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Author Topic: Started Epzicom  (Read 3515 times)

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Offline cwbyway102

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  • Posts: 30
Started Epzicom
« on: August 22, 2011, 05:41:28 PM »
Hi guys,
 
Thought I'd post this just for info purposes.

I've been on Truvada,Reyataz and Norvir for a year and a half.My creatinine was on a slow but steady rise for the last year and is up to 1.6 so my doc has switched me off of the Truvada and onto Epzicom.Other than the rise in Creatinine I've had 0 side effects.
 Last night I took my first dose of Epzicom at my regular scheduled time of 7pm.I've had no side effects so far,but I'll update this post at 2 weeks and 6 weeks.I'll get labs drawn on Sept 20th.
Feb 22.2010-hospitalized PCP pneumonia
Feb 24 2010-diagnosed CD4 <20 3%    VL 1450000  started Truvada & Reyataz 400mg
April 14  CD4 57  6%  VL 1348
June 24  CD4 97  8%  VL 204
June 25 added Norvir decreased Reyataz to 300mg
August 4 CD4 107 10% VL 107
Nov 3  CD4 144 11%   VL UD
Dec 6  CD4 185  14%  VL UD
Jan 10 CD4 181  12%  VL UD
Mar 29 CD4 294  16%  VL UD
June 29 CD4 211 14%  VL UD
August 21 Switched out Truvada for Epzicom
Sept 29  CD4 220  15%  VL UD

Offline Inchlingblue

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Re: Started Epzicom
« Reply #1 on: August 22, 2011, 09:26:14 PM »
I know someone who has been on Epzicom, Reyataz. Norvir (although you technically don't need Norvir with this combo) and he's been doing great, UD and with 1000+ T cells and zero side effects.

Offline WillyWump

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  • Posts: 7,185
Re: Started Epzicom
« Reply #2 on: August 22, 2011, 09:34:08 PM »
I was switched from Tru to Epzicom due to Kidney issues also. Been on Epzicom for about 5 months now, no side effects, I love it. Although It was rough the first few days with vomitting and such. But that happens everytime I start a new med.

-Will
POZ since '08

Last Labs-
6/3/14 CD4- 736, UD 34%
6/25/13 CD4- 1036, UD,
2/4/13, CD4 - 489, UD, 28%

Current Meds: Prezista/Epzicom/ Norvir
.

Offline ad2san

  • Member
  • Posts: 189
Re: Started Epzicom
« Reply #3 on: August 23, 2011, 01:18:30 AM »
Hi, I like this combo better that the one with Truvada: less trouble sleeping; finally loosing weight instead of gaining weight non stop ... More than a year after the switch no regret at all !
Feb   2009 CD4 358 VL 2000 16%
May  2009 CD4 305 VL 3069  14% <---- Started TVD+ATZ/r
Jul  2009 CD4 512 VL <50   18%
Jul 2010 CD4 418 VL <50 24%                     
Switched to Kivexa (Epzicom) + Norvir + Reyataz (due to sleep problem)
Aug 2010 CD4 606 VL <50 25%
Jul 2011 CD4 494 UD 23%
Switched to Kivexa (Epzicom) + Viramune XR (due to kidney problems)
January 2012 CD4 564 UD 31%
October 2012 CD4 684 UD 29%
January 2013 CD4 594 UD 26%
Switched to Kivexa (Epzicom) + Isentress due to BIG increase GammaGT
Feb 2013 CD4 699 UD 28%
May 2013 CD4 385 UD 28%
July 2013 CD4 CD4 636 UD 25%
Oct 2013 CD4 588 UD 39%
Aug 2014 CD4 639 UD 25%

