Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
April 20, 2014, 08:53:12 PM

Login with username, password and session length


Members
Stats
  • Total Posts: 620609
  • Total Topics: 46760
  • Online Today: 273
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: thinking about switching meds to Isentress/Truvada  (Read 3457 times)

0 Members and 1 Guest are viewing this topic.

Offline scotty54

  • Member
  • Posts: 88
thinking about switching meds to Isentress/Truvada
« on: August 24, 2012, 01:48:35 PM »
Hello to all,
New to threads/blogs here.  Poz since 97. On Zerit/Videx/Retrovir/Crixivan from beginning till 2006.  On Atripla 2006 to present.  Moderate to Severe loss of fat and fat redistribution beginning 2001.  Since switch to Atripla have noticed some very gradual positive changes.  I think I am not experiencing additional fat loss...but only very minor fat re-growth. My veins in legs are not as pronounced and the hair loss that I saw has somewhat reversed. (I even have the start of eyebrows). My labs have been good on Atripla.  VL has been undectable since 2002...and CD4 has steadly risen to 600 range. % has risen above 30.  I have read that some have seen more subcutaneous fat with Isentress/Truvada. I have used many fillers (temporary for me) and had my hump liposuctioned about 2 months ago. Have had some re-growth....although fat pad doesnt seem as large or thick...may have to consider excision.  Also have considered PMMA.....but am a bit hesitant.  Any experience/thoughts.....thanks in advance.
Best to all
Mike
I may not agree with you, but will always defend your right to disagree.

Online Miss Philicia

  • Member
  • Posts: 23,569
  • celebrity poster, faker & poser
Re: thinking about switching meds to Isentress/Truvada
« Reply #1 on: August 24, 2012, 01:59:42 PM »
I have a similar history -- meaning the zerit, etc. exposure in the 90's which resulted in lipoatrophy (but not humps/hypertrophy), and have also had fillers in recent years. I went on Isentress/Truvada five years ago and have not seen this regimen worsen what already was there.
"Iíve slept with enough men to know that Iím not gay"

Offline scotty54

  • Member
  • Posts: 88
Re: thinking about switching meds to Isentress/Truvada
« Reply #2 on: August 24, 2012, 04:08:33 PM »
How have your labs been since you made the switch?  Have you had any unusual side effects?  For me it will mean (i think) 3 dosages p/day instead of one.  A local buddy here reported some increased dizziness with Truvada (of course may have been dizzy to start with!). Willing to give it a go though on the hopes of some fat regeneration. Can always go back to the Atripla....but willing to give it a go in hopes of some fat regeneration.  Thank for sharing.
I may not agree with you, but will always defend your right to disagree.

Online Miss Philicia

  • Member
  • Posts: 23,569
  • celebrity poster, faker & poser
Re: thinking about switching meds to Isentress/Truvada
« Reply #3 on: August 24, 2012, 04:29:12 PM »
How can someone have "increased dizziness with Truvada" when Atripla has that in it? Sorry, but that makes no sense.

Anyway, I wasn't on Atripla before I was on Isentress/Truvada, but nevertheless my lab results went way up when I switched.

Personally I don't believe in anything more than marginal reversal of lipo -- not sure what your term "fat regeneration" really aims at. The bottom line is that lipo is a mitochondria dysfunction and as that is cellular level it's not going to eradicated. The damage is basically done. If your labs are fine on Atripla and you don't have side effects, and lipo isn't increasing, it seems silly to change regimens IMO.
"Iíve slept with enough men to know that Iím not gay"

Offline scotty54

  • Member
  • Posts: 88
Re: thinking about switching meds to Isentress/Truvada
« Reply #4 on: August 24, 2012, 05:18:14 PM »
Thanks Miss P for your frank advice.  Thats what I am looking for.  The dizziness was noted by a friend that made the switch.  While my fat loss seems to not be progressing I am willing to make the switch to see if I see any positive changes. Yes I agree that it may not get better and that I may have to use fillers as needed.

If my labs are about the same and I do see even a bit more fat in the legs/arms/face and/or less on the upper back/neck then it was the correct move for me.  I know we are all unique and it is a tough call. Stay well
I may not agree with you, but will always defend your right to disagree.

Offline Ann

  • Administrator
  • Member
  • Posts: 27,947
  • It just is, OK?
    • Num is sum qui mentiar tibi?
Re: thinking about switching meds to Isentress/Truvada
« Reply #5 on: August 25, 2012, 06:24:22 AM »
Wow Scotty, I think I get it why you have Doctors dont always understand "quality of life issues" in your signature line.

I mean, what doctor kept you on the "d" drugs (ddl and d4T) and Crix until 2006?!? There were friendlier combos available quite a few years earlier than that. You may have still been on AZT, but you should have been able to dump those three far earlier than 2006. Makes me angry to think of the extra damage you may have avoided if your combo had been changed sooner. I'm surprised you're not also suffering from PN - or are you? (I hope not!)

