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Author Topic: ATRIPLA AND PARTYING  (Read 4352 times)

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Offline tommy246

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ATRIPLA AND PARTYING
« on: November 11, 2009, 12:48:22 PM »
I am a week into atripla so not drinking or going out at the moment. No real side effects to speak of up to now but with xmas looming on the horizon i have a couple of questions for you wise ones.
1. Alcohol doesnt make atripla any less effective but can make it more toxic is this true,and what is meant exactly by more toxic .



2. would it be ok to take your pill 4 hours late after a night out once a week .



3.What happens if you miss a dose what does this half life i have seen mentioned mean exactly

thankyou.
jan 06 neg
dec 08 pos cd4 505 ,16%, 1,500vl
april 09 cd4 635 ,16%,60,000
july 09 ,cd4 545,17%,80,000
aug 09,hosptal 18days pneumonia cd190,225,000,15%
1 week later cd4 415 20%
nov 09 cd4 591 ,vl 59,000,14%,started atripla
dec 09  cd4 787, vl 266, 16%
march 2010  cd4 720 vl non detectable -20  20%
june 2010  cd4  680, 21%, ND

Offline ruralguy

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  • Posts: 141
Re: ATRIPLA AND PARTYING
« Reply #1 on: November 11, 2009, 01:03:25 PM »
I've only been on it since mid September but here are my thoughts

1. I think the issue with alcohol is that, like atripla, it is metabolized by your liver.  So lightening the load of alcohol lessen's its work load.   Personally, I find I'm drinking less largely because I just don't seem to like it as much.

2. I asked my doc about timing.  After stretching to being more than 3 hours late he began to get a pained look.  So I have the impression that 2 hours is ok but past that is pushing it.  One solution would be to take it 2 hours later the night before you go out.  Then you add another 2 hours the night you go out.  Then you return back to normal.

3. I ws told that if I missed a bedtime dose, take it in the morning anyway....don't wait till the next evening.  The issue is potential resistence but I don't know the specifics.

I'm interested in other's responses and I'm still learning about this drug as well.
tested positive June 19, 2009
7/3/09 vrl 9000 cd4 - 300
8/14/09 cd4 - 350, 20%
started Atripla 9/14/09
10/5/09 vrl undetectable, WOW so fast!
12/28/09 vrl undetectable, CD4 - 615  27% cholesterol down, kidney function normal
4/26/10 vrl undetectable, CD4-600, kidney and liver numbers normal
9/9/10 vrl undetectable, CD4-685
1/3/11 vrl undetectable, CD4-700
all 2011 and Jan 2012 visits vrl undetectable CD4 ranged from 715-645
5/7/2012  vrl undetectable, CD4-615, all liver, kidney, lipids, heart functions, etc normal


On Atripla:  "Your mileage may vary"

Offline Miss Philicia

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Re: ATRIPLA AND PARTYING
« Reply #2 on: November 11, 2009, 02:06:22 PM »
I've thrown back a dozen pills with a shot of tequila, so I'm sure you girls can handle doing the same with one pill.

As far as the liver issue goes, yes it's a concern if you are drinking every day and are an alcoholic.  Switch to snorting cocaine if that's a concern (j/k).
"Iíve slept with enough men to know that Iím not gay"

Offline iking2009

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Re: ATRIPLA AND PARTYING
« Reply #3 on: November 11, 2009, 05:05:04 PM »
I've thrown back a dozen pills with a shot of tequila, so I'm sure you girls can handle doing the same with one pill.

As far as the liver issue goes, yes it's a concern if you are drinking every day and are an alcoholic.  Switch to snorting cocaine if that's a concern (j/k).

LMAO....Ur a crazy lady!! Jk
"One of the keys to happiness is a bad memory."
-- Rita Mae Brown

Offline justaguy

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  • Posts: 83
Re: ATRIPLA AND PARTYING
« Reply #4 on: November 11, 2009, 11:52:35 PM »
I found that if I wait until i get home from the bar to take the meds, I am usually buzzed or drunk and more likely to forget, so I find it easier to just take one with me, and I use whatever I'm drinking, alcoholic or not, to wash it down with at 11pm, EVERY NIGHT NO MATTER WHERE I AM, when my phone reminder beeps at me.  If I want to be discreet, I got to the bathroom or a darker area and take it.

Personally, I don't like taking it the next morning if I forget, because it definitely makes me feel loopy when I'm awake, so I make doubly sure to take it at night. 

