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Author Topic: Isentress/Truvada Switch - And Dreams  (Read 4413 times)

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Offline WildcatCC

  • Member
  • Posts: 91
Isentress/Truvada Switch - And Dreams
« on: April 24, 2010, 08:08:18 AM »
I'll tell you what. When I was on Atripla, I had the most colorful, vivid dreams; dreams that I would recall in detail the next day much to the dismay of my BF who had to hear about them.  >:(

Sadly, the Atripla treatment did not work well for me (stubborn numbers!) and I sought a change. My doc and I discussed the Isentress/Truvada combo. It seemed the right one for me and I made the switch. So far so good. New numbers in May.

But holy crap, the dreams! Now more then ever, the dreams are so real and so detailed yet so very strange. As soon as my head hits the pillow and until I wake up 8 hours later, I am racing through a rain-forest, playing a chello in Macy's, stringing a racquet with Andy Dick and Gwyneth Paltrow or doing beer chasers with my Aunt Bee.

Anyone else having unbelievable dreams on this combo?
Apr  08 - Diagnosed
Apr  08  cd4 8, vl 150k
Meds: Prezista/Norvir/Truvada
June 08 cd4 250, vl 1600
Aug  08 cd4 275, vl 450
Meds: Atripla
Nov  08  cd4  386, vl 255
Jan   09  cd4  415, vl 2100 (spike?)
Feb   09  cd4 460, vl 212
May   09  cd4 515, vl 1200
Aug   09  cd4 717, vl 1535 % 23
Sept  09  cd4 535  vl 1710 % 18
Oct   09  genotype shows mutation. Discussing w/ ID Doc
Nov  09   cd4 480  vl 650   % 19
Dec  09 genotype slight mutation to Epivir and Retrovir
Jan 10   cd4 508 vl 250 (21%)  low vitamin d - on supplement 2000 iu/day
Mar 15 Change to Isentress and Truvada
May 5 cd4 498 vl 1485
June 16 cd4 550 vl undect!!!! (finally dammit)

Offline Billy B

  • Member
  • Posts: 374
Re: Isentress/Truvada Switch - And Dreams
« Reply #1 on: April 24, 2010, 11:35:43 AM »
I'll tell you what. When I was on Atripla, I had the most colorful, vivid dreams; dreams that I would recall in detail the next day much to the dismay of my BF who had to hear about them.  >:(

Sadly, the Atripla treatment did not work well for me (stubborn numbers!) and I sought a change. My doc and I discussed the Isentress/Truvada combo. It seemed the right one for me and I made the switch. So far so good. New numbers in May.

But holy crap, the dreams! Now more then ever, the dreams are so real and so detailed yet so very strange. As soon as my head hits the pillow and until I wake up 8 hours later, I am racing through a rain-forest, playing a chello in Macy's, stringing a racquet with Andy Dick and Gwyneth Paltrow or doing beer chasers with my Aunt Bee.

Anyone else having unbelievable dreams on this combo?

I don't, but then I take the Truvada in the AM. I am concerned about your Andy Dick dreams .....that really must be scary.
Billy
VL 4420 CD4 340 CD4% 24   3/15/10 Started I&T
VL  UD   CD4 340 CD4% 26.5 05/13/10
VL  UD   CD4 360 CD4% 27.1 08/3/10
VL  UD   CD4 310 CD4% 28.4 11/22/10
VL  UD   CD4 420 CD4% 27.9 02/11/11
VL  UD   CD4 370 CD4% 26.4 06/08/11
VL  UD   CD4 360 CD4% 27.7 09/23/11
VL  UD   CD4 370 CD4% 28.3 01/20/12
VL  UD   CD4 430 CD4% 28.8 05/11/12
VL  UD   CD4 370 CD4% 28.1 09/07/12
VL  UD   CD4 390 CD4% 32.3 03/14/13

Offline Hellraiser

  • Member
  • Posts: 4,136
  • Semi-misanthropic
Re: Isentress/Truvada Switch - And Dreams
« Reply #2 on: April 24, 2010, 12:02:00 PM »
OMG I have dreams where I'm working the counter at Macy's too and I have no idea why because I've never worked in a department store in my life.  I've probably had like 3 or 4 dreams where I'm working the counter at Macy's however.  That's so odd.

