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Author Topic: Cure research  (Read 3770 times)

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Offline buginme2

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  • Posts: 3,426
Cure research
« on: July 11, 2011, 05:57:43 PM »
This is interesring.  NIH has made several grants supporting HIV cure research.  Yah NIH.  


« Last Edit: July 11, 2011, 07:19:10 PM by buginme2 »
Don't be fancy, just get dancey

Offline dpb

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  • Posts: 89
Re: Cure research
« Reply #1 on: July 11, 2011, 09:06:21 PM »
This is so refreshing to read.  Cure research has been severely underfunded.  It would appear as though we're finally making progress in eradication research.  Keep the hope alive.
« Last Edit: July 11, 2011, 09:20:44 PM by dpb »
Date        CD4    %    VL
1/15/11    Diagnosed
3/1/11    525    18    168,518
5/12/11    558    16    331,791
5/16/11    Started Atripla
5/31/11    NA    NA    1,200
6/15/11    721    21    330
7/15/11    649    23    231
8/15/11    569    25    UD
11/17/11  752    26    UD
3/1/12    634    27    UD
7/2/12    594    26    UD
2/13       676    30    UD
9/13       662    31    UD

Offline sensual1973

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  • Posts: 197
Re: Cure research
« Reply #2 on: July 12, 2011, 04:59:39 AM »
I think that rich countries should be forced to contribute to AIDS research too,its not the responsibilty of the US or Europe alone.
God grant me the serenity to accept the things i can not change.

Offline LM

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Re: Cure research
« Reply #3 on: July 12, 2011, 08:55:31 AM »
I think that rich countries should be forced to contribute to AIDS research too,its not the responsibilty of the US or Europe alone.

And who else is rich besides US and Europe?

What annoys me is that they dedicate US$ 20mi to research for HIV cure, while US$ 1 trillion is spent with wars.

Offline sensual1973

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Re: Cure research
« Reply #4 on: July 12, 2011, 12:02:21 PM »
Havent you heard of Saudi Arabia ?,UAE?,Brunie? they sit on trillions.
« Last Edit: July 12, 2011, 12:04:28 PM by sensual1973 »
God grant me the serenity to accept the things i can not change.

Offline metekrop

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  • I love you all...
Re: Cure research
« Reply #5 on: July 12, 2011, 06:31:48 PM »
....,its not the responsibilty of the US or Europe alone.

What else countries you know are rich in the world to do research on AIDS other than US and EU?
Diag on Dec 8, 2000, CD 440 VL 44K, No Meds
Dec/08 - Feb/09 CD< 50 & VL >500k hosp'z.
St. Atripla - July/09 CD 179, VL 197k
Oct/09 CD 300 VL UD Chol 267
Mar/10 CD 468 UD, Ch 220
Aug/10 CD 460 UD, Ch 195
Dec/10 CD 492 UD, Ch 172
Mar/11 CD 636 UD, Ch 201
Aug/11 CD 530 UD, Ch 98
Jan/12 cd 616 UD, ch 189
Jul/12 CD 640 UD, Ch ?
Dec/12 CD 669 Ud, Ch 125
May/7 CD711 Ud, Ch?
Nov/ 22 663 UD, Ch,
April 17 CD 797,
Oct, 14 CD 810 UD
Apr, 15 CD 671 UD
Oct 15 CD 694 UD

Offline sensual1973

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Re: Cure research
« Reply #6 on: July 13, 2011, 03:22:03 AM »
all am saying is that other rich countries "must" contribute financially to the research going on in the west,i hope my point is now clear.
God grant me the serenity to accept the things i can not change.

Offline Hellraiser

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Re: Cure research
« Reply #7 on: July 13, 2011, 03:23:33 AM »
What else countries you know are rich in the world to do research on AIDS other than US and EU?

To say the US is rich is almost laughable.  We're in debt up to our eyeballs.

Offline Assurbanipal

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  • Taking a forums break, still see PM's
Re: Cure research
« Reply #8 on: July 13, 2011, 07:37:14 AM »
To say the US is rich is almost laughable.  We're in debt up to our eyeballs.