And as far as drinking and meds go, my doctor said "You're human, we don't expect anyone not to drink at all, that's unrealistic.  Of course we'd prefer you not, because that's better, but it's not a big deal to drink every now and then while on meds."
Estimated infection: 3/2008
Tested HIV positive: 3/31/2009
CD4 136/unknown %/VL 150,000: 4/6/2009
Started Atripla 4/17/2009
CD4 255/19%/VL 409 5/27/2009
CD4 247/??/VL 161 6/27/2009
CD4 257/21%/VL 60 7/22/2009
CD4 352/22%/VL Undetectable 10/21/2009
CD4 490/27%/VL Undetectable 2/15/2010
CD4 397/?/VL Undetectable 7/2/2010

Offline tommy246

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  • Posts: 435
Re: ATRIPLA AND PARTYING
« Reply #5 on: November 12, 2009, 02:34:23 AM »
Thanks thats good to know do you find by taking it at 11 pm when your out drinking makes you drunk easier or feel different from drinking before meds. Im not into hard alcohol i m a beer guzzler and like wine with a meal.
jan 06 neg
dec 08 pos cd4 505 ,16%, 1,500vl
april 09 cd4 635 ,16%,60,000
july 09 ,cd4 545,17%,80,000
aug 09,hosptal 18days pneumonia cd190,225,000,15%
1 week later cd4 415 20%
nov 09 cd4 591 ,vl 59,000,14%,started atripla
dec 09  cd4 787, vl 266, 16%
march 2010  cd4 720 vl non detectable -20  20%
june 2010  cd4  680, 21%, ND

Offline Cosmicdancer

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  • Posts: 154
Re: ATRIPLA AND PARTYING
« Reply #6 on: November 12, 2009, 07:08:56 PM »
If I'm going out drinking on a weekend and expect to be home late, I take my atripla with me and just pop a pill in the bathroom at the bar around my scheduled time.  Now that I've been on it almost 2 years, I find I barely notice any side effects such as being dizzy or off balance if I have a couple of drinks with it.  I'm not a big drinker, just a few on the weekend mainly. 
Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
June, 2008 - undetectable, 612 cd4
January, 2009 - undetectable, 670 cd4
May, 2009 - undetectable, 593 cd4
Sept, 2009 - 83 vl, 763 cd4, 34%
Dec, 2009 - undetectable, 889 cd4, 32%
April, 2010 - undetectable, 860 cd4, 31%
October, 2010 - undetectable, 800 cd4, 38%
April, 2011 - undetectable, t-cell test not done
October, 2011 - undetectable
April, 2012 - undetectable, 850 cd4, 39%
November, 2012 - undetectable, 901 cd4, 41%
April, 2013 - undetectable, 846 cd4, 36%
October, 2013 - undetectable
May, 2014 - undetectable, 784 cd4, 48%
October, 2014 - UD, 1084 cd4, 48%

Offline Rev. Moon

  • Member
  • Posts: 3,783
  • Smart ass faggot ©
Re: ATRIPLA AND PARTYING
« Reply #7 on: November 12, 2009, 10:44:26 PM »
Being that I can't live without my Guinness, I asked my doc if there'd be an issue with Atripla and a few pints.  She said not to worry, just to make sure that I don't get so pissed that I pass out and end up missing doses.  There is no issue with Alcohol reducing effectiveness or absorption. 

Missing one dose won't be a problem, but make sure that it does not become a habit.  The components in Atripla have a long half-life in the body, so being late won't cause resistance issues (especially if you are at an undetectable point).

And is this the only type of "partying" that you are concerned about.  I noticed Philly made a clever suggestion (though jokingly)  ;D
"I have tried hard--but life is difficult, and I am a very useless person. I can hardly be said to have an independent existence. I was just a screw or a cog in the great machine I called life, and when I dropped out of it I found I was of no use anywhere else."

Offline tokyodecadence

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  • A one room disco.
Re: ATRIPLA AND PARTYING
« Reply #8 on: November 12, 2009, 11:02:58 PM »
In the few instances that I do go out (working two jobs and school puts and damper on that). I just take it before I go out. I don't even go out until 2200 at the earliest, so it's not too early for my medicine anyway. I've been undetectable thus far! But my doctor told me that drinking every once in a while isn't going to make a difference, but with anything, in moderation.


Drugs I couldn't tell you about, I don't see the interest in it.
[.Fod„o.]

Offline WildcatCC

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  • Posts: 91
Re: ATRIPLA AND PARTYING
« Reply #9 on: November 13, 2009, 09:58:50 AM »
Is the issue on "timing" really about efficacy of Atripla or more about adherence? I thought I read on these posts that if you take the pill once a day, no matter when, there really isn't a need to take it at nearly the exact same time every day - just that you take it period.

I've switched back and forth between taking it at bedtime and taking it around 5:30 pm before the gym. I wonder if these changes had anything to do with my spikes in VL. 

More questions for my ID doc.

