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Author Topic: Truvada and Viramune....  (Read 2842 times)

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Offline skeebo1969

  • Member
  • Posts: 5,707
Truvada and Viramune....
« on: September 20, 2009, 06:50:40 PM »


   Our HIV doctor is switching my wife's combo from Zerit, Viread, and Viramune to Truvada and Viramune.  Was wondering if anyone here with experience on this combo could possibly share their experiences with it.  I've read some of the issues/side effects and Truvada seems to be the lesser of two evils where Zerit is concerned.  Am I right on this?  Our doctor seems to think she should stay on her current combo, but after reading some of the side effects from Zerit we became concerned.  That is when we started harping to the doctor about switching the combo.

   Her numbers are awesome on the Zerit, Viread, and Viramune combo, however from what I have read Zerit should not be one of the first choices given as a first ever prescribed combo..... her first HIV doctor prescribed this medicine to her in 2004 after she was initially diagnosed.

   Any thoughts, advice, and experiences would be greatly appreciated.

   Thomas
I despise the song Love is in the Air, you should too.

Offline Puckslinger

  • Member
  • Posts: 57
Re: Truvada and Viramune....
« Reply #1 on: September 20, 2009, 07:26:21 PM »
Hi Thomas,

I have had some experience with Zerit.

I took it for several years with Viramune , but I started to develop neuropathy  in my toes; and my doc blamed the Zerit, took me off of it, and the pain and tingling that had started in my toes never became an unbearable issue.

I take Truvada now, with Norvir and Reyataz; and it is the best combo I've ever taken. No diarrhea. No vomiting. No neuropathy. Nothing. Just high CD4count and undetectable viral load.

Wish I could tell you more about the switch; but I would guess that the new combo would be better than anything that included Zerit.

Zerit is also supposed to be rougher on the liver.

Good luck!

Michael
« Last Edit: September 20, 2009, 07:33:12 PM by Puckslinger »

Offline J.R.E.

  • Member
  • Posts: 7,276
  • Joined Dec-2003 Living positive, since 1985.
Re: Truvada and Viramune....
« Reply #2 on: September 20, 2009, 07:40:28 PM »
Tom,

I was started on Zerit, along with Viramune and epivir back in 2003.  The Zerit was dropped, within about 40 days for Ziagen. Thats the only experience I have with Zerit.

I would think however that the Truvada combination ( Emtriva and viread)  should be fine, unless of course you wife has issues with Emtriva ( she is already on viread)

Emtriva is very similar to Epivir.


Ray
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 25 mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


Diagnosed positive in 1985,.. In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started on  HAART on October 24th, 2003.

 As of 8/25/14,  t-cells are at 402, Viral load <40

 Current % is at 11%

  
 63 years young.

Offline skeebo1969

  • Member
  • Posts: 5,707
Re: Truvada and Viramune....
« Reply #3 on: September 24, 2009, 04:54:03 PM »


  I just read mpositive's post regarding  Truvada.  My wife is switching to it today, but will be taking Truvada along with Viramune.  Is this enough?  It seems like others I have read about who are taking Truvada are taking it with something else....  other than what she will be taking.

  Is our doctor advising her correctly in other words?
I despise the song Love is in the Air, you should too.

Offline Miss Philicia

  • Member
  • Posts: 24,506
  • celebrity poster, faker & poser
Re: Truvada and Viramune....
« Reply #4 on: September 24, 2009, 04:56:38 PM »

  I just read mpositive's post regarding  Truvada.  My wife is switching to it today, but will be taking Truvada along with Viramune.  Is this enough?  It seems like others I have read about who are taking Truvada are taking it with something else....  other than what she will be taking.

  Is our doctor advising her correctly in other words?

