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Author Topic: NanoViricides Signs anti-HIV Drug Candidate Testing Agreement with University of  (Read 1031 times)

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Offline Boze

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http://www.marketwatch.com/story/nanoviricides-signs-anti-hiv-drug-candidate-testing-agreement-with-university-of-california-san-francisco-2010-05-17?reflink=MW_news_stmp

NanoViricides Signs anti-HIV Drug Candidate Testing Agreement with University of California, San Francisco


WEST HAVEN, Conn., May 17, 2010 (BUSINESS WIRE) -- NanoViricides, Inc. (OTC BB: NNVC.OB) (the "Company"), announced that it has signed a Research Agreement with the University of California, San Francisco (UCSF) for testing of its anti-HIV drug candidates. Cheryl Stoddart, PhD, Assistant Professor in the UCSF Division of Experimental Medicine, will be the Principal Investigator.

Dr. Stoddart is a recognized investigator in preclinical studies of anti-HIV compounds using the standard SCID-hu Thy/Liv humanized mouse model. In particular, she is well known for her work in validating that this mouse model is capable of accurately predicting clinical antiviral efficacy in humans. The National Institute of Allergy and Infectious Diseases (NIAID), a division of the National Institutes of Health (NIH), has recognized UCSF as an important site for anti-HIV drug screening studies.

Dr. Stoddart's in-vivo testing of anti-HIV nanoviricides will complement the Company's previously announced in-vitro anti-HIV testing that is currently underway at the Southern Research Institute in Frederick, MD.

The Company has previously performed anti-HIV nanoviricides testing in vivo at KARD Scientific, Beverly, MA. In these studies, several nanoviricide drug candidates were shown to have equal effectiveness in terms of multiple parameters to a clinical anti-HIV HAART three-drug cocktail. The HAART cocktail drugs were administered at a much greater total dosage (4,100 mg/kg of HAART) than the nanoviricides (only 150mg/kg of the nanoviricides). This study evaluated several parameters including the reduction of HIV viral load, improvement in CD4+/CD8+ double-positive human T cells, and HIV particle count inside human T cells in the transplant, among others. The best nanoviricide drug candidate was greater than 25X (2,500%) superior to the HAART drug cocktail based on the amount of drug that produced comparable or superior effect. If these results are indicative of clinical response in humans, the Company believes that HIVCide(TM), its lead drug candidate against HIV, may constitute a "functional cure" for HIV/AIDS, either by itself, or in combination with existing therapies.

"We are very interested to find out how our prior results compare to the standardized studies in Dr. Stoddart's lab," said Anil R. Diwan, PhD, President of the Company.

About UCSF:

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. For further information, please visit www.ucsf.edu.

The information stated above was prepared by NanoViricides to report an agreement and reflects solely the opinion of the company. Nothing in this statement shall be construed to imply any support or endorsement of NanoViricides, or any of its products, by The Regents of the University of California, its officers, agents and employees.

About NanoViricides:

NanoViricides, Inc. (www.nanoviricides.com) is a development stage company that is creating special purpose nanomaterials for viral therapy. The Company's novel nanoviricide(R) class of drug candidates are designed to specifically attack enveloped virus particles and to dismantle them. The Company is developing drugs against a number of viral diseases including H1N1 swine flu, H5N1 bird flu, seasonal Influenza, HIV, oral and genital Herpes, viral diseases of the eye including EKC and herpes keratitis, Hepatitis C, Rabies, Dengue fever, and Ebola virus, among others.

This press release contains forward-looking statements that reflect the Company's current expectation regarding future events. Actual events could differ materially and substantially from those projected herein and depend on a number of factors. Certain statements in this release, and other written or oral statements made by NanoViricides, Inc. are "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. You should not place undue reliance on forward-looking statements since they involve known and unknown risks, uncertainties and other factors which are, in some cases, beyond the Company's control and which could, and likely will, materially affect actual results, levels of activity, performance or achievements. The Company assumes no obligation to publicly update or revise these forward-looking statements for any reason, or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if new information becomes available in the future. Important factors that could cause actual results to differ materially from the company's expectations include, but are not limited to, those factors that are disclosed under the heading "Risk Factors" and elsewhere in documents filed by the company from time to time with the United States Securities and Exchange Commission and other regulatory authorities. Although it is not possible to predict or identify all such factors, they may include the following: demonstration and proof of principle in pre-clinical trials that a nanoviricide is safe and effective; successful development of our product candidates; our ability to seek and obtain regulatory approvals, including with respect to the indications we are seeking; the successful commercialization of our product candidates; and market acceptance of our products.

SOURCE: NanoViricides, Inc.


NanoViricides, Inc.
Amanda Schuon, 310-550-7200
info@nanoviricides.com
==========
Aug08 - Seroconversion
Mar10 - Diagnosis; cd4 690 - VL 19,000
Apr10 - cd4 600
May10 - VL 4,500
Jun10 - started Atripla ; VL 113
Jul 10 - UD vl, CD4 590
Aug 10 - UD, CD4 810, 52%
Nov 10 - UD, CD4 980

 


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