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Author Topic: Switched to Combivir, Reyataz and Norvir from Isentress andTruvada  (Read 3023 times)

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Offline Sweet_C

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I switched to a Combivir, Reyataz, and Norivir after being on Isentress and Truvada for nearly a year.  My husband and I are trying to have a baby, so my doctor advised us that this was the most tried and true way to go.  She said Isentress and Truvada would in all likelihood not cause problems, but since it is so new she couldn't guarantee it.

I really hate this combivir stuff.  I've taken it for a week and I've felt nauseous and extremely fatigued at times.  It's starting to get better and it's nothing I can't handle, but I really miss my Isentress/Truvada.  It's really hard for me to believe that this combo is better for a baby than Isentress, which is pretty much side-effect free. 

My doctor is very very cautious but she's also a real believer in Isentress.   I'm almost tempted to ask her to put me back on Isentress when I go back in for my appt. next month.
Tested positive on September 11, 2008

Offline Ann

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Re: Switched to Combivir, Reyataz and Norvir from Isentress andTruvada
« Reply #1 on: October 05, 2009, 09:04:44 AM »
Hi C,

It's likely to be the AZT component of the Combivir that is causing you problems, but unfortunately, AZT is what is recommended for use during pregnancy. It wouldn't be a good idea to go back on Truvada, because of the tenofovir component in it. Studies of tenofovir in monkeys show decreased fetal growth and fetal bone problems.

The boosted Reyataz is also recommended for use in pregnancy.

Do you really want to chance taking a drug (Isentress) that hasn't been approved for use during pregnancy? I know I wouldn't.

You can read more about hiv meds and pregnancy by clicking here.

Good luck getting pregnant, and I hope your side-effects diminish to a do-able point. You can always go back on Truvada and Isentress once you've given birth.

Ann
« Last Edit: October 05, 2009, 09:06:34 AM by Ann »
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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Sweet_C

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Re: Switched to Combivir, Reyataz and Norvir from Isentress andTruvada
« Reply #2 on: October 06, 2009, 09:12:16 PM »
Yeah, I know it's too much of a risk.  It's just so weird to me how Combivir is the safe drug and Isentress is the unsafe one when it has less side effects.

I think my body is starting to adjust though.
Tested positive on September 11, 2008

Online Miss Philicia

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Re: Switched to Combivir, Reyataz and Norvir from Isentress andTruvada
« Reply #3 on: October 06, 2009, 10:30:12 PM »
No, it's not weird if you consider that Isentress was only FDA approved a mere 22 months ago.  The presence of side effects for an adult show nothing in what it would do with a fetus, nor do the test for that stuff until years later anyway.
"Iíve slept with enough men to know that Iím not gay"

Offline elf

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Re: Switched to Combivir, Reyataz and Norvir from Isentress andTruvada
« Reply #4 on: October 07, 2009, 11:45:34 PM »
My current regimen (Kaletra+Combivir) is excellent for pregnancy.  ;D
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Offline elf

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Re: Switched to Combivir, Reyataz and Norvir from Isentress andTruvada
« Reply #5 on: October 07, 2009, 11:48:29 PM »
Yeah, I know it's too much of a risk.  It's just so weird to me how Combivir is the safe drug and Isentress is the unsafe one when it has less side effects.


Maybe because Combivir (and Kaletra) are better for HIV infection prevention?
They are used for PEP for example.


Combivir can block HIV that's out of a CD4 cell, running freely in your bloodstream.
Isentress blocks HIV that has already entered a CD4 cell...
« Last Edit: October 07, 2009, 11:53:29 PM by elf »
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Offline Sweet_C

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Re: Switched to Combivir, Reyataz and Norvir from Isentress andTruvada
« Reply #6 on: October 20, 2009, 05:38:01 PM »
Maybe because Combivir (and Kaletra) are better for HIV infection prevention?
They are used for PEP for example.


Combivir can block HIV that's out of a CD4 cell, running freely in your bloodstream.
Isentress blocks HIV that has already entered a CD4 cell...

Thanks, this does make sense. My side effects have gotten much better.  I feel like myself again.  I had gotten really spoiled with Isentress. 
Tested positive on September 11, 2008

Offline aztecan

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Re: Switched to Combivir, Reyataz and Norvir from Isentress andTruvada
« Reply #7 on: October 21, 2009, 11:43:15 PM »
Thanks, this does make sense. My side effects have gotten much better.  I feel like myself again.  I had gotten really spoiled with Isentress. 

I took Combivir for many years, the majority of which on an empty stomach because I also was taking Crixivan.

I found that eating something usually did away with the upset stomach. I was allowed food an hour after taking the particular dose (there were three in a day back then.) I found crackers or something salty was best for me, not sweets. But, everyone is different.

So, if the nausea persists, you might give taking it with food a try.

Just a thought.

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline Sweet_C

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Re: Switched to Combivir, Reyataz and Norvir from Isentress andTruvada
« Reply #8 on: November 05, 2009, 07:40:45 PM »
Thanks for the tip. :)
Tested positive on September 11, 2008

Offline Ann

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    • Num is sum qui mentiar tibi?
Re: Switched to Combivir, Reyataz and Norvir from Isentress andTruvada
« Reply #9 on: November 06, 2009, 08:14:03 AM »
Thanks, this does make sense. My side effects have gotten much better.  I feel like myself again.  I had gotten really spoiled with Isentress. 

That's good to hear, Sweet. (I don't know how I missed that post when you originally posted it) Having any luck with getting a bun in the oven? :)

Ann
Condoms are a girl's best friend

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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

 


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