Offline cwbyway102

  • Member
  • Posts: 30
Re: Started Epzicom
« Reply #4 on: August 28, 2011, 10:34:23 PM »
Been about a week so far.Nothing to really report except that yesterday I felt a little sore in the center of my chest and today I've had a burning sensation around the area of my liver on the right side.The only reason I mention it is because I've never had that happen before.
Feb 22.2010-hospitalized PCP pneumonia
Feb 24 2010-diagnosed CD4 <20 3%    VL 1450000  started Truvada & Reyataz 400mg
April 14  CD4 57  6%  VL 1348
June 24  CD4 97  8%  VL 204
June 25 added Norvir decreased Reyataz to 300mg
August 4 CD4 107 10% VL 107
Nov 3  CD4 144 11%   VL UD
Dec 6  CD4 185  14%  VL UD
Jan 10 CD4 181  12%  VL UD
Mar 29 CD4 294  16%  VL UD
June 29 CD4 211 14%  VL UD
August 21 Switched out Truvada for Epzicom
Sept 29  CD4 220  15%  VL UD

Offline eric48

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  • Posts: 1,179
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
Re: Started Epzicom
« Reply #5 on: August 29, 2011, 05:37:51 PM »
a little sore in the center of my chest

I have had that and it lasted quite a bit. Hard to say whether was caused by:
- the meds
- stress desorder
- meds induced stress

Mine resolved thanks to aspirin

a burning sensation

same here... was quite intense, then faded away within 2 days

if it does not go away and worsens, talk to your doctor as it could a sign for hypersensitivity with is both rare (about 1%) and potentially health threatening

Mine faded away, but, at that time was quite worried

Cheers

Eric
NVP/ABC/3TC/... UD; CD4 > 1000; CD4/CD8 ~ 2.0   safety stock : 2 months

Offline cwbyway102

  • Member
  • Posts: 30
Re: Started Epzicom
« Reply #6 on: August 30, 2011, 12:56:36 PM »
Last night,the 8th night,about 2 hours after I took my dose,I developed a rash that looked like hives on my shoulders.it lasted for a couple hours then went away.Not sure if it was caused by the Epzicom or something else.
Feb 22.2010-hospitalized PCP pneumonia
Feb 24 2010-diagnosed CD4 <20 3%    VL 1450000  started Truvada & Reyataz 400mg
April 14  CD4 57  6%  VL 1348
June 24  CD4 97  8%  VL 204
June 25 added Norvir decreased Reyataz to 300mg
August 4 CD4 107 10% VL 107
Nov 3  CD4 144 11%   VL UD
Dec 6  CD4 185  14%  VL UD
Jan 10 CD4 181  12%  VL UD
Mar 29 CD4 294  16%  VL UD
June 29 CD4 211 14%  VL UD
August 21 Switched out Truvada for Epzicom
Sept 29  CD4 220  15%  VL UD

Offline Assurbanipal

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  • Posts: 2,173
  • Taking a forums break, still see PM's
Re: Started Epzicom
« Reply #7 on: August 30, 2011, 03:22:07 PM »
Rash in the second week of Epzicom is a reason to call your doctor.  It may be nothing, but if you are going to have hypersensitivity reactions that is when they show up according to the drug section here:

http://www.aidsmeds.com/archive/Epzicom_1580.shtml

An important side effect that doctors and patients need to be aware of is "hypersensitivity." Approximately 5 percent of people who take Ziagen (abacavir), one of the two medications in Epzicom, are allergic to it. This can be serious and generally requires that Epzicom be stopped, and that Epzicom or Ziagen should not be taken again. A hypersensitivity reaction usually appears during the second week of therapy, but it can take as long as six weeks to notice any symptoms. The most common symptoms are fever and rash, followed by headaches, stomach upset, feeling sick or tired, sore throat, cough, and shortness of breath. These symptoms usually get worse over time and it is important that you report them to your doctor immediately. If you need to stop Epzicom because of this hypersensitivity reaction, you will still be able to take Epivir, the other drug in Epzicom.