Generally yeah I think so -- it's a standard two NRTI (truvada is really two meds) plus one NNRTI regimen like Atripla.  My only caveat here is that if your wife was ever once on Sustiva then your doctor should have done a resistance test on her, because it's easy to become resistant to Viramune too if that happens (happened to me) but maybe she's never even been on Sustiva.
"Iíve slept with enough men to know that Iím not gay"

Offline Nashvegas

  • Member
  • Posts: 196
Re: Truvada and Viramune....
« Reply #5 on: September 24, 2009, 04:59:09 PM »
I'm on Truvada and Viramune, and I'm very happy with it.  No side effects whatsoever for me.  There's no need for an additiional medication, because Truvada is already a combo of two other meds.  Hopefully, you're wife will be as happy with the combo as I have been.  Keep us posted. 
8/12/06 - sero-conversion
9/14/06 -- Positive Test results confirmed
9/21/06 -- CD4 - 586; viral load 8,000; 29%
12/25/06 -- CD4 - 373; VL 2,800; 23%
2/10/07 - CD4 - 228; VL 865; 25%
3/15/07 -  CD4 - 365 (no viral load test)
5/1/07 = CD4 - 341; VL 4,358; 27%
8/1/07 - CD4 - 315; VL - 2,300; 25%
9/20/07 - CD4 - 378
11/22/07 - CD4 - 257; VL 7,300;
2/27/08 - CD4 231 (16.5 %), VL 5,960
5/20/08 - CD4 229 (18.3%), VL 11,100
6/17/08 - CD4 166 (14.5%), VL 9,030
6/17/08 - STARTED VIRAMUNE + TRUVADA
7/2/08 - CD4 272 (20%), VL 113  :-)
7/16/08 - CD4 -217 (21.1 %), VL - Undetectable
7/30/08 - CD4 - 220 (20.4%). VL - 92
8/14/08 - CD4 - 280 (22%) VL-undetectable
1/04/09 - CD4 - 250 (28%) VL-UD
5/15/09 - CD4 -393 (28%) VL-UD
8/15/09 - CD4-346, (26%) VL-UD
11/15/09 - CD4-373 (28%)

Offline Puckslinger

  • Member
  • Posts: 57
Re: Truvada and Viramune....
« Reply #6 on: September 24, 2009, 05:09:15 PM »
Hiya Thomas,

When I saw that you had brought your post back to the top of the board, I did a search about *Truvada and Viramune*. Here are the comments made about this combo in 2008. I hope this helps:

http://forums.poz.com/index.php?topic=21323.0

Offline bmancanfly

  • Member
  • Posts: 605
  • Medicare For All !
Re: Truvada and Viramune....
« Reply #7 on: September 24, 2009, 06:07:44 PM »
I've been on Truvada and Viramune once a day for 18 months.  Undetectable VL and zero side effects.

best of luck.
"The trouble with the world is that the stupid are cocksure and the intelligent are full of doubt."

 Bertrand Russell

Offline skeebo1969

  • Member
  • Posts: 5,707
Re: Truvada and Viramune....
« Reply #8 on: September 25, 2009, 06:16:33 AM »



   Thanks a lot everyone for the responses.  We are both very excited that she will finally be getting off the Zerit.  I would have never known about it being one of the least desired regimens to beging with if it had not been some of the experiences you all shared from it ; once again this was the one she was started on 5 years ago shortly after her diagnosis.

   Thanks again.  I'll keep everyone posted on her labs in 2 months.  Right not her Cd4's are 900+..

   Thomas
I despise the song Love is in the Air, you should too.

Offline gaz41

  • Member
  • Posts: 54
Re: Truvada and Viramune....
« Reply #9 on: September 27, 2009, 12:50:04 PM »
I've been taking viramune and truvada for 6 years now and have no problems 

Offline skeebo1969

  • Member
  • Posts: 5,707
Re: Truvada and Viramune....
« Reply #10 on: September 27, 2009, 01:13:32 PM »



    She took her first Truvada pill last night.  She said she woke up in the middle of the night to go to the bathroom and felt dizzy.  She remembers the first time I took Atripla and thinks it's one of those side effects that will go away in a couple of weeks. 

