Quantcast

Subscribe to:
POZ magazine
Newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr Instagram
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
April 27, 2015, 11:42:20 AM

Login with username, password and session length


Members
  • Total Members: 25306
  • Latest: pikker
Stats
  • Total Posts: 662620
  • Total Topics: 50879
  • Online Today: 244
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: 06/10 Starting Viramune (Nevirapine) + Kivexa (Epzicom = 3TC / abacavir)  (Read 63764 times)

0 Members and 1 Guest are viewing this topic.

Offline eric48

  • Member
  • Posts: 1,250
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
With 4 parameters I can fit an elephant. With 5 I can make it wiggle his trunk

recommended reading
Dynamics of Cancer : Incidence, Inheritance, and Evolution by Steven A Frank
http://tinyurl.com/cm8blnc

Dynamics are generally speaking less known to the public. No need to read in detail, just browse thru
This book emphasize the use of speeds (time derivatives) and acceleration, just as we did in previous posts, as a framework for better model validation.

Having a model would be more fun if it were predictive: let's give it a try

Forecast for upcoming blood draw (aka ImmunoForecast)

CD4 % around 49
CD4 > 1100 but less than 1300; estimated at 1100
CD8 % around 23
CD8 estimated at 520
CD4/CD8 around 2.1

Still open:
Quiz : In CD4, what means C , D and 4 ?

« Last Edit: May 06, 2014, 09:24:26 PM by Jeff G »
NVP/ABC/3TC/... UD (non-infectious) ; CD4 > 1000; CD4/CD8 ~ 2.0   stock & donations : 6 months (2013: FOTO= 5d. ON 2d. OFF ; 2014: Clin. Trial NCT02157311 = 4days ON, 3days OFF ; 2015: use of NVP & 3TC generics
https://clinicaltrials.gov/ct2/show/NCT02157311

Offline Hellraiser

  • Member
  • Posts: 4,147
  • Semi-misanthropic
Quiz : In CD4, what means C , D and 4 ?

Cluster of Differentiation 4

Offline eric48

  • Member
  • Posts: 1,250
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
We have not finished. Meds have cured noone (*). And that is the problem

(*) with exception of Viscontis and a handfull of others

Thanks ! Yep ... See:
http://en.wikipedia.org/wiki/CD4

No room on a post like this to explain C and D, but maybe one can easily explain the 4 (in relation to 8)...

Since my previous post included a prediction and blood test was done May 12, I now know the quality of the prediction exceeds my expectations. In order to set expectations right I have published a foreword to put in perspective how a predictive model should be tested and prove its worth.

Here again there is no room here to publish this (too many numbers), so I have published on the Tumblr account. I am new to Tumblr so there is a learning curve. Also I'll wrap this up into graphs , easier to read, but this takes time ...

www.tinyurl.com/HIVPharmaCure-T1

I'll post the graphs here as well.

Visit to Doc:  UD as usual...
He offers Complera, but, no, I want to stay on Viramune. I am starting using generics (Mylan) and I want to report to fellow Viramune users

May 12 started  Boneozard

Quiz : In CD4, what means 4 ?

Stay tuned : @HIVPharmaCure (pls RT)       Cheers ! Eric
pointer : http://tinyurl.com/HIVPharmaCure-24 (please do not copy, do not highjack, thanks!)
NVP/ABC/3TC/... UD (non-infectious) ; CD4 > 1000; CD4/CD8 ~ 2.0   stock & donations : 6 months (2013: FOTO= 5d. ON 2d. OFF ; 2014: Clin. Trial NCT02157311 = 4days ON, 3days OFF ; 2015: use of NVP & 3TC generics
https://clinicaltrials.gov/ct2/show/NCT02157311

Offline eric48

  • Member
  • Posts: 1,250
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
just to add : I have kept this thread active for four years : this is the 4 y. anniversary
Also I'd like to change the quiz question from
Quiz : In CD4, what means 4 ?
to Quiz : In CD8, what means 8 ?  Eric
NVP/ABC/3TC/... UD (non-infectious) ; CD4 > 1000; CD4/CD8 ~ 2.0   stock & donations : 6 months (2013: FOTO= 5d. ON 2d. OFF ; 2014: Clin. Trial NCT02157311 = 4days ON, 3days OFF ; 2015: use of NVP & 3TC generics
https://clinicaltrials.gov/ct2/show/NCT02157311

