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Author Topic: a question that requires a quick answer plzzzzz  (Read 1575 times)

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Offline azprince

  • Member
  • Posts: 153
a question that requires a quick answer plzzzzz
« on: August 09, 2010, 09:32:36 PM »
 
I usually  take Atripla within the window of 2 hours at 8 AM, I wonder if its ok to change this within the coming week so that it will be one day at 8 the other day  at 1 AM , would the 7 hours window cause problems, its kind of a situation that I was just informed of  today, so no time to go back to my Doctor, I know that in the past my Doc. mentioned to me that its ok to switch it from night to morning and even to skip one day by mistake now that I am undetectable , but it was when I was switching from one fixed time at night to another fixed time at morning, unlike the situation now;  where I will have a fluctuation in the time that I take the pill that varies  up to 7 hours, so say one day I might be able to take it at 8 AM the other day at 1 AM, then back at 8 AM and so on for a whole week,
any ideas please ????
I have been on Atripla for a year and half, undetectable one year
Thanks
I have to admit : the good thing is that from now on;  I have no option but to succeed , still its ok to worry :))

Offline phildinftlaudy

  • Member
  • Posts: 2,948
  • sweet Ann what you think babe...
Re: a question that requires a quick answer plzzzzz
« Reply #1 on: August 09, 2010, 09:36:29 PM »
Definitely sounds like a question that your doc would be best to ask - my initial thought is that it shouldn't affect its effectiveness.  I don't know how it will make you feel in regards to any type of wozziness or dizziness...
You would be taking it seven hours early (or 17 hours after your earlier dose), right?  If so, this may make some of the effects more pronounced.
I'm interested to read what others say... ???
September 13, 2008 - diagnosed +
Labs:
Date    CD4    %   VL     Date  CD4  %   VL
10/08  636    35  510   9/09 473  38 2900  12/4/09 Atripla
12/09  540    30    60   
12/10  740    41  <48   
8/11    667    36  <20  
03/12  1,041  42  <20
05/12  1,241  47  <20
08/12   780    37  <20
11/12   549    35  <20
02/12  1,102  42  <20
11/12   549    35  <20

Offline azprince

  • Member
  • Posts: 153
Re: a question that requires a quick answer plzzzzz
« Reply #2 on: August 09, 2010, 09:40:04 PM »
Thank you for the initial thought, I am not that concerned about the side effects as much as I am concerned about issues related to resistance risk... by now the dizziness is much less with me ... trust me if I had time I would have addressed this to my Doctor, but its one of life's things that happen suddenly and you don't want to say my Meds will stop me  ;D
I have to admit : the good thing is that from now on;  I have no option but to succeed , still its ok to worry :))

Offline phildinftlaudy

  • Member
  • Posts: 2,948
  • sweet Ann what you think babe...
Re: a question that requires a quick answer plzzzzz
« Reply #3 on: August 09, 2010, 09:42:10 PM »
Thank you for the initial thought, I am not that concerned about the side effects as much as I am concerned about issues related to resistance risk... by now the dizziness is much less with me ... trust me if I had time I would have addressed this to my Doctor, but its one of life's things that happen suddenly and you don't want to say my Meds will stop me  ;D
I'm thinking that it should't create any substantial risk of resistance as long as you are compliant with the schedule that you detailed and take it daily.
September 13, 2008 - diagnosed +
Labs:
Date    CD4    %   VL     Date  CD4  %   VL
10/08  636    35  510   9/09 473  38 2900  12/4/09 Atripla
12/09  540    30    60   
12/10  740    41  <48   
8/11    667    36  <20  
03/12  1,041  42  <20
05/12  1,241  47  <20
08/12   780    37  <20
11/12   549    35  <20
02/12  1,102  42  <20
11/12   549    35  <20

Offline azprince

  • Member
  • Posts: 153
Re: a question that requires a quick answer plzzzzz
« Reply #4 on: August 09, 2010, 10:12:39 PM »
Hurray... Thx
I have to admit : the good thing is that from now on;  I have no option but to succeed , still its ok to worry :))

Offline ElZorro

  • Member
  • Posts: 535
Re: a question that requires a quick answer plzzzzz
« Reply #5 on: August 09, 2010, 10:22:20 PM »
I'm not a doctor, but....

I recently had this conversation with my doctor because I wanted to take Atripla in the morning as opposed to at bedtime because it was messing with my sleep. I incorrectly assumed that I could just push the time forward for a few days until I was taking it in the mornings (e.g. 11 pm, 1 am, 4 am, 7 am) and then simply stick to the new schedule.

Instead of pushing the time forward, my Dr told me to take it earlier each day until I reached the time of day that I liked the best. Her explanation was that it was better to take the med earlier so that I was maintaining a high level of the drugs in my system as opposed to later when the amount of drug in my system would be reduced.  

Anyway, it made sense to me so that's what I did....I only it made it back from 11 pm to around 6 pm because I started sleeping much better  So, now, I take it when I get home from work. That way I don't have to worry about running out of the house and forgetting (as I do from time to time with my daily vitamin & aspirin) :P

I definitely think you should talk to your doctor though if you're saying that you'll be taking it at 1 am on one day and then at 8 am the next day. I was under the impression that there's a 2-4 hr grace period, but would be concerned about having a lot of days where the difference in the dosing window is 7 hrs. My understanding is that resistance can possibly develop if the level of the drug dips below the level you need in your system to keep the virus in check.

Isn't there another time that would work more consistently? Just a thought...
« Last Edit: August 09, 2010, 10:31:25 PM by ElZorro »

Offline BlueMoon

  • Member
  • Posts: 665
  • Calling from the Fun House
Re: a question that requires a quick answer plzzzzz
« Reply #6 on: August 10, 2010, 06:24:19 AM »
Azprince, what you are suggesting sounds risky to me.  I wouldn't even ask a doctor to give his blessing.  I would just do what it takes to remain adherent. 

That's just a personal opinion with no scientific validity, and I'm sure people have done it with no problems.  But I consider the meds too important for a casual approach. 
...................VL.....CD4.....%
-----------------------------------------
08/10-- ......<40.....290.....42
05/10-- ......<48.....290.....46
02/10-- ......<48.....481.....44
10/09-- ......<48.....277.....46
07/09-- ......<48.....300.....38
05/09-- ........51.....449.....39
03/09-- Added Isentress
02/09-- ........65.....299.....34
11/08-- ........62.....242.....40
08/08-- ........66.....212.....29
05/08-- ......202.....217.....27
03/08-- ....5210.....187.....21
02/08-- Began Truvada/Reyataz/Norvir
12/07-- 273,000.....157.....22
11/07-- 229,000.....209.....22
10/07-- Diagnosis

It's a complex world.

Offline azprince

  • Member
  • Posts: 153
Re: a question that requires a quick answer plzzzzz
« Reply #7 on: August 10, 2010, 08:01:20 PM »
Thanks all for the advice, much appreciated  :-*
I have to admit : the good thing is that from now on;  I have no option but to succeed , still its ok to worry :))

 


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