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Author Topic: Timothy Ray Brown: The First Person To Be Cured of HIV/AIDS  (Read 11182 times)

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Online Miss Philicia

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Re: Timothy Ray Brown: The First Person To Be Cured of HIV/AIDS
« Reply #50 on: December 14, 2010, 11:42:11 PM »
try reading the links and the thread next time, meech
"I’ve slept with enough men to know that I’m not gay"

Online mecch

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Re: Timothy Ray Brown: The First Person To Be Cured of HIV/AIDS
« Reply #51 on: December 15, 2010, 05:50:11 AM »
Gee Miss Snark, I did.

Was just noting it was in the news, and since 2008. And the public doesnt think its "the" cure - rather good news and adds hope for a cure. 

http://news.bbc.co.uk/2/hi/7726118.stm
http://news.doctissimo.fr/sida-vih-indetectable-apres-une-greffe-de-moelle-osseuse_article4509.html

and so on and so on.

I understand the difference between "maybe cure" in 2008 and "cure" in 2010 but in a bigger sense its still the same story today - no everyday cure, which is what was understood in 2008, anyway.

I like the Huff post piece with advice to journalists.

« Last Edit: December 15, 2010, 06:04:54 AM by mecch »
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Inchlingblue

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Re: Timothy Ray Brown: The First Person To Be Cured of HIV/AIDS
« Reply #52 on: December 15, 2010, 09:15:37 AM »

I understand the difference between "maybe cure" in 2008 and "cure" in 2010 but in a bigger sense its still the same story today - no everyday cure, which is what was understood in 2008, anyway.

He has been closely monitored for almost 3 years at this point (maybe longer?) and even his own doctors were loathe to declare that he had in fact been cured, in case the virus came roaring back.

What prompted this latest news is that his doctors have at this point officially declared him, for all intents and purposed, cured. It begins to close the chapter on the debate as to whether or not he was cured.

It also adds more fuel to the possibility that this approach, albeit modified via gene therapy, may actually provide a cure for others.

Offline Jeffreyj

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This gives me hope
« Reply #53 on: December 15, 2010, 09:22:41 AM »
Positive since 1985

Offline metekrop

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Re: This gives me hope
« Reply #54 on: December 15, 2010, 01:32:23 PM »
Does it mean that should we all undergo to stem cell transplant in order to get cured of our friend HIV?  ::)
Diag on Dec 8, 2000, CD 440 VL 44K, No Meds
Dec/08 - Feb/09 CD< 50 & VL >500k hosp'z.
St. Atripla - July/09 CD 179, VL 197k
Oct/09 CD 300 VL UD Chol 267
Mar/10 CD 468 UD, Ch 220
Aug/10 CD 460 UD, Ch 195
Dec/10 CD 492 UD, Ch 172
Mar/11 CD 636 UD, Ch 201
Aug/11 CD 530 UD, Ch 98
Jan/12 cd 616 UD, ch 189
Jul/12 CD 640 UD, Ch ?
Dec/12 CD 669 Ud, Ch 125
May/7 CD711 Ud, Ch?
Nov/ 22 663 UD, Ch,
April 17 CD 797, UD

Offline Realist

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Re: This gives me hope
« Reply #55 on: December 15, 2010, 01:50:25 PM »
Does it mean that should we all undergo to stem cell transplant in order to get cured of our friend HIV?  ::)

No.

It represents a functional cure, but the variables are huge and it isn't a blanket approach.

1. You'd have survive the chemo which would wipe out what little immune system we have already.
2. There wouldn't be enough donors with the right mutation to treat everyone.
3. You'd need to be able to afford it (if you aren't in a country with a social health care system).
4. The stem cell transplant dealt with the CCR5 co-receptors but not the CXCR4 receptors - it remains to be seen whether they may become targetted by any latent virus in this patient.

Its great news but its a hard, hard journey. All has not been rosy in the garden for this patient - he has neurological problems, coordination problems and needs speech therapy. It also took more than one transplant attempt to get him where he is today.

Lets hope the researchers build on this experience and can generate a modified genetic solution which is easier to implement.

As the OP says - it gives hope.
23/02/10 Tests confirmed
25/02/10 13100 220 24%
12/03/10 19800 372 19%
26/03/10 Atripla
30/04/10 58 286 23%
28/05/10 45 222 21%
25/06/10 UD 301 23%
24/09/10 UD 283 22%
01/12/10 UD 319 23%
11/03/11 UD 293 28%
10/06/11 UD 423 24%
23/08/11 UD 389 26%
28/02/11 UD 315 34%

I blogged it all http://notdownnotout.blogspot.com

Offline Hellraiser

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Re: Timothy Ray Brown: The First Person To Be Cured of HIV/AIDS
« Reply #56 on: December 15, 2010, 04:24:56 PM »
Actually I'm assuming he still reliably tests positive, so he would be allowed to post in the forums even though he is no longer infected.  In that way he is still HIV+.