Offline ad2san

  • Member
  • Posts: 195
Re: 06/10 Starting Viramune (Nevirapine) + Kivexa (Epzicom = 3TC / abacavir)
« Reply #154 on: September 07, 2014, 05:52:06 AM »
I think the name CD4 and CD8 is because of there shape ?
Feb   2009 CD4 358 VL 2000 16%
May  2009 CD4 305 VL 3069  14% <---- Started TVD+ATZ/r
Jul  2009 CD4 512 VL <50   18%
Jul 2010 CD4 418 VL <50 24%                     
Switched to Kivexa (Epzicom) + Norvir + Reyataz (due to sleep problem)
Aug 2010 CD4 606 VL <50 25%
Jul 2011 CD4 494 UD 23%
Switched to Kivexa (Epzicom) + Viramune XR (due to kidney problems)
January 2012 CD4 564 UD 31%
October 2012 CD4 684 UD 29%
January 2013 CD4 594 UD 26%
Switched to Kivexa (Epzicom) + Isentress due to BIG increase GammaGT
Feb 2013 CD4 699 UD 28%
May 2013 CD4 385 UD 28%
July 2013 CD4 CD4 636 UD 25%
Oct 2013 CD4 588 UD 39%
Aug 2014 CD4 639 UD 25%

Offline eric48

  • Member
  • Posts: 1,250
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
Re: 06/10 Starting Viramune (Nevirapine) + Kivexa (Epzicom = 3TC / abacavir)
« Reply #155 on: November 06, 2014, 01:15:33 AM »
I think the name CD4 and CD8 is because of there shape ?

Took me a hell of a time to figure out what you might mean by 'there shape'
I found nice pics to illustrate the 'shape' thing , which I have on another PC. I ll get to it...
NVP/ABC/3TC/... UD (non-infectious) ; CD4 > 1000; CD4/CD8 ~ 2.0   stock & donations : 6 months (2013: FOTO= 5d. ON 2d. OFF ; 2014: Clin. Trial NCT02157311 = 4days ON, 3days OFF ; 2015: use of NVP & 3TC generics
https://clinicaltrials.gov/ct2/show/NCT02157311

Offline Saintfranciscus

  • Member
  • Posts: 7
Re: 06/10 Starting Viramune (Nevirapine) + Kivexa (Epzicom = 3TC / abacavir)
« Reply #156 on: April 05, 2015, 05:29:15 PM »
Hey peeps,

Let's see if anyone is still active on this topic, which was extremely pleasant to read...

I am on this combination of meds for four weeks now. And all goes well, it seems, well, we'll see that in two weeks after the next bloodtests. The two-weeks-test showed that liver and kidney are doing well.

Maybe someone can reflect on the things that keep me busy.

1. I feel scared a lot more then before. Seems I think a lot about things that can go wrong, anxiety. I can see my fear is silly, but that doesn't make it less unpleasant.
- is it related to these meds?
- anything I can do about it? (Preferably not adding other meds)
- suggestions, thoughts?
- does it get better later on?

2. Anyone takes them before going to bed? How is that? I take them at ninet in the morning now, but after one hour I feel a bit drugged for a while. Groggy is the term I think. Can I perhaps solve that by taking the meds at 0:00 hrs?

3. I am supposed to take my meds within 60 minutes from the same moment during the day, says my doctor. What if I want to switch to another moment in the day, take a double dose or just miss a few hours.

No worries, I will always double check questions and answers with my doctor anyway, but I would like to have a channel to reflect on all of it during this process.

Thanks people. Plz be kind.
_________
01/15 - Infection
02/15 - Test + diagnose.
02/15 - VL: 141000 - CD4: 0.33
03/15 - Start meds: Kivexa + Nevirapine
04/15 - VL: 1040 - CD4: 0.60

Offline ad2san

  • Member
  • Posts: 195
Re: 06/10 Starting Viramune (Nevirapine) + Kivexa (Epzicom = 3TC / abacavir)
« Reply #157 on: April 06, 2015, 02:04:47 AM »
Hi there, I was on this combo.

1) no scare or something like it on my side. Maybe should you talk with a counselor.
2) I always take the med in the morning because I am almost always home at breakfast and have the pills in a hand reach.
3) the 60mn stuff is theoreticall. Don't polite your life counting the minutes, just take your pills when you go to bed.

Cheers
Feb   2009 CD4 358 VL 2000 16%
May  2009 CD4 305 VL 3069  14% <---- Started TVD+ATZ/r
Jul  2009 CD4 512 VL <50   18%
Jul 2010 CD4 418 VL <50 24%                     
Switched to Kivexa (Epzicom) + Norvir + Reyataz (due to sleep problem)
Aug 2010 CD4 606 VL <50 25%
Jul 2011 CD4 494 UD 23%
Switched to Kivexa (Epzicom) + Viramune XR (due to kidney problems)
January 2012 CD4 564 UD 31%
October 2012 CD4 684 UD 29%
January 2013 CD4 594 UD 26%
Switched to Kivexa (Epzicom) + Isentress due to BIG increase GammaGT
Feb 2013 CD4 699 UD 28%
May 2013 CD4 385 UD 28%
July 2013 CD4 CD4 636 UD 25%
Oct 2013 CD4 588 UD 39%
Aug 2014 CD4 639 UD 25%

Offline eric48

  • Member
  • Posts: 1,250
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
Re: 06/10 Starting Viramune (Nevirapine) + Kivexa (Epzicom = 3TC / abacavir)
« Reply #158 on: April 06, 2015, 05:15:41 PM »
1. I feel scared a lot more then before.

