Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
July 23, 2014, 10:43:38 AM

Login with username, password and session length


Members
Stats
  • Total Posts: 631552
  • Total Topics: 47805
  • Online Today: 263
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: New potential long-lasting NRTI  (Read 2643 times)

0 Members and 1 Guest are viewing this topic.

Offline Cosmicdancer

  • Member
  • Posts: 145
New potential long-lasting NRTI
« on: January 26, 2010, 12:27:45 PM »
This compound is in the early phase of development.  Hopefully it will pan out. 

New Compound Could Be Alternative Strategy for Preventing HIV Infection

ScienceDaily (Jan. 25, 2010) ó With the help of effective drug therapies, HIV patients are living longer, healthier lives. Now, researchers want to improve these drug therapies and develop alternative preventative strategies, such as vaginal gels and creams that contain the same or related compounds used in treatments for people infected with HIV. A University of Missouri researcher is developing a compound that is more potent and longer-lasting than current HIV therapies.

"This new compound, EFdA, is 60,000 times more potent than any other drug that is currently being used to treat HIV," said Stefan Sarafianos, assistant professor of microbiology and immunology in the MU School of Medicine and investigator in the Christopher Bond Life Sciences Center. "This compound has a different chemical makeup than other approved therapies and creates an exceptional amount of antiviral activity. EFdA is activated very quickly and stays long in the body to fight the virus and protect from infection."

When a person is exposed to HIV, the virus invades healthy cells that play an important role in keeping the body's immune system strong. In order to multiply itself and remain in the body, the HIV virus relies on certain proteins. One protein, known as reverse transcriptase, is the main HIV enzyme responsible for viral replication. Effective HIV drugs control the virus by blocking the functions of these viral proteins.

EFdA is a nucleoside reverse transcriptase inhibitor (NRTIs). NRTIs target reverse transcriptase and can stop the virus from duplicating and spreading. Currently, there are eight clinically approved NRTIs, but they can protect cells for only short periods of time. With EFdA, patients could be protected for two days instead of few hours and would not need to take the drug as often, Sarafianos said.

"Infection is the result of an overwhelming attack of the virus, but if you manage to keep the viral load low, the body has a mechanism to defend itself and clean up the virus on its own," Sarafianos said. "The goal of our research is to drop the virus to very low or "undetectable" levels. Patients with suppressed viral loads will have increased life expectancy. Not all drugs work with all patients, and new resistant viral strains develop. Therefore, it's important to keep adding to our possible options for therapy."

Sarafianos hopes EFdA also can double as a preventative agent in the form of a vaginal gel or cream. This would provide additional protection to women whose partners refuse to use condoms.

Sarafianos collaborates with Michael Parniak, at the University of Pittsburgh and Hiroaki Mitsuya at the National Institutes of Health. Sarafianos' recent research was published in The Journal of Biological Chemistry.

http://www.sciencedaily.com/releases/2010/01/100125173448.htm
Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
June, 2008 - undetectable, 612 cd4
January, 2009 - undetectable, 670 cd4
May, 2009 - undetectable, 593 cd4
Sept, 2009 - 83 vl, 763 cd4, 34%
Dec, 2009 - undetectable, 889 cd4, 32%
April, 2010 - undetectable, 860 cd4, 31%
October, 2010 - undetectable, 800 cd4, 38%
April, 2011 - undetectable, t-cell test not done
October, 2011 - undetectable
April, 2012 - undetectable, 850 cd4, 39%
November, 2012 - undetectable, 901 cd4, 41%
April, 2013 - undetectable, 846 cd4, 36%
October, 2013 - undetectable
May, 2014 - undetectable, 784 cd4, 48%

Offline veritas

  • Member
  • Posts: 1,408
Re: New potential long-lasting NRTI
« Reply #1 on: January 26, 2010, 12:55:33 PM »

Cosmicdancer,

Although still in pre-clinicals, EFdA seems promising. Here is some pre-clinical data:

http://antiviralresistance.org/abstract7_2009.pdf


v

Offline Miss Philicia

  • Member
  • Posts: 23,872
  • celebrity poster, faker & poser
Re: New potential long-lasting NRTI
« Reply #2 on: January 26, 2010, 01:15:10 PM »
I actually ponder whether or not an every other day drug regimen would lead to worse adherence for many patients.
"Iíve slept with enough men to know that Iím not gay"

Offline veritas

  • Member
  • Posts: 1,408
Re: New potential long-lasting NRTI
« Reply #3 on: January 26, 2010, 01:28:42 PM »

You might be right Miss P. One would not only have to remember what time of day to take your meds, but also the appropriate day. Of course , if one is organized, such a system could be set up rather easily.