My heart goes out to you, mate.

And by the way, welcome to the forums.
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline scotty54

  • Member
  • Posts: 88
Re: thinking about switching meds to Isentress/Truvada
« Reply #6 on: August 25, 2012, 10:19:12 AM »
I have often thought the same thing Ann.  I guess I should have been more pro-active.  I had a reluctance "to rock the boat" with my infectious disease specialist doctor because he was supportive in so many other ways.  So I am left with lipodystrophy/atrophy issues for a long time.  Some anger/frustration there with my doctor and of course with myself.  I will also have to say in 2002/2003/2004 (for instance) we were just beginning to see and understand the lipo issues, or at least in my case.

Moving along......this is also why I want to make the new change....even if labs are about the same.....but I see a little less lipo issues it is good for me.  Seems that doctors have so many patients these days that they see you as your lab numbers and are hesitant to change. 

When you mentioned PN....I assume you mean peripheral neuropathy.  Fortunately I only had a small touch of that years ago.

I have learned that I have to read/learn/investigate as much as possible.  I think these blogs are a good thing for me.  We are all unique but there are also many out there that share common threads.  Will keep you posted.  Will probably not make the change until the new year.....as will be traveling in Nov....and a bit apprehensive of side effects at that time.  As always, appreciate your and any others valuable input.
I may not agree with you, but will always defend your right to disagree.

Offline Ann

  • Administrator
  • Member
  • Posts: 27,947
  • It just is, OK?
    • Num is sum qui mentiar tibi?
Re: thinking about switching meds to Isentress/Truvada
« Reply #7 on: August 26, 2012, 06:13:11 AM »
Well Scotty, you're certainly not alone in not being more pro-active and not wanting to rock the boat. A lot of people just aren't cut out for learning all this medical stuff that comes with hiv infection and I understand it can be a struggle. It can also be a struggle to challenge your doctor when we're brought up to revere doctors. It's perfectly reasonable to think you can trust your doctor's decision, but unfortunately you can't always. It's not too late to learn.

At least you didn't get the lasting PN issues. Small mercies, eh?

Good luck with your travels in November. Going anywhere nice?
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline scotty54

  • Member
  • Posts: 88
Re: thinking about switching meds to Isentress/Truvada
« Reply #8 on: August 27, 2012, 11:50:26 AM »
Hello Ann,
Thanks for your warm welcome.  Lots of shared information and camaraderie.

I am on a upswing.  It certainly puts some "bounce in my step" when I can keep my labs good and erase (at least some) of the visual presence of the dastardly virus.
Now if I can just budget for the next round! Wish you well....
I may not agree with you, but will always defend your right to disagree.

Offline aztecan

  • Member
  • Posts: 5,358
  • 28 years positive, 56 years a pain in the butt
Re: thinking about switching meds to Isentress/Truvada
« Reply #9 on: August 28, 2012, 12:31:40 AM »
Hey Scotty,

We have a very similar history. I was on Crixivan from 1996 until 2007, but rather than the dreaded "d" drugs, I was on Combivir (AZT and Epivir). I took that latter until 2009.

In my case, it wasn't that I didn't know other, more friendly, combos were out there. I was doing very well on those drugs and had been undetectable since 96. I had heard from various sources that the first regimen is the most viable and switching too often can cause problems.

So, I didn't switch until i found a hump growing on my back.

As Miss P said, I never saw much change in the lipohypertrophy or lipoatrophy after I switched.

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline scotty54

  • Member
  • Posts: 88
Re: thinking about switching meds to Isentress/Truvada
« Reply #10 on: August 28, 2012, 11:47:49 AM »
Hi Mark,
Thanks for your valuable input. Perhaps I will re-think the switch.  I any event I will not make a quick decision.  Miss P relayed that she probably would not make the switch.

Weighing the pros and cons of course....I am doing well on the Atripla except for continued lipodystrophy/lipohypertrophy/lipoatrophy...although seems to have moderated a bit.  The added stress of 3 dosages per day instead of one.  Changing to a new regimen that I might really need down the road.  All in hopes of some sub-cutaneous fat gain that may never occur.  I must give it more thought.

Trust you are loving life hump free.  I hope you have been t-shirt shopping.
I may not agree with you, but will always defend your right to disagree.

Offline phost86

  • Member
  • Posts: 54
Re: thinking about switching meds to Isentress/Truvada
« Reply #11 on: August 28, 2012, 12:06:31 PM »
Well Scotty, you're certainly not alone in not being more pro-active and not wanting to rock the boat. A lot of people just aren't cut out for learning all this medical stuff that comes with hiv infection and I understand it can be a struggle.

So true. It can be fear of what's really going on or not ready to come to terms with being infected.

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.