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Author Topic: Timing / Temp for Truvada / Norvir / Reyataz  (Read 2206 times)

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Offline Ryoma

  • Member
  • Posts: 17
Timing / Temp for Truvada / Norvir / Reyataz
« on: January 12, 2010, 09:09:06 AM »
Hi again,

It looks like I'm going to start on Truvada / Norvir / Reyataz from this Thursday, and I'm just doing some last minute prep work before the big day.

Two questions:

(1) I know that this combo needs to be taken with food, so I'm going to try to do it at breakfast.  So the timing - during the work week, I eat around 7AM.  On the weekends - maybe 10AM.  Can I get away with taking the pills at 7AM during the week and 10AM on the weekends - or will it need to be pretty much the exact same time each day?  Can I start that way or should I aim to take at the same time everyday for the first x days?  A previous post seemed to say that a three or so hour difference was ok but wanted to check with other people taking this combination.   

(2) Is there any way that I can keep the Truvada / Reyataz in the fridge with the Norvir?  All my vitamins are in the fridge already, so it might make it easier if I can keep everything together...if not, I'll move the vitamins out of the fridge and on to the countertop.

Thanks

Ryoma
Exposed and sero-converted October 2009
November 12 2009  CD4 252 VL 3,000,000
December 3 2009 CD4 297 VL 1,000,000
December 22 2009 CD4 352 (VL not measured, it was a different clinic for a different problem...)
January 7 2010 CD4 311 VL50,000
January 15 2010 Start Truvada / Isentress
February 18 2010 CD4 386 VL83
February 25 2010 Switch to Truvada / Reyataz / Norvir
June 23 2010 CD4 387 VL UD!
July 2010 CD4 561 VL UD
Aug 2010 CD4 671 VL UD
Sep 2010 CD4 599 VL <40
Oct 2010 CD4 570 VL UD
Switch to Prezista / Norvir / Isentress
Nov 2010 CD4 738 VL <40
Dec 2010 CD4 773 VL UD
Jan 2010 CD4 570 VL UD

Offline risred1

  • Member
  • Posts: 419
  • My Source for Supps - www.newyorkbuyersclub.org
Re: Timing / Temp for Truvada / Norvir / Reyataz
« Reply #1 on: January 12, 2010, 11:41:52 AM »
I'm on this combo...

I think sometimes we take Strict Adherence to mean that we need to be like a clock... the important thing is to take it every day and not to skip too much or forget.

I don't think a few hour variability is all that bad, I'm vary quite a bit in the morning and I'm maintaining undetectable reliably. I never missed a day... although I was once 12 hours off.

I don't know if Refrigeration is a problem with Reyataz or Truvada.
risred1 - hiv +
02/07 CD4 404 - 27% - VL 15k
10/07 CD4 484 - 31% - VL 45k
05/08 CD4 414 - 26% - VL 70k
01/09 CD4 365 - 23% - VL 65k
05/09 CD4 291 - 23% - VL 115k - Started Meds - Reyataz/Truvada
06/09 CD4 394 - ?% - VL 1200 - Boosted Reyataz with Norvir and Truvada
07/09 CD4 441 - ?% - VL 118 - Boosted Reyataz with Norvir and Truvada
09/09 CD4 375 - ?% - VL Undetectable - Boosted Reyataz with Norvir and Truvada
12/09 CD4 595 - ?% - VL Undetectable - VIT D 34 - Reyataz/Truvada/Norvir

Offline BM

  • Member
  • Posts: 340
Re: Timing / Temp for Truvada / Norvir / Reyataz
« Reply #2 on: January 12, 2010, 01:24:56 PM »
I recently read an article which summarised research indicating that perfect adherence is less important for those who have been undetectable for a year or more. However, the researcher whose work the article was based on stressed the importance of still trying to achieve 100% adherence until more is known.

