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Author Topic: Sudhir Paul, Ph.D. UpDate  (Read 23762 times)

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Offline tatosao24

  • Member
  • Posts: 7
Re: Sudhir Paul, Ph.D. UpDate
« Reply #50 on: May 11, 2012, 12:33:59 AM »
This fund rasing started in Dec 2011. Is for human trials. Previus raising was for pre clinical studies which have already taken place and this allows ARF to go foward to human trials.

Anyone else knows anything else about this?

Offline Cosmicdancer

  • Member
  • Posts: 150
Re: Sudhir Paul, Ph.D. UpDate
« Reply #51 on: February 07, 2013, 09:30:27 PM »
I'm not sure if there's another thread re: abzyme research, but here's the thread I found, even though no one has posted anything in it in over 8 months.  I got an email yesterday from the Abzyme Research Foundation because I made a donation towards their $50,000 goal.  Here's what it said.

"I am thrilled to report that we hit our initial $50,000 goal!  Over 375 donors  came together to make our first presentation to the Federal Drug Administration (FDA) possible. I am incredibly thankful for your support, and very excited to take our first step towards receiving FDA approval for a new HIV/AIDS vaccine.
 
These funds will be used to employ Dr. Ellen Cooper as our chief FDA Regulatory Adviser. ARF is honored to work with such a prominent and respected figure in the field of HIV clinical studies.

Dr. Cooper is a graduate of Case Western (M.D.) and Johns Hopkins (M.P.H.), and her incredible achievements include:
·       Founding Director, Division of Antiviral Drug Products at the FDA (’88)
·       Vice President and Director, Department of Clinical Research and Information at AmFAR, and Chair, (’91-’93)
·       Chair, Therapeutics Coordinating Committee of the Office of AIDS Research at the National Institute of Health.  (’93-’96)
 
In short, we believe there isn’t anyone more qualified to lead an innovative new therapeutic vaccine through the complicated process of FDA approval for testing in humans.

Thanks for supporting us!  This year we tackle the FDA, next year a human trial!

All my best,
 
Zachary Barnett
Founder, Executive Director
Abzyme Research Foundation"
Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
June, 2008 - undetectable, 612 cd4
January, 2009 - undetectable, 670 cd4
May, 2009 - undetectable, 593 cd4
Sept, 2009 - 83 vl, 763 cd4, 34%
Dec, 2009 - undetectable, 889 cd4, 32%
April, 2010 - undetectable, 860 cd4, 31%
October, 2010 - undetectable, 800 cd4, 38%
April, 2011 - undetectable, t-cell test not done
October, 2011 - undetectable
April, 2012 - undetectable, 850 cd4, 39%
November, 2012 - undetectable, 901 cd4, 41%
April, 2013 - undetectable, 846 cd4, 36%
October, 2013 - undetectable
May, 2014 - undetectable, 784 cd4, 48%

Offline Matts

  • Member
  • Posts: 209
Re: Sudhir Paul, Ph.D. UpDate
« Reply #52 on: February 08, 2013, 06:04:45 PM »
Thank you for making a donation:)

will this work against latent cells?
« Last Edit: February 08, 2013, 06:59:51 PM by Matts »
tivicay/kivexa

Offline Cosmicdancer

  • Member
  • Posts: 150
Re: Sudhir Paul, Ph.D. UpDate
« Reply #53 on: February 09, 2013, 11:31:05 AM »
This is a "covalent vaccine" that produces antibodies or "enzymatic abzymes" that target a coat protein on HIV called gp120.  It's a region of HIV that does not mutate, so it is considered an achilles heel of HIV.  I don't know if the vaccine targets latent cells infected with HIV, but if the vaccine works in humans, the memory B-cells would bind to this region and destroy any active HIV before it infected new cells and ultimately eradicate the infection.  It has induced protective antibodies in mice, rabbits and rhesus monkeys according to the Abzyme Research Foundation. 

http://abzymeresearchfoundation.org/science/whats-an-abzyme/

http://abzymeresearchfoundation.org/science/immunotherapy-prophlaxis/

If you enlarge the text in this link, you can see the data from studies in monkeys.
http://www.uth.tmc.edu/pathology/research/circ/documents/PlanqueAIDS2012_poster.pdf
Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
June, 2008 - undetectable, 612 cd4
January, 2009 - undetectable, 670 cd4
May, 2009 - undetectable, 593 cd4
Sept, 2009 - 83 vl, 763 cd4, 34%
Dec, 2009 - undetectable, 889 cd4, 32%
April, 2010 - undetectable, 860 cd4, 31%
October, 2010 - undetectable, 800 cd4, 38%
April, 2011 - undetectable, t-cell test not done
October, 2011 - undetectable
April, 2012 - undetectable, 850 cd4, 39%
November, 2012 - undetectable, 901 cd4, 41%
April, 2013 - undetectable, 846 cd4, 36%
October, 2013 - undetectable
May, 2014 - undetectable, 784 cd4, 48%

Offline Mishma

  • Member
  • Posts: 190
    • Marquis de Vauban
Re: Sudhir Paul, Ph.D. UpDate
« Reply #54 on: February 22, 2013, 12:23:32 PM »
Cosmicdancer: Thanks for the links.

As a free monoclonal catalytic antibody, to my mind, would not have any effect on latently infected cells as they do not express/secrete viral particles until activated.

Since they are produced artificially outside the body they would not have any physical association with the host B cells and thus could not lead to memory cells expressing the catalytic antibody. 

But by altering the the structure of the HIV envelope gp120 they would allow access to other naturally occurring antibodies reactive to newly uncovered regions (epitopes) of the viral membrane. Binding of these, plus additional signals from other cells, of the immune system would allow those reactive B Cells cells to differentiate into activated B-Cells which in turn would become either memory B cells or antibody secreting plasma cells.

I haven't found anything about the half-life of these Mabs, perhaps others here have that answer.

2016 CD4 25% UD (less than 20). 27+ years positive. Isentress, Truvada, Acyclovir, Clonazepam, Zolpidem, Bupropion, Lisinopril, Pravastatin, Quetiapine, Doxcycline, Testosterone, Suatriptan/Naproxen, Restasis, Dorzolamide, Latanoprost, Asprin, lortab, Levothyroxine, Fioricet, Restasis, Triamclinolone, Nitrostat.

Offline harleymc

  • Member
  • Posts: 201
Re: Sudhir Paul, Ph.D. UpDate
« Reply #55 on: February 25, 2013, 08:05:00 AM »
Hate to burst the bubble but...
 I was on a phase II trial of a therapeutic vacine that targeted the same protein during the first half of the 1990's. Big fat zero effect.

Just because people rave on about conspiracies doesn't make the study any more likely to succeed. Save your money.


Offline sam66

  • Member
  • Posts: 277
  • Keep The Faith ; Fight The Fight
Re: Sudhir Paul, Ph.D. UpDate
« Reply #56 on: February 28, 2013, 11:51:34 PM »

 
Hate to burst the bubble but...
 I was on a phase II trial of a therapeutic vacine that targeted the same protein during the first half of the 1990's. Big fat zero effect.

Just because people rave on about conspiracies doesn't make the study any more likely to succeed. Save your money.



   Most will fail few will succeed, doesn't mean you shouldn't try  :'( stupid attitude
december 2007 diagnosed +ve ,

 


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