 An inexpensive laboratory test is available to look for an inherited gene, called HLA-B*5701, that has been linked to the hypersensitivity reaction in HIV-positive people taking Epzicom. While not all people with this gene experience an allergic reaction while taking Epzicom, most do. In turn, if you are tested and found to have this gene, Epzicom (or other medications containing abacavir) should either be avoided or used with caution. If you and your doctor are thinking about starting Epzicom or another abacavir-containing medication for the first time, be sure to discuss this genetic test
5/06 VL 1M+, CD4 22, 5% , pneumonia, thrush -- O2 support 2 months, 6/06 +Kaletra/Truvada
9/06 VL 3959 CD4 297 13.5% 12/06 VL <400 CD4 350 15.2% +Pravachol
2007 VL<400, 70, 50 CD4 408-729 16.0% -19.7%
2008 VL UD CD4 468 - 538 16.7% - 24.6% Osteoporosis 11/08 doubled Pravachol, +Calcium/D
02/09 VL 100 CD4 616 23.7% 03/09 VL 130 5/09 VL 100 CD4 540 28.4% +Actonel (osteoporosis) 7/09 VL 130
8/09  new regimen Isentress/Epzicom 9/09 VL UD CD4 621 32.7% 11/09 VL UD CD4 607 26.4% swap Isentress for Prezista/Norvir 12/09 (liver and muscle issues) VL 50
2010 VL UD CD4 573-680 26.1% - 30.9% 12/10 VL 20
2011 VL UD-20 CD4 568-673 24.7%-30.6%
2012 VL UD swap Prezista/Norvir for Reyataz drop statin CD4 768-828 26.7%-30.7%

Offline Inchlingblue

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  • Chad Ochocinco PETA Ad
Re: Started Epzicom
« Reply #8 on: August 30, 2011, 08:32:22 PM »
An inexpensive laboratory test is available to look for an inherited gene, called HLA-B*5701, that has been linked to the hypersensitivity reaction in HIV-positive people taking Epzicom. 

This test should be performed before starting Epzicom, any doctor worth his stripes would have done that.

To the OP: do you know if your doctor performed this test before starting you on Epzicom?

Offline cwbyway102

  • Member
  • Posts: 30
Re: Started Epzicom
« Reply #9 on: August 31, 2011, 12:00:47 PM »
Yes I had this test done ,it was negative.I couldn't get a hold of my doctor yesterday so I took another dose as scheduled and I didn't have another hives reaction so I'm thinking the hives must've been caused by something else.
« Last Edit: August 31, 2011, 12:18:40 PM by cwbyway102 »
Feb 22.2010-hospitalized PCP pneumonia
Feb 24 2010-diagnosed CD4 <20 3%    VL 1450000  started Truvada & Reyataz 400mg
April 14  CD4 57  6%  VL 1348
June 24  CD4 97  8%  VL 204
June 25 added Norvir decreased Reyataz to 300mg
August 4 CD4 107 10% VL 107
Nov 3  CD4 144 11%   VL UD
Dec 6  CD4 185  14%  VL UD
Jan 10 CD4 181  12%  VL UD
Mar 29 CD4 294  16%  VL UD
June 29 CD4 211 14%  VL UD
August 21 Switched out Truvada for Epzicom
Sept 29  CD4 220  15%  VL UD

Offline eric48

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  • Posts: 1,179
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
Re: Started Epzicom
« Reply #10 on: August 31, 2011, 06:50:20 PM »
I couldn't get a hold of my doctor yesterday ...

This is actually one complaint I have about the way initiation to Epzicom was done in my case.

In our socialized health systems, doctors have a right for extended vacation in the summer. They ALL take a leave at the same time (as if diseases occurs only during business hours...). As a result, when I was in the 'danger' time window for Abacavir (typically week 2 to eight) I realized that not only my doctor but also his replacement were overseas on vacation !

Even the nurse at the clinic.

In case of adverse effect my only option would have to run to the ER where doctors are also on vacation (only young interns remain on duty).

Statistically , if you passed the H+,??*- (can't recall the spelling) test, then adverse effect occurs in a little less than 1 %.

But still, I would hope that doctors leave instructions on how to get hold of them (or a knowledgeable replacement) when patients are at  a risk which is low in occurrence but potentially lethal.

I think that I , myself, have been on the verge of SE that mimic the hypersensitivity reaction and ,as of today, still upset that in such case, I would have no one to turn to.

