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Author Topic: Genotype Mutations- Does anyone know what these specific ones mean?  (Read 3237 times)

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Offline LikeaRock

  • Member
  • Posts: 16
Hey guys- I have my genotype results back. I'v been on Atripla even before they were in. It showed mutations- my Doctor said they were harmless and that people can often have mutations in there HIV. T Would the fact that I was probably positive years before I was diagnosed cause these mutations, or can they happen quick? Harmless or not- it's still scary seeing them and the fact that there was a total of 6! My greatest fear is resistance and dying of course-

Any help or info would be appreciated.

I'll paste my test results here: Please see far below for "RT and PR gene mutations.

                                             HIV Subtype: B
___________________________________________________________
Antiretroviral drugs      Resistance  Mutations Detected
                          Predicted
___________________________________________________________
                               
      NRTIs                     
ZDV (zidovudine or Retrovir)    ! NO!
ABC (abacavir or Ziagen)        ! NO!
ddI (didanosine or Videx)       ! NO!
3TC (lamivudine or Epivir)      ! NO!
FTC (emtricitabine or Emtriva)  ! NO!
d4T (stavudine or Zerit)        ! NO!
TDF (tenofovir or Viread)       ! NO!
________________________________!___!______________________
                                !   !
     NNRTIs                     !   !
ETR (etravirine or Intelence)   ! NO!
EFV (efavirenz or Sustiva)      ! NO!
NVP (nevirapine or Viramune)    ! NO!
________________________________!___!______________________
                                !   !
    PIs                         !   !
FPV (fos-amprenavir or Lexiva)  ! NO!
IDV (indinavir or Crixivan)     ! NO!
NFV (nelfinavir or Viracept)    ! NO!
SQV (saquinavir or Invirase)    ! NO!
LPV (lopinavir or Kaletra)      ! NO!
ATV (atazanavir or Reyataz)     ! NO!
TPV (tipranavir or Aptivus)     ! NO!
DRV (darunavir or Prezista)     ! NO!
                                !   !
________________________________!___!______________________
PRB = PROBABLE OR EMERGING RESISTANCE
OTHER MUTATIONS DETECTED
RT GENE MUTATIONS: K103K/R, R211K
PR GENE MUTATIONS: E35D, I62I/V, L63P, A71T

Offline Allentownboy

  • Member
  • Posts: 10
  • I'll never live the cowboy hat down...
Re: Genotype Mutations- Does anyone know what these specific ones mean?
« Reply #1 on: October 25, 2009, 02:22:37 AM »
I, too, am expecting my geno/pheno tests this coming week, so I am looking forward to someone here having some answers on what it means and how to read it also.  Mutations are pretty common, and I am certain long timers here will tell us newbies not to read too much into any of it.  

I can only say that if your doctor wasn't "concerned", I don't want you to panic.  All of this is so new to both of us, that it is easy to quickly misinterpret or read too deeply into what we read and hear.  Seems like I cause myself a panic attack every other day over-researching practically EVERYTHING.  Be careful not to fall into that trap so early on in this.

If I have learned anything over the past week or so here, it is that long term thrivers here ( I prefer to say that instead of survivors as it gives me hope that there LIFE beyond just making it) have said not to get too absorbed in the numbers, as they can confuse and frighten newly diagnosed people like ourselves who have no experience with how all the pieces fit together.  I have been told to build trust with my doctor (as he is one of the best HIV specialists in the country) and learn to develop a healthy sense of faith that it will all be OK.  Try to believe...it is critical for your long term health.  There is NO reason to think you will die if you do what you are told to do and remain faithful to your meds.  I already told you you have too much to live for!
« Last Edit: October 25, 2009, 02:29:21 AM by Allentownboy »
Sept 22 2009 @ 1:49PM Positive Diagnosis - PCP, CD4 49, VL 75,000
Oct 15 2009 Started on Lexiva,Truvada, Norvir, Isentress
Oct 22 2009 Learned my CD4 percentage is 1.9% - not too good...

Offline max123

  • Member
  • Posts: 377
  • Carpe Diem
Re: Genotype Mutations- Does anyone know what these specific ones mean?
« Reply #2 on: October 25, 2009, 01:39:55 PM »
hey again rock.

i just went through this myself and hearing the word mutation is definitely a little unnerving, but don't panic. while i'm no expert, let me share with you what i learned from my experience. take a peek at my thread about genotyping in the 'i recently tested pos' posts for my history with this issue. in a thread reply, ann had mentioned that there is a mutation guru (matt) on here.

first of all, hiv mutates. this can be over time without meds or resultant of its desire to escape suppression due to meds. we can also get infected with mutant hiv. its ability to mutate is why it has eluded a definitive cure, to date.

your cut & paste shows no resistance to meds. "no" is a good thing. in short, your hiv should be sensitive to all meds listed, it looks like you're good for atripla and your mutations, like mine, appear pretty insignificant, as your doc already confirmed.  ;D

as for the specific mutations noted, you can find more info on them at:

http://hivdb.stanford.edu/  

there are definitely some other bad mutations out there that can hinder effective treatment from what i've read, but it doesn't look like you have to worry much about them. definitely take the info from stanford with a grain of salt and discuss any remaining mutation result concerns with your doc again. as i found, that was the only way to get applicable info to my particular case and am okay with that. i totally understand where you're coming from, so ask him/her the questions you need to so that you can be comfortable with the info.

peace.

max


« Last Edit: October 25, 2009, 02:48:39 PM by max123 »
1/86 - 6/08 (annually): neg elisa
7/09: pos elisa/pos wb
8/09: cd4 560, cd4% 35, vl 13,050
12/09: cd4 568, cd4% 33, vl 2,690
4/10: cd4 557, cd4% 29.3, vl 6,440
7/10: cd4 562, cd4% 29.6, vl 3,780

Offline sreamer17ydr

  • Member
  • Posts: 36
  • me looking good!
Re: Genotype Mutations- Does anyone know what these specific ones mean?
« Reply #3 on: October 26, 2009, 02:06:52 PM »
Looks like your genotype has no major mutations in the gene. Also I got my genotype results back in august, and all my results were green = no resistance to any of the meds. So my docotor has done a 2nd viral load and cd4 count last week and i go see him again in jan.. he has me visit him every 3 months. My first blood work was done in july and showed all green genotype, and viral load 21,000 and cd4 count 566 with cd4% 32
July 1st 09: Tested Poz
August 19th 09: CD4 Count: 566/ Viral Load: 20,653
Nov 10: CD4:623 Viral load: 57,673
Dec 13th: CD4 count 400, viral load-60,000
Feb 1 2010: CD4: 600 Viral load: 67,000
Feb 16 2010: Started Atripla
March 29 2010-CD4 Count: 740, Viral Load: Undetectable, CD4 percentage: 34%
Oct 27th,2010: CD4 Count: 620, Viral Load: Undetectable, CD4 percentage: 32%

Offline mecch

  • Member
  • Posts: 10,735
  • red pill? or blue pill?
Re: Genotype Mutations- Does anyone know what these specific ones mean?
« Reply #4 on: October 26, 2009, 02:32:05 PM »
Maybe you can ask a LTS or your doctor for confirmation, but I don't think anyone dies anymore because of "resistance". I think the worse one can get is a heavy many drug HAART.   

Correct me please, if I am wrong, LTS's.  Or experts.
“From each, according to his ability; to each, according to his need” 1875 K Marx

 


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