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Author Topic: 25 percent of HIV patients develop diabetes  (Read 2672 times)

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Offline smiteler

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  • Posts: 56
25 percent of HIV patients develop diabetes
« on: November 23, 2010, 09:16:43 PM »
my doctor has told me i'm very close to being diabetic  :o
now i know why   :'(

http://www.msnbc.msn.com/id/40345008/ns/health-aids/

Offline wtfimpoz

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Re: 25 percent of HIV patients develop diabetes
« Reply #1 on: November 23, 2010, 09:25:24 PM »
Protease inhibitors were the culprits?  That seems like the sorta thing that a college junior majoring in Health Sciences could've figured out in a statistics class.  Did we really not know they were correllated with higher insulin resistance before?

"Now that we've identified the main mechanism, we will look to develop new drugs that treat HIV but don't cause diabetes."

Unless they're talking about a mechanism of PIs which occurs with other drugs, and not PIs themselves, this all seems redundant. 
09/01/2009-neg
mid april, 2010, "flu like illness".
06/01/2010-weakly reactive ELISA, indeterminant WB
06/06/2010-reactive ELISA, confirmed positive.

DATE       CD4     %     VL
07/15/10  423     33    88k
08/28/10  489     19    189k
09/06/10-Started ATRIPLA
09/15/10  420     38    1400
11/21/10  517     25    51

Online BT65

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Re: 25 percent of HIV patients develop diabetes
« Reply #2 on: November 24, 2010, 05:55:29 AM »
I was diagnosed with diabetes about 12 or 13 years ago.  While I don't like it at all, it's not the end of the world.  Just something else to deal with.
I've never killed anyone, but I frequently get satisfaction reading the obituary notices.-Clarence Darrow

Offline Hellraiser

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Re: 25 percent of HIV patients develop diabetes
« Reply #3 on: November 25, 2010, 03:05:06 AM »
When attempting to allay my fears about being newly Positive my doctor said "I deal with a lot of hiv+ patients as well as patients who have diabetes and if I had to pick between the two I would pick hiv."  That bastard didn't tell me one was causative of the other!

Offline Ann

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Re: 25 percent of HIV patients develop diabetes
« Reply #4 on: November 25, 2010, 08:48:05 AM »
That bastard didn't tell me one was causative of the other!

Did you even read the article? It does NOT say that hiv causes diabetes (and diabetes certainly doesn't cause hiv).

From the article...

The culprit lies in the powerful drugs that prevent the development of AIDS and have extended the lives of many HIV patients, the researchers say. They hope the discovery will allow development of safer antiviral drugs.

The research, published this month in the Journal of Biological Chemistry, shows HIV protease inhibitor drugs directly interfere with the way blood sugar levels are controlled in the body. This leads to insulin resistance, a condition that occurs when the body produces enough insulin but doesn't use it properly.


(emphasis mine so Hell didn't miss the salient points again)
Condoms are a girl's best friend

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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

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Offline elf

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Re: 25 percent of HIV patients develop diabetes
« Reply #5 on: November 25, 2010, 09:32:20 AM »
I avoid sugar, but artificial sweeteners aren't too healthy either.  :-\

It has to do with the liver enzymes:


1. normal people can eat grapefruit, grapefruit inhibits the releasing of insulin

2. people who take PI's or cholesterol lowering drugs mustn't eat grapefruit (or drink its juice)
because the side effects of the drugs are much severe with grapefruit
« Last Edit: November 25, 2010, 09:35:27 AM by elf »
Let's have a Kiki!

Offline Inchlingblue

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Re: 25 percent of HIV patients develop diabetes
« Reply #6 on: November 25, 2010, 09:34:55 AM »
The article mentions "first-generation protease inhibitors" and also mentions ritonavir; it would help if they were more specific about which PIs they found to have a link. It seems it may not be all of them.
« Last Edit: November 25, 2010, 09:36:52 AM by Inchlingblue »

Offline smiteler

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Re: 25 percent of HIV patients develop diabetes
« Reply #7 on: November 25, 2010, 11:01:11 AM »
my doctor has harped on me a few times about what i eat
and asking about my family history because my levels are boarderline diabetic.
the only thing i add sugar to is my coffee,i don't drink sodas
or eat sweets and it doesn't run in my family.
so it was perplexing to me until
i read this article.
now i have ammo to show my doctor its not me.

Offline bocker3

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Re: 25 percent of HIV patients develop diabetes
« Reply #8 on: November 25, 2010, 11:50:59 AM »
Eating too much sugar isn't going to lead to the development of diabetes.  When one talks about insulin regulating blood sugar, it is talking about glucose.  Just about anything you eat will eventually be turned into glucose, because this is what fuels your cells.