2. Anyone takes them before going to bed?

3. I am supposed to take my meds within 60 minutes

Thanks people. Plz be kind.

Hi there,

I have been overall happy with this combo, and I am still on it. no reasons to change.

I have used Viramune 200mg (twice daily) then Viramune 200 mg (all at the same time, 6 months after treatment initiation), then when it became available, I have used Viramune 400 mg XR, and since they became available here, I am using Nevirapine (generic) 2x 200 mg at one dosing a day.

Because 200mg can be taken all in the morning (or night) or 1 in the morning and 1 in the evening, I could play around to see what is causing what.

I did have extra anxiety (it has resolved since) for quite while and attributed it to Kivexa.

Therefore, in order to get a good sleep I take my meds in the morning. At one point I was taking them very early, but, as I said things have come back to normal, so now, I take any time in the morning.

Virumune has a very long half life. In women taking a one time one pill during baby delivery, it has been observed that it was still detectable in blood one month after the one and only dose.

ABC and 3TC (components of Kivexa) both have shorter half lives in serum but higher than (previously) thought intracellular life.

So the rule of thumb is to be strict on schedule at the begining, as your Dr prescribed, until you are UD.
Then, once UD, you can relax and take any time during the designated half of the day.

There are not too many combos that allow this flexibility and do not have meal obligation, so that one fits my lifestyle.

My immunologic response has been excellent. It takes time, of course... But my numbers are in noway different from those of your average HIV negative person.

Of course, I have had my ups and down, but, I have always kept in mind the comment of one poster in this thread
http://forums.poz.com/index.php?action=post;quote=416424;topic=33062.0

Now, consider yourself lucky to be on it... I have been on MANY other combos, .... This one is just .... a dream come through for me.
I surely hope you can stay on it...
xx hermie

I must say, I am grateful to those who encouraged me by posting in this thread.
NVP/ABC/3TC/... UD (non-infectious) ; CD4 > 1000; CD4/CD8 ~ 2.0   stock & donations : 6 months (2013: FOTO= 5d. ON 2d. OFF ; 2014: Clin. Trial NCT02157311 = 4days ON, 3days OFF ; 2015: use of NVP & 3TC generics
https://clinicaltrials.gov/ct2/show/NCT02157311

Offline Saintfranciscus

  • Member
  • Posts: 7
Re: 06/10 Starting Viramune (Nevirapine) + Kivexa (Epzicom = 3TC / abacavir)
« Reply #159 on: April 06, 2015, 05:29:43 PM »
Thank you two. Very clear info, which makes sense.

I think i'll stay connected to this topic for a while. Feels good.
_________
01/15 - Infection
02/15 - Test + diagnose.
02/15 - VL: 141000 - CD4: 0.33
03/15 - Start meds: Kivexa + Nevirapine
04/15 - VL: 1040 - CD4: 0.60

Offline eric48

  • Member
  • Posts: 1,250
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
Re: 06/10 Starting Viramune (Nevirapine) + Kivexa (Epzicom = 3TC / abacavir)
« Reply #160 on: April 06, 2015, 05:38:19 PM »
Yes... feel free to do so... You are living in a 'rich' country where lab test are readily available.

This combo is also used in less rich countries and people rely on the internet to learn about this combo, which, is available everywhere, but gets little media attention (since the original manufacturer is not really interested in the promotio of a molecule that has become generic)

It would be nice, therefore, for the benefit of those who do not have access to more modern drug to learn from the experience of users.