Offline WildcatCC

  • Member
  • Posts: 91
Re: Isentress/Truvada Switch - And Dreams
« Reply #3 on: April 24, 2010, 12:37:55 PM »
I take my Truvada with one Isentress in the AM and the other Isentress in the PM.

Hellraiser - that is odd huh? Maybe we are destined to be counter gals.
Apr  08 - Diagnosed
Apr  08  cd4 8, vl 150k
Meds: Prezista/Norvir/Truvada
June 08 cd4 250, vl 1600
Aug  08 cd4 275, vl 450
Meds: Atripla
Nov  08  cd4  386, vl 255
Jan   09  cd4  415, vl 2100 (spike?)
Feb   09  cd4 460, vl 212
May   09  cd4 515, vl 1200
Aug   09  cd4 717, vl 1535 % 23
Sept  09  cd4 535  vl 1710 % 18
Oct   09  genotype shows mutation. Discussing w/ ID Doc
Nov  09   cd4 480  vl 650   % 19
Dec  09 genotype slight mutation to Epivir and Retrovir
Jan 10   cd4 508 vl 250 (21%)  low vitamin d - on supplement 2000 iu/day
Mar 15 Change to Isentress and Truvada
May 5 cd4 498 vl 1485
June 16 cd4 550 vl undect!!!! (finally dammit)

Offline Forever England

  • Member
  • Posts: 21
Re: Isentress/Truvada Switch - And Dreams
« Reply #4 on: May 10, 2010, 12:23:26 AM »
When did you make the switch? When I moved off Efavirenz I found it took several weeks for my sleep patterns to settle down. The dreams softened quite quickly, but I had enormous trouble waking up for several weeks.

Offline Miss Philicia

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  • Posts: 24,142
  • celebrity poster, faker & poser
Re: Isentress/Truvada Switch - And Dreams
« Reply #5 on: May 10, 2010, 01:31:50 PM »
I've been on Isentress and Truvada for 2.5 years and have not noticed any increase in vivid dreams.
"Iíve slept with enough men to know that Iím not gay"

Offline HowYouDoin

  • Member
  • Posts: 56
  • this is not me but i wish, lol
Re: Isentress/Truvada Switch - And Dreams
« Reply #6 on: June 07, 2010, 11:06:01 AM »
Hi WIldcat, I started taking it this week and this is my 5th night on Isentress and my dreams are vivid and kinna violent. I tend to sleep less on it. Maybe i am less tired on ISentress than i was on Kaletra. I tend to have more energy now on this drug than i had on Isentress.

Offline thom k

  • Member
  • Posts: 18
Re: Isentress/Truvada Switch - And Dreams
« Reply #7 on: June 17, 2011, 11:32:31 AM »
I've been on the Isentress/Truvada combo for about a year, maybe less and recently I've noticed how crazy vivid my dreams are-  not bad- just very day glow.

Offline Betelgeuse

  • Member
  • Posts: 163
Re: Isentress/Truvada Switch - And Dreams
« Reply #8 on: June 17, 2011, 02:03:28 PM »
Very strange. Do you guys suspect it's the Truvada or the Isentress? 

I have absolute no change in my sleep patterns or my inability to dream on this regimen.

-Jimmy
04/19/11 - Diagnosed positive
04/29/11 - CD4 188 @ 12.5% / VL 18k
05/03/11 - CD4 171 @ unk% / VL 7k
06/04/11 - Start Truvada/Isentress
07/11/11 - CD4 not tested / VL UD
09/07/11 - CD4 252 @ unk% / VL UD

Offline Miss Philicia

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  • Posts: 24,142
  • celebrity poster, faker & poser
Re: Isentress/Truvada Switch - And Dreams
« Reply #9 on: June 17, 2011, 04:20:24 PM »
While individual accounts are interesting, these issues (meaning "abnormal dreams"/vivid specifically) are 3 times less frequent with Isentress, and even more so in terms of nightmares (basically nil with isentress). I'd say it's nightmares one should focus on, as I would suspect that's where the tendency to lead to Sustiva-related depression lies.

