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Author Topic: Generic Combivir  (Read 1833 times)

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Offline gregftl

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Generic Combivir
« on: March 19, 2010, 08:55:55 PM »
So I was reading online that the patent for brand name Combivir runs out in May. Anyone think a generic will actually come out or will glaxo pull a trick out of their sleeve and get the patent extended? I take combivir and viramune. I know combivir came out in 1997 and viramune in 1996 according the FDA website. Pretty terrible both of these meds (and most other hiv meds that came out around that time) havent gone generic yet. It sure would save everyone money.......the ADAP/Ryan White programs would save.......14 years to keep a patent.....pitiful!

Offline aztecan

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  • Posts: 5,394
  • 29 years positive, 57 years a pain in the butt
Re: Generic Combivir
« Reply #1 on: March 19, 2010, 11:42:01 PM »
Some of the components of combivir are already available as generic.

AZT, which is sold as a generic under the name Retrovir, was approved for use against HIV in 1987 and has been available as a generic since 2001, I think.

Zerit (D4T), first approved in 1994, and Videx (DDI), first approved in 1991, are both available in the United States as a generic medication.

While we're at it, Viramune and Crixivan were both approved in 1996, so they should be coming off patent soon, if the patents last 14 years.

The problem with this is most people in Western Europe or North America won't take these meds because of their potential for side effects.

That may mean that generic forms of these meds won't be showing up because there is no profit potential for the manufacturer.

Just my 2 worth,

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline gregftl

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Re: Generic Combivir
« Reply #2 on: March 20, 2010, 01:38:36 AM »
Hmm geesh combivir and viramune are the only 2 meds I've ever taken in the 10years i've been poz and i've never had one side effect from them. Not even when I started them. I guess we shall see if they go generic in the US

Offline aztecan

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  • 29 years positive, 57 years a pain in the butt
Re: Generic Combivir
« Reply #3 on: March 20, 2010, 11:08:33 AM »
Hmm geesh combivir and viramune are the only 2 meds I've ever taken in the 10years i've been poz and i've never had one side effect from them. Not even when I started them. I guess we shall see if they go generic in the US

They may well, I hope they do.  I took Combivir, or is componments prior to their being combined into one pill, for a dozen years.

I have had long-term side effects, but that's just me. Not everyone does.

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline gregftl

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Re: Generic Combivir
« Reply #4 on: March 22, 2010, 02:02:12 AM »
Yah and I used to have this stupid doctor at the Broward county health department that kept wanting me to switch my combivir to truvada. This is his exact quote as to why "combivir is an old fashioned drug". Meanwhile my labs at that visit were 900 tcells and undetectable viral load. Needless to say this doctor no longer works with the BCHD and a I have a new doctor says that kind of thinking is just plain stupid. She is like me. If it aint broke dont fix it. I'm lucky to have been able to stay on the same drug regimen for almost 10yrs. I'm luckly. Plus being on the same regimen for so long and never taking any other drugs.......in the future...........if my drugs stop working then I will have LOTS of options to choose from in terms of what meds to take.
« Last Edit: March 22, 2010, 02:04:21 AM by gregftl »

Offline aztecan

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  • 29 years positive, 57 years a pain in the butt
Re: Generic Combivir
« Reply #5 on: March 24, 2010, 02:10:28 PM »
I did that very thing. I stayed with a tried and true regimen that really kicked viral butt.

I took Crixivan for 11 years and Combivir for 12. I finally switched when I developed a buffalo hump and horsecollar neck.

The nice thing is I didn't burn any bridges. If push came to shove and I really needed to go back on that regimen, I could.

I would probably boost the Crixivan to avoid the 3 times a day dosing and food restrictions though.

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline gregftl

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Re: Generic Combivir
« Reply #6 on: March 24, 2010, 04:32:28 PM »
Really you can do that? I thought once you stopped taking a drug(s) and went on a different regiment you got resistance to the drugs you were taking before you switched?

Offline aztecan

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  • 29 years positive, 57 years a pain in the butt
Re: Generic Combivir
« Reply #7 on: March 25, 2010, 01:05:52 AM »
Really you can do that? I thought once you stopped taking a drug(s) and went on a different regiment you got resistance to the drugs you were taking before you switched?

Interesting you should say that. I had the same discussion with someone else recently. Apparently, it is a common misconception.

If your virus is suppressed, especially at undetectable levels, and you switch meds, resistance to the original regimen is not a given.

If there are resistance issues, they usually develop prior to a switch.

In my mind, there are only two good reasons to switch: 1) Because of intolerable side effects; or, 2) Because resistance develops.

I am not one to switch for convenience sake. I don't like to mess around with success, even if I take more pills than the next guy.

But, I digress. The bottom line is if your HIV is well controlled via your drug regimen, and you have to switch for some reason, it should not automatically rule out the drugs you had been taking before the switch.

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline gregftl

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Re: Generic Combivir
« Reply #8 on: March 25, 2010, 07:02:12 PM »
Well, that is a great piece of info to know. I've had very good succes on Combivir and Viramune for almost 10yrs now. For the first 4months i was on Sustiva and Combivir. Oh that Sustiva was horrible it gave me horrible night mares and shot my tryglercerides way up to like 500. So Ive been on the Viramune and Combivir since Aug 2000. I just got my labs back yesterday and have 1140 Tcells and undetectable. I had a resistance test done a couple of years ago my doctor was just curious to see what the outcome would be. I have absolutely no resistance to any of the meds that are out. I mean in the almost 10yrs I've been poz i've missed a dose every once in a while maybe like 1-2 times a year i'll forget to take them but I think most people that get resistance really dont take care of taking their meds and miss taking them ALOT. I think in most instances alot of people screw themselves over when it comes to resistance. Of course there are exceptions to every rule.

Some doctors say if you have sex with someone and they shoot their poz load up you and they have resistance to certain meds then you will get that resistance. Other's disagree with that. I just know that I only have had sex with people that are also poz because I love bareback sex (i'm a bottom) and getting f*cked with a condom isnt pleasurable whatsoever. I've probably had hundreds of poz loads shot up me in the 10yrs I've been poz also and I have never gotten resistance from anyone. I must say though in the last year or so my "whore" days are over though so no chance now of that happening at all. Sex is pretty low on the priority list for me now. I've had my fun.

Offline aztecan

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  • 29 years positive, 57 years a pain in the butt
Re: Generic Combivir
« Reply #9 on: March 25, 2010, 11:42:12 PM »
Wow, I also was on Sustiva and Combivir, but only briefly.  :o It was the first regimen I tried after switching from Crixivan/Combivir. I developed the buffalo hump, chipmunk cheeks and horse collar neck, so it was time to say good by to Crixivan.

But, after two months on Sustiva, I was still hallucinating and having panic attacks, which isn't normal for me.

It didn't seem to affect my lipids that much.

However, after that, I switched first to boosted Reyataz and Combivir, which I liked, but I have GERD and need meds to control stomach acid, which are a no-no with Reyataz.

So, I switched to Lexiva and Combivir. A very effective combo, it worked very well suppressing the bugs, but my cholesterol and triglycerides skyrocketed.

So, last July, I switched to my current combo - Truvada and Isentress. So far, so good. but I do need to get my labs done again in then next two or three months to make sure all is still well.

As for the barebacking, its been so long, I really have trouble remembering when the last time was I had sex, aside from the cruise I took last November. ::)

I think the debate you mention will continue to rage for a while to come yet.

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

 


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