Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
April 20, 2014, 04:50:51 AM

Login with username, password and session length


Members
Stats
  • Total Posts: 620454
  • Total Topics: 46749
  • Online Today: 191
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online
Users: 6
Guests: 157
Total: 163

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Reyataz / Norvir & Truvada question  (Read 2916 times)

0 Members and 1 Guest are viewing this topic.

Offline Dsd09

  • Member
  • Posts: 29
Reyataz / Norvir & Truvada question
« on: April 21, 2010, 01:38:29 PM »
Hi all

My b/f is changing medication next week from Truvada / Kaletra to Truvada / Reyataz & Norvir on grounds of side effects. He has been undetectable since starting treatment six months ago, and other than the side effects all has been fine.

My question is, the nurse advised that he could take Reyataz & Norvir with or without food before going to bed.
But everything I have read suggests that this combo must be taken with food or a snack.

Is this the case, and is this an oversight on the nurse's part?

If so, what sort of food should be eaten with the tablets?

Anyone's experiences would be greatly appreciated, he's going to run for another week on the Kaletra and then switch over


Thanks  :)
07/2009 - Diagnosis
08/2009 - CD4 354 / VL 4700
09/2009 - CD4 286 / VL 3200
10/2009 - CD4 249 / VL n/a - Started Truvada / Sustiva
12/2009 - CD4 318 / VL <40
01/2010 - CD4 316 / VL <40 - Switched Atripla
04/2010 - CD4 370 / VL <40
12/2010 - CD4 342 / VL <40

Offline Hellraiser

  • Member
  • Posts: 4,110
  • Semi-misanthropic
Re: Reyataz / Norvir & Truvada question
« Reply #1 on: April 21, 2010, 01:50:12 PM »
http://www.thebody.com/content/art32285.html

Norvir Gel Capsules are apparently fine without food, but the tablets need to be taken with food.


Edit:  Apparently you should eat food when taking Reyataz as well.
« Last Edit: April 21, 2010, 01:54:07 PM by Hellraiser »

Offline ad2san

  • Member
  • Posts: 182
Re: Reyataz / Norvir & Truvada question
« Reply #2 on: April 21, 2010, 01:51:42 PM »
Hi DSD09,

well, everyone say to take it with food because ... see here for the full story http://natap.org/2010/PK/PK_06.htm

I take it in the morning so it may be with some Muesli or with the full continental breakfast on Weekends  ;D

I hope this will help your BF.

Cheers
Feb   2009 CD4 358 VL 2000 16%
May  2009 CD4 305 VL 3069  14% <---- Started TVD+ATZ/r
Jul  2009 CD4 512 VL <50   18%
Jul 2010 CD4 418 VL <50 24%                     
Switched to Kivexa (Epzicom) + Norvir + Reyataz (due to sleep problem)
Aug 2010 CD4 606 VL <50 25%
Apr 2011 CD4 523 UD 21%
Jul 2011 CD4 494 UD 23%
Switched to Kivexa (Epzicom) + Viramune XR (due to kidney problems)
January 2012 CD4 564 UD 31%
October 2012 CD4 684 UD 29%
January 2013 CD4 594 UD 26%
Switched to Kivexa (Epzicom) + Isentress due to BIG increase GammaGT
Feb 2013 CD4 699 UD 28%
May 2013 CD4 385 UD 28%
July 2013 CD4 CD4 636 UD 25%
Oct 2013 CD4 588 UD 39%

Offline leatherman

  • Member
  • Posts: 5,922
  • Google and HIV meds are Your Friends
Re: Reyataz / Norvir & Truvada question
« Reply #3 on: April 21, 2010, 02:09:21 PM »
Truvada / Reyataz / Norvir (the regimen that I'm on) is best taken with a meal

Norvir Gel Capsules are apparently fine without food
Norvir, even if low doses are used with another protease inhibitor, should be taken with a meal or light snack.
http://www.aidsmeds.com/archive/Norvir_1561.shtml

this info at aidsmeds.com has not been updated to include info about the new tablet version, so here's the info about the tablet from the fda site

Absorption

NORVIR tablets are not bioequivalent to NORVIR capsules. Under moderate fat conditions (857 kcal; 31% fat, 13% protein, 56% carbohydrates), when a single 100 mg NORVIR dose was administered as a tablet compared with a capsule, AUC(0- ∞) met equivalence criteria but mean Cmax was increased by 26% (92.8% confidence intervals: ↑15 -↑39%).

