Quantcast

Subscribe to:
POZ magazine
Newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr Instagram
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
December 18, 2014, 09:44:46 AM

Login with username, password and session length


Members
Stats
  • Total Posts: 649726
  • Total Topics: 49588
  • Online Today: 284
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Removing HIV's 'invisibility cloak' may help defeat the virus  (Read 3910 times)

0 Members and 1 Guest are viewing this topic.

Offline Boze

  • Member
  • Posts: 477
http://news.oneindia.in/2010/05/22/removinghivs-invisibility-cloak-may-help-defeat-theviru.html

London, May 22 (ANI): A new research has suggested that removing a chemical 'invisibility cloak' that makes HIV-infected cells look healthy might be the key to defeating the virus.

Human cells defend themselves against immune attack by displaying proteins on their surface that mark them as "self".


When the immune system detects these proteins, it holds back. One way HIV evades immune attack is by hijacking one of these proteins - CD59 - and using it to disguise itself and the cells it infects as healthy, human cells.

This cloak doesn't kick in directly following HIV infection. First, antigens on HIV's surface prompt the immune system to pump out vast quantities of anti-HIV antibodies, which bind to the antigen and even trigger the destruction of some HIV.

But once the infection is established, the CD59 cloak prevents further immune attack on the viral particles and infected cells, which also display the antigen.

"HIV patients have a very strong antibody response, but unfortunately it doesn't work," New Scientist quoted Qigui Yu of the Indiana University School of Medicine in Indianapolis, as saying.

To kick-start this immune attack, the researchers wanted to find a way to remove this cloak. They knew that a bacterium found in the human throat secretes a toxin called intermedilysin that binds to CD59. By isolating the toxin's binding site they made a small molecule called rILYd4.

When they added this molecule to blood from people with HIV, it enabled the antibodies already in the blood to destroy viral particles. Red blood cells and uninfected immune cells were unscathed, probably because there were no antibodies specific to these cells present.

Yu has preliminary results suggesting rILYd4 fights infected cells too.

The study has been published in The Journal of Immunology. (ANI)
==========
Aug08 - Seroconversion
Mar10 - Diagnosis; cd4 690 - VL 19,000
Apr10 - cd4 600
May10 - VL 4,500
Jun10 - started Atripla ; VL 113
Jul 10 - UD vl, CD4 590
Aug 10 - UD, CD4 810, 52%
Nov 10 - UD, CD4 980

Online mecch

  • Member
  • Posts: 12,156
  • red pill? or blue pill?
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #1 on: May 22, 2010, 08:07:21 AM »
clever!
ďFrom each, according to his ability; to each, according to his needĒ 1875 K Marx

Offline veritas

  • Member
  • Posts: 1,410
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #2 on: May 22, 2010, 08:39:15 AM »

cd59 is a phosphalipid on the virion membrane. This seems to be another ave to attack exposed ps. Here is the abstract:

http://www.ncbi.nlm.nih.gov/pubmed/19955519

This is an interesting concept. I believe John reported about this mechanism in his research thread back in January.

One to watch, since hiv is very clever in hiding from our immune system.

v

Offline Boze

  • Member
  • Posts: 477
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #3 on: May 22, 2010, 10:05:59 AM »
veritas,

i started tracking hiv research news only this year. And it seems like something new is found / developed every week. Has this pace of research been always there or is there an uptick in last few years?
==========
Aug08 - Seroconversion
Mar10 - Diagnosis; cd4 690 - VL 19,000
Apr10 - cd4 600
May10 - VL 4,500
Jun10 - started Atripla ; VL 113
Jul 10 - UD vl, CD4 590
Aug 10 - UD, CD4 810, 52%
Nov 10 - UD, CD4 980

Offline Miss Philicia

  • Member
  • Posts: 24,506
  • celebrity poster, faker & poser
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #4 on: May 22, 2010, 12:02:20 PM »
Very Romulan!
"Iíve slept with enough men to know that Iím not gay"

Offline tednlou2

  • Member
  • Posts: 5,078
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #5 on: May 23, 2010, 03:23:34 AM »
I believe there will be a cure in my lifetime.  If it isn't a total cure, it will be some new treatment that allows our own bodies to keep HIV at bay and asleep.  Or, some treatment we take once a month or something like that.   

Offline cpdh20

  • Member
  • Posts: 33
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #6 on: May 23, 2010, 04:02:27 AM »
i think the cure will arrive in our life time too, maybe even sooner than we think :) im very possitive about it.

Offline WhySoUnfair

  • Member
  • Posts: 69
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #7 on: May 23, 2010, 06:05:09 AM »
I believe there will be a cure in my lifetime.  If it isn't a total cure, it will be some new treatment that allows our own bodies to keep HIV at bay and asleep.  Or, some treatment we take once a month or something like that.   

but the HIV antibody test will be still "positive" right? so you are still "poz"?

I know some people infected with Hep A/B/C will clear it on their own.  For some of the rest, I also believe meds can basically cure it. But HIV seems more clever than Hep A/B/C. 

