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Author Topic: CROI news: Gene treatment (SB-728) boosts CD4s by 200  (Read 2436 times)

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Offline newt

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CROI news: Gene treatment (SB-728) boosts CD4s by 200
« on: February 28, 2011, 03:22:00 PM »
Long and detailed write up of interesting session at important Retrovirus 2011 conference now in progress in Boston. Report from Simon Collins at HIV i-Base. Includes personal experience of guinea pig and activist Matt Sharp:

CROI news: Gene treatment boosts CD4s by 200
http://i-base.info/home/croi-news-gene-treatment-boosts-cd4s/

- matt
"The object is to be a well patient, not a good patient"

Offline Hellraiser

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Re: CROI news: Gene treatment (SB-728) boosts CD4s by 200
« Reply #1 on: March 01, 2011, 02:13:23 AM »
Long and detailed write up of interesting session at important Retrovirus 2011 conference now in progress in Boston. Report from Simon Collins at HIV i-Base. Includes personal experience of guinea pig and activist Matt Sharp:

CROI news: Gene treatment boosts CD4s by 200
http://i-base.info/home/croi-news-gene-treatment-boosts-cd4s/

- matt


This is the same write up in the other threads although there is a disparity in the information.  This article says 10 or 20 billion Tcells reinfused.  The other one said 2.5 or 5 billion.

Offline newt

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Re: CROI news: Gene treatment (SB-728) boosts CD4s by 200
« Reply #2 on: March 01, 2011, 02:20:45 AM »
Report reflects what the abstract says - 1 x 1010 and 2 x 1010 cells.

AIDSMEDS report also says 10 billion ans 20 billion
http://www.aidsmeds.com/articles/HIV_Sangamo_CCR5_2581_19952.shtml

- matt
"The object is to be a well patient, not a good patient"

Offline Hellraiser

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Re: CROI news: Gene treatment (SB-728) boosts CD4s by 200
« Reply #3 on: March 01, 2011, 02:22:37 AM »
Report reflects what the abstract says - 1 x 1010 and 2 x 1010 cells.

AIDSMEDS report also says 10 billion ans 20 billion
http://www.aidsmeds.com/articles/HIV_Sangamo_CCR5_2581_19952.shtml

- matt


Oh matt I trust anything you link to.

Offline Tim Horn

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Re: CROI news: Gene treatment (SB-728) boosts CD4s by 200
« Reply #4 on: March 06, 2011, 10:06:36 AM »
This is the same write up in the other threads although there is a disparity in the information.  This article says 10 or 20 billion Tcells reinfused.  The other one said 2.5 or 5 billion.

Both are right, actually. Though 10 and 20 billion cells were infused in the 1st and 2nd cohorts of the study, respectively, the 2.5 to 5 billion is likely referring to the actual number of CCR5-depleted cells (~25 percent of the total cell volume) infused back into the patients.

Tim

 


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