No information is available comparing NORVIR tablets to NORVIR capsules under fasting conditions

    Effect of Food on Oral Absorption
A food effect is observed for NORVIR tablets. Food decreased the bioavailability of the ritonavir tablets when a single 100 mg dose of NORVIR was administered.  Under high fat conditions (907 kcal; 52% fat, 15% protein, 33% carbohydrates), a 23% decrease in mean AUC(0-∞) [90% confidence intervals: ↓30%-↓15%], and a 23% decrease in mean Cmax [90% confidence intervals: ↓34%-↓11%]) was observed relative to fasting conditions.   Under moderate fat conditions, a 21% decrease in mean AUC(0-∞) [90% confidence intervals: ↓28%-↓13%], and a 22% decrease in mean Cmax [90% confidence intervals: ↓33%-↓9%]) was observed relative to fasting conditions. 

However, the type of meal administered did not change ritonavir tablet bioavailability when high fat was compared to    moderate fat meals.

http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/HIVandAIDSActivities/ucm200179.htm
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Oh my friends, my friends forgive me
That I live and you are gone.
There's a grief that can't be spoken.
There's a pain goes on and on.
Empty chairs at empty tables
Where my friends will meet no more.

"Empty Chairs at Empty Tables" from Les Miserables

Offline Inchlingblue

  • Member
  • Posts: 3,119
  • Chad Ochocinco PETA Ad
Re: Reyataz / Norvir & Truvada question
« Reply #4 on: April 21, 2010, 02:11:40 PM »
Reyataz should be taken with food, for proper absorption:

http://www.natap.org/2010/PK/PK_06.htm

Offline Dsd09

  • Member
  • Posts: 29
Re: Reyataz / Norvir & Truvada question
« Reply #5 on: April 21, 2010, 03:24:32 PM »
Thanks for your quick responses everyone  ;D

So, with food it is.
He wants to take them last thing at night before bed, so would something like a slice of toast be fine?

We don't want to get this wrong and risk issues with failure / resistance etc...  :-\
07/2009 - Diagnosis
08/2009 - CD4 354 / VL 4700
09/2009 - CD4 286 / VL 3200
10/2009 - CD4 249 / VL n/a - Started Truvada / Sustiva
12/2009 - CD4 318 / VL <40
01/2010 - CD4 316 / VL <40 - Switched Atripla
04/2010 - CD4 370 / VL <40
12/2010 - CD4 342 / VL <40

Offline antibody

  • Member
  • Posts: 525
  • "every man thinks his burden is the heaviest"
Re: Reyataz / Norvir & Truvada question
« Reply #6 on: April 21, 2010, 04:09:40 PM »
I made the switch about 2 years ago from Atripla with No side effects what so ever. No diarrhea or gas. Nothing. No yellowing either.
Timbuk      <50/ 794  CD4 10/06 
                 <50/ 1096 CD4 3/07
                 <40/ 1854 CD4 4/09

Started Atripla  7/14/06
Switched to boosted Reyataz Truvada 3/28/07

*Ask me about Medical Marijuana and how it can help you!*

Offline antibody

  • Member
  • Posts: 525
  • "every man thinks his burden is the heaviest"
Re: Reyataz / Norvir & Truvada question
« Reply #7 on: April 21, 2010, 04:12:51 PM »
Make that 3 years ago. I switched back in '07 and had no problems in those 3 years. Very happy with this combo and find it real easy to take. I have never ever missed a dose and always test undetectable.
Timbuk      <50/ 794  CD4 10/06 
                 <50/ 1096 CD4 3/07
                 <40/ 1854 CD4 4/09