Good to hear that your symptoms are receding, and hopefully everything will work fine.

Despite the rough initiation period, I can vouch that, after a year into treatment, it is (now) as easy to take as aspirin or multivitamin.

keep on the look out though and take care

Cheers

Eric
NVP/ABC/3TC/... UD; CD4 > 1000; CD4/CD8 ~ 2.0   safety stock : 2 months

Offline cwbyway102

  • Member
  • Posts: 30
Re: Started Epzicom
« Reply #11 on: September 03, 2011, 03:09:53 PM »
Day 13: all day yesterday I felt like I could never get a full breath of air.I woke up this morning feeling great though.One thing thats really of concern is that since I've been taking the Epzicom I haven't been able to sustain an erection.Is that normal when switching meds?I had no problems in that area before the switch.
 Anyway thanks for the input guys.
Feb 22.2010-hospitalized PCP pneumonia
Feb 24 2010-diagnosed CD4 <20 3%    VL 1450000  started Truvada & Reyataz 400mg
April 14  CD4 57  6%  VL 1348
June 24  CD4 97  8%  VL 204
June 25 added Norvir decreased Reyataz to 300mg
August 4 CD4 107 10% VL 107
Nov 3  CD4 144 11%   VL UD
Dec 6  CD4 185  14%  VL UD
Jan 10 CD4 181  12%  VL UD
Mar 29 CD4 294  16%  VL UD
June 29 CD4 211 14%  VL UD
August 21 Switched out Truvada for Epzicom
Sept 29  CD4 220  15%  VL UD

Offline Assurbanipal

  • Member
  • Posts: 2,173
  • Taking a forums break, still see PM's
Re: Started Epzicom
« Reply #12 on: September 03, 2011, 05:46:43 PM »
You really need to write all these down (or print out this thread) and talk to your doctor about what you are experiencing.  Some people move from regimen to regimen with no problems, but many don't.  And if you are having odd experiences your doctor should (and probably does) want to hear about it in case it is significant. 

There are certain times when things are more likely to go wrong than others.  Those times include:
- when you have a really low tcell count (under 200) or percentage (under 14%)
- when you start a new drug
During those times you and your doctor need to be more vigilant than usual. 

As men, we are used to not going to the doctor; it isn't even recommended that a healthy man have more than a couple of physicals between 25 and 40. And there can be a certain, macho, tough-it-out mentality. 

But that was before. 

Now you have a chronic disease that can kill you, and you need to be more careful with your health.  If you are worried that you are seeing the doctor too often, ask him/her whether you are going more than needed.  Resources are tight, they will be glad to tell you if you are acting too needy, if you invite them to give you feedback.     


Sometimes erectile dysfunction problems can be symptoms of other deeper issues that affect blood flow.  For me, it seems to be the norvir that has that effect; I didn't notice any effect due to Epzicom.

Be well 
A
5/06 VL 1M+, CD4 22, 5% , pneumonia, thrush -- O2 support 2 months, 6/06 +Kaletra/Truvada
9/06 VL 3959 CD4 297 13.5% 12/06 VL <400 CD4 350 15.2% +Pravachol
2007 VL<400, 70, 50 CD4 408-729 16.0% -19.7%
2008 VL UD CD4 468 - 538 16.7% - 24.6% Osteoporosis 11/08 doubled Pravachol, +Calcium/D
02/09 VL 100 CD4 616 23.7% 03/09 VL 130 5/09 VL 100 CD4 540 28.4% +Actonel (osteoporosis) 7/09 VL 130
8/09  new regimen Isentress/Epzicom 9/09 VL UD CD4 621 32.7% 11/09 VL UD CD4 607 26.4% swap Isentress for Prezista/Norvir 12/09 (liver and muscle issues) VL 50
2010 VL UD CD4 573-680 26.1% - 30.9% 12/10 VL 20
2011 VL UD-20 CD4 568-673 24.7%-30.6%
2012 VL UD swap Prezista/Norvir for Reyataz drop statin CD4 768-828 26.7%-30.7%

