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Author Topic: Taking a statin can reduce your risk of dying if your HIV positive.  (Read 3214 times)

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Offline buginme2

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http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021843

The thing I find interesting about this article was that itaking a statin reduced the risk of dying of all causes (including cancer and infection and liver failure)  and not just from heart disease. 

Offline Tim Horn

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  • Posts: 799
This is interesting.

Just like antiretroviral therapy has been shown to be associated with reductions in all-cause mortality--even things like accidents--in people living with HIV, statins have been shown to be associated with reductions in all-cause mortality in HIV-negative patients with a history of cardiovascular disease. What sets this study apart is not only its HIV-positive study population, but it's use as statins to prevent cardiovascular disease events (as opposed to those with a history of CVD events).

While retrospective nature of the study means the conclusion needs to be taken with a grain of salt -- it's difficult to adjust for selection bias and confounders in retrospective studies -- this is definitely worthy of further exploration in prospective studies.

Now if we can just get statin manufacturers to own up to the fact that efficacy trials involving people living with HIV need to be conducted, we'll be all set.

Tim

Offline Coolio_7

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  • Posts: 66
Well Lipitor goes generic the end of November this year. So at the least the drug will cost significantly less in the event that we need to start taking these statins for those wanting Lipitor over Zocor perhaps.

I do like the double benefit of the statins though. Not only do they help in lowering cholesterol but also reduce inflammation.  This beats taking NSAIDs which are can cause stomach bleeding and ulcers with continued use.

I like all the positive articles I'm seeing lately. Sometimes it's just so depressing to read all the time..."HIV linked to increased risk of death" from this and that.


Offline elf

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  • Posts: 607
If your cholesterol is normal, statin does not affect this at all.

Statin is not like aspirin, it must be taken daily (just like HAART, no skipping)
and side effects can be severe...

90% of HAART are metabolized in the liver by the same enzyme as statins,
because of that, statins may be dangerous (side effects go up, while its efficiency goes down)...  :-\

Pharma companies are pushing statins as if they were candies...
Well, candies can be taken whenever you please, while taking statins on this basis
would be very dangerous. Consider statins a lifelong commitment.

---
I am taking Lovaza (3x1g), niacin (3x 50 mg) and acid-resistant aspirin (100 mg), as well as taurine (5g), melatonin (3 mg), selenium (200 mg), vitamin D, olive oil, walnuts, low calorie orange juice (750 mL), tomato juice (500mL), flaxseed, resveratrol, soy protein shake...All of these have been shown to reduce the risk of dying of CVD (do a search at http://www.ncbi.nlm.nih.gov/pubmed/ ).

Statins and Kaletra do not mix well.

From my experience, the best way to lower cholesterol is: jogging and losing weight. :)

Omega-3: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683599/
« Last Edit: July 31, 2011, 04:42:22 AM by elf »
Let's have a Kiki!

Offline elf

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Omega-3: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683599/

Quote
Both DHA and EPA act as precursors for eicosanoids (prostaglandin, thromboxane, and leukotriene) and are thought to play a role in reducing inflammation. In clinical trials, they also worked together in reducing TG levels and mortality rates from CVD.

I wish pharma companies were promoting omega-3 acids and niacin (as well as new pectin products) instead of statins. Statins are pretty expensive drugs and therefore pharma companies are more into them.

« Last Edit: July 31, 2011, 04:45:52 AM by elf »
Let's have a Kiki!

Offline elf

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  • Posts: 607
There is a pressure of drug companies on government: ''the highest upper  limit no CVRisk cholesterol should be moved from 5mmol/L [193 mg/L] to 4 mmol/L. [154mg/l]''

But our government is considering going back to pre2000 values of 6.5 mmol/L  [251 mg/L] because too much public money is spent on statins (health care is free here).

I guess perfect total cholesterol values should be lower than 2.5 mmol/l (100 mg/l), while HDL cholesterol should be above 2.5 ;D (100 mg/L).  ;D  This would mean there should be no LDL cholesterol at all, or it should be negative.  ;D

Omega-3 acids reduce the cardiovascular risk although they make LDL go up (but this LDL is not atherogenic and it's less likely to suffer oxidation):
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683599/table/t2-ptj33_5p271/
« Last Edit: July 31, 2011, 05:40:11 AM by elf »
Let's have a Kiki!

Offline Ann

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  • Posts: 28,140
  • It just is, OK?
    • Num is sum qui mentiar tibi?

I am taking Lovaza (3x1g), niacin (3x 50 mg) and acid-resistant aspirin (100 mg), as well as taurine (5g), melatonin (3 mg), selenium (200 mg), vitamin D, olive oil, walnuts, low calorie orange juice (750 mL), tomato juice (500mL), flaxseed, resveratrol, soy protein shake...All of these have been shown to reduce the risk of dying of CVD (do a search at http://www.ncbi.nlm.nih.gov/pubmed/ ).


I did quite a bit of reading earlier today about melatonin, including things other than sleep (more precisely insomnia) where it is thought there might a benefit to taking melatonin, but reducing the risk of CVD was not one of them.

People taking stuff like melatonin should carefully research the available data and also discuss it with their doctors. I bet not may are aware that melatonin should NOT be used for people with reduced kidney function, something that we see from time to time - and have seen VERY recently (Willy) - in this forum.
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