On a personal note, I'd do it in a minute.

Of course, the decision will not have to be made for awhile.

Offline tommy246

  • member
  • Member
  • Posts: 435
Re: New potential long-lasting NRTI
« Reply #4 on: January 30, 2010, 11:35:13 AM »
I actually ponder whether or not an every other day drug regimen would lead to worse adherence for many patients.

I  suppose it depends on the type of individual but i for one will never forget to take a pill that keeps me alive whether it be once a day or once a month , and secondly this type of discovery i believe will eventually lead to once a week ,once a month, once a year etc
jan 06 neg
dec 08 pos cd4 505 ,16%, 1,500vl
april 09 cd4 635 ,16%,60,000
july 09 ,cd4 545,17%,80,000
aug 09,hosptal 18days pneumonia cd190,225,000,15%
1 week later cd4 415 20%
nov 09 cd4 591 ,vl 59,000,14%,started atripla
dec 09  cd4 787, vl 266, 16%
march 2010  cd4 720 vl non detectable -20  20%
june 2010  cd4  680, 21%, ND

Offline Miss Philicia

  • Member
  • Posts: 23,872
  • celebrity poster, faker & poser
Re: New potential long-lasting NRTI
« Reply #5 on: January 30, 2010, 12:00:47 PM »
Uh, your personal feelings have no bearing on the issue.  It's a matter of the demographics of HIV/AIDS, and what the preponderance of patients would do.  

Duh.
"Iíve slept with enough men to know that Iím not gay"

Offline Assurbanipal

  • Member
  • Posts: 2,173
  • Taking a forums break, still see PM's
Re: New potential long-lasting NRTI
« Reply #6 on: January 30, 2010, 01:19:05 PM »
I actually ponder whether or not an every other day drug regimen would lead to worse adherence for many patients.

tend to agree, here.  With my osteoporosis pill it was very easy to remember the once a week meds -- "if it is Monday I must take a pill".  But it is harder to remember the once a month pill  -- "if it is the 10th, I must take a pill.

Of course that's partly because they have to be taken first thing -- absolutely before anything INCLUDING COFFEE -- and while I can usually remember what day of the week it is WITHOUT COFFEE, which date in the month???  :-[

(did I mention the NO COFFEE part?   ;D )
5/06 VL 1M+, CD4 22, 5% , pneumonia, thrush -- O2 support 2 months, 6/06 +Kaletra/Truvada
9/06 VL 3959 CD4 297 13.5% 12/06 VL <400 CD4 350 15.2% +Pravachol
2007 VL<400, 70, 50 CD4 408-729 16.0% -19.7%
2008 VL UD CD4 468 - 538 16.7% - 24.6% Osteoporosis 11/08 doubled Pravachol, +Calcium/D
02/09 VL 100 CD4 616 23.7% 03/09 VL 130 5/09 VL 100 CD4 540 28.4% +Actonel (osteoporosis) 7/09 VL 130
8/09  new regimen Isentress/Epzicom 9/09 VL UD CD4 621 32.7% 11/09 VL UD CD4 607 26.4% swap Isentress for Prezista/Norvir 12/09 (liver and muscle issues) VL 50
2010 VL UD CD4 573-680 26.1% - 30.9% 12/10 VL 20
2011 VL UD-20 CD4 568-673 24.7%-30.6%
2012 VL UD swap Prezista/Norvir for Reyataz drop statin CD4 768-828 26.7%-30.7%

Offline Hellraiser

  • Member
  • Posts: 4,136
  • Semi-misanthropic
Re: New potential long-lasting NRTI
« Reply #7 on: January 30, 2010, 01:23:13 PM »
I  suppose it depends on the type of individual but i for one will never forget to take a pill that keeps me alive whether it be once a day or once a month , and secondly this type of discovery i believe will eventually lead to once a week ,once a month, once a year etc

Never say Never.