Online mecch

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Re: Timothy Ray Brown: The First Person To Be Cured of HIV/AIDS
« Reply #57 on: December 15, 2010, 05:08:11 PM »
Assuming a cure eventually, and assuming a continuing need for this forum, I'm sure nobody would prevent previously HIV+ people from joining or staying.  ;D
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Inchlingblue

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Re: Timothy Ray Brown: The First Person To Be Cured of HIV/AIDS
« Reply #58 on: December 15, 2010, 05:43:17 PM »
Actually I'm assuming he still reliably tests positive, so he would be allowed to post in the forums even though he is no longer infected.  In that way he is still HIV+.

A previous update on him said they were finding fewer and fewer HIV antibodies so it was expected there would come a point in time that he would actually test negative. That probably hasn't yet happened but it's what they expect based on the declining numbers of antobodies.

Offline Inchlingblue

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Re: Timothy Ray Brown: The First Person To Be Cured of HIV/AIDS
« Reply #59 on: December 16, 2010, 12:10:13 PM »
The article linked below is an excellent, very clearly-written explanation of what precisely happened with Timothy Ray Brown and his treatment that resulted for him in an HIV cure.

LINK:

http://www.webmd.com/hiv-aids/news/20101215/hiv-aids-cure-faq

Offline leatherman

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Re: Timothy Ray Brown: The First Person To Be Cured of HIV/AIDS
« Reply #60 on: December 16, 2010, 03:11:02 PM »
http://www.webmd.com/hiv-aids/news/20101215/hiv-aids-cure-faq
"Few people with HIV would want to go through the grueling and life-threatening cancer treatment that was part of this cure. And so far, the cure has not been duplicated in other HIV-positive leukemia patients who underwent similar treatment."

is there any more information somewhere on how many other "HIV-positive leukemia patients who underwent similar treatment" and were not cured?

leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline Inchlingblue

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Re: Timothy Ray Brown: The First Person To Be Cured of HIV/AIDS
« Reply #61 on: December 16, 2010, 04:03:24 PM »
"Few people with HIV would want to go through the grueling and life-threatening cancer treatment that was part of this cure. And so far, the cure has not been duplicated in other HIV-positive leukemia patients who underwent similar treatment."

is there any more information somewhere on how many other "HIV-positive leukemia patients who underwent similar treatment" and were not cured?


I could be wrong but I don't think it's a question of others not being cured but rather that the "experiment" has not been exactly duplicated because so far for others with HIV and leukemia it has not been possible to find a donor match who also had the delta-32 mutation.

It's not that easy to find, most donor registries don't contain that information so people have to be screened, which is expensive and time consuming. As mentioned above, for Ray it took 61 donor screenings before they found one that was a match and also had the delta-32 mutation.

The article is vague when they say the others underwent "similar" treatment.  There have been bone marrow transplants on those with HIV in the past that did not involve a donor with the delta-32 mutation.

It does say this, though:

A patient with leukemia can't wait very long for treatment, and it's not easy to find a matched donor who carries the double mutation.

"The Germans have tried and we have tried in the U.S., but we have not found another situation where we had an AIDS patient who could go forward for the transplant," Zaia says.
« Last Edit: December 16, 2010, 04:19:33 PM by Inchlingblue »

Offline leatherman

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Re: Timothy Ray Brown: The First Person To Be Cured of HIV/AIDS
« Reply #62 on: December 16, 2010, 04:34:33 PM »
ah! and that's why I was wondering. It phrases it in one place that "the cure was not duplicated in patients who underwent similar treatment" which to me sounds as they tried this/similar treatment in other patients who were not cured - meaning they still had HIV or they might have died during treatment. Yet later it says that they "have not found another situation with a patient that could have the transplant" which sounds as if they haven't actually done this/similar treatment at all.

obviously those statements/situations are very different. Viewing it one way, this patient is the one and only that has tried this procedure and he was cured. Batting 1000. However in the other view, they've done this procedure on 5 patients and he is the only one to survive or be cured. Batting 200. Very different results indeed.

and then as you pointed out there is the vagueness of "similar treatment" which doesn't mean the "same treatment".

thanks ;)
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

 


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