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Author Topic: LONG TERM AFFECTS OF ANTIRETROVIRAL DRUGS?  (Read 1817 times)

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Offline UK_SL

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  • Posts: 51
LONG TERM AFFECTS OF ANTIRETROVIRAL DRUGS?
« on: March 19, 2010, 12:09:37 PM »
Are there any studies on the long term affects of HIV drugs and if so what are they?

I've only been on Atripla for 6 months and am curious to hear from people who have been on meds for a long time and if they are suffering from any long term affects?
05/10/2009 ~ DIAGNOSED, CD4 = 8
22/10/2009 ~ CD4 = 11/VL = 430,000, STARTED ATRIPLA and SEPTRIN
26/11/2009 ~ CD4 = 121/VL = 840
22/12/2009 ~ CD4 = 184 (6%)/VL = 340
11/03/2010 ~ CD4 = 177 (12%)/VL = 72
01/07/2010 ~ CD4 = 247 (12%) VL = 76
20/01/2011 ~ CD4 = 350 / VL = 29

Offline Hellraiser

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  • Posts: 4,140
  • Semi-misanthropic
Re: LONG TERM AFFECTS OF ANTIRETROVIRAL DRUGS?
« Reply #1 on: March 19, 2010, 02:09:10 PM »
Atripla has only been around for 4 years so I highly doubt it.  The component drugs have been around slightly longer, however longterm is kind of up for debate.  The HIV epidemic is only 30 years old and the treatmeant is considerably younger.

Offline leatherman

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  • Google and HIV meds are Your Friends
Re: LONG TERM AFFECTS OF ANTIRETROVIRAL DRUGS?
« Reply #2 on: March 19, 2010, 07:20:09 PM »
HIV epidemic is only 30 years old and the treatmeant is considerably younger.
we're all still guinea pigs really  ;)
but at least we aren't dying as much anymore ;D
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline Miss Philicia

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  • Posts: 24,408
  • celebrity poster, faker & poser
Re: LONG TERM AFFECTS OF ANTIRETROVIRAL DRUGS?
« Reply #3 on: March 19, 2010, 08:19:32 PM »
I'd say getting put on high blood pressure medications at the age of 40 doesn't bode so well... but I digress.
"Iíve slept with enough men to know that Iím not gay"

Offline northernguy

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  • Posts: 1,347
Re: LONG TERM AFFECTS OF ANTIRETROVIRAL DRUGS?
« Reply #4 on: March 19, 2010, 09:53:01 PM »
I'd say getting put on high blood pressure medications at the age of 40 doesn't bode so well... but I digress.

Hey, I resemble that remark.  Its genetic, what can you do?

As to long term effects of HIV meds, that's one the reasons my doc wanted me to hold off starting.  As he pointed out, we have no idea what 20 years on these meds will do to you.  But in the end, push comes to shove and you have to start.
Apr 28/06 cd4 600 vl 10,600 cd% 25
Nov 8/09 cd4 510 vl 49,5000 cd% 16
Jan 16/10 cd4 660 vl 54,309 cd% 16
Feb 17/10 Started Atripla
Mar 7/10 cd4 710 vl 1,076 cd% 21
Apr 18/10 cd4 920 vl 268 cd% 28
Jun 19/10 cd4 450 vl 60 cd% 25
Aug 15/10 cd4 680 vl 205 cd% 27
Apr 3/11 cd4 780 vl <40 cd% 30
Jul 17/11 cd4 960 vl <40 cd%33
April 15/12 cd4 1,010 vl <40 cd% 39
April 20/12 Switched to Viramune + Truvada
Aug 2/12 cd4 1040, vl <40, cd% 38
Oct 19 cd4 1,110 vl <40 cd% 41

Offline Miss Philicia

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  • celebrity poster, faker & poser
Re: LONG TERM AFFECTS OF ANTIRETROVIRAL DRUGS?
« Reply #5 on: March 19, 2010, 10:05:36 PM »
Hey, I resemble that remark.  Its genetic, what can you do?

Uh, no -- I'd say 70% of the guys in my long time survivors support group are on high blood pressure medication after being on HIV meds for 20 years.  Your mileage may vary.

I'd say it's grossly abnormal that I went on blood pressure medication 3 years before my 73 year old mother did. 

