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Author Topic: Atripla's one hour variance  (Read 1650 times)

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Offline wtfimpoz

  • Member
  • Posts: 418
  • Let's make biscuits!
Atripla's one hour variance
« on: October 14, 2010, 11:01:47 PM »
Upon starting treatment, I was told explicitly by my doc that I could safely vary my dosage time by one hour in any direction, earlier or later.  I've been keeping a med log and just realized how much some of my dosing times have varied from one week to the next.  Is there any kind of agreement that this is a safe practice?
09/01/2009-neg
mid april, 2010, "flu like illness".
06/01/2010-weakly reactive ELISA, indeterminant WB
06/06/2010-reactive ELISA, confirmed positive.

DATE       CD4     %     VL
07/15/10  423     33    88k
08/28/10  489     19    189k
09/06/10-Started ATRIPLA
09/15/10  420     38    1400
11/21/10  517     25    51

Offline tednlou2

  • Member
  • Posts: 4,763
Re: Atripla's one hour variance
« Reply #1 on: October 14, 2010, 11:13:06 PM »
I've read it is longer than that--even up to 4 hours.  I'm not the expert here, so others can give you better info.

Offline odyssey

  • Member
  • Posts: 765
  • One Crazy Mofo!
Re: Atripla's one hour variance
« Reply #2 on: October 14, 2010, 11:22:11 PM »
When I was on meds, not Atripla mind you, but Truvada was included in the mix, which is one of the ingredients in Atripla, my doc said the same thing, one hour either direction, with the ideal being at the same time each day.
01/09/09- diagnosed HIV+
01/16/09   CD4-425    22%  VL- 32,415
11/09- started Reyetaz/Norvir/Truvada
03/10- stopped R/N/T
10/18/11   CD4- 328   20%  VL- 84,000
10/25/11   CD4- 386   22%
10/28/11- start Truvada/Reyetaz/Norvir
12/30/11  CD4- 523  29%
03/08/12  CD4- 503  31%  VL 57
07/02/12  CD4- 897  43%
08/31/12  CD4- 745  39%
12/27/12  CD4- 884  40%
03/28/13  CD4- 819  39%
07/19/13  CD4- 739  40%
10/17/13  CD4- 535  36%
01/16/14  CD4- 743  43%

02/14- switched from R/N/T to Tivicay/Epzicom because of CKD 3 suspected from tenofovir.

03/14- switched back to R/N/T due to severe nausea and inability to eat on T/E.
 
04/01/14 CD4- 898  42%   VL-

Offline wtfimpoz

  • Member
  • Posts: 418
  • Let's make biscuits!
Re: Atripla's one hour variance
« Reply #3 on: October 14, 2010, 11:26:13 PM »
They say 95% adherence is the goal, so if you're only 1 hour late in 24, I'd assume that you achieve that as long as you don't miss a dose.  Still, it's kinda scary to see myself take it as late as 1 or 2 some days and a week or so later realize im taking it at 11.  Thanks a lot for the input guys.
09/01/2009-neg
mid april, 2010, "flu like illness".
06/01/2010-weakly reactive ELISA, indeterminant WB
06/06/2010-reactive ELISA, confirmed positive.

DATE       CD4     %     VL
07/15/10  423     33    88k
08/28/10  489     19    189k
09/06/10-Started ATRIPLA
09/15/10  420     38    1400
11/21/10  517     25    51

Offline Hellraiser

  • Member
  • Posts: 4,136
  • Semi-misanthropic
Re: Atripla's one hour variance
« Reply #4 on: October 14, 2010, 11:44:31 PM »
I take it before bed, with up to 6-10 hours variance.  I don't suggest this for anyone else.

Offline wtfimpoz

  • Member
  • Posts: 418
  • Let's make biscuits!
Re: Atripla's one hour variance
« Reply #5 on: October 14, 2010, 11:50:54 PM »
I take it before bed, with up to 6-10 hours variance.  I don't suggest this for anyone else.

LMFAO, I'm not about to, but thanks for the reassurance.  Makes me feel a lot less paranoid about the night of my birthday, when I took it one hour and seven minutes later than the last.
09/01/2009-neg
mid april, 2010, "flu like illness".
06/01/2010-weakly reactive ELISA, indeterminant WB
06/06/2010-reactive ELISA, confirmed positive.

DATE       CD4     %     VL
07/15/10  423     33    88k
08/28/10  489     19    189k
09/06/10-Started ATRIPLA
09/15/10  420     38    1400
11/21/10  517     25    51

Offline sanitex

  • Member
  • Posts: 385
Re: Atripla's one hour variance
« Reply #6 on: October 15, 2010, 02:10:16 AM »


 i personaly took my meds at the same time in some days not all,it happen two days ago
went out with friends and came back late 2am but still took it.my advice is whence you're undetectable
it doesn't mater the time ,but do not miss your dose.i tried it many times and went for my lab
test everything was fine.sometimes two hours or even before the time reach i took it.
« Last Edit: October 15, 2010, 02:17:48 AM by sanitex »
27/12/07 cd4 20 vl 1million
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl undetectable
16/10/08 cd4 196 vl undet
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl undet 23%
24/2/12 cd4 545 vl undet 26%
on 22/2/12 change truvada to Recovir-EM
due to no stock on Truvada.
10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ulu/ml creatinine.eGFR blck 1.5 all fasting test morning.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
regimen ATRIPLA
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs test (quantitative ) Anti-HBs positive
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 % 24

Offline Realist

  • Member
  • Posts: 162
    • NotDownNotOut's Blog
Re: Atripla's one hour variance
« Reply #7 on: October 15, 2010, 03:04:02 AM »
I generally take mine two hours either side of the previous one dose time. But like Hellraiser have taken it later and not had a problem. The components of Atripla have a long half life.
23/02/10 Tests confirmed
25/02/10 13100 220 24%
12/03/10 19800 372 19%
26/03/10 Atripla
30/04/10 58 286 23%
28/05/10 45 222 21%
25/06/10 UD 301 23%
24/09/10 UD 283 22%
01/12/10 UD 319 23%
11/03/11 UD 293 28%
10/06/11 UD 423 24%
23/08/11 UD 389 26%
28/02/11 UD 315 34%

I blogged it all http://notdownnotout.blogspot.com

Offline mecch

  • Member
  • Posts: 11,253
  • red pill? or blue pill?
Re: Atripla's one hour variance
« Reply #8 on: October 15, 2010, 03:26:01 AM »
I take it before bed, with up to 6-10 hours variance.  I don't suggest this for anyone else.

My doc gave me the same OK, by the way.  11PM, 4AM, as long as I got it in me. 
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Hellraiser

  • Member
  • Posts: 4,136
  • Semi-misanthropic
Re: Atripla's one hour variance
« Reply #9 on: October 15, 2010, 04:00:41 AM »
My doc gave me the same OK, by the way.  11PM, 4AM, as long as I got it in me. 

heh heh hehehe

Offline HARLEY_B

  • Member
  • Posts: 67
Re: Atripla's one hour variance
« Reply #10 on: October 15, 2010, 04:58:16 AM »
I'm with Hellraiser on this one. I too have taken it sometimes 4-6 hours after my usual time but for the most part I try to be consistent with the times since I don't like the vary the habit.

 


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