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Author Topic: Alcohol Addiction Drug Tested in HIV Cure Study  (Read 5266 times)

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Offline jeezx

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  • Posts: 21
Alcohol Addiction Drug Tested in HIV Cure Study
« on: June 12, 2011, 03:35:17 PM »

"if researchers can prove that Antabuse is able to activate latently infected cells, it could go into wider scale testing in combination with other drugs with the goal of achieving eradication."


http://www.aidsmeds.com/articles/hiv_antabuse_disulfiram_1667_19875.shtml

http://www.baseline-hiv.co.uk/headline/treatment/2011/05/alcohol-addiction-drug-tested-in-hiv-%E2%80%98cure%E2%80%99-study.html

http://www.thebody.com/content/art60574.html

sounds interesting. cant wait for the results (2012 summer).

Offline MiniPozToyota

  • Member
  • Posts: 203
Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #1 on: June 12, 2011, 04:45:59 PM »
Sounds pretty cool indeed hopefully something will come out of this.
April 2010- tested neg.
Oct-Dec 2010- Came in contact time frame
March 29 2011- tested positive
April 1 2011 -  CD4 346 VL 46856 22% (Hometown hospital)
April 10 2011-  First Actual Appointment
April 11 2011-  CD4 576 VL 11898  44% (Out of state hospital)
May 09 2011- Genotype test no resistance
Jun  02 - CD4 363 VL 22,850  (Hometown hospital)
July 11 2011 - CD4 372 @25% 41,000 (Out of state hospital)
July 27 2011- Started Atripla
Sept 1 2011- CD4 485 VL 73
Oct 17 2011- CD4 389 VL UD @ 25%
Nov 21 2011- CD4 424 VL UD @ 31%
Mar 12 2012- CD4 504 VL UD @ 35%
May 14 2012- CD4 630 VL UD @ 43%
Aug 17 2012- CD4 689 VL UD @ 45%
Nov  6 2012 - CD4 659 VL UD @ 42%
Dec 17 2012 - CD4 859 VL UD @ 48% (out of state hospital)
Mar 18 2013 - CD$ 867 VL UD @ 44%

Offline Ann

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    • Num is sum qui mentiar tibi?
Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #2 on: June 13, 2011, 06:46:11 AM »
Antabuse can be pretty nasty stuff to have to take on a regular basis. It doesn't only effect a person when drinking alcoholic beverages, but it will also effect you if you ingest ANYTHING with an alcohol content, including but not limited to cold remedies and mouthwash.

If it works I suppose it would be worth being hyper-vigilant about any alcohol going past your lips, but wow, Antabuse can really make a person violently ill. I see the articles say that the trials will involve people taking it for only two weeks, but I have my doubts as to whether or not that would be enough time for a sufficient activation to take place.

One to watch, for sure.
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline ngo1

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Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #3 on: June 13, 2011, 11:34:11 AM »
I would not get my hopes high for this.
"Those who pray hundred times a day are not necessarily better than those who masturbate a couple of times a day"......

Offline buginme2

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Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #4 on: June 13, 2011, 10:16:14 PM »
Antabuse can be pretty nasty stuff to have to take on a regular basis. It doesn't only effect a person when drinking alcoholic beverages, but it will also effect you if you ingest ANYTHING with an alcohol content, including but not limited to cold remedies and mouthwash.

If it works I suppose it would be worth being hyper-vigilant about any alcohol going past your lips, but wow, Antabuse can really make a person violently ill. I see the articles say that the trials will involve people taking it for only two weeks, but I have my doubts as to whether or not that would be enough time for a sufficient activation to take place.

One to watch, for sure.


Ugh this doesnt sound pleasant at all. 

Offline LM

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  • Posts: 409
Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #5 on: June 13, 2011, 10:30:39 PM »
Unpleasant or not, the logic is great. Whatever works at flushing out those reservoirs, we'll have a mighty cure on our hands. More drugs will be researched regarding this aspect, so we have to wait and see. And hope.

Offline Jeff G

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  • How am I doing Beren ?
Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #6 on: June 13, 2011, 10:47:03 PM »
Antabuse can be pretty nasty stuff to have to take on a regular basis. It doesn't only effect a person when drinking alcoholic beverages, but it will also effect you if you ingest ANYTHING with an alcohol content, including but not limited to cold remedies and mouthwash.

When I was first diagnosed in the 80's my doc gave me a script for antabuse because it was supposed to raise my CD4 counts . I managed about a month on it till I got a hold of some alcohol by mistake and puked for like what seemed for ever . That was about the same time as around the clock AZT by the handfulls ... jeez those were horrid times .

Offline thunter34

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Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #7 on: June 13, 2011, 11:27:35 PM »
since I prefer hard drugs, i imagine i could get by with the antabuse just fine.

i guess i'd make a prime candidate.
AIDS isn't for sissies.

Offline Ann

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    • Num is sum qui mentiar tibi?
Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #8 on: June 14, 2011, 08:52:20 AM »
since I prefer hard drugs, i imagine i could get by with the antabuse just fine.

i guess i'd make a prime candidate.

You're a prime something or other, Tim. ;D Hard drugs are fine, but puking until you think your stomach is going to come out with the next heave? Not so much.

