Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
September 18, 2014, 01:53:33 PM

Login with username, password and session length


Members
Stats
  • Total Posts: 639249
  • Total Topics: 48525
  • Online Today: 223
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online
Users: 4
Guests: 187
Total: 191

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Vacc-4x Shows Response Seven Years after Inoculation  (Read 2134 times)

0 Members and 1 Guest are viewing this topic.

Offline georgep77

  • Member
  • Posts: 148
Vacc-4x Shows Response Seven Years after Inoculation
« on: July 26, 2010, 02:14:23 PM »
Great news for all, hopefully soon available    :)

Researchers Present Findings Today at the XVIII International AIDS Conference, Vienna Austria
Bionor Immuno's Therapeutic HIV Vaccine Candidate Vacc-4x Targeting Conserved Domains of HIV Produce Immune Response Seven Years after Inoculation

(Vienna, Austria, 22 July 2010) Researchers at Oslo University Hospital and Bionor Pharma's subsidiary, Bionor Immuno AS today presented results from a recently conducted re-vaccination study at Norway's largest hospital, using Vacc-4x, the company's furthest advanced HIV-vaccine candidate. Twenty six of the forty HIV-patients from the 2002/03 phase IIa study were followed-up and re-vaccinated during the period January 2010-June 2010.

The data from 22 Vacc-4x primary responders was presented today in Vienna, Austria at the XVIII International AIDS Conference as a “late breaker” poster titled “Longterm proliferative CD4+ and CD8+ T cell memory detected 7 years after intradermal immunizations against short HIV Gag p24-like peptides targeting dendritic cells.” The abstract number is LB17810.

The 22 patients were studied prior to a voluntary “re-boost” of Vacc-4x. Results from the reboost of the 26 patients are expected in August / September.

"The Vacc-4x immunization technology using short peptide analogues to conserved viral protein domains has shown not only development of surprisingly long-term immunological memory T cells in these immunocompromised patients, but also that viral sequences changes during intermittent treatment interruptions were negligible," said Professor Dag Kvale, Oslo University Hospital, co-author of the study.

“Given this new data, and because Vacc-4x is comprised of 4 modified peptides that target conserved domains of the HIV p24 protein, we are especially optimistic about our ability to control HIV,” said Birger Sørensen, CEO, Bionor Immuno. “The research indicates that the vaccine is stimulating an immune response seven years after injection, which is, in itself, unprecedented in HIV. But we know we have more work to do.”

Vacc-4x has completed an international phase IIb placebo controlled, double-blind, multi-national trial in volunteers with HIV who stopped daily antiretroviral treatment. Data from this study is expected in September/October.

link:
http://www.bionorimmuno.com/crbst_78.html
« Last Edit: July 26, 2010, 02:25:32 PM by georgep77 »
Come on Sangamo,  Geovax,  Bionor immuno, ...Make us happy !!!
+ 2008

Offline mecch

  • Member
  • Posts: 11,677
  • red pill? or blue pill?
Re: Vacc-4x Shows Response Seven Years after Inoculation
« Reply #1 on: July 26, 2010, 03:37:34 PM »
nice news.
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Inchlingblue

  • Member
  • Posts: 3,119
  • Chad Ochocinco PETA Ad
Re: Vacc-4x Shows Response Seven Years after Inoculation
« Reply #2 on: July 26, 2010, 04:03:36 PM »
This is good news but confusing and surprising in light of their announcement that they were abandoning Vacc-4x except for its use as a CD4 booster:

http://forums.poz.com/index.php?topic=27011.msg371055#msg371055

So I guess it's back on track?

Offline veritas

  • Member
  • Posts: 1,410
Re: Vacc-4x Shows Response Seven Years after Inoculation
« Reply #3 on: July 26, 2010, 04:29:44 PM »

George77,

Nice find! Oh the twists and turns of research.

v

Offline moskimo

  • Member
  • Posts: 31
Re: Vacc-4x Shows Response Seven Years after Inoculation
« Reply #4 on: August 09, 2010, 06:53:58 PM »
i am thrilled

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.