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Author Topic: Scientist develops virus that targets HIV  (Read 2038 times)

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Offline Cosmicdancer

  • Member
  • Posts: 138
Scientist develops virus that targets HIV
« on: August 09, 2011, 02:46:46 PM »
This concept seems similar to Peregrine's Bavituximab.  Using a virus (instead of a monoclonal antibody) as a way of tagging HIV infected cells so that they can be destroyed by other drugs.  Not enough info here to know exactly how this works though, and of course human trials are a long way off.

http://www.sciencedaily.com/releases/2011/08/110808154132.htm

Scientist Develops Virus That Targets HIV: Using a Virus to
Kill a Virus

ScienceDaily (Aug. 8, 2011) — In what represents an important step toward curing HIV, a USC scientist has created a virus that hunts down HIV-infected cells.
 

Dr. Pin Wang's lentiviral vector latches onto HIV-infected cells, flagging them with what is called "suicide gene therapy" -- allowing drugs to later target and destroy them.

"If you deplete all of the HIV-infected cells, you can at least partially solve the problem," said Wang, chemical engineering professor with the USC Viterbi School of Engineering.

The process is analogous to the military practice of "buddy lasing" -- that is, having a soldier on the ground illuminate a target with a laser to guide a precision bombing strike from an aircraft.

Like a precision bombing raid, the lentiviral vector approach to targeting HIV has the advantage of avoiding collateral damage, keeping cells that are not infected by HIV out of harm's way. Such accuracy has not been achieved by using drugs alone, Wang said.

So far, the lentiviral vector has only been tested in culture dishes and has resulted in the destruction of about 35 percent of existing HIV cells. While that may not sound like a large percentage, if this treatment were to be used in humans, it would likely be repeated several times to maximize effectiveness.

Among the next steps will be to test the procedure in mice. While this is an important breakthrough, it is not yet a cure, Wang said.

"This is an early stage of research, but certainly it is one of the options in that direction," he said.
Wang's research, which was funded by the National Institutes of Health, appears in the July 23 issue of Virus Research



Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
June, 2008 - undetectable, 612 cd4
January, 2009 - undetectable, 670 cd4
May, 2009 - undetectable, 593 cd4
Sept, 2009 - 83 vl, 763 cd4, 34%
Dec, 2009 - undetectable, 889 cd4, 32%
April, 2010 - undetectable, 860 cd4, 31%
October, 2010 - undetectable, 800 cd4, 38%
April, 2011 - undetectable, t-cell test not done
October, 2011 - undetectable
April, 2012 - undetectable, 850 cd4, 39%
November, 2012 - undetectable, 901 cd4, 41%
April, 2013 - undetectable, 846 cd4, 36%
October, 2013 - undetectable

Offline Coolio_7

  • Member
  • Posts: 66
Re: Scientist develops virus that targets HIV
« Reply #1 on: August 09, 2011, 08:28:40 PM »
Sounds promising! It will be interesting to see how this performs in mice and if it will get to human clnical trials. There is already tough challenges trying to get the CMV vector used in another therapeutic approach safe for humans so we will have to wait to see how his pans out over time.

Although fighting a virus with another virus is a novel approach.  Thanks for the post!

Offline MiniPozToyota

  • Member
  • Posts: 203
Re: Scientist develops virus that targets HIV
« Reply #2 on: August 09, 2011, 11:05:36 PM »
Hopefully this will work.. cant wait to see the trails in the mice cases who knows....
April 2010- tested neg.
Oct-Dec 2010- Came in contact time frame
March 29 2011- tested positive
April 1 2011 -  CD4 346 VL 46856 22% (Hometown hospital)
April 10 2011-  First Actual Appointment
April 11 2011-  CD4 576 VL 11898  44% (Out of state hospital)
May 09 2011- Genotype test no resistance
Jun  02 - CD4 363 VL 22,850  (Hometown hospital)
July 11 2011 - CD4 372 @25% 41,000 (Out of state hospital)
July 27 2011- Started Atripla
Sept 1 2011- CD4 485 VL 73
Oct 17 2011- CD4 389 VL UD @ 25%
Nov 21 2011- CD4 424 VL UD @ 31%
Mar 12 2012- CD4 504 VL UD @ 35%
May 14 2012- CD4 630 VL UD @ 43%
Aug 17 2012- CD4 689 VL UD @ 45%
Nov  6 2012 - CD4 659 VL UD @ 42%
Dec 17 2012 - CD4 859 VL UD @ 48% (out of state hospital)
Mar 18 2013 - CD$ 867 VL UD @ 44%

Offline buginme2

  • Member
  • Posts: 2,742
  • Certified Life Coach
Re: Scientist develops virus that targets HIV
« Reply #3 on: August 10, 2011, 01:47:22 AM »
I like that the article used a military analogy, made for more exciting reading.
"All I need are some tasty waves, a cool buzz, and I'm fine."

http://www.youtube.com/watch?v=6e0gcEC1TWE

Offline mecch

  • Member
  • Posts: 10,710
  • red pill? or blue pill?
Re: Scientist develops virus that targets HIV
« Reply #4 on: August 10, 2011, 07:04:33 AM »
cool.
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Hoover

  • Member
  • Posts: 286
Re: Scientist develops virus that targets HIV
« Reply #5 on: August 10, 2011, 11:15:17 AM »
Imagine getting a virus to kill the HIV virus.
After being infected by the good virus,
would we be asked to do our public service and go have lots of sex to spread it?
 ;D

Hoover
Infection date: March 16, 2010
20/05/10 - CD4 348  VL 58,000  Lymph nodes in jaw painful!  Antioxidants started.
01/06/10 - CD4 428  VL?
24/06/10 - CD4 578  VL 9,800
13/07/10 - CD4 620  VL?
04/09/10 - CD4 648  VL?
01/11/10 - CD4 710  VL?   CD8 972
16/12/10    CD4 738  VL?  CD8  896   
02/02/11    CD4 520 (month of parasites and new lab)
14/03/11 started Truvida and Sustiva (Efavirenz)
04/07/11 CD4 686 VL 75 CD8 588  41%
10/10/11 CD4 757  45%  VL UD

Offline metekrop

  • Member
  • Posts: 351
Re: Scientist develops virus that targets HIV
« Reply #6 on: August 10, 2011, 11:25:24 AM »
I like that the article used a military analogy, made for more exciting reading.

Yea, I am sorry for those mice that will be put under the military practice of "buddy lasting".  8)
Diag on Dec 8, 2000, CD 440 VL 44K, No Meds
Dec/08 - Feb/09 CD< 50 & VL >500k hosp'z.
St. Atripla - July/09 CD 179, VL 197k
Oct/09 CD 300 VL UD Chol 267
Mar/10 CD 468 UD, Ch 220
Aug/10 CD 460 UD, Ch 195
Dec/10 CD 492 UD, Ch 172
Mar/11 CD 636 UD, Ch 201
Aug/11 CD 530 UD, Ch 98
Jan/12 cd 616 UD, ch 189
Jul/12 CD 640 UD, Ch ?
Dec/12 CD 669 Ud, Ch 125
May/7 CD711 Ud, Ch?
Nov/ 22 663 UD, Ch,

Offline Fated2loveyou

  • Member
  • Posts: 8
  • Rawr!
Re: Scientist develops virus that targets HIV
« Reply #7 on: August 12, 2011, 02:01:32 PM »
interesting, thanks for shareing.
i hope a miracle going to happen soon :x
"You only live once, but if you work it right, once is enough."

 


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