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Author Topic: Taking Stribild and have to switch advice?  (Read 946 times)

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Offline socalpoz

  • Member
  • Posts: 90
Taking Stribild and have to switch advice?
« on: July 26, 2015, 10:06:10 AM »
Hey forum it's been a long time since I have posted on here. I have been taking Stribild daily since July '13. Unfortunately I have developed a bad case of acid reflux my MD says it's a side effect of Stribild and I need to switch meds. First in regards to Stribild anyone else have these type of problems? I have always had bloating and gas when taking Stibild but until one month ago, I hadn't experienced these types of problems. It all started with hiccups and burping for 4 days straight, I must admit I don't always take my med with food and I sometimes take my multivitamins at the same time (I don't know if this could have contributed to these problems). So the problems started on a Friday and I finally went to a MD on a Tuesday. The MD (who is not my not my primary or specialist) prescribed prescription strength Pepcid that I take nightly. The hiccups and burping along with the pressure in my chest subsided after a couple of days.

So because of these problems my MD states I need to change my medication. I am really bummed about this as I was getting great results. Latest labs are: HIV still undetectable and my CD4 914 with 44% (the highest to date).

So the options he is suggesting are Complera, Atripla (one a day), Isentress/Truvada or Elivatigravir/Novir with Truvada. I would like to stick to a once a day pill and very anxious and feeling depressed about switching. He (MD) is recommending I switch ASAP!

I have been trying to compare Stribild with Complera but haven't anything that helps to easily identify the differences other than always taking Complera with a meal.

Thanks
Diagnosed Jan. 22, 2011
feb/11 cd4 547, cd4% 37, vl 527
mar/11 cd4 650, cd4% 37, vl 97
may/11 cd4 698, cd4% 37, vl 303
jul/11 cd4 744, cd4% 39, vl 239
aug/12 cd4 675, cd4% 39, Vl 42
Jun/13 cd4 594, cd4% 38, Vl 1860
Jul/3/13 started Stribild
Aug/13 cd4 758 cd4% 43, vl ??

Offline GoForIt

  • Member
  • Posts: 145
Re: Taking Stribild and have to switch advice?
« Reply #1 on: July 26, 2015, 10:40:19 AM »
Read your post and sorry you are getting acid reflux that stinks. 

All of the meds you listed are great meds and my Doctor has talked to me about all of them.

Just wondering, what is your diet like?  Do you think the foods you eat could be causing it?

Also my Doctor says do not take any vitamins unless he tells me to so there is no unwanted interaction with the meds.  And if you do take them try to take them 4 hours later or something.  The only vitamin I take is vitamin D after a meal at dinner and take my meds in the morning.

I am on TAF (since I am in a clinical trial for it, its the new Truvada formula) and Tivicay once a day in the morning.

When I first started medication though, I was put on regular Truvada & Tivicay I always felt very bloated after taking my meds for at least an hour or two.  So if I took it when I ate a meal I felt so full like my stomach was just over filled.

Once I got on the trial for TAF (the much smaller version of Truvada) I totally stopped experiencing the bloated feeling. 

So in my opinion it might be the diet you are on, or it might be the Truvada component + the fact your taking it with food thats making you feel the stomach issues...these are just guesses from my own experience.

Since all of those meds have Truvada components would be interesting to see if you change to one of them if you still have the same stomach issues.

The new TAF comes out soon form what I understand so I would recommend trying that with Tivicay as I have 0 side effects from this combination and am also seeing better and better results with each visit. 

Hope you get it figured out.
08/09/2013   Diagnosed WB positive
08/20/2013   CD4-506(28%)  VL-10,800
09/12/2013   CD4-391(28%)  VL-14,900
09/17/2013   Start ART (Truvada & Tivicay)
10/11/2013   CD4-377(26%)  VL-UD
12/20/2013   CD4-590(??%)  VL-UD
03/18/2014   CD4-660(29%)  VL-UD
07/22/2014   CD4-613(29%)  VL-UD
08/01/2014    Start Phase 3 TAF Clinical Trial
10/09/2014   CD4-498(29.5%) VL-UD
11/06/2014   CD4-600(30.2%) VL-UD
01/30/2015   CD4-529(31.3%) VL-UD
07/25/2015   CD4-742(36.5%) VL-UD

Offline GoForIt

  • Member
  • Posts: 145
Re: Taking Stribild and have to switch advice?
« Reply #2 on: July 26, 2015, 10:46:27 AM »
There is also Triumeq which is a 1 pill formulation of Epzicom & Tivicay. 