Have you guys read about the "Andrew Stimpson" case? (http://en.wikipedia.org/wiki/Andrew_Stimpson)
It seems researchers haven't done any further research on him.

one day without an HIV cure is too long!

Offline veritas

  • Member
  • Posts: 1,410
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #8 on: May 23, 2010, 06:17:07 AM »

borzel,

As Miss P pointed out, HIV is indeed very Romulan and just as insidious. That being said, the amount  of research has reached a frenzied pace. It is indeed a "RACE" for the cure and it's happening on many fronts. The breakthroughs in the last couple of years has put the possibilities of a cure within our grasp.
Where pessimism reigned only a few short years ago, there now resides a real belief that a cure can be found. The knowledge being obtained about the immune system is mindboggling and this knowledge will be translated into cures for other diseases as well as hiv. The workings of the immune system is the driving force that is sparking the research. HIV is the perfect subject to research toward that end. If hiv can "cloak" it's menace from the mechanism that protects our bodies, how many other diseases can do the same?
As cdph20 said, I believe their will be a cure on the therapeutic end. A vaccine might take awhile longer do to the incredible viral ramp up in the first few days of infection, however, even that hurdle will be overcome.

Stay healthy!


v

Offline BlackLion

  • Member
  • Posts: 7
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #9 on: May 23, 2010, 06:39:53 AM »
but the HIV antibody test will be still "positive" right? so you are still "poz"?

I know some people infected with Hep A/B/C will clear it on their own.  For some of the rest, I also believe meds can basically cure it. But HIV seems more clever than Hep A/B/C.  

Have you guys read about the "Andrew Stimpson" case? (http://en.wikipedia.org/wiki/Andrew_Stimpson)
It seems researchers haven't done any further research on him.

one day without an HIV cure is too long!

I think that it's ok if we are still poz but our health is good until we become old and die.
If I were him, i would have sacrificed myself for science. But he didn't do that.

« Last Edit: May 23, 2010, 06:45:14 AM by BlackLion »

Offline Boze

  • Member
  • Posts: 477
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #10 on: May 23, 2010, 10:51:33 AM »
Miss,

Sorry to be a bore, but what do you mean? I looked up Romulan but don't get it :(

Veritas - thanks for the explanation. I do hope all this research yields something for us
==========
Aug08 - Seroconversion
Mar10 - Diagnosis; cd4 690 - VL 19,000
Apr10 - cd4 600
May10 - VL 4,500
Jun10 - started Atripla ; VL 113
Jul 10 - UD vl, CD4 590
Aug 10 - UD, CD4 810, 52%
Nov 10 - UD, CD4 980

Offline Inchlingblue

  • Member
  • Posts: 3,119
  • Chad Ochocinco PETA Ad
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #11 on: May 23, 2010, 11:07:22 AM »
In the fictional Star Trek franchise, cloaking devices were first introduced and used by the Romulans in the original Star Trek episode "Balance of Terror". The invisibility came as a surprise to the crew of the USS Enterprise, who considered it only a theoretical possibility. During a later episode, "The Enterprise Incident", the term "cloaking device" was first coined by writer D.C. Fontana.

LINK:

http://en.wikipedia.org/wiki/Cloaking_device


Romulan 'Cloak of Invisibility' Inches Closer to Reality

LINK:

http://www.gearlog.com/2010/03/romulan_cloak_of_invisibility.php

Offline Boze

  • Member
  • Posts: 477
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #12 on: May 23, 2010, 12:08:45 PM »
Thanks. I guess we have a generation split here :)
==========
Aug08 - Seroconversion
Mar10 - Diagnosis; cd4 690 - VL 19,000
Apr10 - cd4 600
May10 - VL 4,500
Jun10 - started Atripla ; VL 113
Jul 10 - UD vl, CD4 590
Aug 10 - UD, CD4 810, 52%
Nov 10 - UD, CD4 980

Offline Hellraiser

  • Member
  • Posts: 4,143
  • Semi-misanthropic
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #13 on: May 23, 2010, 12:21:14 PM »
Thanks. I guess we have a generation split here :)

No sir, I'm pretty sure everyone else got that reference.

Offline Boze

  • Member
  • Posts: 477
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #14 on: May 23, 2010, 12:24:58 PM »
everybody else born in the 80s?
==========
Aug08 - Seroconversion
Mar10 - Diagnosis; cd4 690 - VL 19,000
Apr10 - cd4 600
May10 - VL 4,500
Jun10 - started Atripla ; VL 113
Jul 10 - UD vl, CD4 590
Aug 10 - UD, CD4 810, 52%
Nov 10 - UD, CD4 980

Offline Miss Philicia

  • Member
  • Posts: 24,506
  • celebrity poster, faker & poser
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #15 on: May 23, 2010, 01:02:33 PM »
everybody else born in the 80s?