Some people have a more violent and immediate reaction to this drug than others. Hell, I knew one guy who had to take Antabuse as a condition of his parole and he could get as drunk as he liked, with only minor nausea. Tough cookie, that guy. And I knew a woman who was on it who only had to use mouthwash and would be puking for the next five hours. Weird stuff, Antabuse.

When I was first diagnosed in the 80's my doc gave me a script for antabuse because it was supposed to raise my CD4 counts . I managed about a month on it till I got a hold of some alcohol by mistake and puked for like what seemed for ever . That was about the same time as around the clock AZT by the handfulls ... jeez those were horrid times .

Horrid times indeed. Did it do anything for your CD4s?
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Jeff G

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  • How am I doing Beren ?
Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #9 on: June 14, 2011, 11:11:36 AM »
Horrid times indeed. Did it do anything for your CD4s?

I really don't remember anything but getting very sick from the antabuse and AZT . I do remember trying my hardest and failing to stay on both drugs . At the time there were no other options to treat HIV and I had just tried and failed with both of them and was feeling rather grim about it all . It only got better , I also lost my health insurance at the same time .   

Offline Cosmicdancer

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Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #10 on: June 20, 2011, 09:18:36 PM »
This is a little tangental, but I've read that as few as 1 in 1 million infected cells are dormant, reservoir cells.  This is very confusing, since when I do the math, I don't know what cells are being referred to (t-cells, macrophages, other cells?)  if someone has a t-cell count of 500 for example (which means 500 t-cells per ML of blood, and the typical 160 pound male has about 5,000 ML of blood), that amounts to a total of 2,500,000 t-cells in the person's body.  So obviously, the reservoir is not just 2 or 3 cells. 

Do they mean 1 out 1 million cells in the entire body?  The average person has about 100 trillion cells in their body, so I don't think that the reservoir of infected cells is 10 million... but I would like to get some idea of what's being talked about, because when I read articles about purging the infected cells, the terms are never really defined. 
Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
June, 2008 - undetectable, 612 cd4
January, 2009 - undetectable, 670 cd4
May, 2009 - undetectable, 593 cd4
Sept, 2009 - 83 vl, 763 cd4, 34%
Dec, 2009 - undetectable, 889 cd4, 32%
April, 2010 - undetectable, 860 cd4, 31%
October, 2010 - undetectable, 800 cd4, 38%
April, 2011 - undetectable, t-cell test not done
October, 2011 - undetectable
April, 2012 - undetectable, 850 cd4, 39%
November, 2012 - undetectable, 901 cd4, 41%
April, 2013 - undetectable, 846 cd4, 36%
October, 2013 - undetectable
May, 2014 - undetectable, 784 cd4, 48%

Offline Hellraiser

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Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #11 on: June 21, 2011, 02:12:40 AM »
Part of this is because they're honestly not sure where all the reservoirs are.  They are relatively sure that the reservoir exists in more than one cell type.

Offline stargate12

  • Member
  • Posts: 30
Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #12 on: June 21, 2011, 04:09:07 PM »
This is a little tangental, but I've read that as few as 1 in 1 million infected cells are dormant, reservoir cells.  This is very confusing, since when I do the math, I don't know what cells are being referred to (t-cells, macrophages, other cells?)  if someone has a t-cell count of 500 for example (which means 500 t-cells per ML of blood, and the typical 160 pound male has about 5,000 ML of blood), that amounts to a total of 2,500,000 t-cells in the person's body.  So obviously, the reservoir is not just 2 or 3 cells.  

Do they mean 1 out 1 million cells in the entire body?  The average person has about 100 trillion cells in their body, so I don't think that the reservoir of infected cells is 10 million... but I would like to get some idea of what's being talked about, because when I read articles about purging the infected cells, the terms are never really defined.  


Your calculations are not accurate.... ( perhaps i m wrong... )
The result is 2.5 bilions....
Did you like algebra at school ? ::) I
« Last Edit: June 21, 2011, 04:12:25 PM by stargate12 »

Offline Cosmicdancer

  • Member
  • Posts: 146
Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #13 on: June 21, 2011, 09:55:08 PM »
LOL, I did enjoy algebra.  But my calculation of 5,000 ml x 500 t-cells was correct.  2.5 million.   But I think Hellraiser is right that since we don't know how many types of cells HIV infects, it's hard to figure out how large the reservoir could be. 
 
Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
June, 2008 - undetectable, 612 cd4
January, 2009 - undetectable, 670 cd4
May, 2009 - undetectable, 593 cd4
Sept, 2009 - 83 vl, 763 cd4, 34%
Dec, 2009 - undetectable, 889 cd4, 32%
April, 2010 - undetectable, 860 cd4, 31%
October, 2010 - undetectable, 800 cd4, 38%
April, 2011 - undetectable, t-cell test not done
October, 2011 - undetectable
April, 2012 - undetectable, 850 cd4, 39%
November, 2012 - undetectable, 901 cd4, 41%
April, 2013 - undetectable, 846 cd4, 36%
October, 2013 - undetectable
May, 2014 - undetectable, 784 cd4, 48%

Offline Pepino2

  • Member
  • Posts: 36
  • Facial wasting need not be...Teach PMMA!
Re: Alcohol Addiction Drug Tested in HIV Cure Study
« Reply #14 on: June 23, 2011, 09:35:04 PM »
All the fears about the effects of Antabuse made me grin.  As a recovering alcoholic, I can only recommend something very simple to avoid them. -  "Don't Drink" LOL!

 


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