Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
August 29, 2014, 10:33:05 PM

Login with username, password and session length


Members
  • Total Members: 23344
  • Latest: TML1991
Stats
  • Total Posts: 636609
  • Total Topics: 48318
  • Online Today: 195
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Meds Change from Atripla to Truvada/Reyataz/Norvir  (Read 4584 times)

0 Members and 1 Guest are viewing this topic.

Offline jayjax

  • Member
  • Posts: 83
Meds Change from Atripla to Truvada/Reyataz/Norvir
« on: August 15, 2010, 08:19:25 AM »
Hey Everyone,

I want to post and see if anyone can provide me with advise or if others have had similar experience. I was on Atripla since Nov 2009 and have just switched to Turvada (200-300 mg), Reyataz (Cap 300 mg) and Norvir Tab (100 mg).

I really felt Atripla was working fine for almost 2 years now.  The once a day dosage was great, however, my liver function tests have steadily climbed out of the normal range and have remained there since December 2009. Also, my last VL went from undetectable to 100.  Both my primary and ID docs have been monitoring it carefully since Dec 09. During my last visit with my ID doc, he recommended a change in meds to see if it was the Atripla causing this. On Frinday this last week, I started taking a new combo of Truvada (Tab 200-300 MG), Reyataz (Cap 300 MG) and Norvir (Tab 100 MG). After I read the possible side effects, I must say I was more hesitant and worried in taking this combo than Atripla (I actually had no side effects with Atripla except the normal light headed during first few weeks). On Friday evening, I started the new meds after a light snack. 

I must say, I woke up on Saturday morning with absolutely no side effects and the same is true on Sunday.

Did anyone have any experiences like this with Atripla (i.e. elevated liver function tests and switching to Turvada, Reyataz and Norvir) ?  If so, what about the new meds ?  Anything I should be really concerned with while on the new combo.

Appreciate any comments,

Thanks all,

JayJax
08 Oct 08:  Diagnosed
18 Oct 08:  1st Lab Work: CD4 - 268, VL 7,000
18 Nov 08:  Started Atripla
28 Jan 09:   CD4 - 195, VL 70
05 May 09:  CD4 - 201, VL = Undetectable
16 Aug 09: CD4 - 235, VL = Undetectable
30 Nov 09 CD4 - 300, VL = Undetectable
30 Mar 10 CD4 - 305, VL = Undetectable
27 Jul 10 CD4 -  301, VL = 100
13 Aug 10 -- Switched to Truvada/Reyataz/Norvir
30 Sep 10 --  CD4 598, VL = Undetectable

Offline leatherman

  • Member
  • Posts: 6,148
  • Google and HIV meds are Your Friends
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #1 on: August 15, 2010, 08:55:54 AM »
I don't have experience with Atripla per se, but I am on the t/r/n regimen now - and loving it. :-* ;D

Round about 1997 or so I took Sustiva (part of Atrip) for 9 months and hated it. The horrible nightmares and dizzy/fuzzy feeling never left. I took it and endured the side effects for so long because in 97 and with my resistance issues, there literally was nothing else for me to take. When I fell down the staircase one morning because of the CNS effects, I swore it off. Luckily (LOL) I became resistant to it and never have to worry again. Over the almost 20 years that I've been treated for HIV/AIDS, I've taken nearly every med that has come out. At one time I was taking 28 pills a day and 8 tablespoons of liquid norvir.

Recently my doctor switched out a couple of my meds to the truvada, reducing me to three pills a day now. Although every other regimen has made me puke at least 6 times a month, I haven't barfed at all on this regimen, only had a few days of intestinal issues switching from the gelcap norvir to the newer tablet, and have had the best most stable numbers in the past two years.

all-n-all with this regimen, this is the best I've ever felt - and ever felt about my meds - in 20 years and I'm loving it.  :-* ;D

best wishes to you with the t/r/n ;)
mikie
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline jayjax

  • Member
  • Posts: 83
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #2 on: August 15, 2010, 09:24:04 AM »
Thanks Mikie,

Appreciate your quick reply and comments.  I was really worried after I read all the side effects of T/R/N ... I even called my ID Doc and see if he made a mistake.  I've never had reactions/major complications with any kind meds I've taken, but worried with these.  Luckily, that was not the case.  I go back in 3 weeks for another look at my Liver Function Test.  Hopefully all will be well.