You have to take the blood test though to see if you have the gene allergy to Epzicom first before taking this med.

As Epzicom has a very fatal side effect if you do have the gene prone to being allergic to it (Which I do...I tested positive for this gene and that is why I must take TAF with my Tivicay instead)
08/09/2013   Diagnosed WB positive
08/20/2013   CD4-506(28%)  VL-10,800
09/12/2013   CD4-391(28%)  VL-14,900
09/17/2013   Start ART (Truvada & Tivicay)
10/11/2013   CD4-377(26%)  VL-UD
12/20/2013   CD4-590(??%)  VL-UD
03/18/2014   CD4-660(29%)  VL-UD
07/22/2014   CD4-613(29%)  VL-UD
08/01/2014    Start Phase 3 TAF Clinical Trial
10/09/2014   CD4-498(29.5%) VL-UD
11/06/2014   CD4-600(30.2%) VL-UD
01/30/2015   CD4-529(31.3%) VL-UD
07/25/2015   CD4-742(36.5%) VL-UD

Offline socalpoz

  • Member
  • Posts: 90
Re: Taking Stribild and have to switch advice?
« Reply #3 on: July 26, 2015, 10:50:41 AM »
Thanks Go for it,

Nothing has changed with my diet since starting Stribild. I do know just prior to the hiccups and burping I had eaten a very spicy meal that I normally wouldn't have eaten. I explained this to my MD, but since normalizing my diet again, the heartburn and acid reflux has not diminished so I continue to take Pepcid. I generally eat pretty healthy with occasional fast food.

Diagnosed Jan. 22, 2011
feb/11 cd4 547, cd4% 37, vl 527
mar/11 cd4 650, cd4% 37, vl 97
may/11 cd4 698, cd4% 37, vl 303
jul/11 cd4 744, cd4% 39, vl 239
aug/12 cd4 675, cd4% 39, Vl 42
Jun/13 cd4 594, cd4% 38, Vl 1860
Jul/3/13 started Stribild
Aug/13 cd4 758 cd4% 43, vl ??

Offline GoForIt

  • Member
  • Posts: 145
Re: Taking Stribild and have to switch advice?
« Reply #4 on: July 26, 2015, 10:56:01 AM »
Spicy foods can definitely cause stomach issues by themselves.  Combined with Truvada at the same time I could totally imagine the stomach feeling that I would experience.  It was a bloated, over stuffed feeling that I really did not like.  I remember once I started the clinical trial to switch out Truvada for TAF, I felt the light-ness of  the TAF.  The pill is much smaller and did not feel heavy on me at all.

So thats just my 2 cents.  It may be neither of the guesses I have made and you could have developed a stomach issue related to the foods you eat or something else over time.  Just trying to throw in my experience with Truvada and upset stomach, especially when taking it near a meal.

The best part about Tivicay is that you do not need to take a meal with it.  I pop it in the morning at 10:30 am and I don't even usually eat until around 12 or 1 or something.
08/09/2013   Diagnosed WB positive
08/20/2013   CD4-506(28%)  VL-10,800
09/12/2013   CD4-391(28%)  VL-14,900
09/17/2013   Start ART (Truvada & Tivicay)
10/11/2013   CD4-377(26%)  VL-UD
12/20/2013   CD4-590(??%)  VL-UD
03/18/2014   CD4-660(29%)  VL-UD
07/22/2014   CD4-613(29%)  VL-UD
08/01/2014    Start Phase 3 TAF Clinical Trial
10/09/2014   CD4-498(29.5%) VL-UD
11/06/2014   CD4-600(30.2%) VL-UD
01/30/2015   CD4-529(31.3%) VL-UD
07/25/2015   CD4-742(36.5%) VL-UD

Offline socalpoz

  • Member
  • Posts: 90
Re: Taking Stribild and have to switch advice?
« Reply #5 on: July 26, 2015, 11:03:55 AM »
GoForIt,

Yeah the food I just don't know, like I said nothing has changed in my diet.

In regards to the TAF is that the new Stribild I saw somewhere on line where its a reduction on one of the combo of meds producing less side effects?  Rumor has it will be approved by the FDA soon.



 
Diagnosed Jan. 22, 2011
feb/11 cd4 547, cd4% 37, vl 527
mar/11 cd4 650, cd4% 37, vl 97
may/11 cd4 698, cd4% 37, vl 303
jul/11 cd4 744, cd4% 39, vl 239
aug/12 cd4 675, cd4% 39, Vl 42
Jun/13 cd4 594, cd4% 38, Vl 1860
Jul/3/13 started Stribild
Aug/13 cd4 758 cd4% 43, vl ??

