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Author Topic: BEST TIME TO TAKE TIVICAY???  (Read 667 times)

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Offline cityboy

  • Member
  • Posts: 142
BEST TIME TO TAKE TIVICAY???
« on: March 08, 2014, 08:14:11 AM »
Will be switching from Reyataz Norvir Truvada to Tivicay and Truvada as soon as meds received. 

Normally take current meds at night since they make me sleepy.   Other than that have never had any side effects.

When is the best time to take Tivicay?   Any notable side effects?

Thanks

CB

Offline Matts

  • Member
  • Posts: 184
Re: BEST TIME TO TAKE TIVICAY???
« Reply #1 on: March 08, 2014, 10:45:39 AM »
I also will switch soon. I recommend the European VIIV Leaflet; it contains more Information than the original  one.
http://www.viivhealthcare.com/media/74706/EU_Tivicay.pdf

some excerpts:
Oral use: Tivicay can be taken with or without food (see section 5.2). In the presence of integrase class resistance, Tivicay should preferably be taken with food to enhance exposure (particularly in patients with Q148 mutations) (see section 5.2). ..
 Absorption  Dolutegravir is rapidly absorbed following oral administration, with median Tmax at 2 to 3 hours post dose for tablet formulation.   
Food increased the extent and slowed the rate of absorption of dolutegravir.  Bioavailability of dolutegravir depends on meal content: low, moderate, and high fat meals increased dolutegravir AUC(0-) by 33%, 41%, and 66%, increased Cmax by 46%, 52%, and 67%, prolonged Tmax to 3, 4, and 5 hours from 2 hours under fasted conditions, respectively. These increases may be clinically relevant in the presence of certain integrase class resistance. Therefore, Tivicay is recommended to be taken with food by patients infected with HIV with integrase class resistance (see section 4.2).

medicines called antacids, to treat indigestion and heartburn: Do not take an antacid during the 6 hours before you take Tivicay, or for at least 2 hours after you take it. (See also Section 3). 
Calcium supplements, iron supplements and multivitamins:  Do not take a calcium supplement, iron supplement or multivitamin during the 6 hours before you take Tivicay, or for at least 2 hours after you take it (see also Section 3).

Calcium supplements, iron supplements or multivitamins: Calcium supplements, iron supplements or multivitamins can stop Tivicay being absorbed into your body and make it less effective. Do not take a calcium or iron supplement during the 6 hours before you take Tivicay, or for at least 2 hours after you take it.     Talk to your doctor for further advice on taking calcium supplements, iron supplements or multivitamins with Tivicay. (they reduce Tivicay up to 74%)

-You can find the "Undesirable effects" section under 4.8

tivicay/kivexa

Offline eric48

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  • Posts: 1,013
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
Re: BEST TIME TO TAKE TIVICAY???
« Reply #2 on: March 08, 2014, 12:32:32 PM »
Other than that have never had any side effects.

Why do you change then ?

I hope you qualify for "with or without" food.

The info posted by Matts is more detailed than the aidsmeds drug page on this matter and indeed very useful

Cheers

Eric

Offline surf18

  • Member
  • Posts: 525
Re: BEST TIME TO TAKE TIVICAY???
« Reply #3 on: March 08, 2014, 03:42:57 PM »
I take it in the morning when I get up . I do not take it with food ,though I typically eat breakfast about and hour after I take it.

Offline buginme2

  • Member
  • Posts: 2,757
  • Certified Life Coach
Re: BEST TIME TO TAKE TIVICAY???
« Reply #4 on: March 08, 2014, 04:08:45 PM »
TAKE IT ONCE PER DAY...THE REST IS GRAVY!!!
"All I need are some tasty waves, a cool buzz, and I'm fine."

http://www.youtube.com/watch?v=6e0gcEC1TWE

Offline lucinda29

  • Member
  • Posts: 3
Re: BEST TIME TO TAKE TIVICAY???
« Reply #5 on: April 15, 2014, 12:18:57 AM »
I took mine at night before I go to bed. Since it is only 2 pills a day, I took both around the same time each night before I go to bed. Try and see what works for you. The key is" to remember to take them at the same time each day, whether you decide to take them in the morning or at night".

Offline Bizkits

  • Member
  • Posts: 98
Re: BEST TIME TO TAKE TIVICAY???
« Reply #6 on: April 15, 2014, 09:25:55 AM »
I'm also about to start Truvada/Tivicay, once I've received them both, that is...still waiting on the Tivicay.

My doc told me it was okay to take with vitamins...hmmm, ok need to read that info and go talk to her...worst case scenario just take them at different times.

Also, she told me the time I take them can be a little flexible, like a couple hours here and there (say sleeping in on Saturday or staying out late if at night) as long as it is around the same time every day...is that true?
« Last Edit: April 15, 2014, 09:28:50 AM by Bizkits »

Offline Miss Philicia

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  • Posts: 23,575
  • celebrity poster, faker & poser
Re: BEST TIME TO TAKE TIVICAY???
« Reply #7 on: April 15, 2014, 10:03:13 AM »
Considering Tivicay is going to be marketed as an all-in-one HIV medication soon (though not with truvada) what's the point of this financial investment when you can't take it with a multi-vitamin, etc.? Seems a bit odd to me.
"Iíve slept with enough men to know that Iím not gay"

Offline Bizkits

  • Member
  • Posts: 98
Re: BEST TIME TO TAKE TIVICAY???
« Reply #8 on: April 15, 2014, 11:29:27 AM »
huh? How is Tivicay, as an integrase inhibitor going to be marketed as a all-in-one? Is that the epzicom/tivicay all-in-one pill they're talking about but is not available yet?

