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Author Topic: Hives - IRIS?  (Read 2997 times)

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Offline littleprince

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Hives - IRIS?
« on: August 06, 2010, 10:24:21 PM »
I've been on Kaletra and Truvada for a few months now. My CD4 count was <10 when I started and I ended up with IRIS related to the PCP infection that I had. I've also had various small skin related problems which I put down to either a shitty immune system or a recovering immune system.

Lately I've been getting hive like lumps on my face. they are not red or rash like, just inflamed and itchy. A bit of cortisone cream cures them but within a week they start back again. I'm trying to work out if the hives are HIV related or an allergy to something totally unrelated. Anyone else end up with hives when your CD4 cont started bouncing back?


Offline Miss Philicia

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Re: Hives - IRIS?
« Reply #1 on: August 07, 2010, 10:52:06 AM »
It may just be this:

http://dermatology.about.com/cs/seborrhea/a/seb_aids.htm

Quote
Seborrheic dermatitis is a common disease that affects 2%-4% of the general population. However, up to 85% of HIV-infected people experience seborrheic dermatitis at some time after they acquire the infection. The cause of seborrheic dermatitis is unknown, but many investigators believe the yeast, Pityrosporum ovale, plays a role in the disease. It is further postulated that the alteration of the immune system in HIV-AIDS changes the way the skin responds to this yeast leading to the higher rate of infection.

Appearance
Seborrheic dermatitis causes redness of the skin, which produces a yellow, waxy scale or flake. In people without HIV-AIDS, the rash of seborrheic dermatitis occurs mainly on the scalp, and around the eyebrows, ears, and mustache. In HIV-infected individuals, the rash also appears on the chest, back, armpits, and groin.

Treatment
Seborrheic dermatitis is treated with antifungal shampoos and topical corticosteroids. These treatments are also used for HIV-infected individuals who need to use them frequently. People with HIV-AIDS who are being treated with antiviral therapy have fewer outbreaks of seborrheic dermatitis. In many cases, the severity of the rash corresponds with the degree of clinical deterioration.

Seeing a Doctor
A health care provider should evaluate cases of seborrheic dermatitis that do not respond to typical over-the-counter treatments. However, this does not necessarily imply that a person is HIV-positive. Someone with HIV-AIDS should notify their physician if they have a red, flaking rash that is getting worse so they can get appropriate treatment.
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Offline debsd222

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Re: Hives - IRIS?
« Reply #2 on: August 07, 2010, 10:22:17 PM »
Boy, don't you all wish they would figure some of this crap out sooner than they do? I fought with red bumps on my face and arms for 3-4 months, rubbing every kind of cream OTC I could find . I even tried clearasil. They itched like crazy, especially at night. Doc finally cultured them and they were staph. I took antibiotics for them and they mostly went away but I had an allergic reaction to the penicillin 8 days in and ended up in the hospital. Now I use hibaclens antimicrobial wash (they have it in my pharmacy) and it keeps it pretty well taken care of. I laugh now when I remember rubbing that clearasil on there. I dont know what I was thinking, Im 58, a little old for acne.
April 08 3 month bout w/ shingles, ongoing nerve pain
Dec 08 pos  cd4 200 %8  VL 18,000
Feb 09 started sustiva, truvada -allergic to sustiva, hospital 4 days.
March 09 started truvada, reyataz and norvir
March 09  cd4 279  % 12 VL 10,000
April 09 cd4 327  %12  VL 300
Aug 09 cd4 392  %16  Vl undetectable
Dec 09 hospital pneumonia 6 days
Dec 09 cd4 462  %20  VL undetectable
Mar 10 cd4 629 27% VL undetectable
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May 2013 cd4 759. 29%. VL. UD

Offline jkinatl2

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Re: Hives - IRIS?
« Reply #3 on: August 07, 2010, 10:46:57 PM »
I would think that IRIS would have manifested a lot sooner, and been a lot more severe. Goddess knows mine took hold in a week, and threw me in a hospital for two more with (not so) latent PCP and junk.

The steroids they gave me to combat that inflammation (and the weaning off thereof) produced legendary hallucinations that plague me to this day.

Crazy stuff, that HIV.

"Many people, especially in the gay community, turn to oral sex as a safer alternative in the age of AIDS. And with HIV rates rising, people need to remember that oral sex is safer sex. It's a reasonable alternative."

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Offline Hellraiser

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Re: Hives - IRIS?
« Reply #4 on: August 08, 2010, 07:42:17 AM »
I would think that IRIS would have manifested a lot sooner, and been a lot more severe. Goddess knows mine took hold in a week, and threw me in a hospital for two more with (not so) latent PCP and junk.

The steroids they gave me to combat that inflammation (and the weaning off thereof) produced legendary hallucinations that plague me to this day.

Crazy stuff, that HIV.



I also manifested IRIS at least within 2 weeks of starting treatment and it didn't resolve for months as my immune system began the slow steady climb out of the valley.  I too had to take tetracycline for the staph on my skin which was causing what seemed like hives.

Offline littleprince

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Re: Hives - IRIS?
« Reply #5 on: August 08, 2010, 02:34:08 PM »
Quote
I too had to take tetracycline for the staph on my skin which was causing what seemed like hives.