Offline GoForIt

  • Member
  • Posts: 145
Re: Taking Stribild and have to switch advice?
« Reply #6 on: July 26, 2015, 11:07:35 AM »
Yes.  It is basically the new Truvada. 

Stribild contains Truvada in its current formulation.

The new Stribild will be updated, taking out the Truvada, and replacing it with the new TAF formula soon enough from what my doctor tells me.

All of the old formulas will get the update including Stribild, Atripla, Complera, etc.

Gilead has found that TAF is a somewhat more effective version of Truvada with some added benefits including less chance at bone reduction, less interaction with kidneys, and also its smaller MG dose (the pill is about 1/4th the size of the Truvada pill) so less of it in your body to cause other issues (one of them I believe to be the over stuffed bloating feeling I would get with Truvada on a daily basis when I first started it)
08/09/2013   Diagnosed WB positive
08/20/2013   CD4-506(28%)  VL-10,800
09/12/2013   CD4-391(28%)  VL-14,900
09/17/2013   Start ART (Truvada & Tivicay)
10/11/2013   CD4-377(26%)  VL-UD
12/20/2013   CD4-590(??%)  VL-UD
03/18/2014   CD4-660(29%)  VL-UD
07/22/2014   CD4-613(29%)  VL-UD
08/01/2014    Start Phase 3 TAF Clinical Trial
10/09/2014   CD4-498(29.5%) VL-UD
11/06/2014   CD4-600(30.2%) VL-UD
01/30/2015   CD4-529(31.3%) VL-UD
07/25/2015   CD4-742(36.5%) VL-UD

Offline GoForIt

  • Member
  • Posts: 145
Re: Taking Stribild and have to switch advice?
« Reply #7 on: July 26, 2015, 11:12:55 AM »
I think HIV does cause stomach issues to be more sensitive just on its own.  I would cut out the fast food completely if I were you.

Try a diet eating some breakfast like cereal in the morning or eggs.  Eat grilled chicken, rice, salad, tea.

Cut out sodas and fast food.  That stuff is terrible on your body to begin with.
08/09/2013   Diagnosed WB positive
08/20/2013   CD4-506(28%)  VL-10,800
09/12/2013   CD4-391(28%)  VL-14,900
09/17/2013   Start ART (Truvada & Tivicay)
10/11/2013   CD4-377(26%)  VL-UD
12/20/2013   CD4-590(??%)  VL-UD
03/18/2014   CD4-660(29%)  VL-UD
07/22/2014   CD4-613(29%)  VL-UD
08/01/2014    Start Phase 3 TAF Clinical Trial
10/09/2014   CD4-498(29.5%) VL-UD
11/06/2014   CD4-600(30.2%) VL-UD
01/30/2015   CD4-529(31.3%) VL-UD
07/25/2015   CD4-742(36.5%) VL-UD

Offline socalpoz

  • Member
  • Posts: 90
Re: Taking Stribild and have to switch advice?
« Reply #8 on: July 26, 2015, 11:18:28 AM »
I hope the switch happens soon.

Good food suggestions. I do have to state I have never been a morning breakfast person. I normally would do an apple or banana, sometimes toast with peanut butter.

Anyway thanks for the info!
Diagnosed Jan. 22, 2011
feb/11 cd4 547, cd4% 37, vl 527
mar/11 cd4 650, cd4% 37, vl 97
may/11 cd4 698, cd4% 37, vl 303
jul/11 cd4 744, cd4% 39, vl 239
aug/12 cd4 675, cd4% 39, Vl 42
Jun/13 cd4 594, cd4% 38, Vl 1860
Jul/3/13 started Stribild
Aug/13 cd4 758 cd4% 43, vl ??

Offline GoForIt

  • Member
  • Posts: 145
Re: Taking Stribild and have to switch advice?
« Reply #9 on: July 26, 2015, 11:31:07 AM »
Same here.  Not a breakfast person.  When I used to work a 9-5 I would take cereal and milk with me to the office and eat a bowl of cereal in my office at 9am.

Now that I'm not working in that job anymore I'm very lazy about eating in the morning and generally skip breakfast.  A banana is great for energy in the morning too.

But ya I could totally imagine how fast food or spicy food + Truvada component can cause unwanted feeling in my stomach. 

Just had a meatball sub yesterday with a soda for lunch (I knew it wasn't the best for me but I was friggin starving)  and immediately upon drinking the soda I start hiccuping, and for the rest of the day I could just feel that meatball sub in me and it was not agreeing.