Offline sfpvguy41

  • Member
  • Posts: 115
Re: Started Epzicom
« Reply #13 on: September 12, 2011, 12:46:05 AM »
My doc originally switched me to epzicom around June to get the tenofovir out of my regimen as I have osteoporosis.  In August I switched from Reyataz 300 with Norvir to Reyataz 400mg no Norvir.  I am so happy with what is happening to my body shape, losing belly and have been able to lose weight! No Epzicom side effects at all. While it will take a while to know of any effects on bones, I think getting off the Norvir is a great reason to go from Truvada to Epzicom if you're on the same regimen and test ok to take epzicom.

Just gave blood for labs so I'll see how it's going in a few days and will post here.
Labs: (undetectable since 2005)
12/13: 634 cdr, 37.3%, 758 cd8, total chol 183, triglycerides 131
8/13: changed to Edurant from Reyataz
12/12: 828 cd4, 34.5%, 1078 cd8, total chol 192, tri 196
12/11: 787 cd4, 37%, 979 cd8.
9/11: 758 cd4, 38%, 944 cd8, und.
8/11 dropped norvir, incr reyataz to 400 mg
6/11: 621 CD4 CD4% 41, CD8 680! Undetectable. Creatinine and eGFR are ok now.
Switched from Truvada to Epzicom in late April 2011
AGT/AST and creatinine back to normal mid-April.
Cut Norvir from regimen.
Switched back to Reyataz/Norvir late Feb 2011
2/11: CD4 664 34%, CD8 963, diagnosed with osteoporosis, high AGT/AST and creatinine.
12/10: CD4: 676 CD4%: 34 CD8: 1012
Switched from Reyataz/norvir to Isentress 10/10
8/10: CD4: 731 CD4%: 40 CD8: 866
Diagnosed Sept. 2002 started meds May 2005.

Offline sfpvguy41

  • Member
  • Posts: 115
Re: Started Epzicom
« Reply #14 on: September 12, 2011, 12:52:53 AM »
Oops sorry I switched in April not June, time flies! But just ditched the Norvir in August.
Labs: (undetectable since 2005)
12/13: 634 cdr, 37.3%, 758 cd8, total chol 183, triglycerides 131
8/13: changed to Edurant from Reyataz
12/12: 828 cd4, 34.5%, 1078 cd8, total chol 192, tri 196
12/11: 787 cd4, 37%, 979 cd8.
9/11: 758 cd4, 38%, 944 cd8, und.
8/11 dropped norvir, incr reyataz to 400 mg
6/11: 621 CD4 CD4% 41, CD8 680! Undetectable. Creatinine and eGFR are ok now.
Switched from Truvada to Epzicom in late April 2011
AGT/AST and creatinine back to normal mid-April.
Cut Norvir from regimen.
Switched back to Reyataz/Norvir late Feb 2011
2/11: CD4 664 34%, CD8 963, diagnosed with osteoporosis, high AGT/AST and creatinine.
12/10: CD4: 676 CD4%: 34 CD8: 1012
Switched from Reyataz/norvir to Isentress 10/10
8/10: CD4: 731 CD4%: 40 CD8: 866
Diagnosed Sept. 2002 started meds May 2005.

Offline cwbyway102

  • Member
  • Posts: 30
Re: Started Epzicom
« Reply #15 on: September 12, 2011, 01:04:11 PM »
Day 23:Things are going pretty good. The little effects I was having before seems to be just random.I talked with my doc the other day and he clarified a little better what side effects would be worth being worried about.
 I go in next week to get my labs drawn,and if everything looks good,hopefully i'll be able to get off of the norvir.
Feb 22.2010-hospitalized PCP pneumonia
Feb 24 2010-diagnosed CD4 <20 3%    VL 1450000  started Truvada & Reyataz 400mg
April 14  CD4 57  6%  VL 1348
June 24  CD4 97  8%  VL 204
June 25 added Norvir decreased Reyataz to 300mg
August 4 CD4 107 10% VL 107
Nov 3  CD4 144 11%   VL UD
Dec 6  CD4 185  14%  VL UD
Jan 10 CD4 181  12%  VL UD
Mar 29 CD4 294  16%  VL UD
June 29 CD4 211 14%  VL UD
August 21 Switched out Truvada for Epzicom
Sept 29  CD4 220  15%  VL UD