Mike
Atripla - Started 12/05
Reyataz/Norvir - Added 6/06
Labs - Pre-Meds
Sep05 T=350/25% VL98,559
Nov05 288/18%  47,564
Current Labs
May2013 691/31% <20

Offline veritas

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Re: 25 percent of HIV patients develop diabetes
« Reply #9 on: November 25, 2010, 12:18:13 PM »

Here's the abstract, first published in Sept, then republished in Nov:

http://www.jbc.org/content/285/47/36395.abstract

I could not find any abstract in humans.

v

Offline newt

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Re: 25 percent of HIV patients develop diabetes
« Reply #10 on: November 25, 2010, 02:13:03 PM »
Quote
Hruz said that about 25 percent of HIV patients develop diabetes.

This is pure speculation, given the low dose of ritonavir most people on PIs take

- matt
"The object is to be a well patient, not a good patient"

Offline Hellraiser

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Re: 25 percent of HIV patients develop diabetes
« Reply #11 on: November 28, 2010, 02:05:22 PM »
Did you even read the article? It does NOT say that hiv causes diabetes (and diabetes certainly doesn't cause hiv).

From the article...

The culprit lies in the powerful drugs that prevent the development of AIDS and have extended the lives of many HIV patients, the researchers say. They hope the discovery will allow development of safer antiviral drugs.

The research, published this month in the Journal of Biological Chemistry, shows HIV protease inhibitor drugs directly interfere with the way blood sugar levels are controlled in the body. This leads to insulin resistance, a condition that occurs when the body produces enough insulin but doesn't use it properly.


(emphasis mine so Hell didn't miss the salient points again)

I know what it said.  Should I boldface some words for you to read?  I was trying to be jocular it obviously sailed right over your head.  All apologies for confusing you.

Offline leatherman

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Re: 25 percent of HIV patients develop diabetes
« Reply #12 on: November 28, 2010, 02:37:16 PM »
Should I boldface some words for you to read?  I was trying to be jocular it obviously sailed right over your head.
I keep on telling you people to use those emoticons  :D ;D

 :-* HR   :-* Ann
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline surf18

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Re: 25 percent of HIV patients develop diabetes
« Reply #13 on: November 28, 2010, 02:58:30 PM »
So if your not a pi then this is less of an issue?
I'm on truvada/selzentry
I don't think there pi's right?

Offline BM

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Re: 25 percent of HIV patients develop diabetes
« Reply #14 on: November 28, 2010, 03:08:04 PM »
So if your not a pi then this is less of an issue?
I'm on truvada/selzentry
I don't think there pi's right?

You're right, they're not PIs: Truvada is an NtRTI + an NRTI, and Selzentry is an entry inhibitor.

Offline surf18

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Re: 25 percent of HIV patients develop diabetes
« Reply #15 on: November 28, 2010, 03:12:21 PM »
thank you!
so i guess my question would be why do dr's still prescribe the PI? I hear there bad to on all the lipo issues too. maybe i heard wrong.

Offline BM

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Re: 25 percent of HIV patients develop diabetes
« Reply #16 on: November 28, 2010, 03:55:59 PM »
thank you!
so i guess my question would be why do dr's still prescribe the PI? I hear there bad to on all the lipo issues too. maybe i heard wrong.

Docs still prescribe PIs because people need them! Yes there are lipo issues but a positive diabetic is better than a dead PI-phobe.

Offline leatherman

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  • Google and HIV meds are Your Friends
Re: 25 percent of HIV patients develop diabetes
« Reply #17 on: November 28, 2010, 04:26:53 PM »
So if your not a pi then this is less of an issue?
....
I don't think there pi's right?
by the way, AM has a lovely list of all the available meds at http://www.aidsmeds.com/list.shtml. click on a med and learn all about it.

and PIs are prescribed many times because they can be an excellent booster, enhancing the effectiveness of the other meds in a regimen, therefore requiring a smaller dosage and/or gaining more bang for the buck.

IF you read the package insert on all of these meds you will learn that for nearly all meds, the majority of those in the original study had NO side effects. (issues like diabetes are simply another side effect) Side effects usually happen to well under 25% of the population else drugs companies would probably not even market these meds. Of course a higher percentage may have some side effects (nausea, vomiting, gas, etc) while getting adjusted to the meds (adjusting to the levels of these chemicals in the body, along with the bodily change in the immune system as the HIV viral load is reduced); but only a few percentage deal with side effects longer than a couple of months.

of course, your mileage may vary according to the drug you are taking and your body, but clearly the facts from the clinical trials show these meds working adequately and without long term side effects for most people who take them.
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

 


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