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Author Topic: Aspirin and Atripla  (Read 5516 times)

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Offline LBpozguy

  • Member
  • Posts: 51
Aspirin and Atripla
« on: October 19, 2009, 05:19:47 PM »
Does anyone know if it is ok to take aspirin while on Atripla?  I have read that Ibuprofin is not good. But if I have a bad headache?  Can I take aspirin? I didn't see anything listed for this med as far as aspirin is concerned!
Feb 08 neg
Sept 08 - First poz test
Sept 08 CD4 558 (% unk) VL 11000
Dec 08 CD4 480 (29%) VL less than 700
Mar 09 CD4 370  VL 25000
June 09 CD4 425 VL 68000
Aug 09 Started Atripla
Sept 09 CD4 639 VL 100
Nov 09  CD4 716 (35%) VL Undet!!!!!!!!!!!!!
Jan 10 CD4 685 VL UND

Offline Allentownboy

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  • Posts: 10
  • I'll never live the cowboy hat down...
Re: Aspirin and Atripla
« Reply #1 on: October 19, 2009, 06:05:16 PM »
I don't know how accurate Drugs.com is, but it says that there is a "major" interaction with aspirin and Tenofovir, a component in Atripla. :-\  No interactions listed for Tylenol though, so that may be an option for you.

You may want to contact your doc to verify before taking anything to be 100% certain.
Sept 22 2009 @ 1:49PM Positive Diagnosis - PCP, CD4 49, VL 75,000
Oct 15 2009 Started on Lexiva,Truvada, Norvir, Isentress
Oct 22 2009 Learned my CD4 percentage is 1.9% - not too good...

Offline GNYC09

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  • Posts: 702
Re: Aspirin and Atripla
« Reply #2 on: October 19, 2009, 07:33:50 PM »
I was prescribed (by various doctors) aspirin multiple times while on Atripla.  It's perfectly fine as long as you keep it within safe levels (under 1000mg/day)

Offline Assurbanipal

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  • Taking a forums break, still see PM's
Re: Aspirin and Atripla
« Reply #3 on: October 19, 2009, 07:37:45 PM »
There is a very useful tool on this website where you can save the list of drugs you take and then look up interactions with additional drugs.  The link is here http://www.aidsmeds.com/cmm/

If you put in aspirin and atripla it will show a serious warning:
"GENERALLY AVOID: Coadministration of tenofovir with other nephrotoxic agents may increase the risk and severity of nephrotoxicity due to additive effects on the kidney. Additionally, renal impairment secondary to the use of these agents may reduce the clearance of tenofovir, which is primarily eliminated by renal excretion. The use of tenofovir has been associated with dose-related nephrotoxicity including cases of acute renal failure and Fanconi syndrome characterized by renal tubular injury with severe hypophosphatemia. Generally, the risk is low in patients with adequate renal function receiving the normally recommended dosage but may increase in patients with underlying renal impairment. MANAGEMENT: The use of tenofovir in patients who have recently received or are receiving treatment with other potentially nephrotoxic agents (e.g., aminoglycosides, polypeptide and polymyxin antibiotics, vancomycin, amphotericin B, adefovir, cidofovir, foscarnet, cisplatin, gallium nitrate, lithium, mesalamine, certain immunosuppressants, intravenous bisphosphonates, intravenous pentamidine, high intravenous dosages of methotrexate, high dosages of nonsteroidal anti-inflammatory agents) should generally be avoided. Renal function should be evaluated prior to and during therapy with tenofovir. Patients with renal insufficiency at baseline or during treatment may require dosage adjustment in accordance with the manufacturer's product labeling."

That said, when I was on tenofovir (the component of Atripla that generates the warning) it was not particularly hard on my kidneys (they were tested each year) and so I took aspirin as needed.
5/06 VL 1M+, CD4 22, 5% , pneumonia, thrush -- O2 support 2 months, 6/06 +Kaletra/Truvada
9/06 VL 3959 CD4 297 13.5% 12/06 VL <400 CD4 350 15.2% +Pravachol
2007 VL<400, 70, 50 CD4 408-729 16.0% -19.7%
2008 VL UD CD4 468 - 538 16.7% - 24.6% Osteoporosis 11/08 doubled Pravachol, +Calcium/D
02/09 VL 100 CD4 616 23.7% 03/09 VL 130 5/09 VL 100 CD4 540 28.4% +Actonel (osteoporosis) 7/09 VL 130
8/09  new regimen Isentress/Epzicom 9/09 VL UD CD4 621 32.7% 11/09 VL UD CD4 607 26.4% swap Isentress for Prezista/Norvir 12/09 (liver and muscle issues) VL 50
2010 VL UD CD4 573-680 26.1% - 30.9% 12/10 VL 20
2011 VL UD-20 CD4 568-673 24.7%-30.6%
2012 VL UD swap Prezista/Norvir for Reyataz drop statin CD4 768-828 26.7%-30.7%

Offline GNYC09

  • Member
  • Posts: 702
Re: Aspirin and Atripla
« Reply #4 on: October 19, 2009, 07:50:47 PM »
Yeah, I personally don't have a lot of trust in that site.  I'm conservative by nature but that site seems to be run by a bunch of overly nervous nellies.  It says, for example, that you shouldn't mix aspirin and garlic (?!). 
I bet they think mixing sleeping pills with wine is also bad...oh well...