    She's really happy and her mother thinks I'm some kind of genius for pointing out the ills of Zerit.  Little does she know I have AM in my back pocket.  I love my mom-in-law anyways, she's always in my corner...lol
I despise the song Love is in the Air, you should too.

Offline Joe K

  • Global Moderator
  • Member
  • Posts: 3,877
  • 31 Years Poz
Re: Truvada and Viramune....
« Reply #11 on: September 27, 2009, 02:00:04 PM »
I have been on Viramune and Truvada for four years and it is the best cocktail I have ever been on.  Virtually no side effects and my CD4s keep climbing and I am undetectable.

Offline Desertguy

  • Member
  • Posts: 183
Re: Truvada and Viramune....
« Reply #12 on: September 28, 2009, 08:34:57 AM »
I'm on Truvada and Viramune for amost a year now,  and I'm very happy with it.  No side effects whatsoever for me.  There's no need for an additiional medication, because Truvada is already a combo of two other meds.  Hopefully, you're wife will be as happy with the combo as I have been.  Keep us posted. 

Offline skeebo1969

  • Member
  • Posts: 5,707
Re: Truvada and Viramune....
« Reply #13 on: September 28, 2009, 11:00:17 PM »


  My wife says the Truvada pill makes her tired after she takes it and she wakes up feeling dizzy.  Could this just be an initial side effect?  She also has had diarrhea since starting it.... Is there any dietary restrictions with the regimen?

  None of it so far seems debilitating in any way.  The two of us are just curious is all...
I despise the song Love is in the Air, you should too.

Offline Nashvegas

  • Member
  • Posts: 196
Re: Truvada and Viramune....
« Reply #14 on: September 28, 2009, 11:02:58 PM »
Hopefully, it's just a temporary side effect.  Not something that I've experienced at all.  Give it a couple of weeks and see how it goes...
8/12/06 - sero-conversion
9/14/06 -- Positive Test results confirmed
9/21/06 -- CD4 - 586; viral load 8,000; 29%
12/25/06 -- CD4 - 373; VL 2,800; 23%
2/10/07 - CD4 - 228; VL 865; 25%
3/15/07 -  CD4 - 365 (no viral load test)
5/1/07 = CD4 - 341; VL 4,358; 27%
8/1/07 - CD4 - 315; VL - 2,300; 25%
9/20/07 - CD4 - 378
11/22/07 - CD4 - 257; VL 7,300;
2/27/08 - CD4 231 (16.5 %), VL 5,960
5/20/08 - CD4 229 (18.3%), VL 11,100
6/17/08 - CD4 166 (14.5%), VL 9,030
6/17/08 - STARTED VIRAMUNE + TRUVADA
7/2/08 - CD4 272 (20%), VL 113  :-)
7/16/08 - CD4 -217 (21.1 %), VL - Undetectable
7/30/08 - CD4 - 220 (20.4%). VL - 92
8/14/08 - CD4 - 280 (22%) VL-undetectable
1/04/09 - CD4 - 250 (28%) VL-UD
5/15/09 - CD4 -393 (28%) VL-UD
8/15/09 - CD4-346, (26%) VL-UD
11/15/09 - CD4-373 (28%)

Offline joemutt

  • Member
  • Posts: 1,042
Re: Truvada and Viramune....
« Reply #15 on: September 29, 2009, 01:37:50 AM »
I hope the nausea and diarrhea your wife experiences will be gone quickly.
« Last Edit: September 29, 2009, 02:08:59 AM by joemutt »

Offline mmj520

  • Member
  • Posts: 23
Re: Truvada and Viramune....
« Reply #16 on: September 29, 2009, 12:05:43 PM »
Truvada / Viramune is my first combo, started in July 2007 with CD4 count in the mid 300s, 22%, 30,000 viral load.  Initially upon starting the medication, I developed a fever within 2 days and was extremely tired.  That cleared up within a week or so, and within a month my viral load was undetectable and there was a decent increase in CD4.   