Thanks again.  I'll update on my prognosis.

JayJax
08 Oct 08:  Diagnosed
18 Oct 08:  1st Lab Work: CD4 - 268, VL 7,000
18 Nov 08:  Started Atripla
28 Jan 09:   CD4 - 195, VL 70
05 May 09:  CD4 - 201, VL = Undetectable
16 Aug 09: CD4 - 235, VL = Undetectable
30 Nov 09 CD4 - 300, VL = Undetectable
30 Mar 10 CD4 - 305, VL = Undetectable
27 Jul 10 CD4 -  301, VL = 100
13 Aug 10 -- Switched to Truvada/Reyataz/Norvir
30 Sep 10 --  CD4 598, VL = Undetectable

Offline mecch

  • Member
  • Posts: 11,493
  • red pill? or blue pill?
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #3 on: August 15, 2010, 09:36:19 AM »
A person can turn a little yellow on Reyataz.  I did. It was no big deal.
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline BlueMoon

  • Member
  • Posts: 665
  • Calling from the Fun House
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #4 on: August 15, 2010, 09:49:33 AM »
A person can turn a little yellow on Reyataz.  I did. It was no big deal.

Same here.  Otherwise no problems in two and a half years.

My friend just began that regimen in June and didn't even get the yellowing. 
...................VL.....CD4.....%
-----------------------------------------
08/10-- ......<40.....290.....42
05/10-- ......<48.....290.....46
02/10-- ......<48.....481.....44
10/09-- ......<48.....277.....46
07/09-- ......<48.....300.....38
05/09-- ........51.....449.....39
03/09-- Added Isentress
02/09-- ........65.....299.....34
11/08-- ........62.....242.....40
08/08-- ........66.....212.....29
05/08-- ......202.....217.....27
03/08-- ....5210.....187.....21
02/08-- Began Truvada/Reyataz/Norvir
12/07-- 273,000.....157.....22
11/07-- 229,000.....209.....22
10/07-- Diagnosis

It's a complex world.

Offline ad2san

  • Member
  • Posts: 187
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #5 on: August 15, 2010, 10:29:43 AM »
Hi Jayjax,

same yellowing here, elevated bilirubin since then. I also have trouble sleeping, thought it came from Truvada so switched to Kivexa / Epzicom but did not become better. I take the combo in the morning, allowing me a +/- 3 hours window, quite comfortable.

take care
Feb   2009 CD4 358 VL 2000 16%
May  2009 CD4 305 VL 3069  14% <---- Started TVD+ATZ/r
Jul  2009 CD4 512 VL <50   18%
Jul 2010 CD4 418 VL <50 24%                     
Switched to Kivexa (Epzicom) + Norvir + Reyataz (due to sleep problem)
Aug 2010 CD4 606 VL <50 25%
Jul 2011 CD4 494 UD 23%
Switched to Kivexa (Epzicom) + Viramune XR (due to kidney problems)
January 2012 CD4 564 UD 31%
October 2012 CD4 684 UD 29%
January 2013 CD4 594 UD 26%
Switched to Kivexa (Epzicom) + Isentress due to BIG increase GammaGT
Feb 2013 CD4 699 UD 28%
May 2013 CD4 385 UD 28%
July 2013 CD4 CD4 636 UD 25%
Oct 2013 CD4 588 UD 39%
Aug 2014 CD4 639 UD 25%

Offline pozoz

  • Member
  • Posts: 70
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #6 on: August 18, 2010, 07:38:33 AM »
Hi Jayjax,

Ditto here on the jaundice, but for me it only lasted a week or so.

Have elevated creatinine but doc was not overly concerned. Went in last week just for urea and creatinine levels testing and waiting on those results now.

Overall, this combo has been better than I expected and I like the once a day option. I take mine after eating dinner.

