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Author Topic: chance for treatment breaks  (Read 3943 times)

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Offline sam66

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chance for treatment breaks
« on: August 21, 2009, 10:26:11 AM »

   hi
        has anyone seen this, anybody got any more onfo.

    http://news.bbc.co.uk/1/hi/health/7541735.stm
december 2007 diagnosed +ve ,

Offline Inchlingblue

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Re: chance for treatment breaks
« Reply #1 on: August 21, 2009, 11:36:29 AM »
This product is very promising. It's been discussed here before, if you do a search with the word "bionor" several threads come up. There is an ongoing clinical trial too.

LINKS:

http://www.bionorimmuno.com/news2009_Bachem.html

http://clinicaltrials.gov/ct2/show/NCT00659789

Offline J220

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Re: chance for treatment breaks
« Reply #2 on: August 21, 2009, 11:53:16 AM »
What I don't know from the data is if the patients have to go back on ARV after the vaccine wears off, or can they just get another shot for another arv-free period. If it does work like the latter, a treatment constisting of a periodic shot, even if it's once a year would be just fantastic. Hey, I would even go for a once a month shot, no problem. But the 34 months average seems to indicate a much longer period, so that is just amazing.
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline sam66

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Re: chance for treatment breaks
« Reply #3 on: August 21, 2009, 12:31:12 PM »
 thanks for the links,

I agree, that's exactly what I'm thinking, even if we have to take a shot once a month, that would be no bad thing. But there may be a limit to how many times we can boost the immune system.
       i think may be this shows the best promise out of all the recent so called "break through" it's a novel approach and it's in phase iii  trials.
december 2007 diagnosed +ve ,

Offline Inchlingblue

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Re: chance for treatment breaks
« Reply #4 on: August 21, 2009, 01:07:17 PM »
.
« Last Edit: August 21, 2009, 01:25:32 PM by Inchlingblue »

Offline TheRoof

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Re: chance for treatment breaks
« Reply #5 on: August 21, 2009, 07:46:19 PM »
Interesting stuff.

Offline sam66

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Re: chance for treatment breaks
« Reply #6 on: August 23, 2009, 11:06:34 AM »
december 2007 diagnosed +ve ,

Offline moskimo

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Re: chance for treatment breaks
« Reply #7 on: August 24, 2009, 05:24:25 AM »
this is wonderful,any latest update on this vaccine trial please tell me.

Offline sam66

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Re: chance for treatment breaks
« Reply #8 on: August 24, 2009, 06:55:47 AM »
 
    This vaccine (vacc 4x ) is currently in Phase III of clinical trails; so pretty much the last hurdle to clear.
     Let's hope it manages to clear it.
     Results are due at the end of this year (2009) only a few months to go, hopefully it will not fall at the last hurdle.
     
      this link will give you a good overview on drug trials in UK       
http://news.bbc.co.uk/1/hi/health/4808090.stm

      this is the link to Bionor Immuno the company that's developing the vaccine

     http://www.bionorimmuno.com/pipeline.html
december 2007 diagnosed +ve ,

Offline Inchlingblue

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Re: chance for treatment breaks
« Reply #9 on: August 24, 2009, 11:38:48 AM »
I didn't realize that Bionor Immuno also has other HIV vaccines in the pipeline. The link you gave mentions Vacc-5q:

Bionor Immuno's second therapeutic vaccine candidate Vacc-5q has completed a phase I/II (safety)study at Ullevål University Hospital in Oslo, Norway. Twenty patients were enrolled where 10 were receiving combination ART and 10 were not on combination ART. Vacc-5q was been found to be
safe, well tolerated and immunogenic in both patient groups (Kvale et al, 2006).


It also has another section under development called "HIV 2nd Generation" about to enter Phase I

That's promising.

Results are due at the end of this year (2009) only a few months to go, hopefully it will not fall at the last hurdle.

Where did you read this? According to clinicaltrials.gov:

Estimated Study Completion Date:   July 2010

LINK:

http://clinicaltrials.gov/ct2/show/NCT00659789?term=vacc-4x&rank=1
« Last Edit: August 24, 2009, 11:53:13 AM by Inchlingblue »

Offline sam66

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Re: chance for treatment breaks
« Reply #10 on: August 24, 2009, 01:44:47 PM »
 
   yes they have a second vaccine (vacc-5q ) which is in phaseI/II
   I think the work they are doing is great, because it appires to be real alternative HARRT, and the daily
   medication also lts nearly at the end of phaseIII.

   As for "results are due end of 2009" I was quoting from a BBC news report on this link :

     http://news.bbc.co.uk/1/hi/health/7541735.stm

     I believe this is still correct, results should in from all the test centres by the end of 2009.
     Then will begin Analysis of the Test Data , which strictly speaking is not testing.

      You are correct analysis of all data and the completion of Phase III is expected to be mid 2010.

        If everything is ok, I hope it will be fast-tracked and available may be within 2 years 
       
       please correct me on any wrong facts and figures I may have given.
       
december 2007 diagnosed +ve ,

Offline sensual1973

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Re: chance for treatment breaks
« Reply #11 on: August 24, 2009, 02:12:43 PM »
somethiing benificial should come out from all those studies atleast,well soon i hope,its about time since the discovery of HAART in the mid 90s.
God grant me the serenity to accept the things i can not change.

Offline xman

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Re: chance for treatment breaks
« Reply #12 on: September 01, 2009, 04:05:48 PM »
somethiing benificial should come out from all those studies atleast,well soon i hope,its about time since the discovery of HAART in the mid 90s.

I received an email today from Bionor Immuno stating that they will begin phase III trials in a couple of years and that availability of the vaccine, if ever, will require several years. So I guess we have to wait at least until 2016.

I prefer having reliable informations directly from the source instead of self interpretations and predictions.
« Last Edit: September 01, 2009, 04:10:44 PM by xman »
sign the petition launched by the aids policy project addressed to the nih aimed to increase the money needed to find the cure:

http://www.aidspolicyproject.org/petition_for_the_nih

we can make a difference and we need to fight. please support them! it doesn't cost you anything. they need it now more than ever!

Offline elf

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Re: chance for treatment breaks
« Reply #13 on: September 02, 2009, 10:32:30 AM »
That vaccine should help traveling.  :D
Let's have a Kiki!

 


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