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Author Topic: Complera or Isentress/Truvada??  (Read 2403 times)

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Offline cjmchgo

  • Member
  • Posts: 38
  • Dx 1992
Complera or Isentress/Truvada??
« on: January 03, 2012, 06:51:13 PM »
     I posted last week about all the craziness I'm having with Atripla after 3 years and really want to change therapy. My doctor gave me a choice of either Complera or Isentress/Truvada and I'm trying to figure out which one is best for me.
Iíve been positive for over 20 years (1991 dx) and Atripla was my first treatment when my t-cells went just below 350 three years ago. My VL has never been over 5,000 so I guess Iím kind of a slow progressor.
I know Isentress/Truvada is twice a day and that really doesn't bother me mostly because I keep hearing from others that they have none to very minimal side effects. Complera sounds nice because itís once a day but it just seems like such a newer regimen and my doctor said I would be the first in his practice on it, which makes me feel like a guinea pig.
I appreciate any feedback
Craig
April/May, 1992: Infected at age 21
Aug 31, 1992: Tested positive
Sep 8, 1992 T-cells 977, 43%
1993-1998: T-cells 675-800
1999-2001: T-cells 500-600
2000-2004: T-cells 425-525 23% VL 500-2000
2005-2008: T-cells 275-375, 20%, VL 950-2500
December 2008: Started Atripla
Dec 2009: T-cells 637, 33%, VL UD
Dec 2010: T-cells 544, 35%, VL UD
Dec 2011: T-cells 596, 41%, VL UD
January 2, 2012 stopped Atripla (CNS issues)
January 4, 2012 started Isentress/Truvada
March 25, 2014 Still on I/T t-cells 673, VL undetectable

Offline Cojo

  • Member
  • Posts: 201
Re: Complera or Isentress/Truvada??
« Reply #1 on: January 03, 2012, 06:56:40 PM »
Hi Craig,

I have been on T&I (my first regimen) since October 2011 (tested poz May 2011), and I can tell you - ZERO side effects. True, it is twice a day, but really in the greater scheme of things - big deal. I keep a days supply on a fob on my key ring which has really come through a few times when I stayed out later than expected or overnight somewhere. I would highly recommend it and don't give it another worry. It also kicked the bugs a*s big time - dropped VL from 60,000 to 54 in 4 weeks! Best to you.
Last thought - a once a day pill known as the quad is on the near horizon with a second generation integrease inhibitor, so we may have our one pill daily regime soon with easy transition over.
May 2011 - Tested Positive
June 2011 - CD4 330   16%   VL182,000 no resistance
Oct 6, 2011 - CD4 300  20%  VL 60,000
Oct 7, 2011 - start Truvada / Isentress
Nov 29, 2011 CD4 280 26% VL 54
Feb 7 2012 CD4 260 25% UD!
Mar 20 2012 CD4 400 28%
June 2012 CD4 330 26% UD
Sept 2012 CD4 450 32% UD
Dec 2012 CD4 310 28% UD
May 2013 CD4 500 32% UD
Oct 2013 CD4 460 33% UD
May 2014 CD4 360 33% UD
Aug 2014 swap out Isentress for Tivicay
Oct 2014 CD4 320 33% UD

Offline cjmchgo

  • Member
  • Posts: 38
  • Dx 1992
Re: Complera or Isentress/Truvada??
« Reply #2 on: January 03, 2012, 06:59:49 PM »
Thanks CoJo! I'll have to buy a fancy fob to store my drugs.  ;D
April/May, 1992: Infected at age 21
Aug 31, 1992: Tested positive
Sep 8, 1992 T-cells 977, 43%
1993-1998: T-cells 675-800
1999-2001: T-cells 500-600
2000-2004: T-cells 425-525 23% VL 500-2000
2005-2008: T-cells 275-375, 20%, VL 950-2500
December 2008: Started Atripla
Dec 2009: T-cells 637, 33%, VL UD
Dec 2010: T-cells 544, 35%, VL UD
Dec 2011: T-cells 596, 41%, VL UD
January 2, 2012 stopped Atripla (CNS issues)
January 4, 2012 started Isentress/Truvada
March 25, 2014 Still on I/T t-cells 673, VL undetectable

