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Author Topic: Understanding meds  (Read 994 times)

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Offline tommy246

  • member
  • Member
  • Posts: 435
Understanding meds
« on: September 17, 2009, 02:52:39 PM »
Would somebody be kind enough to break down the following haart regimens i think there are three types of med in each treatment nntdi,pi etc or something along those lines,thanks.
ATRIPLA
ISSENTRESS AND TRUVADA
REYATAZ ;NORVIR,TRUVADA
jan 06 neg
dec 08 pos cd4 505 ,16%, 1,500vl
april 09 cd4 635 ,16%,60,000
july 09 ,cd4 545,17%,80,000
aug 09,hosptal 18days pneumonia cd190,225,000,15%
1 week later cd4 415 20%
nov 09 cd4 591 ,vl 59,000,14%,started atripla
dec 09  cd4 787, vl 266, 16%
march 2010  cd4 720 vl non detectable -20  20%
june 2010  cd4  680, 21%, ND

Offline markaj

  • Member
  • Posts: 80
Re: Understanding meds
« Reply #1 on: September 17, 2009, 03:11:04 PM »
1. Efavirenz (NNRTI), Emtricitabine and Tenofovir (both NRTI)
2. Isentress (Integrase Inhibitor), Emtricitabine and Tenofovir (both NRTI)
3. Reyataz (PI), Norvir (another PI but low dose ) to boost the Reyataz, Emtricitabine and Tenofovir (both NRTI)
« Last Edit: September 17, 2009, 03:19:06 PM by markaj »
Infected Jan 08 / diagnosed Feb 08
Feb 08 - CD4 230 (9%) VL 3.5 million
Mar 08 - CD4 440 (6%) VL 660.000
Apr 08 - CD4 420 (11%) VL 3 million
Jun 08 - CD4 200 (7%) VL 3 million
Started Kaletra/Truvada Jul 08
Jul 08  - CD4 250 (14%) VL 23.893
Aug 08 - CD4 410 (15%)  VL 4.313
Switched to Sustiva/Truvada Aug 08
Switched to Reyataz/Norvir/Truvada Sep 08
Diagnosed with Hep C, HIV meds stopped for a bit
Nov 08 - CD4 414 (12%) VL 500.000+
Started Isentress/Truvada Nov 2008
Dec 08 - CD4 381 (17%) VL 1.116
Jan 09 - CD4 534 (20%) VL <50
Started Interferon/Ribavirin Jan 09
Feb 09 - CD4 407 (24%) VL <50
Mar 09 - CD4 360 (28%) VL <50
Apr 09 - CD4 279 (30%) VL <50
Jun 09 - CD4 298 (36%) VL <50
Aug 09 - CD4 303 (35%) VL <50

Offline tommy246

  • member
  • Member
  • Posts: 435
Re: Understanding meds
« Reply #2 on: September 17, 2009, 03:20:32 PM »
Wow thanks for the quick reply now without wanting to sound thick if i understand correctly truvada is part of the atripla regime? and what is integrase exactly and is it true the pi meds are generally the ones that give more lipid problems ,thanks.
jan 06 neg
dec 08 pos cd4 505 ,16%, 1,500vl
april 09 cd4 635 ,16%,60,000
july 09 ,cd4 545,17%,80,000
aug 09,hosptal 18days pneumonia cd190,225,000,15%
1 week later cd4 415 20%
nov 09 cd4 591 ,vl 59,000,14%,started atripla
dec 09  cd4 787, vl 266, 16%
march 2010  cd4 720 vl non detectable -20  20%
june 2010  cd4  680, 21%, ND

Offline BlueMoon

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  • Posts: 665
  • Calling from the Fun House
Re: Understanding meds
« Reply #3 on: September 17, 2009, 03:32:27 PM »
You are basically correct about the Truvada and PIs, and integrase has something to do with DNA.  It's pretty technical.

You can read all about it here.
...................VL.....CD4.....%
-----------------------------------------
08/10-- ......<40.....290.....42
05/10-- ......<48.....290.....46
02/10-- ......<48.....481.....44
10/09-- ......<48.....277.....46
07/09-- ......<48.....300.....38
05/09-- ........51.....449.....39
03/09-- Added Isentress
02/09-- ........65.....299.....34
11/08-- ........62.....242.....40
08/08-- ........66.....212.....29
05/08-- ......202.....217.....27
03/08-- ....5210.....187.....21
02/08-- Began Truvada/Reyataz/Norvir
12/07-- 273,000.....157.....22
11/07-- 229,000.....209.....22
10/07-- Diagnosis

It's a complex world.

Offline markaj

  • Member
  • Posts: 80
Re: Understanding meds
« Reply #4 on: September 17, 2009, 03:49:17 PM »
Yes Truvada is 2 of the 3 drugs in Atripla.

HIV has a complex life cycle that involves several steps.  HAART drugs target different steps of this life cycle.

These are the main ones:  

Entry inhibitors
NRTI's
NNRTI's
Integrase inhibitors
Protease inhibitors

So Isentress as an Integrase inhibitor targets the integrase step.  It's very complicated science which I'm not qualified to explain but I'm sure somebody else will dip in with that  :)

PI's can cause lipid elevation issues, but on HAART your bloods will be getting monitored to keep on top of any issue that may crop up in time.
Infected Jan 08 / diagnosed Feb 08
Feb 08 - CD4 230 (9%) VL 3.5 million
Mar 08 - CD4 440 (6%) VL 660.000
Apr 08 - CD4 420 (11%) VL 3 million
Jun 08 - CD4 200 (7%) VL 3 million
Started Kaletra/Truvada Jul 08
Jul 08  - CD4 250 (14%) VL 23.893
Aug 08 - CD4 410 (15%)  VL 4.313
Switched to Sustiva/Truvada Aug 08
Switched to Reyataz/Norvir/Truvada Sep 08
Diagnosed with Hep C, HIV meds stopped for a bit
Nov 08 - CD4 414 (12%) VL 500.000+
Started Isentress/Truvada Nov 2008
Dec 08 - CD4 381 (17%) VL 1.116
Jan 09 - CD4 534 (20%) VL <50
Started Interferon/Ribavirin Jan 09
Feb 09 - CD4 407 (24%) VL <50
Mar 09 - CD4 360 (28%) VL <50
Apr 09 - CD4 279 (30%) VL <50
Jun 09 - CD4 298 (36%) VL <50
Aug 09 - CD4 303 (35%) VL <50

Offline newt

  • Member
  • Posts: 3,885
  • the one and original newt
Re: Understanding meds
« Reply #5 on: September 17, 2009, 04:43:10 PM »
Picture

- matt


[attachment deleted by admin]
"The object is to be a well patient, not a good patient"

 


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