What say yea?
"Iíve slept with enough men to know that Iím not gay"

Offline aztecan

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  • Posts: 5,404
  • 29 years positive, 57 years a pain in the butt
Re: LONG TERM AFFECTS OF ANTIRETROVIRAL DRUGS?
« Reply #6 on: March 19, 2010, 11:14:16 PM »
Uh, no -- I'd say 70% of the guys in my long time survivors support group are on high blood pressure medication after being on HIV meds for 20 years.  Your mileage may vary.

I'd say it's grossly abnormal that I went on blood pressure medication 3 years before my 73 year old mother did. 

What say yea?

Yep., but I'm still not on high blood pressure meds.

As for long term effects, Atripla is too new, but the stuff many of us started on has demonstrated what can happen long term.

I don't have kidney stones any longer, but Crix caused some years ago.

I had some degree of ongoing, and long-term, anemia caused by AZT.

I have a buffalo hump, chipmunk cheeks and a horse collar neck from 11 years on Crixivan, AZT and Epivir, although the Epivir probably is the least offensive of the old meds.

The battle with lipids has been going on for many years - probably at least a decade. That was caused by both my diet and the meds.

But, I have to admit, all of the above are a walk in the park compared to what I saw prior to the meds being available.

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline northernguy

  • Member
  • Posts: 1,347
Re: LONG TERM AFFECTS OF ANTIRETROVIRAL DRUGS?
« Reply #7 on: March 21, 2010, 09:36:33 PM »
Uh, no -- I'd say 70% of the guys in my long time survivors support group are on high blood pressure medication after being on HIV meds for 20 years.  Your mileage may vary.

I'd say it's grossly abnormal that I went on blood pressure medication 3 years before my 73 year old mother did. 

What say yea?

I started blood pressure meds three years before getting HIV.
Apr 28/06 cd4 600 vl 10,600 cd% 25
Nov 8/09 cd4 510 vl 49,5000 cd% 16
Jan 16/10 cd4 660 vl 54,309 cd% 16
Feb 17/10 Started Atripla
Mar 7/10 cd4 710 vl 1,076 cd% 21
Apr 18/10 cd4 920 vl 268 cd% 28
Jun 19/10 cd4 450 vl 60 cd% 25
Aug 15/10 cd4 680 vl 205 cd% 27
Apr 3/11 cd4 780 vl <40 cd% 30
Jul 17/11 cd4 960 vl <40 cd%33
April 15/12 cd4 1,010 vl <40 cd% 39
April 20/12 Switched to Viramune + Truvada
Aug 2/12 cd4 1040, vl <40, cd% 38
Oct 19 cd4 1,110 vl <40 cd% 41

Offline Miss Philicia

  • Member
  • Posts: 24,408
  • celebrity poster, faker & poser
Re: LONG TERM AFFECTS OF ANTIRETROVIRAL DRUGS?
« Reply #8 on: March 22, 2010, 12:13:34 AM »
I started blood pressure meds three years before getting HIV.

And your point is what exactly as regards my earlier comment about the high prevalence in my support group and the fact that nobody in my family has ever had this at the age of 40? 

Oh right, nothing.
"Iíve slept with enough men to know that Iím not gay"

Offline northernguy

  • Member
  • Posts: 1,347
Re: LONG TERM AFFECTS OF ANTIRETROVIRAL DRUGS?
« Reply #9 on: March 22, 2010, 02:34:46 AM »
And your point is what exactly as regards my earlier comment about the high prevalence in my support group and the fact that nobody in my family has ever had this at the age of 40? 

Oh right, nothing.

I'm sorry?  I just meant that some of us had to go on blood pressure meds at a youngish age even before HIV.  ???
Apr 28/06 cd4 600 vl 10,600 cd% 25
Nov 8/09 cd4 510 vl 49,5000 cd% 16
Jan 16/10 cd4 660 vl 54,309 cd% 16
Feb 17/10 Started Atripla
Mar 7/10 cd4 710 vl 1,076 cd% 21
Apr 18/10 cd4 920 vl 268 cd% 28
Jun 19/10 cd4 450 vl 60 cd% 25
Aug 15/10 cd4 680 vl 205 cd% 27
Apr 3/11 cd4 780 vl <40 cd% 30
Jul 17/11 cd4 960 vl <40 cd%33
April 15/12 cd4 1,010 vl <40 cd% 39
April 20/12 Switched to Viramune + Truvada
Aug 2/12 cd4 1040, vl <40, cd% 38
Oct 19 cd4 1,110 vl <40 cd% 41

 


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