Offline Billy B

  • Member
  • Posts: 374
Re: Complera or Isentress/Truvada??
« Reply #3 on: January 04, 2012, 10:04:18 AM »
     I posted last week about all the craziness I'm having with Atripla after 3 years and really want to change therapy. My doctor gave me a choice of either Complera or Isentress/Truvada and I'm trying to figure out which one is best for me.
Iíve been positive for over 20 years (1991 dx) and Atripla was my first treatment when my t-cells went just below 350 three years ago. My VL has never been over 5,000 so I guess Iím kind of a slow progressor.
I know Isentress/Truvada is twice a day and that really doesn't bother me mostly because I keep hearing from others that they have none to very minimal side effects. Complera sounds nice because itís once a day but it just seems like such a newer regimen and my doctor said I would be the first in his practice on it, which makes me feel like a guinea pig.
I appreciate any feedback
Craig

Hello Craig,
My numbers and years of infection is almost a mirror image of yours. As you can see in my sig that I went with the I&T and have had great results. I am an older one so my cd4s haven't bounced back in a big way but I have had a very easy time with these meds. One plus that is not mentioned is that I&T are normal size pills and easy to get down the old throat.
Peace,
Billy
VL 4420 CD4 340 CD4% 24   3/15/10 Started I&T
VL  UD   CD4 340 CD4% 26.5 05/13/10
VL  UD   CD4 360 CD4% 27.1 08/3/10
VL  UD   CD4 310 CD4% 28.4 11/22/10
VL  UD   CD4 420 CD4% 27.9 02/11/11
VL  UD   CD4 370 CD4% 26.4 06/08/11
VL  UD   CD4 360 CD4% 27.7 09/23/11
VL  UD   CD4 370 CD4% 28.3 01/20/12
VL  UD   CD4 430 CD4% 28.8 05/11/12
VL  UD   CD4 370 CD4% 28.1 09/07/12
VL  UD   CD4 390 CD4% 32.3 03/14/13

Offline cjmchgo

  • Member
  • Posts: 38
  • Dx 1992
Re: Complera or Isentress/Truvada??
« Reply #4 on: January 04, 2012, 10:58:43 PM »
Thanks Billy!
Yeah, I just took my first pills about 4 hours ago. Besides the anxiety about having side-effects from this new therapy, I feel fine. I think my mind does a number on me when it comes to HIV drugs.
I'm glad you are doing well on your regimen. Sounds like you've have a good response to them.
Sounds like you've been + for a long time like me. I don't meet many people anymore that are.  :)
Craig
April/May, 1992: Infected at age 21
Aug 31, 1992: Tested positive
Sep 8, 1992 T-cells 977, 43%
1993-1998: T-cells 675-800
1999-2001: T-cells 500-600
2000-2004: T-cells 425-525 23% VL 500-2000
2005-2008: T-cells 275-375, 20%, VL 950-2500
December 2008: Started Atripla
Dec 2009: T-cells 637, 33%, VL UD
Dec 2010: T-cells 544, 35%, VL UD
Dec 2011: T-cells 596, 41%, VL UD
January 2, 2012 stopped Atripla (CNS issues)
January 4, 2012 started Isentress/Truvada
March 25, 2014 Still on I/T t-cells 673, VL undetectable

Offline Billy B

  • Member
  • Posts: 374
Re: Complera or Isentress/Truvada??
« Reply #5 on: January 05, 2012, 02:14:54 PM »
Thanks Billy!
Yeah, I just took my first pills about 4 hours ago. Besides the anxiety about having side-effects from this new therapy, I feel fine. I think my mind does a number on me when it comes to HIV drugs.
I'm glad you are doing well on your regimen. Sounds like you've have a good response to them.
Sounds like you've been + for a long time like me. I don't meet many people anymore that are.  :)
Craig

Craig,
I tested + in late 1994 and managed to live a very normal life except for the visits to my ID every six months. He said early on that I was just one of the lucky few that didn't progress in a hurry. Since my numbers were always very stable he said that new meds were coming and I had the fortunate luxury of being able to wait. The new guildline starting coming out about starting meds when your cd4s were near 500 instead of 350 and Isentress had some good documented history of safety and was so well tolerated that I decided to give it a try.
Peace,
Billy
VL 4420 CD4 340 CD4% 24   3/15/10 Started I&T
VL  UD   CD4 340 CD4% 26.5 05/13/10
VL  UD   CD4 360 CD4% 27.1 08/3/10
VL  UD   CD4 310 CD4% 28.4 11/22/10
VL  UD   CD4 420 CD4% 27.9 02/11/11
VL  UD   CD4 370 CD4% 26.4 06/08/11
VL  UD   CD4 360 CD4% 27.7 09/23/11
VL  UD   CD4 370 CD4% 28.3 01/20/12
VL  UD   CD4 430 CD4% 28.8 05/11/12
VL  UD   CD4 370 CD4% 28.1 09/07/12
VL  UD   CD4 390 CD4% 32.3 03/14/13

 


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