Offline AusShep

  • Member
  • Posts: 126
Re: BEST TIME TO TAKE TIVICAY???
« Reply #9 on: April 15, 2014, 12:41:25 PM »
I take mine in the AM due to the timing with any buffered meds, anti acids, vitamins, etc.  easier to wait 2 hours after my morning dose vs. 6 hours after taking anything else in the 6 hours before taking a dose in the evening.


Converted:      11/1994

Offline Miss Philicia

  • Member
  • Posts: 23,575
  • celebrity poster, faker & poser
Re: BEST TIME TO TAKE TIVICAY???
« Reply #10 on: April 15, 2014, 06:34:52 PM »
Is that the epzicom/tivicay all-in-one pill they're talking about but is not available yet?

Yes
"Iíve slept with enough men to know that Iím not gay"

Offline cityboy

  • Member
  • Posts: 142
Re: BEST TIME TO TAKE TIVICAY???
« Reply #11 on: April 15, 2014, 07:19:22 PM »
Just took an hour ago, feel a little zoned out and fatigued
Some abdominal pain.

Anyone else experience this?


Offline cityboy

  • Member
  • Posts: 142
Re: BEST TIME TO TAKE TIVICAY???
« Reply #12 on: April 15, 2014, 07:40:29 PM »
Thanks for the good iinformation


I also will switch soon. I recommend the European VIIV Leaflet; it contains more Information than the original  one.
http://www.viivhealthcare.com/media/74706/EU_Tivicay.pdf

some excerpts:
Oral use: Tivicay can be taken with or without food (see section 5.2). In the presence of integrase class resistance, Tivicay should preferably be taken with food to enhance exposure (particularly in patients with Q148 mutations) (see section 5.2). ..
 Absorption  Dolutegravir is rapidly absorbed following oral administration, with median Tmax at 2 to 3 hours post dose for tablet formulation.   
Food increased the extent and slowed the rate of absorption of dolutegravir.  Bioavailability of dolutegravir depends on meal content: low, moderate, and high fat meals increased dolutegravir AUC(0-) by 33%, 41%, and 66%, increased Cmax by 46%, 52%, and 67%, prolonged Tmax to 3, 4, and 5 hours from 2 hours under fasted conditions, respectively. These increases may be clinically relevant in the presence of certain integrase class resistance. Therefore, Tivicay is recommended to be taken with food by patients infected with HIV with integrase class resistance (see section 4.2).

medicines called antacids, to treat indigestion and heartburn: Do not take an antacid during the 6 hours before you take Tivicay, or for at least 2 hours after you take it. (See also Section 3). 
Calcium supplements, iron supplements and multivitamins:  Do not take a calcium supplement, iron supplement or multivitamin during the 6 hours before you take Tivicay, or for at least 2 hours after you take it (see also Section 3).

Calcium supplements, iron supplements or multivitamins: Calcium supplements, iron supplements or multivitamins can stop Tivicay being absorbed into your body and make it less effective. Do not take a calcium or iron supplement during the 6 hours before you take Tivicay, or for at least 2 hours after you take it.     Talk to your doctor for further advice on taking calcium supplements, iron supplements or multivitamins with Tivicay. (they reduce Tivicay up to 74%)

-You can find the "Undesirable effects" section under 4.8

Offline AusShep

  • Member
  • Posts: 126
Re: BEST TIME TO TAKE TIVICAY???
« Reply #13 on: April 16, 2014, 10:27:06 AM »
Just took an hour ago, feel a little zoned out and fatigued
Some abdominal pain.

Anyone else experience this?

Nope...  But just switched to Tivicay ~3 weeks ago.  I'm usually having coffee fairly soon after my meds since I can be zoned out in the AM before the meds anyway...
Converted:      11/1994

Offline cityboy

  • Member
  • Posts: 142
Re: BEST TIME TO TAKE TIVICAY???
« Reply #14 on: April 16, 2014, 08:17:32 PM »
Two questions

Do multivitamins include all vitamins or true multis like Centrum?

