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Author Topic: telaprevir and boceprevir  (Read 1782 times)

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Offline bobik

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telaprevir and boceprevir
« on: February 02, 2011, 11:18:36 AM »
Anyone experiences with these two drugs for HCV, and the interactions with HIV medication?

Any info would be great

bobik
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Offline Tim Horn

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Re: telaprevir and boceprevir
« Reply #1 on: February 02, 2011, 12:46:24 PM »
Hi Bobik:

Chances are, there aren't too many AIDSmeds Forums participants with telaprevir or boceprivir experience to report, given that both drugs only recently entered clinical trials involving people infected with both HIV and HCV (the Vertex telapevir study just finished enrollment; Merck's boceprevir study is still enrolling).

As for drug interactions, these are definitely going to complicate things a bit for people coinfected with both viruses. Both telaprevir and boceprivr are metabolized by the same enzyme system (P450 3A4) utilized by HIV protease inhibitors and non-nucleoside analogues. Adding an HCV into the mix can either speed up or slow down the rate at which HIV meds are metabolized... and vice versa. Fortunately, both companies report having a number of drug interaction studies lined up, with various HIV meds at the top of the list.

Tim

 


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