Offline Inchlingblue

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Re: Aspirin and Atripla
« Reply #5 on: October 19, 2009, 07:53:25 PM »
I'm on Truvada and I avoid all NSAIDs: aspirin, naproxen (Aleve), ibuprofen (Advil) because they all affect kidney function which can be compromised with Truvada.

My approach may be too extreme for some and I would say that as long as your lab work shows normal creatinine levels it's probably OK to take NSAIDs once in a while, I would not make a habit of it.

Acetaminophen (Tylenol) mainly affects the liver instead of the kidney. Again, probably OK to take once in a while and not make a habit of it.

Offline LBpozguy

  • Member
  • Posts: 51
Re: Aspirin and Atripla
« Reply #6 on: October 20, 2009, 12:24:40 AM »
Thanks everyone. I have avoided all of them up until now. But had a bad headache tonight and wasn't sure what was ok to take.  :)
Feb 08 neg
Sept 08 - First poz test
Sept 08 CD4 558 (% unk) VL 11000
Dec 08 CD4 480 (29%) VL less than 700
Mar 09 CD4 370  VL 25000
June 09 CD4 425 VL 68000
Aug 09 Started Atripla
Sept 09 CD4 639 VL 100
Nov 09  CD4 716 (35%) VL Undet!!!!!!!!!!!!!
Jan 10 CD4 685 VL UND

Offline scotti2427

  • Member
  • Posts: 14
Re: Aspirin and Atripla
« Reply #7 on: April 25, 2010, 05:53:25 AM »
What pain killers are people using then if your not supposed to use Aspirin or Ibuprofen?

Paracetamol does nothing for me and the only thing left is Codeine.

Scotti

Offline Hellraiser

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  • Posts: 4,136
  • Semi-misanthropic
Re: Aspirin and Atripla
« Reply #8 on: April 25, 2010, 10:43:43 AM »
What pain killers are people using then if your not supposed to use Aspirin or Ibuprofen?

Paracetamol does nothing for me and the only thing left is Codeine.

Scotti

This seems to pop up from time to time, it's not that the drugs interact in any meaningful way it's that they have to be processed by your liver in addition to the atripla, so over time if you were abusing aspirin this could cause liver complications.  As long as you use it at a reasonable level and for short durations there is no big problem in taking Aspirin or Ibuprofen.

http://www.thebody.com/Forums/AIDS/SideEffects/Current/Q189496.html

The last sentence of the doctor's response is what you're looking for.

Offline peteb

  • Member
  • Posts: 202
Re: Aspirin and Atripla
« Reply #9 on: April 25, 2010, 11:18:04 AM »
My Doc told me to take Tylenol Migraine it help no side effects
Pete

Offline Seeker

  • Member
  • Posts: 12
Re: Aspirin and Atripla
« Reply #10 on: April 25, 2010, 06:28:16 PM »
what about people on Atripla that take a low dose asprin daily?
tested positive Aug 2009
Sept 2009   CD4  198  VL  13,090
started Atripla
Oct 2009    CD4  248  VL  820
Feb 2010    CD4  237  VL  undetectable
Jun 2010    CD4  341  VL  undetectable
Oct 2010    CD4  281  VL  undetectable
Mar 2011    CD4  344  VL  undetectable
Jan 2012    CD4  334  VL  30
Jun 2012    CD4  347  VL  20
Nov 2012   CD 4  349  VL  undetectable

Offline Inchlingblue

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  • Posts: 3,119
  • Chad Ochocinco PETA Ad
Re: Aspirin and Atripla
« Reply #11 on: April 25, 2010, 07:45:02 PM »
This seems to pop up from time to time, it's not that the drugs interact in any meaningful way it's that they have to be processed by your liver in addition to the atripla, so over time if you were abusing aspirin this could cause liver complications.    

What you're saying is basically correct except the main issue with using NSAIDs along with Viread/tenofovir (found in Truvada and Atripla) has to do with kidneys not liver.

That's why if I have to take a pain reliever once in a while I take Tylenol/acetaminophen (not considered an NSAID).

There's a newer version of acetaminophen, not yet approved, that supposedly has almost zero liver toxicity.

The bottom line with any of these pain relievers, whether NSAID or not, is not to overdo it and just take them when absolutely necessary.
« Last Edit: April 25, 2010, 09:24:14 PM by Inchlingblue »

 


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