Apr  08 - Diagnosed
Apr  08  cd4 8, vl 150k
Meds: Prezista/Norvir/Truvada
June 08 cd4 250, vl 1600
Aug  08 cd4 275, vl 450
Meds: Atripla
Nov  08  cd4  386, vl 255
Jan   09  cd4  415, vl 2100 (spike?)
Feb   09  cd4 460, vl 212
May   09  cd4 515, vl 1200
Aug   09  cd4 717, vl 1535 % 23
Sept  09  cd4 535  vl 1710 % 18
Oct   09  genotype shows mutation. Discussing w/ ID Doc
Nov  09   cd4 480  vl 650   % 19
Dec  09 genotype slight mutation to Epivir and Retrovir
Jan 10   cd4 508 vl 250 (21%)  low vitamin d - on supplement 2000 iu/day
Mar 15 Change to Isentress and Truvada
May 5 cd4 498 vl 1485
June 16 cd4 550 vl undect!!!! (finally dammit)

Offline Ann

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  • It just is, OK?
    • Num is sum qui mentiar tibi?
Re: ATRIPLA AND PARTYING
« Reply #10 on: November 13, 2009, 10:19:24 AM »
Is the issue on "timing" really about efficacy of Atripla or more about adherence? I thought I read on these posts that if you take the pill once a day, no matter when, there really isn't a need to take it at nearly the exact same time every day - just that you take it period.

I've switched back and forth between taking it at bedtime and taking it around 5:30 pm before the gym. I wonder if these changes had anything to do with my spikes in VL. 

More questions for my ID doc.



Wildcat, from what I understand, you should make sure you're taking it at pretty much the same time every day - at least until you become undetectable and are undetectable for a while. After that, you have more leeway.

Ann
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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline TNDude

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  • Posts: 23
Re: ATRIPLA AND PARTYING
« Reply #11 on: November 18, 2009, 12:02:13 AM »
I take a pill with me when I know I'm going to be out late on Friday and/or Saturday nights. I go to the bathroom and pop my pill with whatever I'm drinking (usually alcoholic) at about 11:30 pm. Seems to work fine. I have noticed I can be moody sometimes after doing this. I am sure mixing the alcohol with the pill is not ideal. I usually deal with it.

Offline ruralguy

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  • Posts: 141
Re: ATRIPLA AND PARTYING
« Reply #12 on: November 18, 2009, 05:14:43 PM »
Is the issue on "timing" really about efficacy of Atripla or more about adherence? I thought I read on these posts that if you take the pill once a day, no matter when, there really isn't a need to take it at nearly the exact same time every day - just that you take it period.

I've switched back and forth between taking it at bedtime and taking it around 5:30 pm before the gym. I wonder if these changes had anything to do with my spikes in VL. 

More questions for my ID doc.


I was told being 2 hours late is ok.  Early is no problem, of course. 
tested positive June 19, 2009
7/3/09 vrl 9000 cd4 - 300
8/14/09 cd4 - 350, 20%
started Atripla 9/14/09
10/5/09 vrl undetectable, WOW so fast!
12/28/09 vrl undetectable, CD4 - 615  27% cholesterol down, kidney function normal
4/26/10 vrl undetectable, CD4-600, kidney and liver numbers normal
9/9/10 vrl undetectable, CD4-685
1/3/11 vrl undetectable, CD4-700
all 2011 and Jan 2012 visits vrl undetectable CD4 ranged from 715-645
5/7/2012  vrl undetectable, CD4-615, all liver, kidney, lipids, heart functions, etc normal


On Atripla:  "Your mileage may vary"

Offline newt

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  • the one and original newt
Re: ATRIPLA AND PARTYING
« Reply #13 on: November 18, 2009, 05:26:23 PM »
4 hours late on the odd occasion with Atripla will make sod all difference.

After 5 days the main drug in Atripla, efavirenz, reaches a steady state and so as long as you take it consistently in a (very) roughly 24 hr period it's okay, the drug level won't dip, and the other drugs, well if your viral load has reached <50 copies it will make diddly squat difference if you do the combo late once in a while. Having a good time is a healthy thing to do. - matt
"The object is to be a well patient, not a good patient"

Offline tommy246

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Re: ATRIPLA AND PARTYING
« Reply #14 on: November 19, 2009, 03:39:52 AM »
Thats justwhat my hiv doc said as well newt 4 hours late now and again after a night out is fine .
jan 06 neg
dec 08 pos cd4 505 ,16%, 1,500vl
april 09 cd4 635 ,16%,60,000
july 09 ,cd4 545,17%,80,000
aug 09,hosptal 18days pneumonia cd190,225,000,15%
1 week later cd4 415 20%
nov 09 cd4 591 ,vl 59,000,14%,started atripla
dec 09  cd4 787, vl 266, 16%
march 2010  cd4 720 vl non detectable -20  20%
june 2010  cd4  680, 21%, ND

 


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