Best of luck...
Seroconverted Aug 2008
Tested Pos      May 2009
May 09 CD4 544 19%   VL 22K
Aug 09 CD4 514  19% VL 25K
Dec 09 CD4 510  20% VL 32K
June10 CD4 502  20% VL 36K
July 5th,10 Start Truvada  Reyataz Norvir July 30  CD4 360  21% VL 339
Oct  22 CD4 459  27% VL 191
Jan 2011CD4 561 33% VL U/D <40
Feb  Add Verimune lead in dose to start switch to Verimune/Truvada  
Mar 17 Viramune x2 + Truvada. Stop PIs   
Apr 29     CD4 528 33% VL U/D
July 2011 CD4 440  %?  VL U/D
Sept 2011CD4 620  %?   VL U/D
Dec 2011 CD4 531 31% VL 224
Jan 2012  CD4 576 36% VL U/D
May 2012 CD4 504 36% U/D (start Viramune XR
July 2012 576 (36%) (test request due to XR issues)
Feb  2013 629  (? %) U/D
July  2013 608 38%.   U/D
Jan  14.    576  36%.   UD

Offline jayjax

  • Member
  • Posts: 83
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #7 on: August 21, 2010, 07:52:53 AM »
Thanks for the info everyone.  It's greatly appreciated.

Its been one week now and have not had any side effects.  I'll take my blood tests in another week and see if the liver function tests come back normal or going in that direction.

Like most of you have stated, I believe this combo is better than Atripla. Although I have 3 different pills, I can still take it the same time of day.
08 Oct 08:  Diagnosed
18 Oct 08:  1st Lab Work: CD4 - 268, VL 7,000
18 Nov 08:  Started Atripla
28 Jan 09:   CD4 - 195, VL 70
05 May 09:  CD4 - 201, VL = Undetectable
16 Aug 09: CD4 - 235, VL = Undetectable
30 Nov 09 CD4 - 300, VL = Undetectable
30 Mar 10 CD4 - 305, VL = Undetectable
27 Jul 10 CD4 -  301, VL = 100
13 Aug 10 -- Switched to Truvada/Reyataz/Norvir
30 Sep 10 --  CD4 598, VL = Undetectable

Offline xman

  • Member
  • Posts: 285
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #8 on: September 01, 2010, 10:41:49 AM »
should drinking a lot help to keep at lowest the chance of visible jaundice?
sign the petition launched by the aids policy project addressed to the nih aimed to increase the money needed to find the cure:

http://www.aidspolicyproject.org/petition_for_the_nih

we can make a difference and we need to fight. please support them! it doesn't cost you anything. they need it now more than ever!

Offline pozoz

  • Member
  • Posts: 70
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #9 on: September 01, 2010, 12:34:30 PM »
I was advised that drinking a bit more WATER may be beneficial for general kidney health while taking T/R/N as some people get kidney toxicity with the Reyataz I believe.

Drinking alcohol, for some, it seems, increases the jaundice, which makes sense as the liver is what breaks down the alcohol (and lots of other things we eat/drink/etc).

Seroconverted Aug 2008
Tested Pos      May 2009
May 09 CD4 544 19%   VL 22K
Aug 09 CD4 514  19% VL 25K
Dec 09 CD4 510  20% VL 32K
June10 CD4 502  20% VL 36K
July 5th,10 Start Truvada  Reyataz Norvir July 30  CD4 360  21% VL 339
Oct  22 CD4 459  27% VL 191
Jan 2011CD4 561 33% VL U/D <40
Feb  Add Verimune lead in dose to start switch to Verimune/Truvada  
Mar 17 Viramune x2 + Truvada. Stop PIs   
Apr 29     CD4 528 33% VL U/D
July 2011 CD4 440  %?  VL U/D
Sept 2011CD4 620  %?   VL U/D
Dec 2011 CD4 531 31% VL 224
Jan 2012  CD4 576 36% VL U/D
May 2012 CD4 504 36% U/D (start Viramune XR
July 2012 576 (36%) (test request due to XR issues)
Feb  2013 629  (? %) U/D
July  2013 608 38%.   U/D
Jan  14.    576  36%.   UD