Study data shows this:

In the study, the most commonly reported AEs in the regimens containing raltegravir and efavirenz, respectively, were diarrhea (6.9 versus 10.5 percent), nausea (12.5 versus 10.5 percent), dizziness (8.8 versus 26.3 percent), headache (8.8 versus 23.7 percent), abnormal dreams (6.3 versus 18.4 percent), insomnia (8.1 versus 10.5 percent) and nightmares (0.0 versus 10.5 percent). Neuropsychiatric AEs overall (of these, abnormal dreams and nightmares in particular) were reported less frequently in the regimen containing raltegravir versus the regimen containing efavirenz, (35 percent versus 61 percent, respectively) through Week 144.
"Iíve slept with enough men to know that Iím not gay"

Offline newt

  • Member
  • Posts: 3,885
  • the one and original newt
Re: Isentress/Truvada Switch - And Dreams
« Reply #10 on: June 17, 2011, 05:01:51 PM »
Erm, 1/3rd, yes but it's new, Isentress. The registration studies for efavirenz had CNS side effects/dreams etc at around 6%. Hmmm. All drugs tarnish (that is the side effects get better known) as they get used more, witness kidney stones and depression on Reyataz. << but generally I believe Isentress is kinder to the mind that efavirenz.

Lots of these effects are down to  a person's genetics interacting with the drugs. Some hospitals with links to good research departments can now test for some of these variations if the want (specifically efavirenz, specifically Liverpool).

- matt
"The object is to be a well patient, not a good patient"

Offline Inchlingblue

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  • Posts: 3,119
  • Chad Ochocinco PETA Ad
Re: Isentress/Truvada Switch - And Dreams
« Reply #11 on: June 17, 2011, 09:56:57 PM »
OMG I have dreams where I'm working the counter at Macy's too and I have no idea why because I've never worked in a department store in my life.  I've probably had like 3 or 4 dreams where I'm working the counter at Macy's however.  That's so odd.

It means you like servicing others.
« Last Edit: June 17, 2011, 09:58:32 PM by Inchlingblue »

Offline sfpvguy41

  • Member
  • Posts: 115
Re: Isentress/Truvada Switch - And Dreams
« Reply #12 on: June 18, 2011, 02:31:11 AM »
I think I was an unusual case:  lots of bad side effects when I switched to Isentress from Reyataz/Norvir, so much so that I switched back.  One of them was very vivid dreams, some intense nightmares that woke me up in a panic screaming.  Problems sleeping too...I'd go for hours and couldn't fall asleep until 4 or 5am, and was exhausted the next day.  I kept with it for 4 months and switched back and never had another problem.  So Isentress definitely can give nightmares, sleep problems, vivid dreams etc.  Some of the other problems I had were things my doctor has seen in his big HIV practice, but do not show up in study data....some also go away as you get used to the meds.
Labs: (undetectable since 2005)
12/13: 634 cdr, 37.3%, 758 cd8, total chol 183, triglycerides 131
8/13: changed to Edurant from Reyataz
12/12: 828 cd4, 34.5%, 1078 cd8, total chol 192, tri 196
12/11: 787 cd4, 37%, 979 cd8.
9/11: 758 cd4, 38%, 944 cd8, und.
8/11 dropped norvir, incr reyataz to 400 mg
6/11: 621 CD4 CD4% 41, CD8 680! Undetectable. Creatinine and eGFR are ok now.
Switched from Truvada to Epzicom in late April 2011
AGT/AST and creatinine back to normal mid-April.
Cut Norvir from regimen.
Switched back to Reyataz/Norvir late Feb 2011
2/11: CD4 664 34%, CD8 963, diagnosed with osteoporosis, high AGT/AST and creatinine.
12/10: CD4: 676 CD4%: 34 CD8: 1012
Switched from Reyataz/norvir to Isentress 10/10
8/10: CD4: 731 CD4%: 40 CD8: 866
Diagnosed Sept. 2002 started meds May 2005.

Offline Hellraiser

  • Member
  • Posts: 4,136
  • Semi-misanthropic
Re: Isentress/Truvada Switch - And Dreams
« Reply #13 on: June 20, 2011, 04:25:06 AM »
It means you like servicing others.

True dat.

 


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