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Author Topic: CD4%  (Read 1105 times)

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Offline wolfter

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CD4%
« on: October 17, 2010, 10:51:38 AM »
I searched the forums and didn't find help with a question about cd4%.  Unforuntately, until recently I wasn't a very informed LTS.  My previous ID doctor never discussed percentages and I never researched it.  My new doctor (as of March 2009) is great and discussed the numbers but I didn't completely understand as I was suffering severe illnesses at the time.  He uses Webview, which allows me to see my results before my appointment.  My latest % indicates it went from 33 to 16.  Can you guys help me understand the relevance of the % and exactly how it's calculated?
Complacency is the enemy.  ;)  Challenge yourself daily for maximum  return on investment.

Offline Miss Philicia

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Re: CD4%
« Reply #1 on: October 17, 2010, 10:57:35 AM »
http://www.aidsmeds.com/articles/TCellTest_4727.shtml


What is the CD4 Percentage?

If you look at your lab report, you will also see something called your CD4+ percentage (%). This is an important number for you and your doctor to know. In healthy adults, the number of CD4 cells make up between 32% and 68% of the total number of lymphocytes a large group of white blood cells that include CD4 cells, CD8 cells (see below), and B-cells. In fact, the lab uses the CD4 percentage to determine the number of CD4 cells in a sample of blood.

The CD4 percentage is sometimes a more reliable measurement than the CD4 count because it tends to vary less between measurements. For example, one person's CD4 count may vary between 200 and 300 over a several month period while their CD4 percentage remains constant at, say, 21%. Provided that the CD4 percentage stays at 21% or higher, the immune system still appears to be functioning properly, regardless of what the CD4 count is. At the same time, a CD4 percentage at or below 13% regardless of what the actual CD4 count is usually means that the immune system is damaged and that it is time to begin prophylactic treatment (drugs to prevent diseases) for opportunistic infections like PCP.
« Last Edit: October 17, 2010, 11:01:55 AM by Miss Philicia »
"Iíve slept with enough men to know that Iím not gay"

Offline ad2san

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Re: CD4%
« Reply #2 on: October 17, 2010, 11:00:37 AM »
Hi there,

you'll find information here http://www.aidsmeds.com/articles/TCellTest_4727.shtml

Take care
Feb   2009 CD4 358 VL 2000 16%
May  2009 CD4 305 VL 3069  14% <---- Started TVD+ATZ/r
Jul  2009 CD4 512 VL <50   18%
Jul 2010 CD4 418 VL <50 24%                     
Switched to Kivexa (Epzicom) + Norvir + Reyataz (due to sleep problem)
Aug 2010 CD4 606 VL <50 25%
Jul 2011 CD4 494 UD 23%
Switched to Kivexa (Epzicom) + Viramune XR (due to kidney problems)
January 2012 CD4 564 UD 31%
October 2012 CD4 684 UD 29%
January 2013 CD4 594 UD 26%
Switched to Kivexa (Epzicom) + Isentress due to BIG increase GammaGT
Feb 2013 CD4 699 UD 28%
May 2013 CD4 385 UD 28%
July 2013 CD4 CD4 636 UD 25%
Oct 2013 CD4 588 UD 39%
Aug 2014 CD4 639 UD 25%

Offline wolfter

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Re: CD4%
« Reply #3 on: October 17, 2010, 12:44:19 PM »
Thanks, I have a good understanding after reading the article.  It was very informative.  I really did try to search for the answer before posting, guess I'm just needing more education in several departments.   


Thanks again and enjoy!
Complacency is the enemy.  ;)  Challenge yourself daily for maximum  return on investment.

Offline eric48

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  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
Re: CD4%
« Reply #4 on: October 17, 2010, 07:54:22 PM »
... exactly how it's calculated? ...

The funny thing about is is that is NOT calculated from your CD4 count as one might think at first. It is the other way around: CD4 % is measured through a lab assay (I do not know the details)

then when it is multiplied to your total lymphocyte, it yields your CD4 counts

So , in fact , it is the CD4 count that is calculated from the CD4% and not the other way around.

Also, while the most used number to characterize the status of one's immune system is the CD4 count, if the CD4 count is over 500, then it is preferable to look at the percentage rather than the count itself.

This is because, statistically, people with a high cd4 count but a low CD4 % are prone to get sick...

What is a low CD4% ?

a fairly good one is above 30
a barely acceptable one is in the range of 15 to 25 % (there is a plateau there where there is not much difference between say 16 and 22 in terms of disease progress)

once that plateau is passed there is a steep decline and 14 % is (or was ? ) a defining criteria for AIDS
(this is the reason why the criteria is 14 and not 13 or 15...)

So your 16 % is a wake up call. You will need closer monitoring and if it remains at the 16 % level, you may want to consider meds. I had made some research at some point since my initial % was 16.

at 16 % AVERAGE (and I underline average, since you are not average you are one and unique) but that said average time-to-Aids (without meds), if I remember well, was 2 and 1/2 years (do not quote me on this, I am telling on the top of my head, but a very concerned head indeed)(statistics from pre-HAART era)

So get your blood monitored closely. It might be a transient, it might be a trend...

If the percentage remain low or is lowering your doc will most likely discuss meds with you

And you'll be fine... They are not that bad after all

Cheers
Eric 
« Last Edit: October 17, 2010, 08:03:36 PM by eric48 »
NVP/ABC/3TC/... UD; CD4 > 1000; CD4/CD8 ~ 2.0   safety stock : 2 months

Offline wolfter

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Re: CD4%
« Reply #5 on: October 17, 2010, 09:05:55 PM »
Thanks Eric.  This wasn't a question of worrying about my number than it was about helping quantify.  I've made it a mission to completely understand every stupid acronym and its relevance to me personally.  Kinda like another thesis.  I started this regiment Aug 08 with CD4 of 69, and VL 6mil+ and % of 7.7  with crypto at the same time.  I'm doing well on my regiment with great numbers.  I've watched the vl go down and t count up to 419. I pretty much spent 20 years learning this was all I needed to know.  T count and VL.  I'm trying to learn why these numbers are great and % got worse.
Complacency is the enemy.  ;)  Challenge yourself daily for maximum  return on investment.

Offline eric48

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  • Posts: 1,173
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
Re: CD4%
« Reply #6 on: October 18, 2010, 05:41:15 PM »
Sorry... I did not have a entire story...

you say : I didn't completely understand as I was suffering severe illnesses at the time ...

Your CD4 % may appear lower because other populations (for example CD8) have increased on the own because of this illness you mention. In which case, this is most likely transient.

Good to know you are under meds (I did not know at first...)

Eric
NVP/ABC/3TC/... UD; CD4 > 1000; CD4/CD8 ~ 2.0   safety stock : 2 months

 


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