When I eat something like a Turkey sandiwch or something light for lunch.  It goes down no problem and much less of an upset stomach compared to something real saucy/spicy.
08/09/2013   Diagnosed WB positive
08/20/2013   CD4-506(28%)  VL-10,800
09/12/2013   CD4-391(28%)  VL-14,900
09/17/2013   Start ART (Truvada & Tivicay)
10/11/2013   CD4-377(26%)  VL-UD
12/20/2013   CD4-590(??%)  VL-UD
03/18/2014   CD4-660(29%)  VL-UD
07/22/2014   CD4-613(29%)  VL-UD
08/01/2014    Start Phase 3 TAF Clinical Trial
10/09/2014   CD4-498(29.5%) VL-UD
11/06/2014   CD4-600(30.2%) VL-UD
01/30/2015   CD4-529(31.3%) VL-UD
07/25/2015   CD4-742(36.5%) VL-UD

Offline Jmarksto

  • Member
  • Posts: 592
Re: Taking Stribild and have to switch advice?
« Reply #10 on: July 26, 2015, 02:48:27 PM »
Hey Socal;


I noticed that Complera is on your list of potential meds.  I was on Complera and switched to Truvada/Tivicay. Complera has Rilprivine in it which is an NNRTI and can have central nervous system side effects, such as mood changes and worse.  Also, while taking it with a meal wasn't that big of a deal, I did find that I ate more than I otherwise would.  I took my meds with lunch, and I would probably over eat to make sure I hit the 400 cal minimum.


Did your doc note which of the components of Stribild is likely causing the issue?  It seems like that information would be key to selecting another med.


Wish you well with this.
03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45% VL 25
02/25/14 CD4   792/37% VL UD
07/09/14 CD4 1004/39% VL UD
11/03/14 CD4   711/34% VL UD
03/13/15 CD4   833/36% VL UD
04/??/15 Truvada & Tivicay
06/01/15 CD4 1100/50% VL UD

Offline socalpoz

  • Member
  • Posts: 90
Re: Taking Stribild and have to switch advice?
« Reply #11 on: July 27, 2015, 06:56:24 AM »
Jmarksto,

I also notice that as a side effect for Complera, it and the eating at least 450 calories with the med has me very concerned. I never get to eat my lunches or dinners at the same time each day due to work and as I said earlier I am just not a breakfast person. I believe my best option is to take it in the morning and each a meal each time and try to adjust the amount I eat at lunch and dinner.

Unfortunately my doctor didn't mention what part of Stribild upsets the stomach.

Thanks for the input.
Diagnosed Jan. 22, 2011
feb/11 cd4 547, cd4% 37, vl 527
mar/11 cd4 650, cd4% 37, vl 97
may/11 cd4 698, cd4% 37, vl 303
jul/11 cd4 744, cd4% 39, vl 239
aug/12 cd4 675, cd4% 39, Vl 42
Jun/13 cd4 594, cd4% 38, Vl 1860
Jul/3/13 started Stribild
Aug/13 cd4 758 cd4% 43, vl ??

Offline socalpoz

  • Member
  • Posts: 90
Re: Taking Stribild and have to switch advice?
« Reply #12 on: August 12, 2015, 01:50:30 PM »
So I switched to Complera and starting taking last Thursday, 6 days ago. I am very concerned and hope to hear from others. My nausea, acid reflux has only gotten worse and the former prescription antacid I was taking can't be taken with compiler. I have left message for my MD the last couple of days (but he is out of the office sick). My questions is this a temporary side effect that will go away or not? At night I sleep sitting even after 5 hours of last meals due to reflux or vomit that comes up while lying down. I am so ready to just stop taking it, I have never felt so miserable not with flu etc!
Diagnosed Jan. 22, 2011
feb/11 cd4 547, cd4% 37, vl 527
mar/11 cd4 650, cd4% 37, vl 97
may/11 cd4 698, cd4% 37, vl 303
jul/11 cd4 744, cd4% 39, vl 239
aug/12 cd4 675, cd4% 39, Vl 42
Jun/13 cd4 594, cd4% 38, Vl 1860
Jul/3/13 started Stribild
Aug/13 cd4 758 cd4% 43, vl ??

Offline GoForIt

  • Member
  • Posts: 145
Re: Taking Stribild and have to switch advice?
« Reply #13 on: August 12, 2015, 06:05:27 PM »
Are you still eating spicy foods/ fast food/ drinking sodas?

I would recommend Tivicay/Truvada as well as it has had 0 side effects for me and done a great job with my labs. (Oh and you don't need a meal with it)

Cooking for myself has really changed my stomach issues which I used to get from eating out almost every meal.