Offline Inchlingblue

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  • Chad Ochocinco PETA Ad
Re: Started Epzicom
« Reply #16 on: September 13, 2011, 08:46:47 PM »
Day 23:Things are going pretty good. The little effects I was having before seems to be just random.I talked with my doc the other day and he clarified a little better what side effects would be worth being worried about.
 I go in next week to get my labs drawn,and if everything looks good,hopefully i'll be able to get off of the norvir.

Good plan.

Offline sfpvguy41

  • Member
  • Posts: 115
Re: Started Epzicom
« Reply #17 on: September 15, 2011, 09:21:10 PM »
Just got labs back and am pretty happy with the results on Epzicom, and 400mg Reyataz with no Norvir.

CD4s are at an almost all time high of 758, CD8s were up to 944 (still too high I think) and undetectable.

You mentioned Creatinine, which was a problem for me in Jan/Feb also.  Since February it has fallen from 1.38 to just now 1.17.  Liver #s are good too. 

I hope results work out well for you too! The results are good, and the best part of the Epzicom to me is being able to get off the Norvir. 
Labs: (undetectable since 2005)
12/13: 634 cdr, 37.3%, 758 cd8, total chol 183, triglycerides 131
8/13: changed to Edurant from Reyataz
12/12: 828 cd4, 34.5%, 1078 cd8, total chol 192, tri 196
12/11: 787 cd4, 37%, 979 cd8.
9/11: 758 cd4, 38%, 944 cd8, und.
8/11 dropped norvir, incr reyataz to 400 mg
6/11: 621 CD4 CD4% 41, CD8 680! Undetectable. Creatinine and eGFR are ok now.
Switched from Truvada to Epzicom in late April 2011
AGT/AST and creatinine back to normal mid-April.
Cut Norvir from regimen.
Switched back to Reyataz/Norvir late Feb 2011
2/11: CD4 664 34%, CD8 963, diagnosed with osteoporosis, high AGT/AST and creatinine.
12/10: CD4: 676 CD4%: 34 CD8: 1012
Switched from Reyataz/norvir to Isentress 10/10
8/10: CD4: 731 CD4%: 40 CD8: 866
Diagnosed Sept. 2002 started meds May 2005.

Offline cwbyway102

  • Member
  • Posts: 30
Re: Started Epzicom
« Reply #18 on: October 21, 2011, 01:07:35 PM »
Sorry it took so long for an update.The epzicom is working out great.Doc said I could drop the Norvir if I wanted,though I think I'll keep on the Norvir till I at least break 300cd4s.
 I have had no side effects whatsoever.The first couple weeks were a little bumpy but as someone said its almost like taking asprin now.I'm feeling better than ever.Basically I feel like I'm back to normal again.
 The only thing to report is that my labs were taken 30 days after I switched to the epzicom and my creatinin was up to 1.71 thats a jump from 1.65.
 My doc said that after 30 days off the Truvada,he didn't expect for my creatinin to come down just yet,so we'll have to wait til the next labs to see if the Truvada was the real culprit.
Feb 22.2010-hospitalized PCP pneumonia
Feb 24 2010-diagnosed CD4 <20 3%    VL 1450000  started Truvada & Reyataz 400mg
April 14  CD4 57  6%  VL 1348
June 24  CD4 97  8%  VL 204
June 25 added Norvir decreased Reyataz to 300mg
August 4 CD4 107 10% VL 107
Nov 3  CD4 144 11%   VL UD
Dec 6  CD4 185  14%  VL UD
Jan 10 CD4 181  12%  VL UD
Mar 29 CD4 294  16%  VL UD
June 29 CD4 211 14%  VL UD
August 21 Switched out Truvada for Epzicom
Sept 29  CD4 220  15%  VL UD

 


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