I know you live deep in FOX country, but you are repeating Republican nonsense/spin that is emotive rather than factual.  In the reality based world....  the US has been at higher debt levels previously --after the Great Depression and world war II -- furthermore current US debt levels as a percent of Gross Domestic Product are comparable or smaller than most other strong economies such as Germany -- and we could fix most of the problem by letting the Bush tax cuts expire and returning to the historically low, but slightly higher, tax rates of the Clinton years) 

As far as rich countries, if you rank them by total GDP then China should step up and so should Japan.  Even on GDP per capita Japan is a very rich country.
5/06 VL 1M+, CD4 22, 5% , pneumonia, thrush -- O2 support 2 months, 6/06 +Kaletra/Truvada
9/06 VL 3959 CD4 297 13.5% 12/06 VL <400 CD4 350 15.2% +Pravachol
2007 VL<400, 70, 50 CD4 408-729 16.0% -19.7%
2008 VL UD CD4 468 - 538 16.7% - 24.6% Osteoporosis 11/08 doubled Pravachol, +Calcium/D
02/09 VL 100 CD4 616 23.7% 03/09 VL 130 5/09 VL 100 CD4 540 28.4% +Actonel (osteoporosis) 7/09 VL 130
8/09  new regimen Isentress/Epzicom 9/09 VL UD CD4 621 32.7% 11/09 VL UD CD4 607 26.4% swap Isentress for Prezista/Norvir 12/09 (liver and muscle issues) VL 50
2010 VL UD CD4 573-680 26.1% - 30.9% 12/10 VL 20
2011 VL UD-20 CD4 568-673 24.7%-30.6%
2012 VL UD swap Prezista/Norvir for Reyataz drop statin CD4 768-828 26.7%-30.7%
2014 VL UD - 48
2015 VL 130 Moved to Triumeq

Offline John2038

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Re: Cure research
« Reply #9 on: July 15, 2011, 02:05:23 PM »
Others recent funding for research seeking for a cure

Expanded Research Effort To Seek Cure For AIDS - July 14, 2011

Funding support, totaling $32 million, comes from the National Institute of Allergy and Infectious Diseases, a member of the National Institutes of Health. The group will pursue a dozen or more projects to determine how HIV remains dormant and almost undetectable in the immune system's T-cells, and to develop possible drug treatments to counter these HIV reservoirs.

"This group approach has me much more optimistic," says Siliciano, whose initial discoveries of the viral reservoirs and their ability to evade antiretroviral drug therapies led him initially to doubt the possibility of a real cure for the disease. Now, he adds, "after years of developing a better understanding of these HIV reservoirs, to the point where we can make and study latently infected T-cells in the laboratory, we are finally ready to go after them." Siliciano is a professor at Johns Hopkins and a Howard Hughes Medical Institute investigator.


$5.6 Million In Federal Funds To Seek A Cure For AIDS - July 13, 2011

The Gladstone Institutes will receive funds totaling $5.6 million over five years as part of the first-ever major funding initiative focusing on HIV eradication. The funds will help three principal investigators at Gladstone, an independent biomedical-research organization, to explore the molecular basis for HIV latency where the virus that causes AIDS "hides" dormant within cells waiting for an opportunity to reemerge when therapy is withdrawn.

With these funds, Dr. Greene's laboratory will seek to identify previously unrecognized products in the cell that help maintain HIV latency - ultimately working to develop inhibitors against these cellular proteins. Dr. Greene's laboratory also will analyze the action and targets of various regulatory molecules known as microRNAs that are present in latently infected CD4 T cells. Eric Verdin, MD, will study the potential role of the cell's chromatin-remodeling machines in the establishment and maintenance of HIV latency; while Melanie Ott, PhD, will examine the role of histone methylation in HIV latency and the effects of small-molecule inhibitors that block the action of various methyl transferases.

"If we can successfully eradicate latency, we might be able to avoid drug therapy altogether," said Dr. Verdin, who is a senior investigator at Gladstone.


Offline Coolio_7

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  • Posts: 66
Re: Cure research
« Reply #10 on: July 15, 2011, 05:05:45 PM »
This all really sounds promising! I'm especially intrigue by the methylation process. If I remember correctly from what i read, if scientists can stop the methylation process then they may be able to override the latency that the cells show when infected.

It would be great if research can continue in terms of finding something that be injected into the infected cells to kill the cells and thus counteract HIVs ability to become dormant. I have read that they already found molecules that can actually seek out HIV latent cells and deliver some kind of peptide or protein to reactivate them. So it should be possible go just kill the cell and thus eradicate all cells infected with HIV.

I'm just happy that his type of research is going on. It gives all of us hope that someday antivirals may not be needed for the rest of our lives!


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