I've not been able to find the article, but if I do I'll post a link.
« Last Edit: January 12, 2010, 01:31:42 PM by BM »

Offline antibody

  • Member
  • Posts: 525
  • "every man thinks his burden is the heaviest"
Re: Timing / Temp for Truvada / Norvir / Reyataz
« Reply #3 on: January 12, 2010, 01:57:51 PM »
Should be no problem with taking your pills in a 3 hour window. I take mine with my first meal of the day. some days it could be early as 9 am or as late 1 or 2 pm, depends what shift I am working but always take the Reyataz, Truvada, Norvir and a multi vitamin with my first meal. This could be 6 hours different from the day before but I have always been undetectable on this combo going on 4 years. I keep a weeks worth of meds in a daily pill thingy and keep the rest in  the fridge till it's ready to refill.
Timbuk      <50/ 794  CD4 10/06 
                 <50/ 1096 CD4 3/07
                 <40/ 1854 CD4 4/09

Started Atripla  7/14/06
Switched to boosted Reyataz Truvada 3/28/07

*Ask me about Medical Marijuana and how it can help you!*

Offline ad2san

  • Member
  • Posts: 184
Re: Timing / Temp for Truvada / Norvir / Reyataz
« Reply #4 on: January 12, 2010, 02:09:27 PM »
Hi,

I made some experiment trying to find the right time to take the combo .....
I first started at lunch time but carrying the meds at work was more a burden than a relief. I did not consider the evening so that I may have a drink around dinner  ;D
I am taking the combo with breakfast at 07:30 allowing me a +/- 3 hours window for variation. I find it practically convenient if I have to catch an early flight or on week end to get some extra sleep   :)

Good luck
Feb   2009 CD4 358 VL 2000 16%
May  2009 CD4 305 VL 3069  14% <---- Started TVD+ATZ/r
Jul  2009 CD4 512 VL <50   18%
Jul 2010 CD4 418 VL <50 24%                     
Switched to Kivexa (Epzicom) + Norvir + Reyataz (due to sleep problem)
Aug 2010 CD4 606 VL <50 25%
Apr 2011 CD4 523 UD 21%
Jul 2011 CD4 494 UD 23%
Switched to Kivexa (Epzicom) + Viramune XR (due to kidney problems)
January 2012 CD4 564 UD 31%
October 2012 CD4 684 UD 29%
January 2013 CD4 594 UD 26%
Switched to Kivexa (Epzicom) + Isentress due to BIG increase GammaGT
Feb 2013 CD4 699 UD 28%
May 2013 CD4 385 UD 28%
July 2013 CD4 CD4 636 UD 25%
Oct 2013 CD4 588 UD 39%

Offline newt

  • Member
  • Posts: 3,877
  • the one and original newt
Re: Timing / Temp for Truvada / Norvir / Reyataz
« Reply #5 on: January 12, 2010, 04:42:47 PM »
I think breakfast regardless of time will be fine. The drugs have a very long life in the body for each dose, long enough to handle the odd late brekkie. The important thing, as has been said, is every day.

You cannot keep Truvada in the fridge, it absorbs moisture. Reyataz and Truvada should be stored at a room temperature (15-30 degrees C)  away from direct heat, moisture, and sunlight (so, in the container then...).

- matt
"The object is to be a well patient, not a good patient"

Offline Ryoma

  • Member
  • Posts: 17
Re: Timing / Temp for Truvada / Norvir / Reyataz
« Reply #6 on: January 13, 2010, 06:25:58 AM »
Again thanks for the good advice.  12 hours to go (give or take), wish me luck!

Ryoma
Exposed and sero-converted October 2009
November 12 2009  CD4 252 VL 3,000,000
December 3 2009 CD4 297 VL 1,000,000
December 22 2009 CD4 352 (VL not measured, it was a different clinic for a different problem...)
January 7 2010 CD4 311 VL50,000
January 15 2010 Start Truvada / Isentress
February 18 2010 CD4 386 VL83
February 25 2010 Switch to Truvada / Reyataz / Norvir
June 23 2010 CD4 387 VL UD!
July 2010 CD4 561 VL UD
Aug 2010 CD4 671 VL UD
Sep 2010 CD4 599 VL <40
Oct 2010 CD4 570 VL UD
Switch to Prezista / Norvir / Isentress
Nov 2010 CD4 738 VL <40
Dec 2010 CD4 773 VL UD
Jan 2010 CD4 570 VL UD

