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Author Topic: Medication as depo?  (Read 2488 times)

0 Members and 1 Guest are viewing this topic.

Offline TabooPrincess

  • Member
  • Posts: 279
Medication as depo?
« on: April 12, 2010, 04:20:28 PM »
I've searched for this and can't seem to find anything....is it right that there is research being done towards a HAART depo? It sounds fabulous but is it an urban myth??
09/ 2008 - Seroconversion
11/2008 - Tested pos, cd4 640 vl 25400
12/2008 - cd4 794 vl 27798, 35%
03/2009 - cd4 844 vl 68846, 35%
06/2009 - cd4 476 vl 49151, 33% (pregnancy confirmed)
08/2009 - cd4 464 vl 54662, 32%
Started meds for pregnancy (Kaletra, AZT, Viread)
09/2009 - cd4 841 vl 3213, 42%
10/2009 - cd4 860 vl 1088, 41%
11/2009 - cd4 771 vl 563, 38%
12/2009 - cd4 885 vl 151 42%
Discontinued meds after baby born
02/2010 - cd4 841 vl 63781, 38%
05/2010 - cd4 1080 vl 113000, 39%
08/2010 - cd4 770 vl 109242
12/2010 - cd4 642 vl 111000, 34%
06/2011 - cd4 450 vl 222000, 33%
11/2011 - cd4 419 vl 212000, 24%
03/2012 - cd4 280 vl 118000, 26% (repeated Cd4 at 360)
05/2012 -cd4 360 vl 99,190
10/2012 Atripla, cd4 690, vl 80
12/2012 Darunavir, norvir, truvada, Cd4 680, vl u/d
07/2013 cd4 750,ud

Offline Inchlingblue

  • Member
  • Posts: 3,119
  • Chad Ochocinco PETA Ad
Re: Medication as depo?
« Reply #1 on: April 12, 2010, 08:04:38 PM »
What is "depo"?

Offline Hellraiser

  • Member
  • Posts: 4,136
  • Semi-misanthropic
Re: Medication as depo?
« Reply #2 on: April 12, 2010, 09:33:30 PM »
I was wondering the same thing.  I think we can rule out depillatory.

Offline georgep77

  • Member
  • Posts: 146
Re: Medication as depo?
« Reply #3 on: April 12, 2010, 11:27:27 PM »
Sounds like Home depo !

                         ;D
Come on Sangamo,  Geovax,  Bionor immuno, ...Make us happy !!!
+ 2008

Offline Matty the Damned

  • Member
  • Posts: 12,228
  • Ninja Please
Re: Medication as depo?
« Reply #4 on: April 13, 2010, 12:17:03 AM »
Depo Provera?

MtD

Offline J220

  • Member
  • Posts: 587
Re: Medication as depo?
« Reply #5 on: April 13, 2010, 01:11:24 AM »
I've searched for this and can't seem to find anything....is it right that there is research being done towards a HAART depo? It sounds fabulous but is it an urban myth??

Your terminology is not making it easy for us to help answer your question.... Are you talking about a long acting injection, like Depo Provera? (Depo Provera is the name of the medication, not a delivery method, so saying "HAART depo" is like saying "HAART Prozac" or "HAART Pepto Bismol", it does not mean anything...you get the drift). Please clarify what you mean and we'll be happy to try to answer or discuss your question.

"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline Hellraiser

  • Member
  • Posts: 4,136
  • Semi-misanthropic
Re: Medication as depo?
« Reply #6 on: April 13, 2010, 01:20:05 AM »
Actually I think I may have figured it out.  Do you mean a time release medication injection for HAART?  So like you get a shot once per year rather than having to remember to take your pills?

Offline J220

  • Member
  • Posts: 587
Re: Medication as depo?
« Reply #7 on: April 13, 2010, 01:26:40 AM »
Yeah I think that's what she meant, let's see if she clarifies.
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline veritas

  • Member
  • Posts: 1,410
Re: Medication as depo?
« Reply #8 on: April 13, 2010, 06:04:01 AM »

Taboo,

They are studying time release medication. There was an abstract at CROI 2009 with maraviroc and Dapivirine (experimental nnrti):

http://www.retroconference.org/2009/PDFs/1069.pdf

v


Offline Inchlingblue

  • Member
  • Posts: 3,119
  • Chad Ochocinco PETA Ad
Re: Medication as depo?
« Reply #9 on: April 13, 2010, 11:41:40 AM »
There are strides being made with nanotechnology (which would not entail daily dosing) as well as long-acting therapeutic vaccines that may be a one-shot deal or maybe once-yearly, as researchers attempt to replicate what occurs in the immune system of elite controllers.

One of the improvements for future versions of HAART will be that it won't entail taking daily pills. The question is how soon will these advances reach the market.

Offline TabooPrincess

  • Member
  • Posts: 279
Re: Medication as depo?
« Reply #10 on: April 14, 2010, 11:28:47 AM »
lol yeh sorry, here I am - I meant an IM injection...us nurses just call them all depos! A lot of medication is in 'depo' form, once weekly/monthly etc.  Yearly would be too ambitious as the muscle can only hold a certain amount of liquid for slow release.  Any one heard anything about this?
09/ 2008 - Seroconversion
11/2008 - Tested pos, cd4 640 vl 25400
12/2008 - cd4 794 vl 27798, 35%
03/2009 - cd4 844 vl 68846, 35%
06/2009 - cd4 476 vl 49151, 33% (pregnancy confirmed)
08/2009 - cd4 464 vl 54662, 32%
Started meds for pregnancy (Kaletra, AZT, Viread)
09/2009 - cd4 841 vl 3213, 42%
10/2009 - cd4 860 vl 1088, 41%
11/2009 - cd4 771 vl 563, 38%
12/2009 - cd4 885 vl 151 42%
Discontinued meds after baby born
02/2010 - cd4 841 vl 63781, 38%
05/2010 - cd4 1080 vl 113000, 39%
08/2010 - cd4 770 vl 109242
12/2010 - cd4 642 vl 111000, 34%
06/2011 - cd4 450 vl 222000, 33%
11/2011 - cd4 419 vl 212000, 24%
03/2012 - cd4 280 vl 118000, 26% (repeated Cd4 at 360)
05/2012 -cd4 360 vl 99,190
10/2012 Atripla, cd4 690, vl 80
12/2012 Darunavir, norvir, truvada, Cd4 680, vl u/d
07/2013 cd4 750,ud