Offline Miss Philicia

  • Member
  • Posts: 23,872
  • celebrity poster, faker & poser
Re: New potential long-lasting NRTI
« Reply #8 on: January 30, 2010, 01:26:53 PM »

(did I mention the NO COFFEE part?   ;D )

Oh dear, that would mess me up too :)
"Iíve slept with enough men to know that Iím not gay"

Offline tommy246

  • member
  • Member
  • Posts: 435
Re: New potential long-lasting NRTI
« Reply #9 on: January 30, 2010, 10:13:18 PM »
Uh, your personal feelings have no bearing on the issue.  It's a matter of the demographics of HIV/AIDS, and what the preponderance of patients would do.  

Duh.
This website is about personal opinions and you love giving out yours  i merely stated that for me it wouldnt be an issue , this site is for everybody to give there opinion not just about you and your arrogant attitude and constant urge to pick a cat fight with anybody im astounded the mods put up with your constant bitching , grow up and get a life , either help people on here or move on if you have nothing worth saying.
jan 06 neg
dec 08 pos cd4 505 ,16%, 1,500vl
april 09 cd4 635 ,16%,60,000
july 09 ,cd4 545,17%,80,000
aug 09,hosptal 18days pneumonia cd190,225,000,15%
1 week later cd4 415 20%
nov 09 cd4 591 ,vl 59,000,14%,started atripla
dec 09  cd4 787, vl 266, 16%
march 2010  cd4 720 vl non detectable -20  20%
june 2010  cd4  680, 21%, ND

Offline Miss Philicia

  • Member
  • Posts: 23,872
  • celebrity poster, faker & poser
Re: New potential long-lasting NRTI
« Reply #10 on: January 30, 2010, 10:21:10 PM »
This website is about personal opinions and you love giving out yours  i merely stated that for me it wouldnt be an issue , this site is for everybody to give there opinion not just about you and your arrogant attitude and constant urge to pick a cat fight with anybody im astounded the mods put up with your constant bitching , grow up and get a life , either help people on here or move on if you have nothing worth saying.

In your effort to take offense and, once again, boil everything down to your own experience you missed my larger point.  When drug research moves into a certain level I'd assume that they'd not be so interested in what 1, 2 or 10 people can do with the proposed dosing, but what 100 or more can do satisfactory in terms of adherence.  I hope this makes more sense to you. 

This has nothing to do with the nature of internet message boards and the posting of opinions.  It's about which opinion is more informed.  If you find my reasoning above faulty then by all means say so, but explain why.  Thank you, and have a nice weekend.
"Iíve slept with enough men to know that Iím not gay"

Offline Nestor

  • Member
  • Posts: 430
  • What we love, we shall grow to resemble.
Re: New potential long-lasting NRTI
« Reply #11 on: January 30, 2010, 11:20:17 PM »

Under normal circumstances, I too think that every other day would be harder for me to keep track of than every day.  But in another thread we were talking about people who want to travel extensively or live abroad for a year.  If this is a stepping-stone to something that would be once a week, it would have huge implications for freedom of movement.  Imagine someone who was going to spend a year travelling around the world.  52 pills would be a lot easier to carry than 365. 
Summer 2004--became HIV+
Dec. 2005--found out

Date          CD4    %       VL
Jan. '06    725    25      9,097
Nov. '06    671    34     52,202
Apr. '07    553    30      24,270
Sept. '07  685    27       4,849
Jan. '08    825    29       4,749
Mar. '08    751    30     16,026
Aug. '08    653    30       3,108
Oct. '08     819    28     10,046
Jan '09      547    31     13,000
May '09     645   25        6,478
Aug. '09    688   30      19,571
Nov. '09     641    27       9,598
Feb. '10     638    27       4,480
May '10      687      9    799,000 (CMV)
July '10      600     21      31,000
Nov '10      682     24     15,000
June '11     563    23     210,000 (blasto)
July  '11      530    22      39,000
Aug '11      677     22      21,000
Sept. '12    747     15      14,000

Offline Okealyshire

  • Member
  • Posts: 139
Re: New potential long-lasting NRTI
« Reply #12 on: January 31, 2010, 02:31:55 AM »
I suspect for most people that rituals can be easy to adopt. For example, I wear 30-day extended wear disposable contact lenses. Every Sunday night I remove the lenses and soak overnight in an enzyme cleaner. On the first of each month I remove the pair I'm wearing and insert a new one. These procedures are easy to remember.