Uh, there's also the movie franchise that featured the cloaking device in one of the highest grossing films of 2009.  Don't blame others for your own cultural inadequacies (and I'm not even what one would label a Trekie).

http://en.wikipedia.org/wiki/Star_Trek_(film)
"Iíve slept with enough men to know that Iím not gay"

Offline Ann

  • Administrator
  • Member
  • Posts: 28,140
  • It just is, OK?
    • Num is sum qui mentiar tibi?
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #16 on: May 23, 2010, 01:23:01 PM »

everybody else born in the 80s?


My daughter was born in 1987.

I'm a 1962 vintage; it was a very good year. Full bodied and full of nuance and flavour.


Have you guys read about the "Andrew Stimpson" case? (http://en.wikipedia.org/wiki/Andrew_Stimpson)
It seems researchers haven't done any further research on him.


Yes, ad nauseum.

If I remember correctly, it all turned out to be a load of poopie-business and that's why it was never properly followed up. Andrew kinda melted into the woodwork because he knew he was full of the said poopie-business.
« Last Edit: May 23, 2010, 01:24:59 PM by Ann »
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Miss Philicia

  • Member
  • Posts: 24,506
  • celebrity poster, faker & poser
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #17 on: May 23, 2010, 01:29:20 PM »
"Iíve slept with enough men to know that Iím not gay"

Offline Boze

  • Member
  • Posts: 477
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #18 on: May 23, 2010, 10:13:27 PM »
First of all I was not blaming anybody - only reflecting on whether Star Trek trivia crosses the generation/geek barrier.

Listen, if you guys want to believe that random Star Trek trivia is part of the popular culture - be my guests. The geek crew from Big Bang theory would surely agree but I'm more with Penny in this debate.

The problem with 'highest grossing franchise' is that the movie business is so marketing driven. Movies are made for teenagers who are bombarded with tv ads into making the opening weekend. I don't think that gross truly reflects cultural impact (teenagers will watch anything). Transformers has grossed 2x of Star Trek - do you expect anybody past 21  to have seen that?



==========
Aug08 - Seroconversion
Mar10 - Diagnosis; cd4 690 - VL 19,000
Apr10 - cd4 600
May10 - VL 4,500
Jun10 - started Atripla ; VL 113
Jul 10 - UD vl, CD4 590
Aug 10 - UD, CD4 810, 52%
Nov 10 - UD, CD4 980

Offline J220

  • Member
  • Posts: 587
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #19 on: May 24, 2010, 12:37:35 AM »
UDon't blame others for your own cultural inadequacies...

Isn't that a little harsh? I dont think borzel meant his post in a rude way. And besides, how is not knowing about certain movies "cultural inadequacies"?? Since when does Hollywood = culture??
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline Hellraiser

  • Member
  • Posts: 4,143
  • Semi-misanthropic
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #20 on: May 24, 2010, 12:50:25 AM »
It's really just a pop culture reference that he didn't get I am a little surprised though, considering there have been something like 10 movies, and 5 or 6 different series.  Not to mention numerous cross referenced terms in other series/movies/entertainment.

It would be like someone asking for clarification on what a hobbit is.

Offline leatherman

  • Member
  • Posts: 6,322
  • Google and HIV meds are Your Friends
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #21 on: May 24, 2010, 01:25:33 AM »
something like 10 movies, and 5 or 6 different series.
11 movies, 6 series (if u count the animated one. Voyager is my fav!)
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline Boze

  • Member
  • Posts: 477
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #22 on: May 24, 2010, 09:21:01 AM »
I think I understand where (my) confusion lies. I didn't realize they made so many star trek movies or that it was that popular of a TV series (I do remember it being cancelled in mid 90s). So I thought everybody who likes Star Trek must have seen it back in the day of the original series.
That said - I do still think it's more of a niche, kinda like Monty Python. Those who like it assume that any educated grown up living in the English speaking world should be familiar with it, while those who don't consider them harmless eccentrics.
==========
Aug08 - Seroconversion
Mar10 - Diagnosis; cd4 690 - VL 19,000
Apr10 - cd4 600
May10 - VL 4,500
Jun10 - started Atripla ; VL 113
Jul 10 - UD vl, CD4 590
Aug 10 - UD, CD4 810, 52%
Nov 10 - UD, CD4 980

Offline Ann

  • Administrator
  • Member
  • Posts: 28,140
  • It just is, OK?
    • Num is sum qui mentiar tibi?
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #23 on: May 24, 2010, 10:19:17 AM »

It would be like someone asking for clarification on what a hobbit is.


Hobbit? Wazzat? ;D
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline mpositive

  • Member
  • Posts: 298
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #24 on: May 24, 2010, 02:14:09 PM »
Where is Skeebo when you need him?   LOL

Offline john33

  • Member
  • Posts: 407
Re: Removing HIV's 'invisibility cloak' may help defeat the virus
« Reply #25 on: May 24, 2010, 09:17:12 PM »
Hobbit? Wazzat? ;D

Well Anne,
 you know what they say about men with big feet ;)

John

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.