This combo is not widely popular. but this thread is the most viewed in this section of the forum (62.000 views as of today)
So it would be nice to revive it a bit 
NVP/ABC/3TC/... UD (non-infectious) ; CD4 > 1000; CD4/CD8 ~ 2.0   stock & donations : 6 months (2013: FOTO= 5d. ON 2d. OFF ; 2014: Clin. Trial NCT02157311 = 4days ON, 3days OFF ; 2015: use of NVP & 3TC generics
https://clinicaltrials.gov/ct2/show/NCT02157311

Offline Saintfranciscus

  • Member
  • Posts: 7
Re: 06/10 Starting Viramune (Nevirapine) + Kivexa (Epzicom = 3TC / abacavir)
« Reply #161 on: April 06, 2015, 06:20:30 PM »
Deal. I'll post my data here. Always good to reflect on it.
_________
01/15 - Infection
02/15 - Test + diagnose.
02/15 - VL: 141000 - CD4: 0.33
03/15 - Start meds: Kivexa + Nevirapine
04/15 - VL: 1040 - CD4: 0.60

Offline Saintfranciscus

  • Member
  • Posts: 7
Re: 06/10 Starting Viramune (Nevirapine) + Kivexa (Epzicom = 3TC / abacavir)
« Reply #162 on: April 19, 2015, 01:37:04 PM »
I will get my results this wednesday.

Anyone experience weight gain due to these meds or am I eating too much?
_________
01/15 - Infection
02/15 - Test + diagnose.
02/15 - VL: 141000 - CD4: 0.33
03/15 - Start meds: Kivexa + Nevirapine
04/15 - VL: 1040 - CD4: 0.60

Offline eric48

  • Member
  • Posts: 1,250
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
Re: 06/10 Starting Viramune (Nevirapine) + Kivexa (Epzicom = 3TC / abacavir)
« Reply #163 on: April 20, 2015, 03:12:41 PM »
Not so much of a problem here, at least for the first 2-3 years.

You may want to be careful though. Rats fed with Nevirapine (aka Viramune) had a tendancy to over-eat.

It takes a while for the liver to adjust to the medication.

From your post, I understand that you are not reporting any rash. So most likely you are on the safe side for this by now.
Your doctor will check you liver enzyme and tell you if it is OK to proceed and ramp up to 400 mg / day (the normal dose)

Once you have passed that, most of the good work is done with Viramune. and is unlikely to be a concern in the future.

You should remain on the watch out for Abacavir hypersensitivity reaction that may appear in the first 2 months. But this is very rare...

So let's see what the doc says about the liver and things will proceed from there.
Keep posting the good news !

Cheers! eric
NVP/ABC/3TC/... UD (non-infectious) ; CD4 > 1000; CD4/CD8 ~ 2.0   stock & donations : 6 months (2013: FOTO= 5d. ON 2d. OFF ; 2014: Clin. Trial NCT02157311 = 4days ON, 3days OFF ; 2015: use of NVP & 3TC generics
https://clinicaltrials.gov/ct2/show/NCT02157311

Offline Saintfranciscus

  • Member
  • Posts: 7
Re: 06/10 Starting Viramune (Nevirapine) + Kivexa (Epzicom = 3TC / abacavir)
« Reply #164 on: April 20, 2015, 05:32:40 PM »
Hey there!

I think I'm passed that. They firstly did a test to see if I am allergic for that substance you are aiming at. And then the step from 200 to 400 mg exactly as I read in your previous posts.

About the hipfatties: I think it's spring probably, I eat too much. I will do more sports then.

I heard somewhere that getting to UD takes longer with this regimen. Is there any knowledge on this? And that the viral load figure can be somewhat unsure due to NRA. I dont even know what that is actually, does this ring any bells?

Again, reading this forum feels good. I have decided to tell no one about all this, but this way I feel i'm not alone at all.

I'm very curious for the CD4 and VL.

Banzai!
Greetz,
Francis
« Last Edit: April 20, 2015, 05:40:09 PM by Saintfranciscus »
_________
01/15 - Infection
02/15 - Test + diagnose.
02/15 - VL: 141000 - CD4: 0.33
03/15 - Start meds: Kivexa + Nevirapine
04/15 - VL: 1040 - CD4: 0.60

Offline Saintfranciscus

  • Member
  • Posts: 7
Re: 06/10 Starting Viramune (Nevirapine) + Kivexa (Epzicom = 3TC / abacavir)
« Reply #165 on: April 22, 2015, 06:19:19 AM »
Hey peeps,

The doctor said the results are excellent.

Viral load dropped from 141000 in feb. to 1040 now.
CD4 grew, allthough I don't quite understand how this figure works, from 0,33 to 0,60. (Apparently the treshold is 0,40)

So the treatment is going well, liver and kidneys are managing well, and weight gain can be the result of a body that no longer needs to fight an infection as much as before. He called an infection 'an unhealthy way of weightloss' since it burns calories.

Okay that's it. All good it seems. Hmmm... I just realised that I haven't had sex since this all started... Djeez, I'm becoming a nun.

Greetings!
_________
01/15 - Infection
02/15 - Test + diagnose.
02/15 - VL: 141000 - CD4: 0.33
03/15 - Start meds: Kivexa + Nevirapine
04/15 - VL: 1040 - CD4: 0.60

 


Terms of Membership for these forums
 

© 2015 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.