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Author Topic: What do some get more blips than others?  (Read 1065 times)

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Offline mecch

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  • red pill? or blue pill?
What do some get more blips than others?
« on: October 06, 2011, 03:52:17 PM »
Just got my second blip in 18 months, 3rd blip since I started 3 years ago.  Anyone know if there is a theory why some people get them and others don't.  If we are working under the assumptions that a blip was only a blip when the next test is undetectable again.

Do I have borderline viral suppression??


“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline newt

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Re: What do some get more blips than others?
« Reply #1 on: October 06, 2011, 04:07:49 PM »
Well, noone really knows, plus the type of test (ie more modern) makes a difference to this. Are you on an NNRTI?

- matt
"The object is to be a well patient, not a good patient"

Offline eric48

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Re: What do some get more blips than others?
« Reply #2 on: October 06, 2011, 04:39:59 PM »
Hi,

The following article may be a bit obscure but seems to be one of the most recent addressing your question

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084212/?tool=pubmed

It is a tough read, I must admit...

Cheers

Eric
NVP/ABC/3TC/... UD; CD4 > 1000; CD4/CD8 ~ 2.0   safety stock : 3 months (2013: FOTO= 5d. ON 2d. OFF)

Offline mecch

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Re: What do some get more blips than others?
« Reply #3 on: October 06, 2011, 05:41:43 PM »
Isentress and Truvada

Hey thanks for the article!

My blips have been 100-200.  Which seems to be the OK kind -- not a sign of trouble.
« Last Edit: October 06, 2011, 05:45:20 PM by mecch »
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline eric48

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Re: What do some get more blips than others?
« Reply #4 on: October 07, 2011, 11:31:12 AM »
Hi,

In one thread one guy reported a seasonnal blip.

He is followed every 3 months and always has a blip in the Oct - Nov follow up.

Vaccination or entering the flu / cold season could be a reason for this...

The other source (as discussed in the artcle) are reservoirs: cell volumes that are unaffected by meds.

the smaller the size of the drug the more in goes into 'details' of your body.

For exemple, 80% of long term (>3 years) nevirapine users are in fact at VL < 1 vs 50% for Efavirenz. Better penetration through the blood/brain barrier is the proposed rationale.

Isentress has a lesser penetration and therefore it is not impossible that 'some' replication' 'may' take place in some 'isolated' areas. But this is at noise level and sofar no clinical relevance has ever been demonstrated (according to recent discussion with my doc about the interest there would be in improving current VL detection limit - the best commercially available being 20) 

Unless they come with a real method to completly ERADICATE it does not seem to make much difference between VL = 1 or 5 or 20 or even 50 (casual blips included...)

At least that is what the doc says...

Cheers

Eric
 
NVP/ABC/3TC/... UD; CD4 > 1000; CD4/CD8 ~ 2.0   safety stock : 3 months (2013: FOTO= 5d. ON 2d. OFF)

 


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