2 years, 3 months later -- CD4 is in the mid 600s and 42%; undetectable (labs done 9/18/2009). The highest CD4 so far was 740, 43%.   

At my recent doctor visit, he commented that my response to the combo was better than he expected.

It is EXTREMELY encouraging to see the 6 year and 4 year successes mentioned above.  Thanks for sharing that gaz41 & killfoile.

The only possible side effect still affecting me personally is lack of appetite and occasional nausea.  I say possible side effect because I don't know if it's the Truvada/Viramune or the wellbutrin I take for depression.  During the times I've stopped the Wellbutrin, my mood drops and that affects appetite as well. 

Overall, I am very pleased with the combo of 3 pills daily.  I take the Viramune roughly 12 hours apart typically.  There are some nights I skip the second Viramune if my stomach is upset. 

Best of luck to your wife, Skeebo1969, as she adjusts to the new combo.

Offline skeebo1969

  • Member
  • Posts: 5,707
Re: Truvada and Viramune....
« Reply #17 on: September 29, 2009, 03:52:59 PM »


 
   We had an argument last night.  Have not had one of those in a very long time.  Is this a side effect?  I'm just joking though....  the argument was just me being a man of course...  and ummm, well her being a very tired woman who worked all day.

  Anyone care to guess what it was about?  If you read the cryptic words above I'm sure someone can guess correctly...

  Shame on me... :-[

  Thanks everyone for sharing your experiences. 
I despise the song Love is in the Air, you should too.

Offline Miss Philicia

  • Member
  • Posts: 24,506
  • celebrity poster, faker & poser
Re: Truvada and Viramune....
« Reply #18 on: September 29, 2009, 06:16:49 PM »

  My wife says the Truvada pill makes her tired after she takes it and she wakes up feeling dizzy.  Could this just be an initial side effect?

Isn't there a large yellow sticky label on the bottle stating that this med can cause dizzyness?  Mine does, though I don't get dizzy.
"Iíve slept with enough men to know that Iím not gay"

Offline skeebo1969

  • Member
  • Posts: 5,707
Re: Truvada and Viramune....
« Reply #19 on: September 29, 2009, 07:08:59 PM »
Isn't there a large yellow sticky label on the bottle stating that this med can cause dizzyness?  Mine does, though I don't get dizzy.

   I guess it would help if I read the stickers on the side of the bottle first.  You know me, laziness just exudes from my pores.  For arguements sake it's not yellow though, her's is red.  I think red is a much better color.
I despise the song Love is in the Air, you should too.

Offline tony_wdc20001

  • Member
  • Posts: 12
Re: Truvada and Viramune....
« Reply #20 on: September 29, 2009, 11:28:42 PM »
I am on Truvada and Viramune.  No side effects, although after the first two weeks when I had to start to double the dosage of viramune I started to have dizzy spells for the first three days.  The combination seems to be working because my CD4 jumped 50% and my VL went down from 40803 to 207.  I go in next week for second blood work since being on therapy (August 12, 2009) -- I hope they numbers do continue to improve.

The other side effect I had was when I increased Viramune to 2x day, it elevated by liver count numbers, so doctor is continuing to monitor it every two weeks.

Good luck
-------
05/08 - Tested negative (oral)
09/08 - Tested negative (blood)
02/09 - Flu-like symptoms
02/09 - Tested negative (blood)
07/09 - Tested positive (blood)
07/30/09 - CD4 147 (12%),  VL 40803
08/13/09 - Started Viramune/Truvada (1 tablet each 1x day)
08/23/09 - Increase Viramune (1 tablet 2x day)
09/09/09 - CD4 380 (22%), VL 207
10/05/09 - CD4 441 (24%), VL 90
10/27/09 - CD4 479 (26%), VL 111
12/16/09 - CD4 455 (31%), VL 50
02/24/10 - CD4 646 (32%), VL undetectable
06/14/10 - CD4 590 (30%), VL undetectable

 


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