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Author Topic: changing meds  (Read 1468 times)

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Offline blamdambadderstiddle

  • Member
  • Posts: 4
changing meds
« on: October 07, 2009, 03:23:27 PM »
Hello chaps,

My first post. My partner has been on meds for more or less three years. Trizivir has seen her CD4 go back to over 700 and viral load remain undetectable.

All this is provided free of charge in the country we currently live in.

Problem is, I plan to retire next year and we are aiming to relocate to a SE Asian country where Trizivir is not currently available.

When asked about this ,our current doctor was not very helpful. Maybe the ingredients of trizivir can be had over there he opined. Not a good idea to change meds, he added.

Anybody got experience of the wisdom, or folly, of changing meds overnight. We really want to relocate but meds, and the cost of them, is clearly a very important factor. Any advice? Many thanks in advance.

Blamdambadderstiddle

Offline newt

  • Member
  • Posts: 3,885
  • the one and original newt
Re: changing meds
« Reply #1 on: October 07, 2009, 06:07:09 PM »
Trizivir is 3 drugs: 3TC (lamivudine), AZT (zidovudine) and abacavir -- these are available singly, certainly the 1st two will be, possibly even combined into one pill. The drugs may well be generic (non-brand name) formulations but just as good. It does not matter if you take the 3 separate drugs rather than Trizivir.

- matt
"The object is to be a well patient, not a good patient"

Offline blamdambadderstiddle

  • Member
  • Posts: 4
Re: changing meds
« Reply #2 on: October 08, 2009, 02:07:31 PM »
Thanks Newt.
Any other views welcome.
Blamdam......etc(why did I choose this stupid login)

Offline aztecan

  • Member
  • Posts: 5,400
  • 29 years positive, 57 years a pain in the butt
Re: changing meds
« Reply #3 on: October 09, 2009, 11:02:56 AM »
As Newt said, the components of Trizivir should be available.

Before you pull up stakes though, I would check out available medical care and meds, if you are able. I would also try to ascertain the costs involved.

Perhaps if you mention the Southeast Asia country or region, others familiar with it could respond.

Good luck and hang in there.

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline blamdambadderstiddle

  • Member
  • Posts: 4
Re: changing meds
« Reply #4 on: October 09, 2009, 12:51:17 PM »
Yes, sorry it's no secret.

The country is Thailand, my partner is Thai and entitled to state medical care. I have checked costs with Bumrungrad which is top end hospital and reckon where we will likely be has to be cheaper.

There is apparently no generic version of abacavir as yet, which will be the main expense.

Any experience of complete change of meds. Can that be done, is it ever a good idea? New to us so any advice appreciated.

Blamdambadderstiddle

Offline Ann

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  • Posts: 28,140
  • It just is, OK?
    • Num is sum qui mentiar tibi?
Re: changing meds
« Reply #5 on: October 09, 2009, 01:35:36 PM »
Hi Blam, welcome to the forum.

Is your partner on Trizivir only? If so, she might want to change her meds anyway as that is not an optimal combo on its own. All three drugs in this med are from a single class - NRTIs - and a good combo is made from two or more classes.

For HIV-positive adults beginning anti-HIV drug therapy for the first time, Trizivir—used without other HIV medications—is listed as a "possible" treatment option by the United States Department of Health and Human Services in its treatment guidelines. This means that it can be used, but because of lingering concerns about effectiveness and/or safety, it is considered to be inferior to "preferred" or "alternative" drug combinations. The use of Trizivir without other HIV medications is only recommended when a preferred or alternative protease inhibitor (PI)- or a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen cannot be used because of side effects or significant drug-drug interactions. source

You can read more about the different drugs and what classes they are in by reading through the Drug Information section of this website. You can read about what combos are preferred by reading through The Big Treatment Questions, found in the Lessons section of this website.

It is totally possible - and probably preferable - for her to switch meds, but it should be done under her doctor's supervision. Hope the info above helps.

Ann
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline blamdambadderstiddle

  • Member
  • Posts: 4
Re: changing meds
« Reply #6 on: October 09, 2009, 02:50:13 PM »
Thanks Ann,
All I can say is that Trizivir is what was prescribed here and it has seen her numbers go from  CD4 212 to 702 in the last 3 years with viral load remaining undetectable and no discernable side effects. That looks pretty good to me.

Your view on this much appreciated.

Blamdam.....

Offline Ann

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  • Posts: 28,140
  • It just is, OK?
    • Num is sum qui mentiar tibi?
Re: changing meds
« Reply #7 on: October 09, 2009, 03:00:37 PM »
Hi Blam,

Well, her results are certainly impressive. However, I have to say I wouldn't trust that combo myself. I'd be too afraid that an accidental missed dose or two could too easily lead to resistance of pretty much the whole NRTI class.

A more standard and reliable combo would give her good results too. Of course, this is something she'll have to research, think about and talk to her doctor about. You'll also have to look into just what combos are available in Thailand. There are a few members here who live in Thailand, hopefully some of them will see your thread sometime soon and give you some information.

Ann
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline aztecan

  • Member
  • Posts: 5,400
  • 29 years positive, 57 years a pain in the butt
Re: changing meds
« Reply #8 on: October 09, 2009, 10:41:44 PM »
Hey Blam,

Regarding a complete switch, that is possible, but it should be done under the supervision of a doctor who would be able to monitor your partner for the first few months to make sure all is well.

I have completely switched meds, although I have stayed with one particular class of meds in part. Switching meds when undetectable isn't uncommon when other side effects are taking place - or I would suppose if the meds aren't available.

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

 


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