Offline TabooPrincess

  • Member
  • Posts: 279
Re: Medication as depo?
« Reply #11 on: April 14, 2010, 11:31:43 AM »
Oh and it's actually depot, with a 't' on the end.  This is recognised terminology and refers to the method of preparing the medication for injection form.  Hope this clears it up!

de·pot injection (dp, dp)
n.
An injection of a substance in a form that tends to keep it at the site of injection so that absorption occurs over a prolonged period.

« Last Edit: April 14, 2010, 11:33:42 AM by TabooPrincess »
09/ 2008 - Seroconversion
11/2008 - Tested pos, cd4 640 vl 25400
12/2008 - cd4 794 vl 27798, 35%
03/2009 - cd4 844 vl 68846, 35%
06/2009 - cd4 476 vl 49151, 33% (pregnancy confirmed)
08/2009 - cd4 464 vl 54662, 32%
Started meds for pregnancy (Kaletra, AZT, Viread)
09/2009 - cd4 841 vl 3213, 42%
10/2009 - cd4 860 vl 1088, 41%
11/2009 - cd4 771 vl 563, 38%
12/2009 - cd4 885 vl 151 42%
Discontinued meds after baby born
02/2010 - cd4 841 vl 63781, 38%
05/2010 - cd4 1080 vl 113000, 39%
08/2010 - cd4 770 vl 109242
12/2010 - cd4 642 vl 111000, 34%
06/2011 - cd4 450 vl 222000, 33%
11/2011 - cd4 419 vl 212000, 24%
03/2012 - cd4 280 vl 118000, 26% (repeated Cd4 at 360)
05/2012 -cd4 360 vl 99,190
10/2012 Atripla, cd4 690, vl 80
12/2012 Darunavir, norvir, truvada, Cd4 680, vl u/d
07/2013 cd4 750,ud

Offline Inchlingblue

  • Member
  • Posts: 3,119
  • Chad Ochocinco PETA Ad
Re: Medication as depo?
« Reply #12 on: April 14, 2010, 12:35:01 PM »
Yes, as mentioned above, there are studies of therapeutic vaccines as well as medications using nanotechnologies and even some ARV medications with very long half-lives, not to mention gene therapy, that won't require daily dosing.

I don't think it would technically be considered "depot" but it would have the same effect, i.e. less frequent dosing (in the case of therapeutic vaccines it could be once a year for example).

Any of these things would be several years away but research is happening.
« Last Edit: April 14, 2010, 12:39:49 PM by Inchlingblue »

Offline TabooPrincess

  • Member
  • Posts: 279
Re: Medication as depo?
« Reply #13 on: April 14, 2010, 12:36:32 PM »
Yes, as mentioned above, there are studies of therapeutic vaccines as well as medications using nanotechnologies and even some ARV medications, not to mention gene therapy, that won't require daily dosing.

I don't think it would technically be considered "depot" but it would have the same effect, i.e. less frequent dosing (in the case of therapeutic vaccines it could be once a year for example).

Any of these things would be several years away but research is happening.


Oh brilliant - that's really good news :-)
09/ 2008 - Seroconversion
11/2008 - Tested pos, cd4 640 vl 25400
12/2008 - cd4 794 vl 27798, 35%
03/2009 - cd4 844 vl 68846, 35%
06/2009 - cd4 476 vl 49151, 33% (pregnancy confirmed)
08/2009 - cd4 464 vl 54662, 32%
Started meds for pregnancy (Kaletra, AZT, Viread)
09/2009 - cd4 841 vl 3213, 42%
10/2009 - cd4 860 vl 1088, 41%
11/2009 - cd4 771 vl 563, 38%
12/2009 - cd4 885 vl 151 42%
Discontinued meds after baby born
02/2010 - cd4 841 vl 63781, 38%
05/2010 - cd4 1080 vl 113000, 39%
08/2010 - cd4 770 vl 109242
12/2010 - cd4 642 vl 111000, 34%
06/2011 - cd4 450 vl 222000, 33%
11/2011 - cd4 419 vl 212000, 24%
03/2012 - cd4 280 vl 118000, 26% (repeated Cd4 at 360)
05/2012 -cd4 360 vl 99,190
10/2012 Atripla, cd4 690, vl 80
12/2012 Darunavir, norvir, truvada, Cd4 680, vl u/d
07/2013 cd4 750,ud

Offline xman

  • Member
  • Posts: 285
Re: Medication as depo?
« Reply #14 on: April 14, 2010, 01:38:52 PM »
Oh brilliant - that's really good news :-)

That depends on what Inch means with several years. Many of us are out of options and don't have so much time.
sign the petition launched by the aids policy project addressed to the nih aimed to increase the money needed to find the cure:

http://www.aidspolicyproject.org/petition_for_the_nih

we can make a difference and we need to fight. please support them! it doesn't cost you anything. they need it now more than ever!

 


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