Offline risred1

  • Member
  • Posts: 419
  • My Source for Supps - www.newyorkbuyersclub.org
Re: Timing / Temp for Truvada / Norvir / Reyataz
« Reply #7 on: January 13, 2010, 09:08:05 AM »
i don't know if you saw this, but here is my daily log when I started Reyataz, Truvada... Norvir..

http://forums.poz.com/index.php?topic=27269.0

It was not only my experience, but questions and followup commentary on the experience.

:)
risred1 - hiv +
02/07 CD4 404 - 27% - VL 15k
10/07 CD4 484 - 31% - VL 45k
05/08 CD4 414 - 26% - VL 70k
01/09 CD4 365 - 23% - VL 65k
05/09 CD4 291 - 23% - VL 115k - Started Meds - Reyataz/Truvada
06/09 CD4 394 - ?% - VL 1200 - Boosted Reyataz with Norvir and Truvada
07/09 CD4 441 - ?% - VL 118 - Boosted Reyataz with Norvir and Truvada
09/09 CD4 375 - ?% - VL Undetectable - Boosted Reyataz with Norvir and Truvada
12/09 CD4 595 - ?% - VL Undetectable - VIT D 34 - Reyataz/Truvada/Norvir

Offline Ryoma

  • Member
  • Posts: 17
Re: Timing / Temp for Truvada / Norvir / Reyataz
« Reply #8 on: January 14, 2010, 09:15:13 AM »
Well it looks like I was wrong...as it turns out, the doctors here are starting me on Truvada /Isentress.  Timing won't be an issue - guess I'll just have to wake up earlier on the weekends!    Thanks again for the advice.

Ryoma
Exposed and sero-converted October 2009
November 12 2009  CD4 252 VL 3,000,000
December 3 2009 CD4 297 VL 1,000,000
December 22 2009 CD4 352 (VL not measured, it was a different clinic for a different problem...)
January 7 2010 CD4 311 VL50,000
January 15 2010 Start Truvada / Isentress
February 18 2010 CD4 386 VL83
February 25 2010 Switch to Truvada / Reyataz / Norvir
June 23 2010 CD4 387 VL UD!
July 2010 CD4 561 VL UD
Aug 2010 CD4 671 VL UD
Sep 2010 CD4 599 VL <40
Oct 2010 CD4 570 VL UD
Switch to Prezista / Norvir / Isentress
Nov 2010 CD4 738 VL <40
Dec 2010 CD4 773 VL UD
Jan 2010 CD4 570 VL UD

Offline Okealyshire

  • Member
  • Posts: 139
Re: Timing / Temp for Truvada / Norvir / Reyataz
« Reply #9 on: January 29, 2010, 12:45:22 AM »
Mornings have been the best for me simply because it fits well into my routine. The meds sit in the cabinet with all the other post-shower morning accouterments, so really I never forget to take them. When I was on Norvir I'd keep one open bottle in the cabinet while the others stayed in the refrigerator.

I used to travel internationally a lot and first tried to keep on a 24-hour schedule -- meaning that once I landed in Singapore or India my dose time would switch to the evening. It was monumentally challenging to remember to (1) put the pills in my pocket in the morning and (2) scarf them down while engaged in something else in the evening and (3) explain that it was "time for my allergy medications." I gave that up and instead went to strictly morning-only dosing. This created a long 36-hour gap between doses during the outbound flight to Asia and a short 12-hour gap between doses during the return. My ID doc had no qualms about that at all -- apparently Truvada stays in the blood almost 50 hours, and the Reyataz + Norvir can tolerate large swings too. My labs backed this up: VL has stayed undetectable and CD4+ continues to rise.

All in all I've been extremely pleased with my response. Went from VL >1,000,000 copies/ml and CD4+ of 295 back in November 2007 to undetectable VL and CD4+ of 390 in six months. Now my CD4+ is 600.

 


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