Offline mewithu

  • Member
  • Posts: 160
  • mewithu
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #10 on: September 01, 2010, 09:50:51 PM »
Drink plenty of fluids to keep from getting kidney trouble, and other things. Eat regular and good diet. All the normal things you need to do anyway having a disease.
1997 is when I found out, being deathly ill. I had to go to the hospital due to extreme headache and fever. I fell coma like,  two months later weighing 95 pounds and in extreme pain and awoke to knowledge of Pancreatis, Cryptococcal Meningitis, Thrush,Severe Diarea,  Wasting, PCP pneumonia. No eating, only through tpn. Very sick, I was lucky I had good insurance with the company I worked for. I was in the hospital for three months that time. 
(2010 Now doing OK cd4=210  VL= < 75)
I have become resistant to many nukes and non nukes, Now on Reyataz, , Combivir. Working well for me not too many side effects.  I have the wasting syndrome, Fatigue  . Hard to deal with but believe it or not I have been through worse. Three Pulmonary Embolism's in my life. 2012 520 t's <20 V load

Offline camille07

  • Member
  • Posts: 570
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #11 on: October 07, 2010, 04:06:20 PM »
Jayjax-  This (reyetaz, truvada, norvir) was my first experience with hiv meds.  I wanted atripla, since it seemed so simple with a one pill regimen.  Instead, I took part in it the trial since I work from home and felt if it helped gather some important information, then why not.   I've been off the trial and continue to take the meds.  I've been on them for 2 years now.

I feel really great for one thing.  Another thing is that my numbers continue to climb (cd4 and percentage).  My liver enzymes are low, along with my kidney function. 

I take pain meds in addition, but they do not affect my levels.  I drink a lot of water, dandelion tea and eat well.  I would recommend this combo to anyone.  However, after reading many of the posts over the years, I think everyone's body reacts differently.  I hope it works for you  :)
Best wishes,

Camms

Offline madcowcorn

  • Member
  • Posts: 4
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #12 on: October 26, 2010, 02:11:23 PM »
first night taking it and woke up and threw up
Atripla was worse though
did anyone else have this?

was in trizivir and handled it fine ;( but viral load was 200 an doc wanted to change

Offline jayjax

  • Member
  • Posts: 83
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #13 on: November 06, 2010, 03:27:00 PM »
Camms,

Thanks for the good info.  I just had my last set of labs completed and my VL undetectable and CD4 has spiked upward from around 300 to almost 600 in less than 8 weeks. Needless to say I was very pleased with the results.  BTW, my Liver Function Tests were starting to come back to normal range.  Wish me luck and hope it continues.

You are right, I would prefer to stay on Atripla (1 pill a day), but RTN has really been great for me and I do feel better.  Only draw back is 3 meds, but I take them all like I would have taken Atripla.

Later,

JayJax
08 Oct 08:  Diagnosed
18 Oct 08:  1st Lab Work: CD4 - 268, VL 7,000
18 Nov 08:  Started Atripla
28 Jan 09:   CD4 - 195, VL 70
05 May 09:  CD4 - 201, VL = Undetectable
16 Aug 09: CD4 - 235, VL = Undetectable
30 Nov 09 CD4 - 300, VL = Undetectable
30 Mar 10 CD4 - 305, VL = Undetectable
27 Jul 10 CD4 -  301, VL = 100
13 Aug 10 -- Switched to Truvada/Reyataz/Norvir
30 Sep 10 --  CD4 598, VL = Undetectable

Offline tag_man08

  • Member
  • Posts: 118
  • Keep Dreaming!!!
Re: Meds Change from Atripla to Truvada/Reyataz/Norvir
« Reply #14 on: December 19, 2010, 02:08:29 PM »
thats good news...
08/30/07:  The HIV diagnosis...
09/07/07:  CD4 299 (21%)  VL 160K
01/07/08:  CD4 396 (26%)  VL 125K
04/21/08:  CD4 478 (25%)  VL 92K
09/03/08:  CD4 313 (23%)  VL 10K
11/03/08:  CD4 338 (23%)  VL 30K
11/21/08:  Isentress & Truvada
12/05/08:  CD4 485 (29%)  VL  undetectable in two weeks
03/13/09:  CD4 575 (30%)  VL  undetectable

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.