Even though sometimes I crave McDonalds I can tell you if I do go and grab it I feel like dying right after I am finished eating.  I sweat and feel greasy and want to just throw up and can't even get to sleep.  So I've completely knocked fast food out of my diet.
08/09/2013   Diagnosed WB positive
08/20/2013   CD4-506(28%)  VL-10,800
09/12/2013   CD4-391(28%)  VL-14,900
09/17/2013   Start ART (Truvada & Tivicay)
10/11/2013   CD4-377(26%)  VL-UD
12/20/2013   CD4-590(??%)  VL-UD
03/18/2014   CD4-660(29%)  VL-UD
07/22/2014   CD4-613(29%)  VL-UD
08/01/2014    Start Phase 3 TAF Clinical Trial
10/09/2014   CD4-498(29.5%) VL-UD
11/06/2014   CD4-600(30.2%) VL-UD
01/30/2015   CD4-529(31.3%) VL-UD
07/25/2015   CD4-742(36.5%) VL-UD

Offline socalpoz

  • Member
  • Posts: 90
Re: Taking Stribild and have to switch advice?
« Reply #14 on: August 13, 2015, 11:49:11 AM »
No fast food. Spoke with the doctor yesterday. My message that I was considering stopping I guess finally got passed on. So he advices I stop taking Complera for a couple of days then call him. If the gastric issues have improved or gone away then we need to find me a new med. If not we need to look into other possible causes. I will keep people posted
Diagnosed Jan. 22, 2011
feb/11 cd4 547, cd4% 37, vl 527
mar/11 cd4 650, cd4% 37, vl 97
may/11 cd4 698, cd4% 37, vl 303
jul/11 cd4 744, cd4% 39, vl 239
aug/12 cd4 675, cd4% 39, Vl 42
Jun/13 cd4 594, cd4% 38, Vl 1860
Jul/3/13 started Stribild
Aug/13 cd4 758 cd4% 43, vl ??

Offline socalpoz

  • Member
  • Posts: 90
Re: Taking Stribild and have to switch advice?
« Reply #15 on: August 19, 2015, 09:59:22 AM »
So my MD has had me off my meds for almost a week now, to see if my acid reflux goes away. It has gotten better but I am now going in for an ultrasound to rule out my gallbladder as a possible culprit. I must admit I am more than anxious to be off my meds this long. :(
Diagnosed Jan. 22, 2011
feb/11 cd4 547, cd4% 37, vl 527
mar/11 cd4 650, cd4% 37, vl 97
may/11 cd4 698, cd4% 37, vl 303
jul/11 cd4 744, cd4% 39, vl 239
aug/12 cd4 675, cd4% 39, Vl 42
Jun/13 cd4 594, cd4% 38, Vl 1860
Jul/3/13 started Stribild
Aug/13 cd4 758 cd4% 43, vl ??

Offline socalpoz

  • Member
  • Posts: 90
Re: Taking Stribild and have to switch advice?
« Reply #16 on: August 26, 2015, 08:59:05 AM »
So update on my situation. I was off my HIV meds for 11 days, which has been driving me crazy. The results of the ultrasound are back and I am not having any gall bladder problems and MD says that my medication was NOT contributing to my acid reflux or the nausea. So I have resumed my Stribild, yay! But the ultrasound did reveal another issue not sure what, MD couldn't tell from the image or the person reading it.  I am being referred to a GI specialist and will be post an update when I get results. Anyway so happy to be back on my meds!
Diagnosed Jan. 22, 2011
feb/11 cd4 547, cd4% 37, vl 527
mar/11 cd4 650, cd4% 37, vl 97
may/11 cd4 698, cd4% 37, vl 303
jul/11 cd4 744, cd4% 39, vl 239
aug/12 cd4 675, cd4% 39, Vl 42
Jun/13 cd4 594, cd4% 38, Vl 1860
Jul/3/13 started Stribild
Aug/13 cd4 758 cd4% 43, vl ??

Offline sohotoronto

  • Member
  • Posts: 18
Re: Taking Stribild and have to switch advice?
« Reply #17 on: August 26, 2015, 08:57:23 PM »
Good to see that you are back on Mede. I was on stribild and switched to triumeq a couple of months ago. I had GI symptoms that included the issues you identified. Before for the change I went through a battery of tests and I was found to have a hiatus hernia and severe lactose intolerance. (Lactose intolernce developed this year). These two were contributing to my condition and I noticed the change. It might be something to consider. I changed drugs because I still had GI issues and fatigue challenges.

 


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