Many of us can also take advantage of tools to help remind us of regular activity. As an example, you could create a recurring event in a Google calendar to take your weekly or monthly NNRTI on a certain date, and have the calendar send you a reminder email or deliver a text message to your phone.

Offline tommy246

  • member
  • Member
  • Posts: 435
Re: New potential long-lasting NRTI
« Reply #13 on: January 31, 2010, 04:48:35 AM »
Uh, your personal feelings have no bearing on the issue.  It's a matter of the demographics of HIV/AIDS, and what the preponderance of patients would do.  

Duh.

I am english and we dont start sentences with UH and end them in DUH thats just you trying to be offensive and trying to belittle me and my comments, Your personal opinion is that you think adherence would be more difficult taking a pill every two days instead of everyday , my personal opinion is that it wouldnt be ,its not rocket science . We all have different methods when it comes to taking our meds i personally use a pill box by the side of my bed i would quite simply remove the pills from the days i dont need to take them,now do you understand you gave your opinion and i gave mine . Thats my final say on the matter .
jan 06 neg
dec 08 pos cd4 505 ,16%, 1,500vl
april 09 cd4 635 ,16%,60,000
july 09 ,cd4 545,17%,80,000
aug 09,hosptal 18days pneumonia cd190,225,000,15%
1 week later cd4 415 20%
nov 09 cd4 591 ,vl 59,000,14%,started atripla
dec 09  cd4 787, vl 266, 16%
march 2010  cd4 720 vl non detectable -20  20%
june 2010  cd4  680, 21%, ND

Offline Miss Philicia

  • Member
  • Posts: 23,872
  • celebrity poster, faker & poser
Re: New potential long-lasting NRTI
« Reply #14 on: January 31, 2010, 09:53:06 AM »
Thanks Tommy.  I know how insightful the experience is of someone on Atripla for two months versus someone who has dealt with non-one-drug-a-day regimens now for 17 years.  In fact, I've been on all of these, many of which (at the time) had food/no food restrictions.

Zidovudine (AZT) (1993)
Epivir (3TC) (1995)
Emtriva (2003)
Viread (2001)
Videx (ddI) (1993)
Zerit (d4T) (1994)
Ziagen (1998)
Hivid (ddC) (1992)

Sustiva (1998)
Viramune (1996)

Invirase (saquinavir)(1995)
Kaletra (2000)
Norvir (1996)
Prezista (2006)
Viracept (1997)

Fuzeon (2003)

Isentress (2007)

Hydrozyurea

The simple fact is that once you go from something (somewhat) simple such as twice daily though with food restrictions, though still much more complex than Atripla, to something like three times a day -- two doses with food, one without, it all becomes wildly more difficult (speaking from experience, of course).

I've also done enough volunteering with HIV/AIDS, and live in an urban environment with a hugh HIV infection rate, to know that a huge, huge sector of the HIV patient pool consists of people where you want to make adherence easier, not more difficult.  Having them on one NRTI that they take once a week, with other drugs they take daily, will lead to higher incidences of resistance in the larger HIV population.  If they can make an entire drug regimen that is once a week then I would find this useful, but not until then.

To use your phrase, Tommy, "its not rocket science".
« Last Edit: January 31, 2010, 10:07:15 AM by Miss Philicia »
"Iíve slept with enough men to know that Iím not gay"

Offline Ann

  • Administrator
  • Member
  • Posts: 28,134
  • It just is, OK?
    • Num is sum qui mentiar tibi?
Re: New potential long-lasting NRTI
« Reply #15 on: January 31, 2010, 10:08:13 AM »
Tommy, Miss P, everyone is entitled to their opinion, even if that opinion is wrong or misguided. All we ask is that when someone presents their personal opinion, they make it clear that's what it is - their personal opinion.

Can we please stop bickering now? Thanks! :)

Ann
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.