Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
July 12, 2014, 06:15:28 AM

Login with username, password and session length


Members
Stats
  • Total Posts: 630054
  • Total Topics: 47680
  • Online Today: 203
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online
Users: 2
Guests: 143
Total: 145

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Complera & 400 Calorie Meal  (Read 4077 times)

0 Members and 1 Guest are viewing this topic.

Offline sanduneboi

  • Member
  • Posts: 18
Complera & 400 Calorie Meal
« on: April 30, 2012, 04:19:20 PM »
Not sure if this should go here or in the nutrition area.

My question is what are the issues if I take my medication without taking it with at least 400 calories? Will it be less effective in some way?
Diagnosed 1/27/12 VL 279,000 CD4 90
               4/16/12 VL <500     CD4 (Not Tested)

Offline leatherman

  • Member
  • Posts: 6,018
  • Google and HIV meds are Your Friends
Re: Complera & 400 Calorie Meal
« Reply #1 on: April 30, 2012, 05:23:35 PM »
Will it be less effective in some way?
Yes. drugs with the requirement to be taken with food, absorb differently and less effectively without being accompanied by food. Too maintain the correct level of meds in your system complera must be taken with food. as to how many calories, you would have to look at the information on the package insert to find out that.
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline Hellraiser

  • Member
  • Posts: 4,134
  • Semi-misanthropic
Re: Complera & 400 Calorie Meal
« Reply #2 on: May 01, 2012, 01:01:34 AM »
Yes. drugs with the requirement to be taken with food, absorb differently and less effectively without being accompanied by food. Too maintain the correct level of meds in your system complera must be taken with food. as to how many calories, you would have to look at the information on the package insert to find out that.

It's 400, like in the thread title.

Offline leatherman

  • Member
  • Posts: 6,018
  • Google and HIV meds are Your Friends
Re: Complera & 400 Calorie Meal
« Reply #3 on: May 01, 2012, 01:16:34 AM »
a little googling ("complera package insert") and I found this in the Pharmacokinetics section:
Quote
total calorie content of the meal was approximately 400 kcal with approximately 13 grams of fat

Single-dose administration of Complera tablet to healthy subjects under fasted conditions provided approximately 25% higher exposure of rilpivirine
so the answer to what happens w/o food is that the level of rilpivirine/Edurant is about 25% higher than it would be with 13 grams of fat in a 400 kcal meal

the package insert (http://www.gilead.com/pdf/complera_pi.pdf) does provide this caveat also:
Quote
Effects of Food on Oral Absorption 
Take COMPLERA with a meal. A food effect trial was not conducted for COMPLERA.
Therefore, the specific effect of food with COMPLERA tablets on rilpivirine, emtricitabine and tenofovir exposure has not been established. The recommendation to administer COMPLERA with a meal is based on the increased exposure that was observed when rilpivirine tablets were administered under fed conditions.
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline sanduneboi

  • Member
  • Posts: 18
Re: Complera & 400 Calorie Meal
« Reply #4 on: May 01, 2012, 04:05:49 AM »
a little googling ("complera package insert") and I found this in the Pharmacokinetics section:so the answer to what happens w/o food is that the level of rilpivirine/Edurant is about 25% higher than it would be with 13 grams of fat in a 400 kcal meal

the package insert (http://www.gilead.com/pdf/complera_pi.pdf) does provide this caveat also:

 ;D Thank you for that.
Diagnosed 1/27/12 VL 279,000 CD4 90
               4/16/12 VL <500     CD4 (Not Tested)

Offline 2manyquestions

  • Member
  • Posts: 18
Re: Complera & 400 Calorie Meal
« Reply #5 on: May 01, 2012, 05:13:36 AM »
One question I have is : is it better to take complera without a meal or wait to take it with a meal?

Today, I missed me standard "time" that I take my meds.  Being new to this I had a meal and forgot to take them.  I realized this 30 min later and wasn't sure if I should take it immediately or wait for my next meal?  I chose to eat another 500 cal meal within a few hours to play it safe as I've heard the life of complera in your system is around 36 hours.

Any thoughts?

Offline surf18

  • Member
  • Posts: 525
Re: Complera & 400 Calorie Meal
« Reply #6 on: May 01, 2012, 07:25:14 AM »
that is exactly why i said no thanks to this drug when it came out. too much work to have to take with a meal. ha
ill wait for quad pill.
also the drama that happens if you take it with acid reflux meds too.
way to many rules for a pill in this day and age.

Offline leatherman

  • Member
  • Posts: 6,018
  • Google and HIV meds are Your Friends
Re: Complera & 400 Calorie Meal
« Reply #7 on: May 01, 2012, 09:45:58 AM »
too much work to have to take with a meal.
that's funny. LOL
I pop a Reyataz/Norvir/Truvada with dinner every night (because a person's gotta eat sometime during the day, right?) and think nothing of it. Taking pills with a meal is one of the easiest regimens out there. To be honest, it's just as easy as taking a pill at any other time of the day. (quite a few meds have restrictions about antacids because, just like food, that affects absorption)
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline leatherman

  • Member
  • Posts: 6,018
  • Google and HIV meds are Your Friends
Re: Complera & 400 Calorie Meal
« Reply #8 on: May 01, 2012, 09:47:25 AM »
I realized this 30 min later and wasn't sure if I should take it immediately or wait for my next meal?
30 mins later? I would have taken the pill.
An hour and a half later or more? I would have taken it with the next meal, or had a snack later on.
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline Miss Philicia

  • Member
  • Posts: 23,835
  • celebrity poster, faker & poser
Re: Complera & 400 Calorie Meal
« Reply #9 on: May 01, 2012, 10:26:34 AM »
ONE pill a day, with food -- my my folks, that is just so damn difficult. It's not like we all eat every day... something.
"Iíve slept with enough men to know that Iím not gay"

Offline sanduneboi

  • Member
  • Posts: 18
Re: Complera & 400 Calorie Meal
« Reply #10 on: May 01, 2012, 01:11:54 PM »
ONE pill a day, with food -- my my folks, that is just so damn difficult. It's not like we all eat every day... something.

HA!
Diagnosed 1/27/12 VL 279,000 CD4 90
               4/16/12 VL <500     CD4 (Not Tested)

Offline gadawg1979

  • Member
  • Posts: 140
Re: Complera & 400 Calorie Meal
« Reply #11 on: June 19, 2012, 01:24:25 AM »
To be blunt I have found if you are not at 400 it gives me a massive case of the runs.....
Diagnosed March 2012
Initial CD4- 156 VL 200K (started Complera) Genotype test no resistance
First labs on meds CD4- 246 VL 2K Taken after 30 days on Complera
90 Day labs VL 306 No CD4 Drawn
8/21/2012 CD4 474 VL Undetectable (40) %20.6
11/27/2012 CD 4 522 VL Undetectable (40)
2/14/2013 CD 4 464 VL Undetecable (30) 19.6%
6/8/3013 CD 4 528 VL Undetectable (30)
9/24/2013 CD 4 546 VL Undetectable (40)
1/30/2014 CD4 660 VL Undetectable (40) 22 %

Offline Hellraiser

  • Member
  • Posts: 4,134
  • Semi-misanthropic
Re: Complera & 400 Calorie Meal
« Reply #12 on: June 19, 2012, 10:13:06 AM »
The only problem I've had with it is the nausea.  When I wake up the next morning I am nauseous for probably an hour or so.  When I eat it seems to go away.

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.