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Author Topic: DermaVir Therapeutic Vaccine  (Read 4729 times)

0 Members and 1 Guest are viewing this topic.

Offline loneranger

  • Member
  • Posts: 16
DermaVir Therapeutic Vaccine
« on: March 02, 2010, 07:32:58 PM »
Any one come across this before? Interesting concept and apparently showing good results in phase II trials.

http://www.earthtimes.org/articles/show/genetic-immunity-presents-dermavir-at,1187000.shtml

Offline Inchlingblue

  • Member
  • Posts: 3,119
  • Chad Ochocinco PETA Ad
Re: DermaVir Therapeutic Vaccine
« Reply #1 on: April 21, 2010, 12:48:19 PM »
Yes, this seems promising.

There have been a few threads:

http://forums.poz.com/index.php?topic=26715.0

Offline xman

  • Member
  • Posts: 283
Re: DermaVir Therapeutic Vaccine
« Reply #2 on: April 21, 2010, 01:51:54 PM »
Promising but very long in development. Results of the current phase II will not be available until 2015. If the Maya's were correct, the world will end 3 years earlier.
sign the petition launched by the aids policy project addressed to the nih aimed to increase the money needed to find the cure:

http://www.aidspolicyproject.org/petition_for_the_nih

we can make a difference and we need to fight. please support them! it doesn't cost you anything. they need it now more than ever!

Offline J220

  • Member
  • Posts: 587
Re: DermaVir Therapeutic Vaccine
« Reply #3 on: April 21, 2010, 05:41:50 PM »
Promising but very long in development. Results of the current phase II will not be available until 2015. If the Maya's were correct, the world will end 3 years earlier.

If the mayas were correct, then why worry about a cure at all? Guess I'll make my reservations for the next Berlin Love Parade (Saturday July 24th 2010 in Duisburg, Germany) so I can get my freak on one last time before it's all over! lol
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline sam66

  • Member
  • Posts: 277
  • Keep The Faith ; Fight The Fight
Re: DermaVir Therapeutic Vaccine
« Reply #4 on: May 10, 2010, 07:51:29 AM »
If the mayas were correct, then why worry about a cure at all?

   Not sure if the Mayans got the dates correct, but 2029 and 2036 looks pretty dangerous;

    On April 13 2029 asteroid Apophis will pass within 22,124 miles of Earth, which is "close"!
    then again if it hasn't hit on Aug 2036 .

     http://www.guardian.co.uk/science/2005/dec/07/spaceexploration.research
    
     http://www.cfa.harvard.edu/iau/lists/PHACloseApp.html

 I just hope I can make it to 2029

 Sam
« Last Edit: May 10, 2010, 01:23:37 PM by sam66 »
december 2007 diagnosed +ve ,

Offline InOurLifetime

  • member
  • Posts: 2
Re: DermaVir Therapeutic Vaccine
« Reply #5 on: August 02, 2010, 01:05:02 PM »
Dr Lisziewicz presented Phase II data on DermaVir at the IAS AIDS 2010 conference in Vienna.

http://www.businesswire.com/news/home/20100719005463/en/Immunacia%E2%80%99s-Genetic-Immunity-Reports-Phase-II-Data

Offline mbpoz6

  • Member
  • Posts: 82
Re: DermaVir Therapeutic Vaccine
« Reply #6 on: April 11, 2011, 08:56:35 PM »
http://www.marketwire.com/press-release/Power-Dream-Ventures-Genetic-Immunity-Announces-Positive-Phase-II-Data-DermaVir-HIV-1425557.htm


Power of the Dream Ventures, Genetic Immunity Announces Positive Phase II Data for DermaVir HIV therapeutic Vaccine; Results Show 70% Viral Load Reduction

BUDAPEST, HUNGARY--(Marketwire - April 11, 2011) - Power of the Dream Ventures, Inc. (OTCBB: PWRV), Hungary's premier technology acquisition and development company, is pleased to announce Genetic Immunity's Phase II trial results for the Company's Lead Product candidate called DermaVir, based on a previously announced agreement whereby Power of the Dream Ventures will issue communications for Genetic Immunity on a going forward basis.

DermaVir, the world's first topical dendritic cell-targeting HIV therapeutic vaccine candidate, employs nanotechnology to boost the patient's own immune responses and to kill HIV-infected cells. The goal of DermaVir immune boosting therapy is to decrease antiretroviral drug exposure while maintaining undetectable HIV-RNA levels and achieve a remission (functional cure) in HIV-infected patients.

In a randomized, placebo-controlled, dose-ranging Phase II study conducted in Hamburg, Germany, thirty-six HIV-infected individuals, not yet taking antiretroviral drugs, received one of three DermaVir doses, or the placebo, every six weeks. "The treatments were very well-tolerated and CD4+ cell counts did not decrease," explained the study's Principle Investigator, Jan van Lunzen, MD of the University Medical Center Hamburg-Eppendorf, Infectious Diseases Unit. "At 24 weeks, the individuals' HIV viral loads were compared to their baseline values. A statistically significant reduction of 0.5 log10 copies/mL, a 70 percent reduction equivalent to that produced by several anti-HIV drugs, was seen in the cohort receiving 0.4 mg DermaVir vaccinations. Also in this group, HIV gag-specific precursor/memory T cells increased by 97 percent as the viral load decreased, a result not seen with antiretroviral drugs. Based upon our study the immune boosting and antiviral activity of DermaVir immunizations may provide a unique treatment approach for people with HIV/AIDS."

DermaVir features all key technological elements of Genetic Immunity's Immune Therapy Technology Platform. The Active Pharmaceutical Ingredient of DermaVir is a single plasmid DNA immunogen safely expressing 15 HIV antigens, the broadest antigen repertoire seen among HIV vaccine candidates to date. DermaVir Product is a "pathogen-like" nanomedicine and it is administered topically with a medical device, called DermaPrep. This technology in vivo targets the antigens to dendritic cells to prime na´ve T cells and expand the HIV-specific T cell pool to kill HIV-infected cells.

"Unlike traditional vaccines that prevent disease, therapeutic vaccines are given to people who are already infected to boost the body's immune response. To live a better and longer life, HIV-infected people boost their immune systems with vitamins, dietary supplements and herbs. We designed DermaVir to specifically boost their immune system to kill their HIV-infected cells and win the battle. Our Phase II trial provides the human proof of concept that immune boosting with DermaVir can reduce HIV viral load by killing the infected cells," said Julianna Lisziewicz, PhD and CEO of Genetic Immunity.

 


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