Good to know, thanks. Finally managed to get rid of all the hives today with some antihistamines. If they keep coming back a trip to my Dr may be in order.

Offline Zohar

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Re: Hives - IRIS?
« Reply #6 on: November 28, 2010, 07:42:37 AM »
Interesting. I've been having 'hives' for the last few months too, although I've noticed that some don't quickly resolve within around 12 hours as classic hives are supposed to. I might mention this to my doc at some point in the not too distant future and see if it's worth checking for staph.
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Offline mecch

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Re: Hives - IRIS?
« Reply #7 on: November 28, 2010, 07:56:58 AM »
Careful with the cortisone cream. Unless a doctor and preferably a dermatologist tells you to use it as maintenance. On a regular basis for a long time, its not great for the skin.
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline poz91

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Re: Hives - IRIS?
« Reply #8 on: November 28, 2010, 03:24:33 PM »
Careful with the cortisone cream. Unless a doctor and preferably a dermatologist tells you to use it as maintenance. On a regular basis for a long time, its not great for the skin.

...I suspect that even short-term use is bad.

It was several years after having used a prescription corticosteroid cream to treat my dermatitis before the telangiectasia (spider veins) started to develop on my face... a common, permanent, and progressively worsening side effect of this medication.

Definitely a case where the short-term benefits aren't worth the long-term risks!

Offline mecch

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Re: Hives - IRIS?
« Reply #9 on: November 28, 2010, 03:31:38 PM »
It is very important that a dermatologist be consulted when dealing with cortisone. I have heard of many people with permanent damage to skin. 
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline littleprince

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Re: Hives - IRIS?
« Reply #10 on: November 29, 2010, 03:59:15 AM »
Quote
I would think that IRIS would have manifested a lot sooner, and been a lot more severe. Goddess knows mine took hold in a week, and threw me in a hospital for two more with (not so) latent PCP and junk.

Oh no, I was the same. the IRIS hit me about a month after starting meds and put me back in hospital. Almost knocked me down as hard as the original PCP. The hives didn't come till later.


Quote
Interesting. I've been having 'hives' for the last few months too, although I've noticed that some don't quickly resolve within around 12 hours as classic hives are supposed to. I might mention this to my doc at some point in the not too distant future and see if it's worth checking for staph.

Mine ended up being mostly controlled by Claratyne. I was taking it daily for 2 months. Finally off it now. 


Quote
Careful with the cortisone cream. Unless a doctor and preferably a dermatologist tells you to use it as maintenance. On a regular basis for a long time, its not great for the skin.

Good point. I'll have to talk to my GP about it next time. I don't use it much anymore but still get the strangest dry patches in random places. Mainly on my face but the latest was right on the ankle. Weird.

Offline jkinatl2

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Re: Hives - IRIS?
« Reply #11 on: November 29, 2010, 04:21:11 AM »
If this was IRIS, then it is vastly important to stay adherent. Do what it takes. Therapy, whatever. Because you simply do not have a buttload of IRIS incidents in you. You survived one. Cool. VERY cool.

Survive another, and we go to Lucky. Go for three, and you are really skating the curve.

This is when the shit gets real.
"Many people, especially in the gay community, turn to oral sex as a safer alternative in the age of AIDS. And with HIV rates rising, people need to remember that oral sex is safer sex. It's a reasonable alternative."

-Kimberly Page-Shafer, PhD, MPH

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Offline Ann

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Re: Hives - IRIS?
« Reply #12 on: November 29, 2010, 09:36:40 AM »
I don't use it much anymore but still get the strangest dry patches in random places. Mainly on my face but the latest was right on the ankle. Weird.


Dry patches or lumpy, itchy hives like you were getting in August? If it's just dry patches, don't use cortisone cream. I get dry patches myself at times and a good moisturiser - one without irritating perfumes etc - usually helps. My skin has been very much on the dry side since I've been poz and exfoliating and moisturising has become a way of life.
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Offline newhorizon80

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Re: Hives - IRIS?
« Reply #13 on: November 29, 2010, 03:38:49 PM »

Almost two weeks into my treatment (Prezista/Tru/Nor) (day 10) I developed hives on my arms, chest, and legs.  I immediately started taking Claratin once a day with Benadryl at night.  The hives on my arms faded within a few days, but the red marks on my legs (looked more like bruises) took a little longer to fade.  Now, one week later, no more hives.  However! Last Wednesday, near my lip, a area of swelling started, looked like a cold sore (which I've never had), woke up in the morning day after Thanksgiving and I had welts/scabs all over my cheeks and chin.  I had impetigo (staph)--- been on antibiotics since Friday and it has already started to clear (no new staph outbreaks). 

The past month (with my Reyataz jaundice, flu, Prezista stomach aches) has been hell, I finally may be on the home stretch to no more side effecs and illness.  ;)
10/30/08: CD4: 486 VL: 13,000
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Offline mecch

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Re: Hives - IRIS?
« Reply #14 on: November 29, 2010, 04:05:42 PM »
Here here to sunnier days, NewHorizon! Like your name by the way.
“From each, according to his ability; to each, according to his need” 1875 K Marx

 


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