Welcome, Guest. Please login or register.
December 09, 2016, 07:20:28 PM

Login with username, password and session length

  • Total Posts: 704700
  • Total Topics: 56103
  • Online Today: 271
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 AM)
Users Online
Users: 3
Guests: 72
Total: 75


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Smallpox vaccine may offer protection against HIV infection  (Read 1462 times)

0 Members and 1 Guest are viewing this topic.

Offline Matts

  • Member
  • Posts: 268
Smallpox vaccine may offer protection against HIV infection
« on: January 06, 2011, 05:34:41 PM »
Smallpox vaccine may offer protection against HIV infection

According to a recent study  published in BMC Immunology, inoculation with the vaccinia virus, the smallpox vaccine, may offer protection against primary HIV infection.

HIV-1 and HIV-2 are believed to have entered  human populations starting around 1931 from primate species (chimpanzees for HIV-1 and sooty mangabeys for HIV-2). But "beginning in the mid-to-late 1950s, both types of HIV entered a phase of exponential spread, first within Africa and then around the world." Explanations for this epidemic include long-standing states of war, poor hospital practices and behavioral factors.

The authors of the study (Weinstein et al) hypothesized that the cessation of smallpox vaccination programs once smallpox was eradicated may have left populations more susceptible to primary infection with HIV.

The human subjects of the study were all HIV-negative and included 10 subjects that were previously vaccinated with the vaccinia virus and 10 that were naive to the virus (never vaccinated). Blood was drawn from each subject and fresh peripheral blood mononuclear cells (mostly lymphocytes and monocytes) were grown in cell cultures. Two strains of HIV were added to the cells and incubated appropriately to enhance infection of the cells with the HIV virus.

Under the various experimental conditions, the blood cells from the vaccinated subjects showed a statistically significant reduction in viral replication (up to a 5-fold decrease of viral replication on day 13)  compared to the viral replication in blood cells from unvaccinated subjects. The results were the most pronounced when infecting with the viral strain requiring the co-receptor CCR5. This result is significant since primary HIV-1 infections are caused almost exclusively by the CCR5-tropic HIV-1 strains.

The authors speculate "that prior immunization with vaccinia virus might play a role in providing an individual with some degree of protection to subsequent HIV infection and/or disease progression."*

Recent studies suggest that the smallpox vaccine provides some level of defense against HIV. Both the smallpox and HIV exploit a receptor called CCR5, which is expressed on the surface of white blood cells. Researchers theorize that one factor in the sudden spread of HIV in the early 1980s was the result of eradication of smallpox in the late 1970s, and the subsequent and abrupt decline in smallpox vaccinations worldwide. #



Full Study:
« Last Edit: January 06, 2011, 05:42:50 PM by Matts »


Terms of Membership for these forums

© 2016 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.