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Author Topic: Atripla and NSAID interactions?  (Read 2184 times)

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Offline dpb

  • Member
  • Posts: 89
Atripla and NSAID interactions?
« on: March 05, 2012, 03:32:15 PM »
I've been on Atripla for about 9 1/2 months, and currently undetectable. 

Today I was prescribed Diclofenac (a nonsteroidal anti-inflammatory drug) which is used to "relieve pain, swelling (inflammation), and joint stiffness caused by arthritis."  My primary care manager was absent today, and the rheumatology specialist I've seen over the last year had never prescribed me anything for my condition, instead opting to wait until my immune system was stronger and to see if my condition improved, which it did until last week.  According to http://www.drugs.com/drug-interactions/efavirenz-emtricitabine-tenofovir,atripla.html, Diclofenac is listed as having a "major interaction" with Atripla.  This doctor and pharmacist should've had access to my current medications and I would presume that he would not prescribe me anything unless it was relatively safe.  Should I be concerned?  I also notice that website lists 689 drug interactions with Atripla, which seems a bit high.

I take Atripla at 9 PM.  If I was to consume alcohol, what would be a safe timeframe to do it in either before or after I take Atripla?  Thanks.
Date        CD4    %    VL
1/15/11    Diagnosed
3/1/11    525    18    168,518
5/12/11    558    16    331,791
5/16/11    Started Atripla
5/31/11    NA    NA    1,200
6/15/11    721    21    330
7/15/11    649    23    231
8/15/11    569    25    UD
11/17/11  752    26    UD
3/1/12    634    27    UD
7/2/12    594    26    UD
2/13       676    30    UD
9/13       662    31    UD

Offline newt

  • Member
  • Posts: 3,887
  • the one and original newt
Re: Atripla and NSAID interactions?
« Reply #1 on: March 05, 2012, 05:19:25 PM »
According to the University of Liverpool interactions website (www.hiv-druginteractions.org) there are no known interactions between diclofenac and and of the three drugs in Atripla.

drugs.com points out that efavirenz, one of the drugs in Atripla, affects the liver and so do many other drugs, that's all. Hence the long list. It does not indicate a studied or clinically reported interaction with NSAIDs.

NSAIDs long-term with tenofovir, another of the drugs in Atripla, may be hard on your kidneys, something to watch perhaps.

The alcohol thing is very individual with Atripla (specifically the efavirenz it contains since this makes alcohol concentrations in your body higher and last longer). It's safe to drink with this combination, but whether you like the effect is another matter.

- matt
"The object is to be a well patient, not a good patient"

Offline dpb

  • Member
  • Posts: 89
Re: Atripla and NSAID interactions?
« Reply #2 on: March 05, 2012, 08:18:16 PM »
Thanks a lot newt, I greatly appreciate the feedback!
Date        CD4    %    VL
1/15/11    Diagnosed
3/1/11    525    18    168,518
5/12/11    558    16    331,791
5/16/11    Started Atripla
5/31/11    NA    NA    1,200
6/15/11    721    21    330
7/15/11    649    23    231
8/15/11    569    25    UD
11/17/11  752    26    UD
3/1/12    634    27    UD
7/2/12    594    26    UD
2/13       676    30    UD
9/13       662    31    UD

Offline Bunny

  • Member
  • Posts: 70
Re: Atripla and NSAID interactions?
« Reply #3 on: March 06, 2012, 11:58:01 AM »
How can one check any other drug interaction with HIV drug on http://www.hiv-druginteractions.org. I tried but I failed to do so.

I have so many doubts on this. My neurologist proscribed some tablets. I am waiting to see my HIV Doctor if there is any interaction with my neurologist prescribed tablets. Please can any one explain me with step by step if possible
August 2010, CD4 320
December 2010, CD4 250
June 2011 CD4 ?,(started lamivudine, nevirapine, stavudine )
September 2011, CD4 488
January 2012, Switched drugs due to severe Peripheral neuropathy (Started lamivudine, nevirapine, Zidovudine)
February 2012, CD4 485
August 2012,CD4 472
October 2012, Switched drugs to Lamivudine, Tenofavir, Effavirenz
Jan 2012, CD4 600
Sept 2013, CD4 555
Mar 2014, CD4 612
Sep 2014, CD4 427

Offline newt

  • Member
  • Posts: 3,887
  • the one and original newt
Re: Atripla and NSAID interactions?
« Reply #4 on: March 06, 2012, 12:44:51 PM »
Hi Bunny

- Click the big "Drug Interactions Charts" panel/button on the homepage
- Select your HIV meds and click "next"
- Choose if you want to select drugs by A-Z list or drug class and click "next"
- Select the drugs you want to check for an interaction and click "next"
- The results appear

www.hiv-druginteractions.org

Hope this helps

- matt
"The object is to be a well patient, not a good patient"

Offline Bunny

  • Member
  • Posts: 70
Re: Atripla and NSAID interactions?
« Reply #5 on: March 07, 2012, 05:21:39 AM »
Thanks Newt..

Got it...
August 2010, CD4 320
December 2010, CD4 250
June 2011 CD4 ?,(started lamivudine, nevirapine, stavudine )
September 2011, CD4 488
January 2012, Switched drugs due to severe Peripheral neuropathy (Started lamivudine, nevirapine, Zidovudine)
February 2012, CD4 485
August 2012,CD4 472
October 2012, Switched drugs to Lamivudine, Tenofavir, Effavirenz
Jan 2012, CD4 600
Sept 2013, CD4 555
Mar 2014, CD4 612
Sep 2014, CD4 427

 


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