only 2-4%?
« Reply #2 on: July 01, 2012, 11:54:11 AM »
I was hoping to get an answer from you Newt. :)

If you find the time, please post some links, thx.

The question originally came up when I read up on the "blood brain barrier" thing and meds able to cross that barrier. Made me think of choosing another regimen than Atripla even thou getting UD. Any thoughts?
2011 May - Neg.
2012 June CD4:205, 16% VL:2676 Start Truvada/Stocrin
2012 July  CD4:234, 18% VL:88
2012 Sep  CD4:238, 17% VL:UD
2013 Feb  CD4:257, 24% VL:UD -viramune/truvada
2013 May CD4:276, 26% VL:UD

Offline eric48

  • Member
  • Posts: 1,112
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
Re: HIV prevalence in blood only 2-4%?
« Reply #3 on: July 01, 2012, 07:10:59 PM »
Current CNS Penetration-Effectiveness (CPE) 2010 ranking

can be found here
http://www.natap.org/2011/CROI/croi_139.htm

(you will have to scroll down)

Atripla has a score of 7 (which is not bad).

hope this is what you where looking for

Eric

PS :
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227164/

is good reading too...
« Last Edit: July 01, 2012, 07:22:06 PM by eric48 »

Offline newt

  • Member
  • Posts: 3,877
  • the one and original newt
Re: HIV prevalence in blood only 2-4%?
« Reply #4 on: July 02, 2012, 04:23:18 PM »
Overview from a lay perspective of the topic in general (not a study).

http://i-base.info/ttfa/section-2/211-compartments-and-sanctuary-sites

While many studies show in some populations HIV viral load is 1 log higher in the genitals this still is probably not important (esp given the error or margin on viral load tests is 1 log), eg in gay men (v up to date this article and one of many and also shows importance of other things on localised viral load eg inflammatory infection in your gentials):

http://journals.lww.com/aidsonline/Abstract/publishahead/Highly_active_antiretroviral_therapy_does_not.98952.aspx


Also on this topic is a news item from a while ago on this topic from AIDSMEDS (or course it helps if you are on treatment and take your pills)

http://www.aidsmeds.com/articles/hiv_semen_transmission_1667_22190.shtml


This shows lower viral load in the genital tract. I include this link just to how the story is not clear cut:

http://jcm.asm.org/content/38/4/1414.full


This is a biggie for me, cos viral load relates to transmission and here low blood viral load = low/0 transmission (or thereabouts), therefore low blood viral load = low viral load elsewhere:

http://journals.lww.com/aidsonline/Fulltext/2009/07170/Sexual_transmission_of_HIV_according_to_viral_load.13.aspx

The whole blood/brain barrier penetration thing being important is unproven, in the short term yes, perhaps, but I personally think it;s the length of therapy that counts here.

- matt
"The object is to be a well patient, not a good patient"

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.