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Author Topic: Zinc Fingers Disrupts CCR5/HIV Entry; Sangamo and the University of Pennsylvania  (Read 1339 times)

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Offline red_Dragon888

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New Gene Therapy Disrupts CCR5/HIV Entry: Establishment of HIV-1 ...
Sangamo BioSciences, Inc., Point Richmond Tech Center II, 501 Canal Blvd., Suite A100, Richmond, California 94804, USA. 4. Present address: Process Science ...
www.natap.org/2009/HIV/020409_02.htm


"....HIV-1-infected mice engrafted with ZFN-modified CD4+ T cells had lower viral loads and higher CD4+ T-cell counts than mice engrafted with wild-type CD4+ T cells, consistent with the potential to reconstitute immune function in individuals with HIV/AIDS by maintenance of an HIV-resistant CD4+ T-cell population...."In summary, the present results support the clinical development of adoptive immunotherapy in the setting of HIV-1 infection to reconstitute or preserve the memory cell pool of HIV-infected patients with ZFN-modified ex vivo expanded, polyclonal CD4+ T cells that are intrinsically resistant to HIV infection.

http://www.natap.org/2009/HIV/020409_02.htm
http://www.youtube.com/watch?feature=player_embedded&v=I3ba3lnFHik

“Neither look forward where there is doubt nor backward where there is regret. Look inward and ask not if there is anything o

Offline Inchlingblue

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This is a promising therapy. There have been a few threads about it.

There is a current Phase I clinical trial looking at ZFN and CCR5 disruption.

LINKS:

http://forums.poz.com/index.php?topic=21770.0

http://forums.poz.com/index.php?topic=25597.0

http://www.wired.com/wiredscience/2009/02/hivtreatment/
« Last Edit: December 29, 2009, 07:25:35 PM by Inchlingblue »

 


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