Do antacids include H2 receptors like Zantac


I also will switch soon. I recommend the European VIIV Leaflet; it contains more Information than the original  one.
http://www.viivhealthcare.com/media/74706/EU_Tivicay.pdf

some excerpts:
Oral use: Tivicay can be taken with or without food (see section 5.2). In the presence of integrase class resistance, Tivicay should preferably be taken with food to enhance exposure (particularly in patients with Q148 mutations) (see section 5.2). ..
 Absorption  Dolutegravir is rapidly absorbed following oral administration, with median Tmax at 2 to 3 hours post dose for tablet formulation.   
Food increased the extent and slowed the rate of absorption of dolutegravir.  Bioavailability of dolutegravir depends on meal content: low, moderate, and high fat meals increased dolutegravir AUC(0-) by 33%, 41%, and 66%, increased Cmax by 46%, 52%, and 67%, prolonged Tmax to 3, 4, and 5 hours from 2 hours under fasted conditions, respectively. These increases may be clinically relevant in the presence of certain integrase class resistance. Therefore, Tivicay is recommended to be taken with food by patients infected with HIV with integrase class resistance (see section 4.2).

medicines called antacids, to treat indigestion and heartburn: Do not take an antacid during the 6 hours before you take Tivicay, or for at least 2 hours after you take it. (See also Section 3). 
Calcium supplements, iron supplements and multivitamins:  Do not take a calcium supplement, iron supplement or multivitamin during the 6 hours before you take Tivicay, or for at least 2 hours after you take it (see also Section 3).

Calcium supplements, iron supplements or multivitamins: Calcium supplements, iron supplements or multivitamins can stop Tivicay being absorbed into your body and make it less effective. Do not take a calcium or iron supplement during the 6 hours before you take Tivicay, or for at least 2 hours after you take it.     Talk to your doctor for further advice on taking calcium supplements, iron supplements or multivitamins with Tivicay. (they reduce Tivicay up to 74%)

-You can find the "Undesirable effects" section under 4.8

Offline AusShep

  • Member
  • Posts: 126
Re: BEST TIME TO TAKE TIVICAY???
« Reply #15 on: April 16, 2014, 09:12:52 PM »
Two questions

Do multivitamins include all vitamins or true multis like Centrum?

Do antacids include H2 receptors like Zantac

Multi-vitamins like Centrum can't be taken with Tivicay.  I checked that out myself and verified with my pharmacist.  Anything containing aluminum, calcium, iron, magnesium or sucralfate (ulcer med) needs to be 2 hours after taking Tivicay, or 6 hours before (again that's why I take Tivicay in the morning, 1/2 dose multivitamin and zinc in the evening)

Zantac doesn't show as a problem on a drug interaction checker, but I'd verify with your Doctor or Pharmacist if you plan on taking them close together.  Antacid is probably a warning based on calcium.



Converted:      11/1994

Offline cityboy

  • Member
  • Posts: 142
Re: BEST TIME TO TAKE TIVICAY???
« Reply #16 on: April 17, 2014, 08:02:40 PM »
Thanks, that helps. 


Multi-vitamins like Centrum can't be taken with Tivicay.  I checked that out myself and verified with my pharmacist.  Anything containing aluminum, calcium, iron, magnesium or sucralfate (ulcer med) needs to be 2 hours after taking Tivicay, or 6 hours before (again that's why I take Tivicay in the morning, 1/2 dose multivitamin and zinc in the evening)

Zantac doesn't show as a problem on a drug interaction checker, but I'd verify with your Doctor or Pharmacist if you plan on taking them close together.  Antacid is probably a warning based on calcium.

Offline Bizkits

  • Member
  • Posts: 98
Re: BEST TIME TO TAKE TIVICAY???
« Reply #17 on: April 21, 2014, 10:00:28 AM »
I just started taking Truvada/Tivicay last Thursday as my first regimen ever. The pharmacist told me to stop taking zinc supplements period. She said there's a small amount of zinc in multi-vitamins which isn't a huge deal but to stop the extra. She also said it would be best to take multi-vitamin apart from tivicay, as has already been mentioned.

I have been taking the Truvada/Tivicay in the morning and maybe have noticed a very teeny bit of gastric upset...like a small bloating/gas-like feeling but it goes away within an hour or 2 and really is not bad at all to begin with. No other effects at all. :)

Offline AusShep

  • Member
  • Posts: 126
Re: BEST TIME TO TAKE TIVICAY???
« Reply #18 on: April 21, 2014, 01:29:29 PM »
I just started taking Truvada/Tivicay last Thursday as my first regimen ever. The pharmacist told me to stop taking zinc supplements period. She said there's a small amount of zinc in multi-vitamins which isn't a huge deal but to stop the extra. She also said it would be best to take multi-vitamin apart from tivicay, as has already been mentioned.


IDK...  The detailed drug guide doesn't say anything specifically about zinc, but it is a polyvalent cation; but so is potassium, and it doesn't say not to eat a banana with breakfast...  I'm taking 50 mg 12 hours apart from Tivicay, but good catch, I'll verify low zinc supplement with my doc in addition to my 1/2 dose multi.

The detailed info shows a 1/3 reduction in Tivicay efficacy if taken at the same time as a multi.  But even Maalox, which reduces efficacy 75% if taken together, is down to 20% two hours later, the minimum recommended wait.  Hopefully after 12 hours there's no impact at all.


Quote
Medications containing polyvalent cations

(e.g., Mg, Al, Fe, or Ca)
Cation-containing antacidsa or laxatives Sucralfate
Oral iron supplements Oral calcium supplements
Buffered medications

TIVICAY should be administered
2 hours before or 6 hours after taking medications containing polyvalent cations.
Converted:      11/1994

 


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