Quantcast

Subscribe to:
POZ magazine
Newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr Instagram
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
October 21, 2014, 06:43:45 AM

Login with username, password and session length


Members
Stats
  • Total Posts: 642851
  • Total Topics: 48904
  • Online Today: 221
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online
Users: 3
Guests: 135
Total: 138

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Lyrica (pregabalin) No Good For Diabetes Or HIV Associated Neuropathic Pain  (Read 1048 times)

0 Members and 1 Guest are viewing this topic.

Offline J.R.E.

  • Member
  • Posts: 7,213
  • Joined Dec-2003 Living positive, since 1985.


http://www.medicalnewstoday.com/articles/245032.php


Lyrica (pregabalin) failed in two separate human trials to reduce neuropathic pain linked to diabetes or HIV, said makers Pfizer today. One of the trials - Phase III HIV neuropathy - was stopped early because no benefits were found in an interim analysis on 246 patients out of a planned 416.

The other study, also a placebo-controlled Phase III trial, involving 665 individuals, looked at Lyrica for peripheral diabetic neuropathy (second-line therapy). Other treatments had been ineffective.

The participants were switched to pregabalin (single-blind) for a period of six, and then randomly selected to be administered either more pregabalin or placebo for a further 13 weeks (double blind).

The patients on pregabalin did improve from baseline to the end of the trial period. However, there was not a significant difference when compared to the placebo - on a standard 10-point scale the difference was 3.9 versus 3.5.

Pregabalin is approved as first-line treatment for diabetic neuropathy, fibromyalgia, partial onset seizures, and postherpetic neuralgia.

Steven J. Romano, M.D., senior vice president, Head, Medicines Development Group, Global Primary Care Business Unit, Pfizer Inc., said:

    "The results of this study show the complexities of studying pain, particularly in a difficult-to-treat condition such as neuropathic pain associated with HIV neuropathy for which there are no approved medications in the United States.

    The study of Lyrica for this condition is an example of Pfizer's dedication to better understanding neuropathic pain and to providing data and developing treatments to address areas of patient need."

What is neuropathic pain
Neuropathic pain is chronic pain caused by a nervous system injury. The injury may be in the brain or spinal cord (central nervous system) or nerves outside the spinal cord or brain (peripheral nervous system).

Neuropathic pain can be the result of trauma and many diseases, such as multiple sclerosis, diabetes, HIV, and stroke.

Neuropathic pain affects approximately 2 million people in the USA. It is often very hard to treat properly.

Written by Christian Nordqvist

Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 12.5mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


 In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started my first  HAART regimen  on October 24th,03.

 As of 8/2514,  t-cells are at 402, Viral load <40

 Current % is at 11%

  
 62 years young.

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.