Started Atripla  7/14/06
Switched to boosted Reyataz Truvada 3/28/07

*Ask me about Medical Marijuana and how it can help you!*

Offline leatherman

  • Member
  • Posts: 5,922
  • Google and HIV meds are Your Friends
Re: Reyataz / Norvir & Truvada question
« Reply #8 on: April 21, 2010, 04:28:46 PM »
would something like a slice of toast be fine?
no. toast doesn't really count for "taking with food". :D  (I don't think toast even counts as a snack LOL)

He could experience failure with that little though because the possibility would exist he wouldn't get the right absorption; but even if that didn't happen, he will quite likely experience gastro issues (gas and diarrhea) and/or puking without taking enough food with these meds. ;) there has to be a fair amount of carbos and fat taken the meds to get the right absorption. (moderate fat conditions (857 kcal; 31% fat, 13% protein, 56% carbohydrates) from the FDA link).

Have him take the meds with dinner ;)
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Oh my friends, my friends forgive me
That I live and you are gone.
There's a grief that can't be spoken.
There's a pain goes on and on.
Empty chairs at empty tables
Where my friends will meet no more.

"Empty Chairs at Empty Tables" from Les Miserables

Offline Inchlingblue

  • Member
  • Posts: 3,119
  • Chad Ochocinco PETA Ad
Re: Reyataz / Norvir & Truvada question
« Reply #9 on: April 21, 2010, 04:32:26 PM »
Thanks for your quick responses everyone  ;D

So, with food it is.
He wants to take them last thing at night before bed, so would something like a slice of toast be fine?

We don't want to get this wrong and risk issues with failure / resistance etc...  :-\

The people I know who take Reyataz usually take it with whatever meal they are most consistent with. So, for example, if he regularly eats breakfast then it might be best to take it in the morning with breakfast. It does not matter what time of the day he takes it but taking it at night before bed would be hard to do unless he wants to eat a meal right before bed time.

aidsmeds.com recommends the following:

Reyataz should be taken with food, preferably a complete nutritious meal, to ensure proper absorption of the drug into the bloodstream.

I know people who take Reyataz with more of a snack as opposed to a complete meal. I don't think a piece of toast is enough, though. I believe there should be some fat in the food.

I'm sure others who take Reyataz will give their advice here based on what they eat.
« Last Edit: April 21, 2010, 04:37:26 PM by Inchlingblue »

Offline newt

  • Member
  • Posts: 3,868
  • the one and original newt
Re: Reyataz / Norvir & Truvada question
« Reply #10 on: April 21, 2010, 06:11:44 PM »
They key here is two fold:

1. Norvir needs some fat, not much, perhaps a glass of (full fat) milk will  do.

2. Reyataz needs an acid environment to be taken in properly, so a small amount of feed even toast, cereal or a Snickers bar will do (or orange juice or even a coffee really).

But overall, this combo is better with a proper meal or more substantial snack, like two rounds of toast with real butter/cereal/round of sandwiches minimum (strictly speaking 7-9g fat min for the PIs). Food also reduces farting and increased intake for the tenofovir in Truvada, and reduces stomach effects for the PIs.

Slice of cheese and glass of wine works in emergencies (for me  :))

- matt

"The object is to be a well patient, not a good patient"

Offline Dsd09

  • Member
  • Posts: 29
Re: Reyataz / Norvir & Truvada question
« Reply #11 on: April 22, 2010, 01:29:17 PM »
Thanks everyone again for the feedback  :)

Definately some food for thought there, as it were  ;)
07/2009 - Diagnosis
08/2009 - CD4 354 / VL 4700
09/2009 - CD4 286 / VL 3200
10/2009 - CD4 249 / VL n/a - Started Truvada / Sustiva
12/2009 - CD4 318 / VL <40
01/2010 - CD4 316 / VL <40 - Switched Atripla
04/2010 - CD4 370 / VL <40
12/2010 - CD4 342 / VL <40

Offline risred1

  • Member
  • Posts: 419
  • My Source for Supps - www.newyorkbuyersclub.org
Re: Reyataz / Norvir & Truvada question
« Reply #12 on: April 23, 2010, 12:37:00 AM »
my breakfast is just that.... and then I take this combo.

