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Author Topic: ICAAC 2014  (Read 448 times)

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Offline buginme2

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  • Posts: 3,118
ICAAC 2014
« on: September 12, 2014, 10:54:42 AM »
The news out of ICAAC this year is that, there is no news!  The conference was September 5-9 and I didn't hear anything this year.  That's a little disappointing as previous years have been full of new research and optimism.

There has been some discussion if the whole hiv "cure" research is worth it as so far it hasn't returned much value for the investment and the money spent on cure research could be used to develop better, less toxic, super duper meds. 

From the body "A bad year for HIV cure research? Experts mix realism and hope"

http://www.thebodypro.com/content/74961/a-bad-year-for-hiv-cure-research-experts-mix-reali.html


More interesting and exciting (to me at least) is that the new NRTI BMS-986001 did well in a phase 2 trial.  Seems to have the same efficacy as Tenofovir but with less toxicity ie bone and kidney issues.  Will be awhile before approved but hopefully we will be able to ditch the Tenofovir.  I'd switch just to stick it to Gilead since they have been sitting on TAF until the Tenofovir patent expires fully knowing the kidney and bone issues it's causing..that's a royal screw you to the aids peeps.

http://www.thebodypro.com/content/74948/new-hiv-drug-bms-986001-safe-and-effective-in-trea.html

And..it seems hep c is transmitted through sexual contact between men so keep it in your pants.





Offline Matts

  • Member
  • Posts: 223
Re: ICAAC 2014
« Reply #1 on: September 12, 2014, 09:49:16 PM »
I thought that Festinavir is "dead".

"Licensing agreement between Oncolys and BMS has been terminated and the compound returned to Oncolys for continued development"
http://www.pipelinereport.org/2014/arv

"
Conclusions
At Week 24/48, higher doses of BMS-986001 demonstrated comparable efficacy to TDF when combined with EFV+3TC; however, a higher % of sbj developed resistance to study drug(s) in the BMS-986001 arms. BMS-986001 was generally well tolerated."
((6-14% resistances in the Festinavir  group (with different doses) vs. 1% in the TDF group))

I think that we will hear of BMS-986001 never again :) But maybe I'm wrong.

tivicay/kivexa

Offline freewillie99

  • Member
  • Posts: 311
Re: ICAAC 2014
« Reply #2 on: September 13, 2014, 10:56:10 AM »
About the best, i.e. most positive, comment in the article:

"The second major approach is utilizing our knowledge of genomics and gene therapy to do one of two things: either to delete virus from infected cells, or to produce cells that are resistant to HIV infection that can then be reintroduced to individuals with chronic infection. Neither of these two approaches for cure strategies have yet achieved the kind of gains that we would like them to, but I think they have the potential for transforming what we now think of as functional cures of HIV infection."

- Constance Benson, M.D.

Dr. Benson is a professor of medicine and senior attending physician in the Division of Infectious Diseases at University of California-San Diego. This is an excerpt from her presentation at ICAAC 2014.

Beware Romanians bearing strange gifts

 


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