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Author Topic: Hepatotoxicity due to HIV meds?  (Read 643 times)

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Offline pozpinoynurse

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Hepatotoxicity due to HIV meds?
« on: October 19, 2015, 07:26:17 AM »
I am currently on my 4th week of medication trial on Lamivudine, Zidovudine & Nevirapine.

On my 3rd week, I started manifesting signs of liver toxicity. Jaundice, dark yellow urine, pale stools, nausea, vomiting, fatigue.. Seeked consult. The doctor advised me to stop taking Nevirapine & continue LamiZido. Blood was collected for AST / ALT. Waiting for the results. It's been 4 days since I stopped taking Nevirapine. I'm still yellow, a bit nauseated, but I'm feeling better. I hope that it's just the Nevi I'm  reacting to.

Im scared. What if I react to the next drug as well? I'm from the Philippines & I don't have that many options when it comes to ARVs.

Offline pozpinoynurse

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Re: Hepatotoxicity due to HIV meds?
« Reply #1 on: October 19, 2015, 07:30:35 AM »
Has anyone experienced Jaundice? I've had it for a week now. It started once I doubled my dose on Nevirapine.

How long will this jaundice last?

I'm  still taking Lamivudine and Zidovudine.. doctor advised me to stop taking Nevirapine in the meantime.

Offline Jeff G

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  • How am I doing Beren ?
Re: Hepatotoxicity due to HIV meds?
« Reply #2 on: October 19, 2015, 07:36:52 AM »
I moved both of your post on the same subject into the same thread... it helps us help you if you keep this in one thread so its all together. I would suggest seeing your doctor again ... you didn't mention if you have been tested for HEP A - B - C ?

I have not been on those meds so maybe another member can assist. Best of luck !

Offline ChefDD

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Re: Hepatotoxicity due to HIV meds?
« Reply #3 on: October 19, 2015, 10:41:30 AM »
Yes, I got severe  hepatotoxicity  back in 2000. I was hospitalized for 9 days. The jaundice does go away in about a month.
ChefDD ( White Whisker )

Offline eric48

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Re: Hepatotoxicity due to HIV meds?
« Reply #4 on: October 20, 2015, 12:31:21 PM »
Dr Google and Dr Forums are not certified doctors, but you may find some info useful.

Nevirapine will last long. It can still be measured in plasma as long as 1 month after stopping treatment.

Your doctor asked you to remain on the other 2 meds. This is called covering the tail. The NVP tail... If you don't then, NVP remains, alone, at low concentration and this is not favorable.

Covering the tail is standard procedure.

The one thing I do not know is how long you should do this, because at some point NVP will be very low and then you are basically under AZT/3TC dual therapy.
Staying on Lamivudine/Zidovudine dual therapy, longer than needed for covering the tail, may not be favorable either.

Has Doctor given you some instructions already for a replacement drug, or when to stop  LamiZido ?
NVP/ABC/3TC/... UD (non-infectious) ; CD4 > 1000; CD4/CD8 ~ 2.0   stock & donations : 6 months (2013: FOTO= 5d. ON 2d. OFF ; 2014: Clin. Trial NCT02157311 = 4days ON, 3days OFF ; 2015: use of NVP & 3TC generics

Offline pozpinoynurse

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Re: Hepatotoxicity due to HIV meds?
« Reply #5 on: October 31, 2015, 07:25:47 AM »
I have been screened for Hepatitis B. Negative.

I am okay now.. latest SGPT is 100. Far from my results 3 weeks ago which was at 330. I am no longer yellow. I've been drinking a lot of water. My urine is pale yellow in color now. My stool is no longer clay colored. Appetite is back!

I am generally feeling a lot better.

Stopped Nevirapine for 2 weeks. Then started on Efavirenz  a few days ago. Been dreaming a lot lately. And I feel sleepy during the day even though I get full 8 hours of sleep. Aside from that, everything's ok! I just hate that people notice that I lost weight.

Offline Wade

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Re: Hepatotoxicity due to HIV meds?
« Reply #6 on: October 31, 2015, 10:01:24 AM »
Hi glad to hear things are improving for you.
Is this the first regimen you have been on ?
« Last Edit: November 03, 2015, 07:49:37 AM by Wade »
"Who put the pepper in the....Vaseline  ? " Coffee Butler


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