I have a english  muffin with Peanut Butter, 8 oz of OJ and a cup of coffee....

Then the meds.

Followed by a psyillium fiber drink with glutamine and my supps. (multifitamin, vit D, and some other stuff)...

So far so good. doc says its fine.

And i can have a egg based breakfast or a sandwich...
risred1 - hiv +
02/07 CD4 404 - 27% - VL 15k
10/07 CD4 484 - 31% - VL 45k
05/08 CD4 414 - 26% - VL 70k
01/09 CD4 365 - 23% - VL 65k
05/09 CD4 291 - 23% - VL 115k - Started Meds - Reyataz/Truvada
06/09 CD4 394 - ?% - VL 1200 - Boosted Reyataz with Norvir and Truvada
07/09 CD4 441 - ?% - VL 118 - Boosted Reyataz with Norvir and Truvada
09/09 CD4 375 - ?% - VL Undetectable - Boosted Reyataz with Norvir and Truvada
12/09 CD4 595 - ?% - VL Undetectable - VIT D 34 - Reyataz/Truvada/Norvir

Offline antibody

  • Member
  • Posts: 525
  • "every man thinks his burden is the heaviest"
Re: Reyataz / Norvir & Truvada question
« Reply #13 on: April 24, 2010, 11:34:38 PM »
most days I eat a full meal but sometimes I take them with a cracker or toast. 200 calories is what my Doctor said will work fine.
Timbuk      <50/ 794  CD4 10/06 
                 <50/ 1096 CD4 3/07
                 <40/ 1854 CD4 4/09

Started Atripla  7/14/06
Switched to boosted Reyataz Truvada 3/28/07

*Ask me about Medical Marijuana and how it can help you!*

Offline palerider

  • Member
  • Posts: 15
Re: Reyataz / Norvir & Truvada question
« Reply #14 on: May 02, 2010, 04:25:30 PM »
Hi, my first post.
I've been taking these three drugs for three years.
Never took them with food, and never needed to.
At the start I did, because I was terrified I would chuck and not be able to keep them down, but I've never felt the slightest nausea or bad stuff from not taking food when taking tabs.
I take mine in the morning, by the way, because I forget more at night.

Offline chguy78

  • Member
  • Posts: 67
Re: Reyataz / Norvir & Truvada question
« Reply #15 on: May 03, 2010, 04:38:45 PM »
I try to take mine with a full breakfast every day.  On those days when that's not possible, they go down better (and my stomach doesn't get the least bit queasy) if I have at least a glass of milk.  This is my one and only combo and it's agreed with me.
01/11: CD4=753 (36%), VL=Undetectable
07/10: CD4=531 (33%), VL=Undetectable
04/10: CD4=746 (33%), VL=Undetectable
01/10: CD4=566 (35%), VL=Undetectable
10/09: CD4=436 (31%), VL=405
07/09: CD4=631 (27%), VL=847
06/09: Started: Truvada, Reyataz, Norvir
05/09: CD4=426 (28%), VL=38,300
04/09: Positive; CD4=466 (28%), VL=39,700
10/08: Negative

Offline odyssey

  • Member
  • Posts: 763
  • One Crazy Mofo!
Re: Reyataz / Norvir & Truvada question
« Reply #16 on: May 05, 2010, 07:40:39 PM »
I was on this combo for awhile before I had to stop due to some rough side effects. What my doctor told me regarding eating with the meds was that the most important component to have with the drugs was something containing fat. He said at a minimum, have a full glass of whole milk. Anything more than that was just a bonus. Of course, something with the equivalent amount of fat works just as well, so sometimes I would eat a nutrition bar or something. But never take it on an empty stomach, according to my doc, and I believe, the med instructions.
01/09/09- diagnosed HIV+
01/16/09   CD4-425    22%     VL- 32415
11/09- started Truvada/Reyetaz/Norvir
03/10- stopped Truvada/Reyetaz/Norvir
10/18/11   CD4- 328   20%     VL- 84,000
10/25/11   CD4- 386   22%
10/28/11- start Truvada/Reyetaz/Norvir
3/8/12      CD4- 503   31%     VL 57

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.